DD274423A5 - Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten - Google Patents

Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten Download PDF

Info

Publication number
DD274423A5
DD274423A5 DD88318652A DD31865288A DD274423A5 DD 274423 A5 DD274423 A5 DD 274423A5 DD 88318652 A DD88318652 A DD 88318652A DD 31865288 A DD31865288 A DD 31865288A DD 274423 A5 DD274423 A5 DD 274423A5
Authority
DD
German Democratic Republic
Prior art keywords
compound
general formula
substituted
alkyl
group
Prior art date
Application number
DD88318652A
Other languages
German (de)
English (en)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
�������`�����@�������k��
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by �������`�����@�������k�� filed Critical �������`�����@�������k��
Publication of DD274423A5 publication Critical patent/DD274423A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
DD88318652A 1987-08-04 1988-08-03 Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten DD274423A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
DD274423A5 true DD274423A5 (de) 1989-12-20

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
DD88318652A DD274423A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten
DD88326917A DD299067A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD88326917A DD299067A5 (de) 1987-08-04 1988-08-03 Verfahren zur herstellung von zwischenprodukten fuer epipodophyllotoxinglucosid-4'-phosphat-derivate

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD274423A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU202547B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK541288A3 (enExample)
YU (3) YU143688A (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (enExample) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
WO1996040886A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
IL125895A (en) * 1996-04-01 2001-09-13 Epix Medical Inc Use of an image-enhancing moiety in the preparation of a bioactivated nmr or optical imaging contrast agent from a prodrug
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
MXPA05000652A (es) 2002-07-15 2005-08-19 Univ Texas Anticuerpos seleccionados y peptidos de duramicina que se enlazan a fosfolipidos anionicos y aminofosfolipidos y sus usos en el tratamiento de infecciones virales y del cancer.
EP2260874A1 (en) * 2003-01-06 2010-12-15 Angiochem Inc. Aprotinin analogs as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
JP5175108B2 (ja) * 2005-02-18 2013-04-03 アンジオケム・インコーポレーテッド 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
DK2233156T3 (da) * 2005-07-15 2013-08-05 Angiochem Inc Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CA2705152C (en) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
EA201000947A1 (ru) 2007-12-20 2011-02-28 Новартис Аг Производные тиазола, применимые в качестве ингибиторов киназы pi3
PL2279008T3 (pl) * 2008-04-18 2020-03-31 Angiochem Inc. Kompozycje farmaceutyczne paklitakselu, analogów paklitakselu lub koniugatów paklitakselu oraz powiązane sposoby wytwarzania i zastosowanie
EP2346896A4 (en) 2008-10-15 2014-06-25 Angiochem Inc ETOPOSID AND DOXORUBICIN CONJUGATES FOR ACTIVITY EXTRACTION
MX2011004017A (es) 2008-10-15 2011-06-24 Angiochem Inc Conjugados de agonistas glp-1 y usos de los mismos.
BRPI0922689A2 (pt) * 2008-12-05 2018-11-06 Angiochem Inc. conjugados de neurotensina ou análogos de neurotensina e usos dos mesmos
AU2009327267A1 (en) 2008-12-17 2011-07-14 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
EP2421562B1 (en) 2009-04-20 2019-03-13 Angiochem Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
CA2766537A1 (en) 2009-07-02 2011-01-06 Angiochem Inc. Multimeric peptide conjugates and uses thereof
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
EP2539337A1 (en) 2010-02-22 2013-01-02 F. Hoffmann-La Roche AG Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
EP2670753B1 (en) 2011-01-31 2016-10-19 Novartis AG Novel heterocyclic derivatives
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EA023935B1 (ru) 2011-10-28 2016-07-29 Новартис Аг Производные пурина и их применение для лечения заболевания
JP2015500833A (ja) * 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
SG11201406550QA (en) 2012-05-16 2014-11-27 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
SI3076969T1 (sl) 2013-12-06 2021-12-31 Novartis Ag Režim omderjanja izooblike alfa selektivnega zaviralca fosfatidilino- zitol 3-kinaze
CN107921143B (zh) 2015-06-15 2021-11-19 安吉奥开米公司 用于治疗软脑膜癌病的方法
US20180280370A1 (en) 2015-11-02 2018-10-04 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (enExample) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
HK6392A (en) 1992-01-17
NL970042I1 (nl) 1998-03-02
FI883596A7 (fi) 1989-02-05
NO172440C (no) 1993-07-21
GB8818462D0 (en) 1988-09-07
LU87290A1 (fr) 1990-02-07
LU90138I2 (fr) 1997-11-26
GB2207674B (en) 1991-09-11
YU10490A (en) 1990-06-30
YU10390A (en) 1990-06-30
HU211960A9 (en) 1996-01-29
SK279325B6 (sk) 1998-10-07
DK11992A (da) 1992-01-31
IT1226825B (it) 1991-02-19
US4904768A (en) 1990-02-27
HU202547B (en) 1991-03-28
FR2622193B1 (fr) 1993-12-17
DK434088A (da) 1989-02-05
CN1061225A (zh) 1992-05-20
CY1625A (en) 1992-07-10
CA1310637C (en) 1992-11-24
NO1998002I1 (no) 1998-01-14
NL192683B (enExample) 1997-08-01
PT88186A (pt) 1989-06-30
IT8821535A0 (it) 1988-07-28
US5041424A (en) 1991-08-20
NO920277L (no) 1989-02-24
ATA195588A (de) 1994-07-15
SK541288A3 (en) 1998-10-07
NO920277D0 (no) 1992-01-22
JPH0699465B2 (ja) 1994-12-07
AT398974B (de) 1995-02-27
GR1000490B (el) 1992-07-30
SG101291G (en) 1992-01-17
NO172440B (no) 1993-04-13
IE61040B1 (en) 1994-09-07
NO170284C (no) 1992-09-30
NL192683C (nl) 1997-12-02
CZ541288A3 (cs) 1999-12-15
NL8801934A (nl) 1989-03-01
GB2207674A (en) 1989-02-08
NO883299D0 (no) 1988-07-26
PT88186B (pt) 1995-07-03
KR900006230B1 (ko) 1990-08-27
HUT47303A (en) 1989-02-28
CH676716A5 (enExample) 1991-02-28
SE8802815D0 (sv) 1988-08-03
KR890003790A (ko) 1989-04-18
NO170284B (no) 1992-06-22
DK169344B1 (da) 1994-10-10
USRE35524E (en) 1997-06-03
MX173843B (es) 1994-03-30
NO883299L (no) 1989-02-24
DK11992D0 (da) 1992-01-31
NZ225615A (en) 1991-06-25
SE8802815L (sv) 1989-02-05
JPH01100188A (ja) 1989-04-18
DD299067A5 (de) 1992-03-26
DK434088D0 (da) 1988-08-03
FI87790C (fi) 1993-02-25
IL87290A (en) 1993-01-31
DE3826562A1 (de) 1989-02-16
BE1002982A4 (fr) 1991-10-15
IE882378L (en) 1989-02-04
HU208147B (en) 1993-08-30
NL970042I2 (enExample) 2005-06-01
DE3826562C2 (enExample) 1993-04-08
SE502214C2 (sv) 1995-09-18
FR2622193A1 (fr) 1989-04-28
NO920665L (no) 1989-02-24
GR880100512A (en) 1989-05-25
IL87290A0 (en) 1989-01-31
CN1027169C (zh) 1994-12-28
FI883596A0 (fi) 1988-08-01
CZ286893B6 (cs) 2000-07-12
AU610619B2 (en) 1991-05-23
YU143688A (en) 1990-04-30
FI87790B (fi) 1992-11-13
NO920665D0 (no) 1992-02-20
HU905862D0 (en) 1991-03-28
MY104321A (en) 1994-03-31
AU2030688A (en) 1989-06-08
ES2010775A6 (es) 1989-12-01
MX9202851A (es) 1992-06-30

