DK2326302T3 - Hyaluronsyre-baserede geler, der indbefatter lidocainhydrochlorid - Google Patents

Hyaluronsyre-baserede geler, der indbefatter lidocainhydrochlorid Download PDF

Info

Publication number
DK2326302T3
DK2326302T3 DK09785850.0T DK09785850T DK2326302T3 DK 2326302 T3 DK2326302 T3 DK 2326302T3 DK 09785850 T DK09785850 T DK 09785850T DK 2326302 T3 DK2326302 T3 DK 2326302T3
Authority
DK
Denmark
Prior art keywords
lidocaine
gel
crosslinked
hyaluronic acid
composition
Prior art date
Application number
DK09785850.0T
Other languages
English (en)
Inventor
Pierre Lebreton
Original Assignee
Allergan Ind Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41608613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2326302(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allergan Ind Sas filed Critical Allergan Ind Sas
Application granted granted Critical
Publication of DK2326302T3 publication Critical patent/DK2326302T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0029—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Fremgangsmåde til fremstilling af en sammensætning til udfyldning af blødt væv, hvilken fremgangsmåde omfatter trinnene med: tilvejebringelse af en hyaluronsyrebestanddel, der er tværbundet med mindst én tværbindingsmiddel udvalgt fra gruppen bestående af 1,4-butandioldiglycidylether (BDDE), l,2-bis(2,3-epoxypropoxy)ethylen og 1-(2,3-epoxypropyl)-2,3-epoxycyclohexan, eller kombinationer deraf; hvor hyaluronsyrebestanddelen omfatter mere end 10 % ikke-tværbundet hyaluronsyre i volumen; tilpasning af hyaluronsyrebestanddelens pH til et tilpasset pH på over 7,2; og tilsætning af en opløsning, der indeholder mindst ét anæstetisk middel til hyaluronsyrebestanddelen, der har det tilpassede pH for at opnå en hyaluronsyrebaseret sammensætning til udfyldning af blødt væv, hvor mindst det ene anæstetiske middel er lidocain HCI.
2. Fremgangsmåde ifølge krav 1, hvor hyaluronsyrebestanddelen omfatter mindst 20 % ikke-tværbundet hyaluronsyre i volumen.
DK09785850.0T 2008-08-04 2009-03-02 Hyaluronsyre-baserede geler, der indbefatter lidocainhydrochlorid DK2326302T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US8595608P 2008-08-04 2008-08-04
US8793408P 2008-08-11 2008-08-11
US9627808P 2008-09-11 2008-09-11
US12/393,768 US8450475B2 (en) 2008-08-04 2009-02-26 Hyaluronic acid-based gels including lidocaine
US12/393,884 US8357795B2 (en) 2008-08-04 2009-02-26 Hyaluronic acid-based gels including lidocaine
PCT/IB2009/005046 WO2010015900A1 (en) 2008-08-04 2009-03-02 Hyaluronic acid-based gels including anesthetic agents

Publications (1)

Publication Number Publication Date
DK2326302T3 true DK2326302T3 (da) 2016-11-14

Family

ID=41608613

Family Applications (3)

Application Number Title Priority Date Filing Date
DK09785852.6T DK2323617T3 (da) 2008-08-04 2009-03-02 Hyaluronsyrebaserede geler indbefattende anæstætiske midler
DK09785850.0T DK2326302T3 (da) 2008-08-04 2009-03-02 Hyaluronsyre-baserede geler, der indbefatter lidocainhydrochlorid
DK13004017.3T DK2674147T3 (da) 2008-08-04 2009-03-02 Fremgangsmåde til fremstilling af en hyaluronsyre-baseret gel, som inkluderer lidocain HCl.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09785852.6T DK2323617T3 (da) 2008-08-04 2009-03-02 Hyaluronsyrebaserede geler indbefattende anæstætiske midler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13004017.3T DK2674147T3 (da) 2008-08-04 2009-03-02 Fremgangsmåde til fremstilling af en hyaluronsyre-baseret gel, som inkluderer lidocain HCl.

Country Status (20)

