DK0443471T3 - 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater - Google Patents

2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Info

Publication number
DK0443471T3
DK0443471T3 DK91102225.9T DK91102225T DK0443471T3 DK 0443471 T3 DK0443471 T3 DK 0443471T3 DK 91102225 T DK91102225 T DK 91102225T DK 0443471 T3 DK0443471 T3 DK 0443471T3
Authority
DK
Denmark
Prior art keywords
deoxy
preparations
processes
preparation
methylidenecytidine
Prior art date
Application number
DK91102225.9T
Other languages
English (en)
Inventor
Atsushi Sakai
Toshiyuki Shibata
Takayuki Ogawa
Shinji Sakata
Takanori Miyashita
Kazuhiko Kondo
Original Assignee
Yoshitomi Pharmaceutical
Yamasa Shoyu Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical, Yamasa Shoyu Kk filed Critical Yoshitomi Pharmaceutical
Application granted granted Critical
Publication of DK0443471T3 publication Critical patent/DK0443471T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK91102225.9T 1990-02-19 1991-02-16 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater DK0443471T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2037695A JPH0615557B2 (ja) 1990-02-19 1990-02-19 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Publications (1)

Publication Number Publication Date
DK0443471T3 true DK0443471T3 (da) 1995-06-26

Family

ID=12504690

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91102225.9T DK0443471T3 (da) 1990-02-19 1991-02-16 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Country Status (9)

Country Link
US (2) US5183882A (da)
EP (1) EP0443471B1 (da)
JP (1) JPH0615557B2 (da)
KR (2) KR960010947B1 (da)
AT (1) ATE118012T1 (da)
CA (1) CA2036507C (da)
DE (1) DE69107098T2 (da)
DK (1) DK0443471T3 (da)
ES (1) ES2067780T3 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401726A (en) * 1988-08-25 1995-03-28 Yoshitomi Pharaceutical Industries, Ltd. 2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
ES2139753T3 (es) * 1993-08-19 2000-02-16 Merck & Co Inc Forma cristalina termodinamicamente estable de la sal del acido benzoico de la 4''-desoxi-4''-epi-metilamino avermectina b1a/b1b y procedimiento para su preparacion.
ATE186732T1 (de) * 1994-01-07 1999-12-15 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydr t
WO1996001834A1 (en) * 1994-07-12 1996-01-25 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted methylidene)-4'-thionucleoside
US5665711A (en) * 1995-12-12 1997-09-09 Yoshitomi Pharmaceutical Industries, Ltd. Antitumor composition for oral administration
EP2106788A1 (en) * 2008-04-04 2009-10-07 Ipsen Pharma Liquid and freeze dried formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3854110T2 (de) * 1987-03-19 1995-11-30 Yamasa Shoyu Kk 2'-alkyliden-pyrimidin-nukleosid-derivate, verfahren zur herstellung und verwendung.
JPS63258818A (ja) * 1987-04-16 1988-10-26 Yoshitomi Pharmaceut Ind Ltd 制ガン剤
DE68922899T2 (de) * 1988-12-07 1995-10-12 Yamasa Shoyu Kk Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden.
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Also Published As

Publication number Publication date
EP0443471A1 (en) 1991-08-28
CA2036507C (en) 1996-09-10
DE69107098D1 (de) 1995-03-16
EP0443471B1 (en) 1995-02-01
KR0174212B1 (ko) 1999-02-01
US5183882A (en) 1993-02-02
US5412089A (en) 1995-05-02
JPH03240794A (ja) 1991-10-28
ES2067780T3 (es) 1995-04-01
DE69107098T2 (de) 1995-06-29
ATE118012T1 (de) 1995-02-15
KR970005016A (ko) 1997-01-29
KR910021351A (ko) 1991-12-20
KR960010947B1 (ko) 1996-08-14
JPH0615557B2 (ja) 1994-03-02
CA2036507A1 (en) 1991-08-20

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