GR1000490B - Μεθοδος παρασκευης 4-φωσφορικων παραγωγων γλυκοζιτη επιποδοφυλλ οτοξινης. - Google Patents

Μεθοδος παρασκευης 4-φωσφορικων παραγωγων γλυκοζιτη επιποδοφυλλ οτοξινης.

Info

Publication number
GR1000490B
GR1000490B GR880100512A GR880100512A GR1000490B GR 1000490 B GR1000490 B GR 1000490B GR 880100512 A GR880100512 A GR 880100512A GR 880100512 A GR880100512 A GR 880100512A GR 1000490 B GR1000490 B GR 1000490B
Authority
GR
Greece
Prior art keywords
production
otoxinis
glykoziti
repair
phosphoric
Prior art date
Application number
GR880100512A
Other languages
English (en)
Other versions
GR880100512A (en
Inventor
F John Kadow
G Mark Saulnier
D Peter Senter
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of GR880100512A publication Critical patent/GR880100512A/el
Publication of GR1000490B publication Critical patent/GR1000490B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)

Abstract

Τα φωσφορικά παράγωγα γλυκοζιτών της 4-απομεθυλοεπιποδοφυλλοτοξίνης είναι νέοι παράγοντες κατά του όγκου και τα άλατα αυτών, προσφέρουν το φαρμακευτικό πλεονέκτημα της μεγάλης διαλυτότητας στο νερό. ω
GR880100512A 1987-08-04 1988-08-04 Μεθοδος παρασκευης 4-φωσφορικων παραγωγων γλυκοζιτη επιποδοφυλλ οτοξινης. GR1000490B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
GR880100512A GR880100512A (en) 1989-05-25
GR1000490B true GR1000490B (el) 1992-07-30

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
GR880100512A GR1000490B (el) 1987-08-04 1988-08-04 Μεθοδος παρασκευης 4-φωσφορικων παραγωγων γλυκοζιτη επιποδοφυλλ οτοξινης.

Country Status (34)

Country Link
US (3) US4904768A (el)
JP (1) JPH0699465B2 (el)
KR (1) KR900006230B1 (el)
CN (1) CN1027169C (el)
AT (1) AT398974B (el)
BE (1) BE1002982A4 (el)
CA (1) CA1310637C (el)
CH (1) CH676716A5 (el)
CY (1) CY1625A (el)
CZ (1) CZ286893B6 (el)
DD (2) DD299067A5 (el)
DE (1) DE3826562A1 (el)
DK (2) DK169344B1 (el)
ES (1) ES2010775A6 (el)
FI (1) FI87790C (el)
FR (1) FR2622193B1 (el)
GB (1) GB2207674B (el)
GR (1) GR1000490B (el)
HK (1) HK6392A (el)
HU (3) HU208147B (el)
IE (1) IE61040B1 (el)
IL (1) IL87290A (el)
IT (1) IT1226825B (el)
LU (2) LU87290A1 (el)
MX (1) MX173843B (el)
MY (1) MY104321A (el)
NL (2) NL192683C (el)
NO (4) NO170284C (el)
NZ (1) NZ225615A (el)
PT (1) PT88186B (el)
SE (1) SE502214C2 (el)
SG (1) SG101291G (el)
SK (1) SK541288A3 (el)
YU (3) YU143688A (el)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (el) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
AU726914B2 (en) 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
BR0206206A (pt) * 2001-10-26 2005-01-11 Centre Nat Rech Scient Derivados de etoposide e análogos, e composições farmacêuticas contendo os mesmos
US7572442B2 (en) 2002-07-15 2009-08-11 Board Of Regents, The University Of Texas System Selected antibody compositions for binding to aminophospholipids
CN1747747B (zh) * 2003-01-06 2012-09-05 安吉奥开米公司 作为穿过血脑屏障的载体的抑酶肽及类似物
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
CN101160403B (zh) * 2005-02-18 2014-08-13 安吉奥开米公司 转运化合物穿过血脑屏障的分子
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US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
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US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
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CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481094A (de) * 1966-12-13 1969-11-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
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Also Published As

Publication number Publication date
GB8818462D0 (en) 1988-09-07
CN1027169C (zh) 1994-12-28
NO920277D0 (no) 1992-01-22
ATA195588A (de) 1994-07-15
SG101291G (en) 1992-01-17
MX173843B (es) 1994-03-30
DE3826562C2 (el) 1993-04-08
US4904768A (en) 1990-02-27
FI883596A0 (fi) 1988-08-01
DK11992D0 (da) 1992-01-31
NO172440C (no) 1993-07-21
HU211960A9 (en) 1996-01-29
IE61040B1 (en) 1994-09-07
NO170284C (no) 1992-09-30
GR880100512A (en) 1989-05-25
NO883299D0 (no) 1988-07-26
AU610619B2 (en) 1991-05-23
NL8801934A (nl) 1989-03-01
NO920665D0 (no) 1992-02-20
LU90138I2 (fr) 1997-11-26
USRE35524E (en) 1997-06-03
NO172440B (no) 1993-04-13
NL970042I2 (el) 2005-06-01
DE3826562A1 (de) 1989-02-16
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
DK11992A (da) 1992-01-31
IT8821535A0 (it) 1988-07-28
IL87290A0 (en) 1989-01-31
AU2030688A (en) 1989-06-08
US5041424A (en) 1991-08-20
FI883596A7 (fi) 1989-02-05
NZ225615A (en) 1991-06-25
GB2207674A (en) 1989-02-08
AT398974B (de) 1995-02-27
KR900006230B1 (ko) 1990-08-27
SE502214C2 (sv) 1995-09-18
NO883299L (no) 1989-02-24
YU10490A (en) 1990-06-30
SK279325B6 (sk) 1998-10-07
LU87290A1 (fr) 1990-02-07
YU143688A (en) 1990-04-30
FR2622193A1 (fr) 1989-04-28
PT88186A (pt) 1989-06-30
SK541288A3 (en) 1998-10-07
CZ541288A3 (cs) 1999-12-15
HU202547B (en) 1991-03-28
CN1061225A (zh) 1992-05-20
CH676716A5 (el) 1991-02-28
IL87290A (en) 1993-01-31
MY104321A (en) 1994-03-31
FI87790B (fi) 1992-11-13
YU10390A (en) 1990-06-30
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
GB2207674B (en) 1991-09-11
DK434088A (da) 1989-02-05
DD299067A5 (de) 1992-03-26
BE1002982A4 (fr) 1991-10-15
FR2622193B1 (fr) 1993-12-17
CZ286893B6 (cs) 2000-07-12
IE882378L (en) 1989-02-04
DD274423A5 (de) 1989-12-20
DK169344B1 (da) 1994-10-10
CY1625A (en) 1992-07-10
DK434088D0 (da) 1988-08-03
NO170284B (no) 1992-06-22
NL192683B (el) 1997-08-01
ES2010775A6 (es) 1989-12-01
HUT47303A (en) 1989-02-28
HU208147B (en) 1993-08-30
JPH0699465B2 (ja) 1994-12-07
SE8802815L (sv) 1989-02-05
NO920665L (no) 1989-02-24
NO920277L (no) 1989-02-24
NL970042I1 (nl) 1998-03-02
JPH01100188A (ja) 1989-04-18
CA1310637C (en) 1992-11-24
PT88186B (pt) 1995-07-03
KR890003790A (ko) 1989-04-18
MX9202851A (es) 1992-06-30
SE8802815D0 (sv) 1988-08-03
NL192683C (nl) 1997-12-02
HK6392A (en) 1992-01-17

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