Country Link
US (22) US8357795B2 (da)
EP (6) EP3205332A1 (da)
JP (5) JP5670900B2 (da)
KR (2) KR101672562B1 (da)
CN (3) CN103285423B (da)
AU (2) AU2009278883B2 (da)
BR (3) BRPI0917588A2 (da)
CA (6) CA2732928A1 (da)
CY (2) CY1118281T1 (da)
DK (3) DK2323617T3 (da)
ES (3) ES2599763T3 (da)
HK (2) HK1156883A1 (da)
HU (3) HUE048366T2 (da)
MX (3) MX2011001322A (da)
PL (3) PL2674147T3 (da)
PT (2) PT2326302T (da)
RU (2) RU2496473C2 (da)
SG (2) SG10202104803SA (da)
SI (2) SI2323617T1 (da)
WO (2) WO2010015900A1 (da)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
US20050226936A1 (en) 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
US20080293637A1 (en) * 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
US20110077737A1 (en) * 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US20120071437A1 (en) 2007-07-30 2012-03-22 Allergan, Inc. Tunable crosslinked polysaccharide compositions
US8318695B2 (en) * 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
SI2818184T1 (sl) 2007-11-16 2019-03-29 Aclaris Therapeutics, Inc. Sestava in postopki za zdravljenje purpure
US20090143348A1 (en) * 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394782B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8394784B2 (en) * 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US20130102563A1 (en) * 2008-08-04 2013-04-25 Allergan, Inc. Dermal filler with lidocaine
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
EP3184552B1 (en) 2008-09-02 2020-08-12 Tautona Group LP Threads of hyaluronic acid, methods of making thereof and uses thereof
BRPI0922629A2 (pt) 2008-12-02 2016-01-05 Allergan Inc dispositivo de injeção
IT1395392B1 (it) * 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110171310A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use
US20110171286A1 (en) * 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171311A1 (en) * 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
AU2015234293B2 (en) * 2010-01-13 2017-04-27 Allergan Industrie Sas Stable hydrogel compositions including additives
JP5749283B2 (ja) 2010-03-12 2015-07-15 アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｉｎｄｕｓｔｒｉｅ Ｓａｓ 皮膚状態を改善するための流体組成物
DK3078388T3 (da) 2010-03-22 2019-05-20 Allergan Inc Tværbundne hydrogeler til blødvævsforøgelse
WO2012008722A2 (ko) * 2010-07-12 2012-01-19 신풍제약 주식회사 조직 증강용 충전 조성물
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
HUE034824T2 (en) * 2010-11-08 2018-03-28 Allergan Ind Sas Hyaluronic acid-based preparations
EP3818993A1 (en) * 2010-11-08 2021-05-12 Allergan Industrie, SAS Soft tissue filler
FR2968305B1 (fr) 2010-12-06 2014-02-28 Teoxane Procede de preparation d'un gel reticule
KR20140049964A (ko) * 2011-01-06 2014-04-28 씨. 로웰 파슨즈 국부 마취제, 헤파리노이드 및 버퍼를 포함하는 조성물의 제조 방법
AU2012205418B2 (en) * 2011-01-13 2015-03-26 Allergan Industrie, Sas Stable hydrogel compositions including additives
EP2484387A1 (en) * 2011-02-03 2012-08-08 Q-Med AB Hyaluronic acid composition
KR102073027B1 (ko) * 2011-04-05 2020-02-04 삼성전자 주식회사 반송파 집적 기술을 사용하는 무선통신시스템에서 복수 개의 타임 정렬 타이머 운용 방법 및 장치
EP2675491A2 (en) 2011-02-17 2013-12-25 Allergan, Inc. Compositions and improved soft tissue replacement methods
EP2606828B1 (en) * 2011-12-20 2018-04-11 Angioclinic AG Hyaluronic acid and its use for treating venous insufficiency and varicose veins
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
CN107412002A (zh) 2011-06-03 2017-12-01 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
RU2613887C2 (ru) * 2011-08-10 2017-03-21 Гликорес 2000 С.Р.Л. Устойчивый к расщеплению сшитый низкомолекулярный гиалуронат
EP3590495A1 (en) 2011-08-25 2020-01-08 Allergan, Inc. Dermal filler compositions including antioxidants
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
CN104105474B (zh) 2011-09-14 2018-04-06 阿勒根公司 用于细纹治疗的真皮填充剂组合物
ES2823148T3 (es) * 2011-10-11 2021-05-06 Allergan Holdings France S A S Hebras de ácido hialurónico reticulado y métodos de uso de las mismas
EP2581079B1 (en) * 2011-10-11 2016-12-07 BioPolymer GmbH & Co. KG Combination of hyaluronic acid and prilocaine
DK2787959T3 (da) 2011-12-08 2020-09-21 Allergan Ind Sas Dermale fyldstofsammensætninger
CN102552974A (zh) * 2012-02-17 2012-07-11 上海白衣缘生物工程有限公司 皮肤注射填充用凝胶组合物及其制备
BR112014031412B1 (pt) * 2012-06-15 2021-01-05 Merz Pharma Gmbh & Co. Kgaa método de preparação de uma composição
TR201802330T4 (tr) 2012-07-18 2018-03-21 Allergan Ind Sas Piruvat içeren hiyalüronik asit formülasyonu.
CH705713B1 (de) * 2012-09-21 2013-05-15 Labo Cosprophar Ag Dermokosmetische Zusammensetzung zur topischen Anwendung.
AU2013327489B2 (en) 2012-10-02 2018-01-04 Allergan, Inc. Dermal filler hydrogels with vitamin A/cyclodextrin inclusion complexes
WO2014055895A1 (en) 2012-10-05 2014-04-10 Allergan, Inc. Injectable device and method for sculpting, augmenting or correcting facial features such as the chin
US20140124514A1 (en) * 2012-11-08 2014-05-08 Onpharma, Inc. Method and apparatus for adding buffers and other substances to medical cartridges
PL2945612T3 (pl) 2013-01-17 2024-07-01 Damian NAQVI Zwiększanie objętości mięśni u człowieka przy zastosowaniu kwasu hialuronowego
AU2014254472A1 (en) * 2013-01-28 2015-08-20 Urigen Pharmaceuticals, Inc. Stable compositions comprising heparinoid, acute-acting anesthetic, and buffer
EP3995109A1 (en) 2013-03-08 2022-05-11 Ultradent Products, Inc. Wax-based compositions, articles made therefrom, and methods of manufacture and use
FR3006689A1 (fr) * 2013-06-11 2014-12-12 Benedicte Vincente Tauzin Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu
CN104225677B (zh) * 2013-06-13 2016-09-21 山东省生物药物研究院 交联透明质酸细胞支架材料及其制备方法和应用
MX2015017273A (es) * 2013-06-14 2016-08-03 Galderma Sa Composiciones que comprenden acido hialuronico reticulado y ciclodextrina.
WO2015005345A1 (ja) * 2013-07-08 2015-01-15 電気化学工業株式会社 コアシェル型架橋ヒアルロン酸ゲル粒子、その製造方法及び医用材料
US9421198B2 (en) 2013-07-30 2016-08-23 Teoxane Composition comprising hyaluronic acid and mepivacaine
EP3049055B1 (en) * 2013-09-27 2018-04-25 Anteis S.A. Method for obtaining an injectable hydrogel based on hyaluronic acid containing lidocaine added in powder form, and an alkaline agent, sterilized with heat
EP3052529B1 (en) 2013-09-30 2017-10-04 Galderma S.A. Single-step functionalization and cross-linking of hyaluronic acid
JP6877139B2 (ja) 2013-10-11 2021-05-26 ウルトラデント プロダクツ インコーポレイテッド ワックスを基剤とした組成物、それから作製される物品、ならびに、製造および使用の方法
KR102133526B1 (ko) * 2013-10-31 2020-07-13 삼성전자주식회사 USB 어플리케이션 데이터의 QoS를 고려한 무선 전송 지원 기법
WO2015073919A1 (en) * 2013-11-14 2015-05-21 University Medical Pharmaceuticals Corporation Microneedles for therapeutic agent delivery with improved mechanical properties
FR3015290B1 (fr) * 2013-12-23 2017-01-13 Lab Vivacy Compositions d'acide hyaluronique compreant de la mepivacaine
WO2015112907A1 (en) * 2014-01-27 2015-07-30 Allergan Holdings France S.A.S. Spherical forms of cross-linked hyaluronic acid and methods of use thereof
AR099900A1 (es) * 2014-04-01 2016-08-24 Merz Pharma Gmbh & Co Kgaa Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso
AU2015240385B2 (en) 2014-04-01 2019-02-28 Klox Technologies Inc. Tissue filler compositions and methods of use
WO2015149946A1 (en) * 2014-04-02 2015-10-08 Merz Pharma Gmbh & Co. Kgaa In vivo degradation of polysaccharide-containing fillers
WO2015164533A1 (en) * 2014-04-22 2015-10-29 Allergan, Inc. Dry dermal filler compositions and methods of reconstitution
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016057607A1 (en) * 2014-10-08 2016-04-14 Therakine Micronized hydrophilic cross-linked biopolymer systems and method of making same
US20180265652A1 (en) * 2014-10-08 2018-09-20 Therakine Biodelivery Gmbh Cross-linked biopolymer macroscopic systems and method of making same
TWI716365B (zh) * 2014-11-13 2021-01-21 德商梅茲製藥有限兩合公司 注射型真皮填充劑組合物及其套組、製備方法、與使用
EP3226835A4 (en) 2014-12-02 2018-09-26 Silk Therapeutics, Inc. Silk performance apparel and products and methods of preparing the same
FR3029928B1 (fr) 2014-12-15 2018-03-09 Teoxane Gel reticule
