DK0443471T3 - 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater - Google Patents

2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Info

Publication number
DK0443471T3
DK0443471T3 DK91102225.9T DK91102225T DK0443471T3 DK 0443471 T3 DK0443471 T3 DK 0443471T3 DK 91102225 T DK91102225 T DK 91102225T DK 0443471 T3 DK0443471 T3 DK 0443471T3
Authority
DK
Denmark
Prior art keywords
deoxy
preparations
processes
preparation
methylidenecytidine
Prior art date
Application number
DK91102225.9T
Other languages
English (en)
Inventor
Atsushi Sakai
Toshiyuki Shibata
Takayuki Ogawa
Shinji Sakata
Takanori Miyashita
Kazuhiko Kondo
Original Assignee
Yoshitomi Pharmaceutical
Yamasa Shoyu Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical, Yamasa Shoyu Kk filed Critical Yoshitomi Pharmaceutical
Application granted granted Critical
Publication of DK0443471T3 publication Critical patent/DK0443471T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DK91102225.9T 1990-02-19 1991-02-16 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater DK0443471T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2037695A JPH0615557B2 (ja) 1990-02-19 1990-02-19 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Publications (1)

Publication Number Publication Date
DK0443471T3 true DK0443471T3 (da) 1995-06-26

Family

ID=12504690

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91102225.9T DK0443471T3 (da) 1990-02-19 1991-02-16 2-Deoxy-2-methylidencytidin-dihydrat, fremgangsmåder til fremstilling heraf, samt præparater

Country Status (9)

Country Link
US (2) US5183882A (da)
EP (1) EP0443471B1 (da)
JP (1) JPH0615557B2 (da)
KR (2) KR960010947B1 (da)
AT (1) ATE118012T1 (da)
CA (1) CA2036507C (da)
DE (1) DE69107098T2 (da)
DK (1) DK0443471T3 (da)
ES (1) ES2067780T3 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401726A (en) * 1988-08-25 1995-03-28 Yoshitomi Pharaceutical Industries, Ltd. 2'methylidenepyrimidine nucleoside compounds, their use and method for production thereof
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
HU217769B (hu) * 1993-08-19 2000-04-28 Merck & Co. Inc. 4"-Dezoxi-4"-epi-metil-amino-avermektin-B1a/B1b benzoesavas sójának termodinamikailag stabil kristályformája és eljárás annak előállítására, hatóanyagként ezt tartalmazó kompozíció és eljárás rovarok lekűzdésére
JPH09511227A (ja) * 1994-01-07 1997-11-11 メレルファーマスーティカルズ インコーポレイテッド （ｅ）−２’−デオキシ−２’−（フルオロメチレン）シチジンの一水和物
US5811408A (en) * 1994-07-12 1998-09-22 Yamasa Corporation 2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
US5665711A (en) * 1995-12-12 1997-09-09 Yoshitomi Pharmaceutical Industries, Ltd. Antitumor composition for oral administration
EP2106788A1 (en) * 2008-04-04 2009-10-07 Ipsen Pharma Liquid and freeze dried formulations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910008800B1 (ko) * 1987-03-19 1991-10-21 야마사 쇼오유 가부시끼가이샤 2'-알킬리덴 피리미딘 누클레오시드 유도체, 그 제조법, 및 그 용도
JPS63258818A (ja) * 1987-04-16 1988-10-26 Yoshitomi Pharmaceut Ind Ltd 制ガン剤
EP0373485B1 (en) * 1988-12-07 1995-05-31 Yamasa Shoyu Co., Ltd. Pyrimidine 2'-methylidene nucleoside compounds
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶

Also Published As

Publication number Publication date
US5412089A (en) 1995-05-02
JPH0615557B2 (ja) 1994-03-02
US5183882A (en) 1993-02-02
CA2036507A1 (en) 1991-08-20
KR960010947B1 (ko) 1996-08-14
CA2036507C (en) 1996-09-10
DE69107098D1 (de) 1995-03-16
ATE118012T1 (de) 1995-02-15
KR970005016A (ko) 1997-01-29
KR910021351A (ko) 1991-12-20
EP0443471B1 (en) 1995-02-01
EP0443471A1 (en) 1991-08-28
JPH03240794A (ja) 1991-10-28
ES2067780T3 (es) 1995-04-01
DE69107098T2 (de) 1995-06-29
KR0174212B1 (ko) 1999-02-01

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