BE1002982A4 - Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. - Google Patents

Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. Download PDF

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Publication number
BE1002982A4
BE1002982A4 BE8800898A BE8800898A BE1002982A4 BE 1002982 A4 BE1002982 A4 BE 1002982A4 BE 8800898 A BE8800898 A BE 8800898A BE 8800898 A BE8800898 A BE 8800898A BE 1002982 A4 BE1002982 A4 BE 1002982A4
Authority
BE
Belgium
Prior art keywords
phosphate derivatives
glucosides
epipodophyllotoxin glucosides
epipodophyllotoxin
phosphate
Prior art date
Application number
BE8800898A
Other languages
English (en)
French (fr)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of BE1002982A4 publication Critical patent/BE1002982A4/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
BE8800898A 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine. BE1002982A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
BE1002982A4 true BE1002982A4 (fr) 1991-10-15

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8800898A BE1002982A4 (fr) 1987-08-04 1988-08-03 Derives de 4'-phosphates de glucosides d'epipodophyllotoxine.

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD299067A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU208147B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK279325B6 (enExample)
YU (3) YU143688A (enExample)

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US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (enExample) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
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US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
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US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
EP1438319A1 (en) * 2001-10-26 2004-07-21 Centre National De La Recherche Scientifique (Cnrs) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
KR20120068769A (ko) 2002-07-15 2012-06-27 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
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Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

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CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
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US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation

Non-Patent Citations (1)

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Title
PROCEEDINGDS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 85, no. 13, July 1988, pages 4842-4846; P.D. SENTER et al.: "Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination wth etoposide phosphate" *

Also Published As

Publication number Publication date
IE61040B1 (en) 1994-09-07
JPH0699465B2 (ja) 1994-12-07
FI883596A7 (fi) 1989-02-05
CZ541288A3 (cs) 1999-12-15
SK541288A3 (en) 1998-10-07
MY104321A (en) 1994-03-31
NL192683B (enExample) 1997-08-01
US4904768A (en) 1990-02-27
NL192683C (nl) 1997-12-02
IL87290A (en) 1993-01-31
NO170284C (no) 1992-09-30
NO170284B (no) 1992-06-22
DK169344B1 (da) 1994-10-10
DK434088A (da) 1989-02-05
NL8801934A (nl) 1989-03-01
CZ286893B6 (cs) 2000-07-12
DE3826562C2 (enExample) 1993-04-08
KR900006230B1 (ko) 1990-08-27
MX173843B (es) 1994-03-30
DE3826562A1 (de) 1989-02-16
US5041424A (en) 1991-08-20
GR1000490B (el) 1992-07-30
IT8821535A0 (it) 1988-07-28
KR890003790A (ko) 1989-04-18
AT398974B (de) 1995-02-27
HK6392A (en) 1992-01-17
SE502214C2 (sv) 1995-09-18
NO883299D0 (no) 1988-07-26
IT1226825B (it) 1991-02-19
FI883596A0 (fi) 1988-08-01
IE882378L (en) 1989-02-04
CN1027169C (zh) 1994-12-28
NL970042I2 (enExample) 2005-06-01
ATA195588A (de) 1994-07-15
PT88186A (pt) 1989-06-30
CY1625A (en) 1992-07-10
SK279325B6 (sk) 1998-10-07
NO920665L (no) 1989-02-24
NO172440B (no) 1993-04-13
HU208147B (en) 1993-08-30
YU10490A (en) 1990-06-30
FR2622193A1 (fr) 1989-04-28
NO920277L (no) 1989-02-24
FI87790C (fi) 1993-02-25
DK434088D0 (da) 1988-08-03
JPH01100188A (ja) 1989-04-18
GB8818462D0 (en) 1988-09-07
HU211960A9 (en) 1996-01-29
NO172440C (no) 1993-07-21
SG101291G (en) 1992-01-17
USRE35524E (en) 1997-06-03
GB2207674A (en) 1989-02-08
HU202547B (en) 1991-03-28
AU610619B2 (en) 1991-05-23
ES2010775A6 (es) 1989-12-01
NL970042I1 (nl) 1998-03-02
FI87790B (fi) 1992-11-13
AU2030688A (en) 1989-06-08
IL87290A0 (en) 1989-01-31
SE8802815L (sv) 1989-02-05
YU143688A (en) 1990-04-30
HU905862D0 (en) 1991-03-28
SE8802815D0 (sv) 1988-08-03
MX9202851A (es) 1992-06-30
PT88186B (pt) 1995-07-03
NO920277D0 (no) 1992-01-22
HUT47303A (en) 1989-02-28
DK11992D0 (da) 1992-01-31
NO920665D0 (no) 1992-02-20
GR880100512A (en) 1989-05-25
CA1310637C (en) 1992-11-24
GB2207674B (en) 1991-09-11
LU87290A1 (fr) 1990-02-07
DD274423A5 (de) 1989-12-20
NO883299L (no) 1989-02-24
DD299067A5 (de) 1992-03-26
FR2622193B1 (fr) 1993-12-17
CH676716A5 (enExample) 1991-02-28
LU90138I2 (fr) 1997-11-26
NZ225615A (en) 1991-06-25
YU10390A (en) 1990-06-30
NO1998002I1 (no) 1998-01-14
CN1061225A (zh) 1992-05-20
DK11992A (da) 1992-01-31

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