JP2018505726A (ja) * 2015-01-16 2018-03-01 スピネオベイションズ・インコーポレーテッド 脊椎円板を処置する方法
CN105878051B (zh) * 2015-01-26 2019-02-26 华熙福瑞达生物医药有限公司 蜂巢状透明质酸及其制备方法
AU2016211457B2 (en) 2015-01-28 2020-05-21 Allergan, Inc. Joint fat pad formulations, and methods of use thereof
WO2016128783A1 (en) * 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
WO2016132167A1 (en) * 2015-02-16 2016-08-25 Allergan Industrie, Sas Implants for sculpting, augmenting or correcting facial features such as the chin
CN107207784B (zh) * 2015-02-13 2022-08-23 (株)安道德玛 利用交联透明质酸水凝胶的微结构体及其的制造方法
AU2016217792B2 (en) 2015-02-13 2020-07-02 Allergan Industrie, Sas Implants for sculpting, augmenting or correcting facial features such as the chin
FR3036035B1 (fr) 2015-05-11 2018-10-05 Laboratoires Vivacy Compositions comprenant au moins un polyol et au moins un anesthesique
US10004824B2 (en) 2015-05-11 2018-06-26 Laboratoires Vivacy Compositions comprising at least one polyol and at least one anesthetic
FR3037797B1 (fr) 2015-06-24 2018-08-17 Kylane Laboratoires Sa Procede de preparation d'un hydrogel reticule injectable; hydrogel obtenu; utilisation de l'hydrogel obtenu
EP3316921B1 (en) * 2015-06-30 2021-05-05 Merz Pharma GmbH & Co. KGaA Method for producing crosslinked hyaluronic acid
US20180177707A1 (en) 2015-06-30 2018-06-28 Merz Pharma Gmbh & Co. Kgaa Method of preparing a composition based on hyaluronic acid
AU2016294611B2 (en) 2015-07-14 2022-08-11 Evolved By Nature, Inc. Silk performance apparel and products and methods of preparing the same
EP3328351A1 (en) 2015-07-27 2018-06-06 Galderma S.A. A process for efficient cross-linking of hyaluronic acid
CN105107018B (zh) * 2015-08-19 2018-08-24 李媚 一种无菌可注射材料的制备方法
CN105131348B (zh) * 2015-08-19 2018-01-16 李媚 一种无菌可注射材料
KR101720426B1 (ko) 2015-09-01 2017-04-14 (주)시지바이오 히알루론산 조성물 및 그의 제조방법
EP3162813A1 (en) * 2015-11-02 2017-05-03 Merz Pharma GmbH & Co. KGaA Process for depleting epoxide species in crosslinked poly-saccharide gel compositions and compositions obtained thereby
BR112018009337A8 (pt) 2015-11-10 2019-02-26 E Perito Paul sistema e método para o aumento não cirúrgico da circunferência peniana
RU2697671C1 (ru) * 2015-11-24 2019-08-16 БиЭмАй КОРЕЯ КО., ЛТД Композиция для инъекций гиалуроновой кислоты, содержащей производное гиалуроновой кислоты и ДНК фракцию, и ее применение
FR3044557B1 (fr) 2015-12-07 2017-12-01 Benedicte Vincente Gavard Molliard Tauzin Nouvelle composition injectable; procede de preparation de ladite composition; utilisation de ladite composition
KR102139337B1 (ko) 2016-03-17 2020-07-29 주식회사 엘지생활건강 미세바늘패치를 이용한 히알루론산 필러
TWI727014B (zh) * 2016-03-24 2021-05-11 德商梅茲製藥有限兩合公司 修飾透明質酸與其製造方法及其用途
KR101660211B1 (ko) * 2016-06-07 2016-09-26 동국제약 주식회사 단일상과 이성상의 특성을 동시에 갖는 히알루론산 가교체, 이의 제조 방법 및 이의 용도
AU2016426150B2 (en) 2016-10-13 2022-06-30 Allergan, Inc. Coacervate hyaluronan hydrogels for dermal filler applications
FR3058064B1 (fr) 2016-10-28 2020-08-07 Lab Vivacy Composition a base d'acide hyaluronique comprenant de la mepivacaine
EP3538066B1 (en) * 2016-11-11 2021-12-29 Anteis SA Hyaluronic acid dermal fillers crosslinked with citric acid, method for making same and uses thereof
KR101879065B1 (ko) * 2016-12-12 2018-07-17 구태훈 구형 입자를 갖는 연조직용 필러 및, 그 제조방법
KR101922711B1 (ko) * 2016-12-28 2018-11-27 주식회사 유영제약 가교된 히알루론산겔의 정제 방법
KR102363007B1 (ko) * 2017-01-18 2022-02-14 구태훈 모노-페이직 ha 필러의 특성과 바이-페이직 ha 필러의 특성을 함께 갖는 ha 필러, 필러 주입에 사용되는 주사기 및, 필러의 제조방법
EP3590545B1 (en) * 2017-02-28 2024-06-26 CG Bio Co., Ltd. Composition for injection into skin
CN110573189B (zh) * 2017-02-28 2022-01-25 Cg生物技术有限公司 皮肤注入用组合物
JP6887514B2 (ja) * 2017-02-28 2021-06-16 シージー バイオ カンパニー，リミテッド 皮膚注入用組成物
CA3055985A1 (en) 2017-03-22 2018-09-27 Genentech, Inc. Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
KR101917026B1 (ko) 2017-03-24 2019-01-24 박원진 피부 주름 개선 또는 예방용 화장료 조성물
CA3061891A1 (en) * 2017-04-12 2018-10-18 Urigen Pharmaceuticals, Inc. Article of manufacture comprising local anesthetic, buffer, and glycosaminoglycan in syringe with improved stability
UA127350C2 (uk) 2017-06-26 2023-07-26 Іволвд Бай Нейчер, Інк. Тканинний філер на основі шовку і гіалуронової кислоти
US20230190997A1 (en) * 2017-06-26 2023-06-22 Evolved By Nature, Inc. Silk-hyaluronic acid based tissue filers and methods of using the same
CN111712514A (zh) 2017-09-27 2020-09-25 自然进化公司 丝涂布织物和产品及其制备方法
WO2019079672A1 (en) 2017-10-19 2019-04-25 Lifecell Corporation ACELLULAR TISSUE MATRIX PRODUCTS FLUIDS AND METHODS OF PRODUCTION
KR102091452B1 (ko) * 2017-12-19 2020-03-20 대화제약 주식회사 국소 마취제 및 히알루론산 하이드로겔을 포함하는 사전충전형 주사기의 제조방법
ES2909623T3 (es) * 2017-12-29 2022-05-09 Matex Lab S P A Procedimiento para preparar un relleno con una base de ácido hialurónico que comprende una etapa de neutralización
US11530302B2 (en) * 2017-12-29 2022-12-20 Matex Lab S.P.A. Method to prepare a filler with a hyaluronic acid base using specific crosslinking agents
WO2019130360A1 (en) * 2017-12-29 2019-07-04 Matex Lab S.P.A. Method to prepare filler with a hyaluronic acid base comprising a neutralization step
IT201800001890A1 (it) * 2018-01-25 2019-07-25 Fidia Farm Spa Composizioni farmaceutiche per il trattamento del dolore postoperatorio
CN112384258A (zh) 2018-05-09 2021-02-19 约翰·霍普金斯大学 用于细胞和组织递送的纳米纤维-水凝胶复合物
EP3790601A1 (en) 2018-05-09 2021-03-17 The Johns Hopkins University Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration
CN108653817B (zh) * 2018-05-24 2021-02-02 上海其胜生物制剂有限公司 一种新型胶原刺激剂的制备方法
TWI708607B (zh) * 2018-07-06 2020-11-01 南韓商Ｌｇ化學股份有限公司 同時具有高度黏彈性和內聚性之玻尿酸填料
ES2974233T3 (es) * 2018-07-10 2024-06-26 Lg Chemical Ltd Relleno de ácido hialurónico con alta capacidad de elevación y baja fuerza de inyección
BR112021001515A2 (pt) 2018-08-07 2021-04-27 Merz Pharma Gmbh & Co. Kgaa método para filtração dinâmica de um hidrogel reticulado
KR20200046649A (ko) 2018-10-25 2020-05-07 (주)뉴크레이티브랩 혼합상 히알루론산 제조방법
BR112021012042A2 (pt) * 2018-12-20 2021-09-21 Lg Chem, Ltd. Preenchedor com excelentes propriedades de preenchedor compreendendo hidrogel de ácido hialurônico
US20220016313A1 (en) * 2018-12-21 2022-01-20 Lg Chem, Ltd. Filler comprising hyaluronic acid hydrogel having excellent filling properties
US20220160934A1 (en) * 2019-03-24 2022-05-26 Allergan Pharmaceuticals International Limited Injectable homogeneous gels comprising multiple forms of hyaluronic acid and methods for manufacturing thereof
CA3140715A1 (en) * 2019-05-17 2020-11-26 The Governing Council Of The University Of Toronto Sustained release local anesthetic hydrogel composition
KR102566288B1 (ko) * 2019-12-24 2023-08-11 주식회사 엘지화학 마취제, 완충 용액 및 히알루론산 하이드로겔을 포함하는 주사용 조성물 및 이의 제조방법
US11058640B1 (en) 2020-04-07 2021-07-13 Amc Group, Llc Hyaluronate compositions and soft tissue fillers
FR3109153B1 (fr) * 2020-04-10 2022-07-15 Teoxane SA Compositions à base d’au moins deux glycosaminoglycanes
US20230172968A1 (en) * 2020-04-17 2023-06-08 Prohibix Llc Controlled release hyaluronic acid compositions
KR102417671B1 (ko) * 2020-04-28 2022-07-06 충남대학교산학협력단 자가가교 시스템을 가지는 히알루론산 기반 연조직 충전 조성물 및 이의 제조방법
KR102425496B1 (ko) 2020-05-08 2022-07-26 주식회사 종근당 고탄성, 고점도 및 고유효 가교율을 갖는 히알루론산 가교체, 및 이의 제조방법
FR3111903B1 (fr) 2020-06-24 2022-12-02 Lab Vivacy Procede d’incorporation de composes organiques en solution au sein d’un hydrogel
CN111643730A (zh) * 2020-07-14 2020-09-11 华熙生物科技股份有限公司 注射用交联透明质酸凝胶的制备方法及应用
US20220160689A1 (en) * 2020-09-29 2022-05-26 Ziropa, Inc. Compositions and methods for pain relief and numbing
TR202101065A1 (tr) * 2021-01-25 2022-08-22 Hacettepe Ueniversitesi Hyaluroni̇k asi̇t jel i̇çeren bi̇r doku dolgu malzemesi̇ ve üreti̇m yöntemi̇
KR102581434B1 (ko) * 2021-02-09 2023-09-22 (주)제테마 히알루론산 필러 조성물의 제조에 사용되는 용액 및 이를 이용한 히알루론산 필러 조성물
CN113449476B (zh) * 2021-07-08 2022-07-05 浙江大学 基于Stacking的脱丁烷塔中丁烷含量软测量方法
KR102348467B1 (ko) * 2021-07-14 2022-01-07 주식회사 휴메딕스 Dna 분획물을 포함하는 필러 제조방법 및 이로부터 제조된 필러
KR102640893B1 (ko) * 2021-11-12 2024-02-27 주식회사 유영제약 히알루론산 가교물을 포함하는 조성물의 제조방법
CN116212108B (zh) * 2023-04-18 2023-10-20 杭州科腾生物制品有限公司 一种含利多卡因的双层交联凝胶及其制备方法和应用