Similar Documents

Publication Publication Date Title
DD274423A5 (de) Verfahren zur herstellung von epipodophyllotoxinglucosid-4'-phosphat derivaten
EP0369182A1 (de) Tumorhemmende Saccharid-Konjugate
EP0099068B1 (de) Neue Glycerinderivate zur Synthese von Phospholipiden
DD201799A5 (de) Verfahren zur herstellung von oxazaphosphorin-4-thioalkansulfonsaeuren und ihrer neutralen salze
EP0229128B1 (de) Glycero-3(2)-phospho-l-serinderivate und diese enthaltende pharmazeutischen präparate
DE60116081T2 (de) Bis-(n,n'-bis-(2-haloethyl)amino) phosphoramidate als antitumor-mittel
EP0594999B1 (de) Phospholipidderivate, die höhere Elemente der V. Hauptgruppe enthalten
EP1521761B1 (de) Cdg-therapie mit mannose
AT393505B (de) Arzneimittel, welche alkylphosphoamine in kombination mit einem alkylglycerin enthalten
DE102009052034A1 (de) Synthese von Phosphorestern
DE4400310A1 (de) Neue Nukleosid-Lipid-Addukte, ihre Herstellung und ihre pharmazeutische Verwendung
DE3631004A1 (de) Saccharid-phosphate und ihre ester und verfahren zu ihrer herstellung
DE19750508A1 (de) Neue Phospholipid-Addukte des 9-beta-D-Arabinofuranosyl-2-fluoradenins, ihre Herstellung und ihre pharmazeutische Verwendung
DE3606633A1 (de) Neue phosphoverbindungen und diese enthaltende arzneimittel
DE3641377A1 (de) Neue phosphorverbindungen und diese enthaltende arzneimittel
EP0224925A2 (de) Neue Phosphoverbindungen und diese enthaltende Arzneimittel

Legal Events

Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20080804