GB2207674B - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives

Info

Publication number
GB2207674B
GB2207674B GB8818462A GB8818462A GB2207674B GB 2207674 B GB2207674 B GB 2207674B GB 8818462 A GB8818462 A GB 8818462A GB 8818462 A GB8818462 A GB 8818462A GB 2207674 B GB2207674 B GB 2207674B
Authority
GB
United Kingdom
Prior art keywords
podophyllotoxin derivatives
podophyllotoxin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB8818462A
Other languages
English (en)
Other versions
GB2207674A (en
GB8818462D0 (en
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Co
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co, Bristol Myers Squibb Co filed Critical Bristol Myers Co
Publication of GB8818462D0 publication Critical patent/GB8818462D0/en
Publication of GB2207674A publication Critical patent/GB2207674A/en
Application granted granted Critical
Publication of GB2207674B publication Critical patent/GB2207674B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
GB8818462A 1987-08-04 1988-08-03 Podophyllotoxin derivatives Expired - Lifetime GB2207674B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (3)

Publication Number Publication Date
GB8818462D0 GB8818462D0 (en) 1988-09-07
GB2207674A GB2207674A (en) 1989-02-08
GB2207674B true GB2207674B (en) 1991-09-11

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8818462A Expired - Lifetime GB2207674B (en) 1987-08-04 1988-08-03 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD299067A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU202547B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK541288A3 (enExample)
YU (3) YU143688A (enExample)

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US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (enExample) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
WO1996040886A1 (en) * 1995-06-07 1996-12-19 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
BR9708470A (pt) * 1996-04-01 1999-04-13 Epix Medical Inc Agentes de contraste bioativados para formação de imagem para diagnósticos
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
EP2283868B1 (en) 2002-07-15 2016-03-30 Board of Regents, The University of Texas System Peptides binding to phosphatidylethanolamine and their use in treating viral infections and cancer
ES2368941T3 (es) * 2003-01-06 2011-11-23 Angiochem Inc. Angiopep-1, compuestos relacionados y utilizaciones correspondientes.
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
RU2408605C2 (ru) * 2005-02-18 2011-01-10 Анджиокем Инк. Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
PL2233156T3 (pl) * 2005-07-15 2013-09-30 Angiochem Inc Zastosowanie polipeptydów aprotyninowych jako nośników w koniugatach farmaceutycznych
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
BRPI0820722A2 (pt) 2007-12-20 2015-06-16 Novartis Ag Derivados de tiazol usados como inibidores de pi 3 cinases
JP5860698B2 (ja) * 2008-04-18 2016-02-16 アンジオケム，インコーポレーテッド パクリタキセル、パクリタキセル類似体またはパクリタキセルコンジュゲートの医薬組成物ならびに関連する調製方法および使用方法
EP2346906A4 (en) 2008-10-15 2013-04-24 Angiochem Inc CONJUGATES FROM GLP-1 AGONISTS AND THEIR USE
JP5705118B2 (ja) 2008-10-15 2015-04-22 アンジオケム インコーポレーテッド 薬物送達のためのエトポシドおよびドキソルビシン複合体
JP5759379B2 (ja) * 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド ニューロテンシンまたはニューロテンシンアナログおよびその使用
WO2010069074A1 (en) 2008-12-17 2010-06-24 Universite Du Quebec A Montreal Membrane type-1 matrix metalloprotein inhibitors and uses thereof
EP2421562B1 (en) 2009-04-20 2019-03-13 Angiochem Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
EP2539337A1 (en) 2010-02-22 2013-01-02 F. Hoffmann-La Roche AG Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
MX343706B (es) 2011-01-31 2016-11-18 Novartis Ag Derivados heterocíclicos novedosos.
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
BR112014009890A2 (pt) 2011-10-28 2020-10-27 Novartis Ag derivados de purina e seu uso no tratamento de doença
CA2855994A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
BR112014028420A2 (pt) 2012-05-16 2017-09-19 Novartis Ag regime de dosagem para um inibidor de quinase pi-3
WO2014098877A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
PL3076969T3 (pl) 2013-12-06 2022-01-17 Novartis Ag Schemat dawkowania selektywnego inhibitora 3-kinazy fosfatydynozytolu alfa-izoformy
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
MX2018005298A (es) 2015-11-02 2018-06-22 Novartis Ag Regimen de dosificacion para un inhibidor de fosfatidilinositol 3-quinasa.
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3408441A (en) * 1965-12-14 1968-10-29 Sandoz Ltd Epipodophyllotoxin-beta-d-glucosides and derivatives thereof
US3524844A (en) * 1965-09-21 1970-08-18 Sandoz Ag Epipodophyllotoxin glucoside derivatives