Family Cites Families (270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2128827A (en) 1938-03-09 1938-08-30 Frank B Killian Method and apparatus for manufacturing thin rubber articles
CA807629A (en) 1966-06-30 1969-03-04 Eigen Edward Lotion and detergent compositions
JPS4838158B1 (da) 1970-10-05 1973-11-15
CA949965A (en) 1971-12-03 1974-06-25 Robert H. Marchessault Method of preparing cross-linked starch and starch derivatives
US3769009A (en) * 1971-12-29 1973-10-30 Xerox Corp Inking system for liquid particle migration on automatic machines
US3949073A (en) 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
CA1073360A (en) 1975-10-22 1980-03-11 John R. Daniels Non-antigenic collagen and articles of manufacture
US4233360A (en) 1975-10-22 1980-11-11 Collagen Corporation Non-antigenic collagen and articles of manufacture
JPS581933Y2 (ja) 1979-04-23 1983-01-13 株式会社日本製鋼所 ケ−ブルのクランプ装置
JPS55153711A (en) 1979-05-19 1980-11-29 Pola Chem Ind Inc Cosmetic lotion
US4279812A (en) 1979-09-12 1981-07-21 Seton Company Process for preparing macromolecular biologically active collagen
JPS6052129B2 (ja) 1979-10-04 1985-11-18 呉羽化学工業株式会社 医療用コラ−ゲン繊維の製造法
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4501306A (en) 1982-11-09 1985-02-26 Collagen Corporation Automatic syringe filling system
SE442820B (sv) 1984-06-08 1986-02-03 Pharmacia Ab Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4605691A (en) 1984-12-06 1986-08-12 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4636524A (en) 1984-12-06 1987-01-13 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
SE8501022L (sv) 1985-03-01 1986-09-02 Pharmacia Ab Format alster och forfarande for dess framstellning
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4642117A (en) 1985-03-22 1987-02-10 Collagen Corporation Mechanically sheared collagen implant material and method
SE452469B (sv) 1986-06-18 1987-11-30 Pharmacia Ab Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
FR2608456B1 (fr) 1986-12-18 1993-06-18 Mero Rousselot Satia Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention
US5091171B2 (en) 1986-12-23 1997-07-15 Tristrata Inc Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use
US5385938B1 (en) 1986-12-23 1997-07-15 Tristrata Inc Method of using glycolic acid for treating wrinkles
US5079236A (en) 1987-05-27 1992-01-07 Hyal Pharmaceutical Corporation Pure, sterile, pyrogen-free hyaluronic acid formulations their methods of preparation and methods of use
FR2623167B2 (fr) 1987-08-14 1992-08-07 Genus Int Perfectionnement aux articles munis d'articulations elastiques se rigidifiant lors de leur mise en tension
US6174999B1 (en) 1987-09-18 2001-01-16 Genzyme Corporation Water insoluble derivatives of polyanionic polysaccharides
US5017229A (en) 1990-06-25 1991-05-21 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
IT1219587B (it) 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US5565519A (en) 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5643464A (en) 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
SE462587B (sv) 1988-11-30 1990-07-23 Wiklund Henry & Co Anordning vid maerkning av arbetsstycken med skrift- eller andra tecken
JPH02215707A (ja) 1989-02-15 1990-08-28 Chisso Corp 皮膚化粧料
DE69019779T2 (de) 1989-05-19 1995-12-14 Hayashibara Biochem Lab Alpha-Glycosyl-L-ascorbinsäure und ihre Herstellung und Verwendungen.
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
EP0416250A3 (en) 1989-08-01 1991-08-28 The Research Foundation Of State University Of New York N-acylurea and o-acylisourea derivatives of hyaluronic acid
CA2023922A1 (en) 1989-09-05 1991-03-06 James M. Curtis Method of manufacturing an implantable article provided with a micropillared surface
JP2832848B2 (ja) 1989-10-21 1998-12-09 株式会社林原生物化学研究所 結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
US4996787A (en) * 1990-05-29 1991-03-05 Jack N. Holcomb SigSauer pistol with concealed radio transmitter
US5246698A (en) 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5143724A (en) 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5283671A (en) * 1991-02-20 1994-02-01 Stewart John R Method and apparatus for converting RGB digital data to optimized CMYK digital data
JP3115625B2 (ja) 1991-03-30 2000-12-11 帝國製薬株式会社 リドカイン含有外用貼付剤
US5314874A (en) 1991-04-19 1994-05-24 Koken Co., Ltd. Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen
DE4200080A1 (de) 1992-01-03 1993-09-30 Reinmueller Johannes Pharmazeutische Zusammensetzung zur Wund-, Narben- und Keloidbehandlung
ES2152248T3 (es) 1992-02-28 2001-02-01 Collagen Corp Composiciones de colageno de alta concentracion.
IT1260154B (it) 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5980930A (en) 1993-01-20 1999-11-09 Bristol-Myers Squibb Company Fibres
WO1994021299A1 (en) 1993-03-19 1994-09-29 Medinvent A composition and a method for tissue augmentation
US5531716A (en) 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
CA2146090C (en) 1994-05-10 1998-11-24 Mark E. Mitchell Apparatus and method of mixing materials in a sterile environment
US5616689A (en) 1994-07-13 1997-04-01 Collagen Corporation Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation
AU706434B2 (en) 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US20050186673A1 (en) 1995-02-22 2005-08-25 Ed. Geistlich Soehne Ag Fuer Chemistrie Industrie Collagen carrier of therapeutic genetic material, and method
US5612027A (en) 1995-04-18 1997-03-18 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US5972326A (en) 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
FR2733427B1 (fr) 1995-04-25 2001-05-25 W K Et Associes Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique
FR2733426B1 (fr) 1995-04-25 1997-07-18 Debacker Yves Dispositif medical pour le comblement des deformations du volume de la peau telles que rides et cicatrices par injection de 2 formes physico-chimiques differentes d'un polymere biologique
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
US5571503A (en) 1995-08-01 1996-11-05 Mausner; Jack Anti-pollution cosmetic composition
US6007843A (en) 1995-09-29 1999-12-28 Lam Pharmaceuticals Corp. Sustained release delivery system
US6833408B2 (en) 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
IT1277707B1 (it) 1995-12-22 1997-11-11 Chemedica Sa Formulazione oftalmica a base di ialuronato di sodio per uso nella chirurgia oculare
US5980948A (en) 1996-08-16 1999-11-09 Osteotech, Inc. Polyetherester copolymers as drug delivery matrices
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
