DK3336097T3 - Fremstilling af ikke-krystallinsk obeticholsyre - Google Patents

Fremstilling af ikke-krystallinsk obeticholsyre Download PDF

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Publication number
DK3336097T3
DK3336097T3 DK17202916.7T DK17202916T DK3336097T3 DK 3336097 T3 DK3336097 T3 DK 3336097T3 DK 17202916 T DK17202916 T DK 17202916T DK 3336097 T3 DK3336097 T3 DK 3336097T3
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DK
Denmark
Prior art keywords
preparation
obeticholic acid
crystalline obeticholic
crystalline
acid
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DK17202916.7T
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English (en)
Inventor
André Steiner
Poulsen Heidi Waenerlund
Emilie Jolibois
Ralf Gross
Emma Sharp
Fiona Dubas-Fisher
Alex Eberlin
Melissa Rewolinski
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Intercept Pharmaceuticals Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48741553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3336097(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
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Publication of DK3336097T3 publication Critical patent/DK3336097T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
DK17202916.7T 2012-06-19 2013-06-17 Fremstilling af ikke-krystallinsk obeticholsyre DK3336097T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661531P 2012-06-19 2012-06-19
EP13733181.5A EP2861613A1 (en) 2012-06-19 2013-06-17 Preparation, uses and solid forms of obeticholic acid

Publications (1)

Publication Number Publication Date
DK3336097T3 true DK3336097T3 (da) 2020-09-28

Family

ID=48741553

Family Applications (1)

Application Number Title Priority Date Filing Date
DK17202916.7T DK3336097T3 (da) 2012-06-19 2013-06-17 Fremstilling af ikke-krystallinsk obeticholsyre

Country Status (25)

Country Link
US (8) US9238673B2 (da)
EP (4) EP2861613A1 (da)
JP (6) JP2015521621A (da)
KR (4) KR20190121871A (da)
CN (2) CN111228278A (da)
AU (5) AU2013277429B2 (da)
BR (2) BR112014031828B1 (da)
CA (3) CA3047776C (da)
CL (2) CL2014003475A1 (da)
CO (1) CO7240414A2 (da)
DK (1) DK3336097T3 (da)
EA (2) EA201990211A1 (da)
ES (1) ES2822375T3 (da)
HK (1) HK1211296A1 (da)
IL (3) IL236231A0 (da)
IN (1) IN2014MN02561A (da)
MX (2) MX365059B (da)
NZ (3) NZ734451A (da)
PH (1) PH12014502835A1 (da)
PL (1) PL3336097T3 (da)
PT (1) PT3336097T (da)
SG (3) SG10201610434YA (da)
SI (1) SI3336097T1 (da)
TW (1) TWI673284B (da)
WO (1) WO2013192097A1 (da)

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* Cited by examiner, † Cited by third party
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BR112014031828A2 (pt) 2021-07-06
IL236231A0 (en) 2015-02-01
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SG10201610434YA (en) 2017-02-27
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WO2013192097A1 (en) 2013-12-27
JP2018184443A (ja) 2018-11-22
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US20170226149A1 (en) 2017-08-10
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AU2013277429A1 (en) 2015-01-22
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MX2019005819A (es) 2019-10-21
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JP2020125317A (ja) 2020-08-20
IN2014MN02561A (da) 2015-09-04
HK1211296A1 (en) 2016-05-20
KR20190121871A (ko) 2019-10-28
PT3336097T (pt) 2020-10-29
US10155787B2 (en) 2018-12-18
AU2016200832B2 (en) 2017-05-18
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MX2014016062A (es) 2015-07-17
EA032347B1 (ru) 2019-05-31
SG11201408501UA (en) 2015-01-29
US20160074419A1 (en) 2016-03-17
NZ719360A (en) 2017-08-25
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US10047117B2 (en) 2018-08-14
MX365059B (es) 2019-05-22

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