FR2622193B1 - Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant - Google Patents

Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant

Info

Publication number
FR2622193B1
FR2622193B1 FR8810258A FR8810258A FR2622193B1 FR 2622193 B1 FR2622193 B1 FR 2622193B1 FR 8810258 A FR8810258 A FR 8810258A FR 8810258 A FR8810258 A FR 8810258A FR 2622193 B1 FR2622193 B1 FR 2622193B1
Authority
FR
France
Prior art keywords
epipodophyllotoxins
glucoside
compositions containing
phosphate derivatives
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8810258A
Other languages
English (en)
Other versions
FR2622193A1 (fr
Inventor
G. Saulnier Mark
D. Senter Peter
F. Kadow John
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2622193A1 publication Critical patent/FR2622193A1/fr
Application granted granted Critical
Publication of FR2622193B1 publication Critical patent/FR2622193B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
FR8810258A 1987-08-04 1988-07-29 Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant Expired - Lifetime FR2622193B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
FR2622193A1 FR2622193A1 (fr) 1989-04-28
FR2622193B1 true FR2622193B1 (fr) 1993-12-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8810258A Expired - Lifetime FR2622193B1 (fr) 1987-08-04 1988-07-29 Derives d'epipodophyllotoxines glucosides 4'-phosphate leur utilisation et les compositions les contenant

Country Status (34)