IT1287967B1 (it) 1996-10-17 1998-09-10 Fidia Spa In Amministrazione S Preparazioni farmaceutiche per uso anestetico locale
FR2759577B1 (fr) 1997-02-17 1999-08-06 Corneal Ind Implant de sclerectomie profonde
FR2759576B1 (fr) 1997-02-17 1999-08-06 Corneal Ind Implant de sclero-keratectomie pre-descemetique
US5935164A (en) 1997-02-25 1999-08-10 Pmt Corporaton Laminated prosthesis and method of manufacture
FR2764514B1 (fr) 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6391336B1 (en) 1997-09-22 2002-05-21 Royer Biomedical, Inc. Inorganic-polymer complexes for the controlled release of compounds including medicinals
FR2778336A1 (fr) 1998-05-11 1999-11-12 Jean Pierre Perraud Implant injectable en sous-cutane et en sous-gingival resorbable a base de maltodextrine micro-encapsulee et resorbable en un temps determine
FR2780730B1 (fr) 1998-07-01 2000-10-13 Corneal Ind Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
IT1303738B1 (it) 1998-11-11 2001-02-23 Aquisitio S P A Processo di reticolazione di polisaccaridi carbossilati.
US20020016637A1 (en) * 1998-12-16 2002-02-07 Mark A. Anton Soft tissue filler
DK172900B1 (da) 1998-12-18 1999-09-27 Per Julius Nielsen Præparat samt kit til brug ved intraoculære operationer
GB9902412D0 (en) 1999-02-03 1999-03-24 Fermentech Med Ltd Process
GB9902652D0 (en) 1999-02-05 1999-03-31 Fermentech Med Ltd Process
US6767928B1 (en) 1999-03-19 2004-07-27 The Regents Of The University Of Michigan Mineralization and biological modification of biomaterial surfaces
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
JP4734816B2 (ja) * 1999-12-16 2011-07-27 株式会社ニコン バヨネットマウント
US6521223B1 (en) * 2000-02-14 2003-02-18 Genzyme Corporation Single phase gels for the prevention of adhesions
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
KR20010096388A (ko) 2000-04-19 2001-11-07 진세훈 귀두확대성형재료 및 이 재료를 이용한 귀두의 확대시술방법
FR2811671B1 (fr) 2000-07-17 2003-02-28 Corneal Ind Hydrogel de polymere(s), resistant a la biodegration, preparation et utilisation a titre de support de regeneration tissulaire
FR2811996B1 (fr) 2000-07-19 2003-08-08 Corneal Ind Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations
CA2416126C (en) 2000-07-28 2011-07-05 Anika Therapeutics, Inc. Bioabsorbable composites of derivatized hyaluronic acid
US6620196B1 (en) 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
US6773723B1 (en) 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
JP4187917B2 (ja) 2000-09-08 2008-11-26 独立行政法人科学技術振興機構 組織再生マトリックス用グリコサミノグリカン−コラーゲン複合体の製造方法
US6924273B2 (en) 2000-10-03 2005-08-02 Scott W. Pierce Chondroprotective/restorative compositions and methods of use thereof
AU2001294459A1 (en) 2000-10-06 2002-04-15 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation
KR100375299B1 (ko) 2000-10-10 2003-03-10 주식회사 엘지생명과학 히알루론산의 가교결합형 아마이드 유도체와 이의 제조방법
EP1404516A2 (en) 2000-12-13 2004-04-07 Purdue Research Foundation Microencapsulation of drugs by solvent exchange
US6979440B2 (en) 2001-01-29 2005-12-27 Salvona, Llc Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric
US7119062B1 (en) 2001-02-23 2006-10-10 Neucoll, Inc. Methods and compositions for improved articular surgery using collagen
EP1390085B1 (en) * 2001-05-01 2009-08-05 A.V. Topchiev Institute of Petrochemical Synthesis Hydrogel compositions
TW574301B (en) 2001-05-02 2004-02-01 Ind Tech Res Inst Manufacturing method of epoxide crosslinked polysaccharides matrix
US20050227936A1 (en) 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TGF-beta and TGF-beta receptor gene expression using short interfering nucleic acid (siNA)
WO2003007782A2 (en) 2001-06-29 2003-01-30 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
US6749841B2 (en) 2001-07-26 2004-06-15 Revlon Consumer Products Corporation Stabilized aqueous acidic antiperspirant compositions and related methods
JP4230135B2 (ja) 2001-08-21 2009-02-25 独立行政法人科学技術振興機構 多官能性架橋剤によって架橋したグリコサミノグリカン−コラーゲン複合体の製造法
US20060189516A1 (en) 2002-02-19 2006-08-24 Industrial Technology Research Institute Method for producing cross-linked hyaluronic acid-protein bio-composites
JP3916516B2 (ja) 2002-06-10 2007-05-16 独立行政法人科学技術振興機構 硬組織−軟組織界面再生用足場材料
US6780366B2 (en) 2002-08-15 2004-08-24 Mentor Corporation Drip retainer
KR100523953B1 (ko) 2002-08-27 2005-10-25 주식회사 엘지생명과학 천연다당류와 히알루론산의 마이크로비드 및 이의 제조 방법
KR100507545B1 (ko) 2002-09-03 2005-08-09 주식회사 엘지생명과학 히알루론산 유도체 및 그의 제조방법
US20040127932A1 (en) 2002-09-12 2004-07-01 Shah Tilak M. Dip-molded polymeric medical devices with reverse thickness gradient, and method of making same
DE10246340A1 (de) 2002-10-04 2004-04-29 Wohlrab, David, Dr. Kombinationspräparat aus Hyaluronsäure und mindestens einem Lokalanästhetikum und dessen Verwendung
US20040101959A1 (en) * 2002-11-21 2004-05-27 Olga Marko Treatment of tissue with undifferentiated mesenchymal cells
CA2511484A1 (en) 2002-12-30 2004-07-22 Angiotech International Ag Silk-containing stent graft
TWI251596B (en) 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
WO2004073759A1 (en) 2003-02-19 2004-09-02 Aventis Pharmaceuticals Holdings Inc. Composition and method for intradermal soft tissue augmentation
CA2520012A1 (en) 2003-03-25 2004-10-14 Biocure, Inc. Hydrogel string medical device
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
JP2004323453A (ja) 2003-04-25 2004-11-18 Chisso Corp 分解性ゲル及びその製造法
CN100352031C (zh) 2003-05-13 2007-11-28 三益半导体工业株式会社 晶片分离方法、晶片分离装置及晶片分离转移机
DE10323794A1 (de) * 2003-05-23 2004-12-09 Dr. Suwelack Skin & Health Care Ag Verfahren zur Herstellung von Alginat-haltigen porösen Formkörpern
US20060246137A1 (en) 2003-07-30 2006-11-02 Laurence Hermitte Complex matrix for biomedical use
EP1681306B1 (en) 2003-10-29 2013-02-20 Teijin Limited Hyaluronic acid compound, hydrogel thereof and material for treating joint
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20070224278A1 (en) 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20090148527A1 (en) 2007-12-07 2009-06-11 Robinson Michael R Intraocular formulation
US20060141049A1 (en) 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
AU2004293030A1 (en) 2003-11-20 2005-06-09 Angiotech International Ag Electrical devices and anti-scarring agents
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
CN100537606C (zh) * 2003-12-30 2009-09-09 建新公司 源自交联的透明质酸和/或hylan的粘性凝胶、其制备和用途
US8524213B2 (en) 2003-12-30 2013-09-03 Genzyme Corporation Polymeric materials, their preparation and use
DE102004002001A1 (de) * 2004-01-14 2005-08-11 Reinmüller, Johannes, Dr.med. Mittel zur Behandlung von entzündlichen Erkrankungen