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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US3524844A (en) * 1965-09-21 1970-08-18 Sandoz Ag Epipodophyllotoxin glucoside derivatives
US3408441A (en) * 1965-12-14 1968-10-29 Sandoz Ltd Epipodophyllotoxin-beta-d-glucosides and derivatives thereof

Also Published As

Publication number Publication date
NO920277D0 (no) 1992-01-22
CZ286893B6 (cs) 2000-07-12
SK279325B6 (sk) 1998-10-07
PT88186A (pt) 1989-06-30
FR2622193B1 (fr) 1993-12-17
FR2622193A1 (fr) 1989-04-28
GR880100512A (en) 1989-05-25
NZ225615A (en) 1991-06-25
PT88186B (pt) 1995-07-03
BE1002982A4 (fr) 1991-10-15
IT8821535A0 (it) 1988-07-28
IL87290A (en) 1993-01-31
CN1027169C (zh) 1994-12-28
NO883299L (no) 1989-02-24
SG101291G (en) 1992-01-17
IT1226825B (it) 1991-02-19
CY1625A (en) 1992-07-10
HUT47303A (en) 1989-02-28
KR900006230B1 (ko) 1990-08-27
US4904768A (en) 1990-02-27
GR1000490B (el) 1992-07-30
AU610619B2 (en) 1991-05-23
FI87790B (fi) 1992-11-13
YU10490A (en) 1990-06-30
AT398974B (de) 1995-02-27
DK11992D0 (da) 1992-01-31
MY104321A (en) 1994-03-31
JPH01100188A (ja) 1989-04-18
DK434088A (da) 1989-02-05
NL192683B (enExample) 1997-08-01
AU2030688A (en) 1989-06-08
DK434088D0 (da) 1988-08-03
NO170284C (no) 1992-09-30
DD274423A5 (de) 1989-12-20
YU143688A (en) 1990-04-30
IE882378L (en) 1989-02-04
DK11992A (da) 1992-01-31
ATA195588A (de) 1994-07-15
SE502214C2 (sv) 1995-09-18
ES2010775A6 (es) 1989-12-01
LU90138I2 (fr) 1997-11-26
NO920665D0 (no) 1992-02-20
IE61040B1 (en) 1994-09-07
NL192683C (nl) 1997-12-02
FI883596A7 (fi) 1989-02-05
USRE35524E (en) 1997-06-03
NO172440B (no) 1993-04-13
IL87290A0 (en) 1989-01-31
DE3826562A1 (de) 1989-02-16
CH676716A5 (enExample) 1991-02-28
NO170284B (no) 1992-06-22
HK6392A (en) 1992-01-17
JPH0699465B2 (ja) 1994-12-07
HU208147B (en) 1993-08-30
SE8802815D0 (sv) 1988-08-03
US5041424A (en) 1991-08-20
DK169344B1 (da) 1994-10-10
KR890003790A (ko) 1989-04-18
CZ541288A3 (cs) 1999-12-15
CN1061225A (zh) 1992-05-20
YU10390A (en) 1990-06-30
SE8802815L (sv) 1989-02-05
LU87290A1 (fr) 1990-02-07
NL970042I2 (enExample) 2005-06-01
HU202547B (en) 1991-03-28
GB2207674A (en) 1989-02-08
NL8801934A (nl) 1989-03-01
SK541288A3 (en) 1998-10-07
CA1310637C (en) 1992-11-24
GB8818462D0 (en) 1988-09-07
NO172440C (no) 1993-07-21
NO920277L (no) 1989-02-24
FI883596A0 (fi) 1988-08-01
FI87790C (fi) 1993-02-25
HU211960A9 (en) 1996-01-29
NL970042I1 (nl) 1998-03-02
DD299067A5 (de) 1992-03-26
MX9202851A (es) 1992-06-30
NO920665L (no) 1989-02-24
MX173843B (es) 1994-03-30
NO883299D0 (no) 1988-07-26
HU905862D0 (en) 1991-03-28
NO1998002I1 (no) 1998-01-14
DE3826562C2 (enExample) 1993-04-08

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Free format text: PRODUCT NAME: ETOPOSIDE PHOSPHATE, OPTIONALLY IN THE FORM OF A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF; REGISTERED: SE 12512 19960412; UK 11184/0052 19960523

Spc suppl protection certif: SPC/GB96/044

Filing date: 19960923

Expiry date: 20080803

Extension date: 20110411