US7552442B1 (en) 2004-01-27 2009-06-23 Honeywell International Inc. Military data link integration apparatus and method
JP2007519756A (ja) 2004-01-30 2007-07-19 アンジオテック インターナショナル アーゲー 拘縮を治療するための組成物および方法
FR2865737B1 (fr) 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
US20050226936A1 (en) 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
US8288362B2 (en) 2004-05-07 2012-10-16 S.K. Pharmaceuticals, Inc. Stabilized glycosaminoglycan preparations and related methods
US20050281880A1 (en) * 2004-05-20 2005-12-22 Wei Wang Methods for making injectable polymer hydrogels
US7651702B2 (en) * 2004-05-20 2010-01-26 Mentor Corporation Crosslinking hyaluronan and chitosanic polymers
WO2006002050A1 (en) 2004-06-15 2006-01-05 Encore Therapeutics, Inc. Phospholipid compositions and methods for their preparation and use
WO2006002365A2 (en) 2004-06-24 2006-01-05 Angiotech International Ag Microparticles with high loadings of a bioactive agent
BRPI0515191A (pt) 2004-08-13 2008-07-08 Angiotech Internac Ag composição farmacêutica, método para aumentar osso ou substituir perda óssea, método para reduzir a dor associada com cicatriz pós-cirúrgica, método para prevenir aderência cirúrgicas, método para aumento ou reparo de pele ou tecido, método para manter volume em fluido ocular durante cirurgia ocular, método para reduzir a dor associada com osteoartrite, método para tratar doença de refluxo gastroesofágico, método para tratar ou prevenir incontinência urinária, método para tratar ou prevenir incontinência fecal, implante método e dispositivo médico
US20060040895A1 (en) 2004-08-19 2006-02-23 Kipling Thacker Aesthetic use of hyaluronan
US20060058238A1 (en) * 2004-09-15 2006-03-16 Lee Laurent-Applegate Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
US7414021B2 (en) 2004-10-01 2008-08-19 Vincent Carmine Giampapa Method and composition for restoration of age related tissue loss in the face or selected areas of the body
KR100762928B1 (ko) 2004-10-29 2007-10-04 재단법인서울대학교산학협력재단 견 피브로인 나노섬유로 이루어진 부직포 형태의 골조직유도 재생용 차폐막 및 그 제조방법
US20060105022A1 (en) 2004-11-15 2006-05-18 Shiseido Co., Ltd. Process for preparing crosslinked hyaluronic acid gel
ES2636998T3 (es) 2004-11-24 2017-10-10 Albumedix A/S Método de reticulación de ácido hialurónico con divinil sulfona
FR2878444B1 (fr) 2004-11-30 2008-04-25 Corneal Ind Soc Par Actions Si Solutions viscoelastiques renfermant du hyaluronate de sodiu et de l'hydroxypropylmethylcellulose, preparation et utilisations
WO2006067608A1 (en) 2004-12-22 2006-06-29 Laboratoire Medidom S.A. Aqueous formulations based on sodium hyaluronate for parenteral use
WO2006102676A1 (en) 2005-03-23 2006-09-28 Tissue Engineering Refraction, Inc. Injectable polyethylene oxide dermal fillers and related devices
WO2006122183A2 (en) 2005-05-10 2006-11-16 Cytophil, Inc. Injectable hydrogels and methods of making and using same
EP1726299A3 (en) 2005-05-27 2007-04-18 StratoSphere Pharma AB Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
US7491709B2 (en) 2005-07-01 2009-02-17 Wayne Carey Treatment with hyaluronic acid
EP1932530A4 (en) 2005-08-11 2009-04-29 Hayashibara Biochem Lab MEANS FOR IMPROVING COLLAGEN PRODUCTION AND ITS USE
JP4982718B2 (ja) 2005-08-31 2012-07-25 株式会社林原 美肌用の経口摂取用組成物
WO2007041627A1 (en) 2005-10-03 2007-04-12 Pinsky Mark A Compositions and methods for improved skin care
US20070202084A1 (en) 2005-12-14 2007-08-30 Anika Therapeutics, Inc. Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects
US20070203095A1 (en) 2005-12-14 2007-08-30 Anika Therapeutics, Inc. Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid
FR2894827B1 (fr) 2005-12-21 2010-10-29 Galderma Res & Dev Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation,et leurs utilisations
FR2895907B1 (fr) 2006-01-06 2012-06-01 Anteis Sa Gel viscoelastique a usage dermatologique
US20070184087A1 (en) 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
US20070212385A1 (en) 2006-03-13 2007-09-13 David Nathaniel E Fluidic Tissue Augmentation Compositions and Methods
US7919111B2 (en) 2006-03-15 2011-04-05 Surmodics, Inc. Biodegradable hydrophobic polysaccharide-based drug delivery implants
FR2900575B1 (fr) * 2006-05-05 2008-10-17 Anteis Sa Gel biocompatible a liberation controlee, son procede de preparation et son utilisation
EP2019647A4 (en) 2006-05-19 2010-04-28 Univ Boston NOVEL HYDROPHILIC POLYMERS AS GELS AND LUBRICANTS FOR MEDICAL USE
US20070298005A1 (en) 2006-06-22 2007-12-27 Marie-Josee Thibault Injectable composition for treatment of skin defects or deformations
WO2008003321A2 (en) 2006-07-07 2008-01-10 Novozymes Biopolymer A/S Compositions with several hyaluronic acid fractions for cosmetic use
JP4557939B2 (ja) 2006-07-18 2010-10-06 株式会社ジェイテック Ｘ線ミラーの高精度姿勢制御法およびｘ線ミラー
WO2008034176A1 (en) 2006-09-19 2008-03-27 Ultraceuticals R & D Pty Ltd Cross-linked polysaccharide gels
FR2908415B1 (fr) 2006-11-10 2009-01-23 Abr Dev Sarl Acide hyaluronique reticule et son procede de preparation
FR2909560B1 (fr) * 2006-12-06 2012-12-28 Fabre Pierre Dermo Cosmetique Gel d'acide hyaluronique pour injection intradermique
EP2121026B1 (en) 2006-12-11 2017-06-28 CHIT2GEL Ltd. Novel injectable chitosan mixtures forming hydrogels
KR100759091B1 (ko) 2006-12-13 2007-09-17 조강선 피부 충전제 조성물
AU2007336692B2 (en) 2006-12-22 2013-12-12 Croma-Pharma Gesellschaft M.B.H. Use of polymers
US20080226724A1 (en) 2007-01-19 2008-09-18 Genentech, Inc. Prevention of hydrogel viscosity loss
WO2008098019A2 (en) 2007-02-05 2008-08-14 Carbylan Biosurgery, Inc. Polymer formulations for delivery of bioactive agents
US20080188416A1 (en) 2007-02-05 2008-08-07 Freedom-2, Inc. Tissue fillers and methods of using the same
US7776840B2 (en) 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial
US7939578B2 (en) 2007-02-23 2011-05-10 3M Innovative Properties Company Polymeric fibers and methods of making
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US11078262B2 (en) 2007-04-30 2021-08-03 Allergan, Inc. High viscosity macromolecular compositions for treating ocular conditions
WO2008139122A2 (fr) 2007-05-11 2008-11-20 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
CA2686558A1 (fr) 2007-05-11 2008-12-11 Galderma Research & Development Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation, et leurs utilisations
CA2687983A1 (en) 2007-05-23 2008-12-04 Allergan, Inc. Coated hyaluronic acid particles
US20080293637A1 (en) 2007-05-23 2008-11-27 Allergan, Inc. Cross-linked collagen and uses thereof
WO2008157608A1 (en) 2007-06-18 2008-12-24 Cartlix, Inc. Composite scaffolds for tissue regeneration
WO2009005790A2 (en) 2007-06-29 2009-01-08 Carbylan Biosurgery, Inc. Sterile thiol-derivatized hyaluronic acid polymer compositions and uses thereof
PL2182960T3 (pl) 2007-07-27 2014-08-29 Galderma Laboratories Inc Związki, preparaty i sposoby zmniejszania zmarszczek, zwiotczenia i pofałdowania skóry
AU2008282922B2 (en) 2007-07-27 2014-01-16 Humacyte, Inc. Compositions comprising human collagen and human elastin and methods for soft tissue augmentation
US20110077737A1 (en) 2007-07-30 2011-03-31 Allergan, Inc. Tunably Crosslinked Polysaccharide Compositions
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US20120071437A1 (en) 2007-07-30 2012-03-22 Allergan, Inc. Tunable crosslinked polysaccharide compositions
US8455459B2 (en) 2007-08-02 2013-06-04 Medicis Pharmaceutical Corporation Method of applying an injectable filler
FR2920000B1 (fr) 2007-08-13 2010-01-29 Oreal Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement
CA2734577A1 (en) 2007-08-16 2009-02-26 Carnegie Mellon University Inflammation-regulating compositions and methods
KR100813224B1 (ko) 2007-08-24 2008-03-13 한양대학교 산학협력단 단백질 약물전달용 온도 가역성 코아세르베이트 조합 겔
FR2920968B1 (fr) 2007-09-14 2009-11-13 Oreal Procede cosmetique de traitement esthetique et/ou reparateur de la peau
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US7910134B2 (en) 2007-10-29 2011-03-22 Ayman Boutros Alloplastic injectable dermal filler and methods of use thereof
JP5035900B2 (ja) 2007-11-21 2012-09-26 株式会社アイ・エイチ・アイ マリンユナイテッド 温度分布履歴推定方法
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
FR2924615B1 (fr) 2007-12-07 2010-01-22 Vivacy Lab Hydrogel cohesif biodegradable.
US9161970B2 (en) 2007-12-12 2015-10-20 Allergan, Inc. Dermal filler
AU2008345068A1 (en) 2007-12-26 2009-07-09 Mark A. Pinsky Collagen formulations for improved skin care
US20090291986A1 (en) 2008-05-22 2009-11-26 Apostolos Pappas Composition and method of treating facial skin defect
US20090297632A1 (en) 2008-06-02 2009-12-03 Waugh Jacob M Device, Methods and Compositions to Alter Light Interplay with Skin
WO2010003797A1 (en) 2008-07-09 2010-01-14 Novozymes Biopharma Dk A/S Hyaluronic acid for corneal wound healing
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
US20130102563A1 (en) * 2008-08-04 2013-04-25 Allergan, Inc. Dermal filler with lidocaine
EP3184552B1 (en) 2008-09-02 2020-08-12 Tautona Group LP Threads of hyaluronic acid, methods of making thereof and uses thereof
WO2010027471A2 (en) 2008-09-04 2010-03-11 The General Hospital Corporation Hydrogels for vocal cord and soft tissue augmentation and repair
GB0816496D0 (en) 2008-09-10 2008-10-15 Zhao Xiaobin Hyaluronic acid cryogel
JP5683957B2 (ja) 2008-09-30 2015-03-11 電気化学工業株式会社 光安定化された医薬組成物
US20100098794A1 (en) 2008-10-17 2010-04-22 Armand Gerard Topical anti-wrinkle and anti-aging moisturizing cream
US20100111919A1 (en) 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
US9248165B2 (en) 2008-11-05 2016-02-02 Hancock-Jaffe Laboratories, Inc. Composite containing collagen and elastin as a dermal expander and tissue filler
US8658219B2 (en) 2008-11-07 2014-02-25 Klox Technologies Inc. Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
FR2938187B1 (fr) 2008-11-07 2012-08-17 Anteis Sa Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur
ITRM20080636A1 (it) 2008-11-28 2010-05-29 Univ Palermo Procedimento per la produzione di derivati funzionalizzati dell acido ialuronico e relativi idrogeli.
US20100136070A1 (en) 2008-12-03 2010-06-03 Jakk Group, Inc. Methods, devices, and compositions for dermal filling
SE533818C2 (sv) 2009-02-04 2011-01-25 Roxtec Ab Excentrisk del av en rör- eller kabelgenomföring
EP2236523B1 (en) 2009-03-30 2018-02-21 Scivision Biotech Inc. Method for producing cross-linked hyaluronic acid
DK2413894T3 (da) 2009-04-02 2017-04-03 Allergan Inc Håragtigt formede hydrogeler til forstærkning af blødvæv
US9371402B2 (en) 2009-04-09 2016-06-21 Scivision Biotech Inc. Method for producing cross-linked hyaluronic acid
JP2012528130A (ja) 2009-05-29 2012-11-12 ガルデルマ・リサーチ・アンド・デヴェロップメント アドレナリン受容体アゴニストα−１またはα−２、好ましくはブリモニジンの、充填剤、好ましくはヒアルロン酸との組み合わせ
IT1395392B1 (it) 2009-08-27 2012-09-14 Fidia Farmaceutici Geli viscoelastici come nuovi filler
US8657795B2 (en) 2009-12-30 2014-02-25 Cook Medical Technologies Llc Vascular port
US20110171286A1 (en) 2010-01-13 2011-07-14 Allergan, Inc. Hyaluronic acid compositions for dermatological use
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
US20110171311A1 (en) 2010-01-13 2011-07-14 Allergan Industrie, Sas Stable hydrogel compositions including additives
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
DE102010009460A1 (de) 2010-02-26 2011-09-01 Siemens Aktiengesellschaft Verfahren zur Übermittlung mehrerer medizinischer Bilddatensätze und System zur Verwaltung von Bilddatensätzen
JP5749283B2 (ja) 2010-03-12 2015-07-15 アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｉｎｄｕｓｔｒｉｅ Ｓａｓ 皮膚状態を改善するための流体組成物
DK3078388T3 (da) 2010-03-22 2019-05-20 Allergan Inc Tværbundne hydrogeler til blødvævsforøgelse
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
ES2645860T3 (es) 2010-10-20 2017-12-11 Allergan Holdings France S.A.S. Hilos de ácido hialurónico reticulado y uso de los mismos
US9299476B2 (en) 2010-10-22 2016-03-29 Newsouth Innovations Pty Limited Polymeric material
FR2968305B1 (fr) 2010-12-06 2014-02-28 Teoxane Procede de preparation d'un gel reticule
FR2968306B1 (fr) 2010-12-06 2014-02-28 Teoxane Procede de preparation d'un gel reticule
US20120142628A1 (en) * 2010-12-07 2012-06-07 Allergan, Inc. Methods for treating crepitus
US8793408B2 (en) 2010-12-21 2014-07-29 Nikon Corporation Electronic device and program
US20140178512A1 (en) 2011-02-22 2014-06-26 Merz Pharma Gmbh & Co. Kgaa In situ formation of a filler
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
CN107412002A (zh) 2011-06-03 2017-12-01 阿勒根公司 包括抗氧化剂的皮肤填充剂组合物
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US20130116411A1 (en) 2011-09-06 2013-05-09 Allergan, Inc. Methods of making hyaluronic acid/collagen compositions
US20130116190A1 (en) 2011-09-06 2013-05-09 Allergan, Inc. Hyaluronic acid-collagen matrices for tissue engineering
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US20140011980A1 (en) 2012-07-03 2014-01-09 Allergan, Inc. Methods for sterilizing compositions and resulting compositions
US9627808B2 (en) 2015-04-13 2017-04-18 Tyco Electronics Brasil Ltda One piece connector with integral latching members

Also Published As

Publication number Publication date
EP2674147B1 (en) 2020-01-01
PT2326302T (pt) 2016-11-02
US9089519B2 (en) 2015-07-28
SG10202104803SA (en) 2021-06-29
US10391202B2 (en) 2019-08-27
JP2016000350A (ja) 2016-01-07
RU2496473C2 (ru) 2013-10-27
JP2011529763A (ja) 2011-12-15
CN103285423A (zh) 2013-09-11
US20100028437A1 (en) 2010-02-04
US20160279296A1 (en) 2016-09-29
DK2674147T3 (da) 2020-03-30
HK1156883A1 (zh) 2012-06-22
CA2732928A1 (en) 2010-02-11
JP2011529762A (ja) 2011-12-15
US20140148406A1 (en) 2014-05-29
US20140213547A1 (en) 2014-07-31
KR20110040966A (ko) 2011-04-20
US10485896B2 (en) 2019-11-26
AU2009278884B2 (en) 2013-07-04
JP2014237718A (ja) 2014-12-18
CA3209175A1 (en) 2010-02-11
US9089518B2 (en) 2015-07-28
PL2323617T3 (pl) 2017-08-31
US20130041039A1 (en) 2013-02-14
US9089517B2 (en) 2015-07-28
MX342613B (es) 2016-10-06
US11173232B2 (en) 2021-11-16
US9358322B2 (en) 2016-06-07
US20130131011A1 (en) 2013-05-23
US20150045321A1 (en) 2015-02-12
RU2011107878A (ru) 2012-09-10
US20130041038A1 (en) 2013-02-14
CY1118281T1 (el) 2017-06-28
HUE048366T2 (hu) 2020-08-28
PL2674147T3 (pl) 2020-11-16
BRPI0917588B1 (pt) 2018-03-13
AU2009278883B2 (en) 2015-08-06
HUE031483T2 (hu) 2017-07-28
SI2323617T1 (sl) 2017-07-31
CA3023168A1 (en) 2010-02-11
US8450475B2 (en) 2013-05-28
CN102170855B (zh) 2013-04-24
BRPI0917573A2 (da) 2017-07-11
BRPI0917573B1 (pt) 2018-03-13
CA2944734C (en) 2018-12-18
CA3112106A1 (en) 2010-02-11
BRPI0917588A2 (pt) 2017-07-11
JP5808848B2 (ja) 2015-11-10
JP5670900B2 (ja) 2015-02-18
CN102170856B (zh) 2013-05-22
MX2011001322A (es) 2011-07-29
US20210283313A1 (en) 2021-09-16
KR20110043730A (ko) 2011-04-27
US20130244970A1 (en) 2013-09-19
EP3205332A1 (en) 2017-08-16
US20190343990A1 (en) 2019-11-14
AU2009278883A1 (en) 2010-02-11
CA3023168C (en) 2021-05-04
US20200086009A1 (en) 2020-03-19
CA2732788A1 (en) 2010-02-11
EP2326302A1 (en) 2011-06-01
EP3662889A1 (en) 2020-06-10
AU2009278884A1 (en) 2010-02-11
CN103285423B (zh) 2014-11-26
PL2326302T3 (pl) 2017-01-31
KR101672562B1 (ko) 2016-11-03
EP2323617A1 (en) 2011-05-25
ES2622708T3 (es) 2017-07-07
MX2011001321A (es) 2011-03-25
US20140213546A1 (en) 2014-07-31
SI2326302T1 (sl) 2017-01-31
WO2010015901A1 (en) 2010-02-11
EP2323617B1 (en) 2017-01-18
US20220313870A1 (en) 2022-10-06
JP5670899B2 (ja) 2015-02-18
US11020512B2 (en) 2021-06-01
ES2599763T3 (es) 2017-02-03
US20120172328A1 (en) 2012-07-05
KR101747441B1 (ko) 2017-06-14
ES2780190T3 (es) 2020-08-24
US20150297790A1 (en) 2015-10-22
CA2944734A1 (en) 2010-02-11
DK2323617T3 (da) 2017-04-24
EP2674147A1 (en) 2013-12-18
US20100028438A1 (en) 2010-02-04
EP2326302B1 (en) 2016-07-27
HUE031598T2 (hu) 2017-07-28
RU2011107877A (ru) 2012-09-10
EP3988082A1 (en) 2022-04-27
US20190076579A1 (en) 2019-03-14
CA3112106C (en) 2023-10-17
US8357795B2 (en) 2013-01-22
SG10201505441TA (en) 2015-08-28
CN102170855A (zh) 2011-08-31
CN102170856A (zh) 2011-08-31
US9238013B2 (en) 2016-01-19
RU2496474C2 (ru) 2013-10-27
US20190076580A1 (en) 2019-03-14
PT2323617T (pt) 2017-04-24
CY1118821T1 (el) 2018-01-10
US20190350832A1 (en) 2019-11-21
US10328180B2 (en) 2019-06-25
US20180000992A1 (en) 2018-01-04
JP2014237719A (ja) 2014-12-18
US20110118206A1 (en) 2011-05-19
HK1189518A1 (en) 2014-06-13
WO2010015900A1 (en) 2010-02-11
CA2732788C (en) 2017-01-10
US8822676B2 (en) 2014-09-02
US20190134275A9 (en) 2019-05-09

Similar Documents

Publication Publication Date Title
DK2326302T3 (da) Hyaluronsyre-baserede geler, der indbefatter lidocainhydrochlorid
JP2011529762A5 (da)
JP2011529763A5 (da)
AU2020267294B2 (en) Hyaluronic acid-based gels including anesthetic agents