Country Link
US (3) US4904768A (fr)
JP (1) JPH0699465B2 (fr)
KR (1) KR900006230B1 (fr)
CN (1) CN1027169C (fr)
AT (1) AT398974B (fr)
BE (1) BE1002982A4 (fr)
CA (1) CA1310637C (fr)
CH (1) CH676716A5 (fr)
CY (1) CY1625A (fr)
CZ (1) CZ286893B6 (fr)
DD (2) DD274423A5 (fr)
DE (1) DE3826562A1 (fr)
DK (2) DK169344B1 (fr)
ES (1) ES2010775A6 (fr)
FI (1) FI87790C (fr)
FR (1) FR2622193B1 (fr)
GB (1) GB2207674B (fr)
GR (1) GR1000490B (fr)
HK (1) HK6392A (fr)
HU (3) HU202547B (fr)
IE (1) IE61040B1 (fr)
IL (1) IL87290A (fr)
IT (1) IT1226825B (fr)
LU (2) LU87290A1 (fr)
MX (1) MX173843B (fr)
MY (1) MY104321A (fr)
NL (2) NL192683C (fr)
NO (4) NO170284C (fr)
NZ (1) NZ225615A (fr)
PT (1) PT88186B (fr)
SE (1) SE502214C2 (fr)
SG (1) SG101291G (fr)
SK (1) SK279325B6 (fr)
YU (3) YU143688A (fr)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (fr) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (fr) * 1991-12-23 1996-07-16 Uday Shankar Gogate Hexahydrate stable d'etoposide-4'-phosphate, sel disodique
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
EP0835303A4 (fr) * 1995-06-07 2000-09-13 Univ Jefferson Agents antifongiques et leurs procedes d'identification et d'utlisation
BR9708470A (pt) * 1996-04-01 1999-04-13 Epix Medical Inc Agentes de contraste bioativados para formação de imagem para diagnósticos
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (fr) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology DERIVES D'ACETAL DE 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
US20050009759A1 (en) * 2001-10-26 2005-01-13 Claude Monneret Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
CA2491310C (fr) 2002-07-15 2015-10-06 Board Of Regents, The University Of Texas System Compositions comprenant des derives de la duramycine impermeants vis-a-vis des parois cellulaires
PT1583562E (pt) * 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, compostos relacionados, e suas utilizações
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
CA2597958C (fr) * 2005-02-18 2019-01-15 Angiochem Inc. Polypeptides d'aprotinine pour transporter un compose a travers une barriere sang-cerveau
DK2433653T3 (da) * 2005-07-15 2019-08-19 Angiochem Inc Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CA2705152C (fr) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Compositions d'anticorps anti-vegf et procedes correspondants
PA8809001A1 (es) 2007-12-20 2009-07-23 Novartis Ag Compuestos organicos
EP2279008B1 (fr) * 2008-04-18 2019-03-06 Angiochem Inc. Compositions pharmaceutiques de paclitaxel, d'analogues de paclitaxel ou de conjugués de paclitaxel et procédés de préparation et d'utilisation correspondants
JP2012505637A (ja) 2008-10-15 2012-03-08 アンジオケム，インコーポレーテッド Ｇｌｐ−１アゴニストのコンジュゲート及びその使用
AU2009304505A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
CN102307904A (zh) * 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
CN102300987A (zh) 2008-12-17 2011-12-28 安吉奥开米公司 膜型-1基质金属蛋白抑制剂及其用途
US9173891B2 (en) 2009-04-20 2015-11-03 Angiochem, Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
RU2012103240A (ru) 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
EP2539337A1 (fr) 2010-02-22 2013-01-02 F. Hoffmann-La Roche AG Composés de pyrido[3,2-d]pyrimidine inhibiteurs de pi3k delta et procédés d'utilisation
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
PE20140293A1 (es) 2011-01-31 2014-03-19 Novartis Ag Novedosos derivados heterociclicos
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
EP2771342B1 (fr) 2011-10-28 2016-05-18 Novartis AG Dérivés de purine et utilisation de ceux-ci dans le traitement d'une maladie
JP2015500833A (ja) * 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
AU2013263043B2 (en) 2012-05-16 2016-06-16 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
WO2014098877A1 (fr) 2012-12-20 2014-06-26 Demerx, Inc. Noribogaïne substituée
TN2016000179A1 (en) 2013-12-06 2017-10-06 Novartis Ag Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor.
ES2826827T3 (es) 2015-06-15 2021-05-19 Angiochem Inc Métodos para el tratamiento de carcinomatosis leptomeníngea
RU2018119085A (ru) 2015-11-02 2019-12-04 Новартис Аг Схема введения ингибитора фосфатидилинозитол-3-киназы
WO2018060833A1 (fr) 2016-09-27 2018-04-05 Novartis Ag Schéma posologique pour l'alpelisib, un inhibiteur de la phosphatidylinositol 3-kinase spécifique de l'isoforme alpha
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (fr) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
LU87290A1 (fr) 1990-02-07
NO170284C (no) 1992-09-30
ES2010775A6 (es) 1989-12-01
HK6392A (en) 1992-01-17
DK169344B1 (da) 1994-10-10
NO883299L (no) 1989-02-24
HUT47303A (en) 1989-02-28
GR1000490B (el) 1992-07-30
CY1625A (en) 1992-07-10
US5041424A (en) 1991-08-20
SE8802815D0 (sv) 1988-08-03
KR900006230B1 (ko) 1990-08-27
CZ286893B6 (cs) 2000-07-12
NO170284B (no) 1992-06-22
IL87290A (en) 1993-01-31
DE3826562A1 (de) 1989-02-16
IT1226825B (it) 1991-02-19
NO883299D0 (no) 1988-07-26
YU10390A (en) 1990-06-30
AT398974B (de) 1995-02-27
DK434088D0 (da) 1988-08-03
BE1002982A4 (fr) 1991-10-15
MY104321A (en) 1994-03-31
HU905862D0 (en) 1991-03-28
FI87790C (fi) 1993-02-25
IE882378L (en) 1989-02-04
USRE35524E (en) 1997-06-03
GB8818462D0 (en) 1988-09-07
US4904768A (en) 1990-02-27
NL192683C (nl) 1997-12-02
CN1027169C (zh) 1994-12-28
HU208147B (en) 1993-08-30
SK541288A3 (en) 1998-10-07
DD299067A5 (de) 1992-03-26
FR2622193A1 (fr) 1989-04-28
JPH0699465B2 (ja) 1994-12-07
FI87790B (fi) 1992-11-13
NO920277D0 (no) 1992-01-22
DE3826562C2 (fr) 1993-04-08
GB2207674A (en) 1989-02-08
GR880100512A (en) 1989-05-25
FI883596A (fi) 1989-02-05
DD274423A5 (de) 1989-12-20
AU610619B2 (en) 1991-05-23
PT88186A (pt) 1989-06-30
KR890003790A (ko) 1989-04-18
NO920665L (no) 1989-02-24
GB2207674B (en) 1991-09-11
IL87290A0 (en) 1989-01-31
MX173843B (es) 1994-03-30
NZ225615A (en) 1991-06-25
CN1061225A (zh) 1992-05-20
SE502214C2 (sv) 1995-09-18
CZ541288A3 (cs) 1999-12-15
NO920277L (no) 1989-02-24
YU10490A (en) 1990-06-30
HU202547B (en) 1991-03-28
CH676716A5 (fr) 1991-02-28
SE8802815L (sv) 1989-02-05
IE61040B1 (en) 1994-09-07
NO1998002I1 (no) 1998-01-14
IT8821535A0 (it) 1988-07-28
SK279325B6 (sk) 1998-10-07
LU90138I2 (fr) 1997-11-26
SG101291G (en) 1992-01-17
DK11992D0 (da) 1992-01-31
FI883596A0 (fi) 1988-08-01
CA1310637C (fr) 1992-11-24
NO172440B (no) 1993-04-13
NL970042I1 (nl) 1998-03-02
JPH01100188A (ja) 1989-04-18
DK434088A (da) 1989-02-05
NL970042I2 (fr) 2005-06-01
HU211960A9 (en) 1996-01-29
DK11992A (da) 1992-01-31
NL192683B (fr) 1997-08-01
ATA195588A (de) 1994-07-15
NL8801934A (nl) 1989-03-01
YU143688A (en) 1990-04-30
AU2030688A (en) 1989-06-08
NO920665D0 (no) 1992-02-20
MX9202851A (es) 1992-06-30
PT88186B (pt) 1995-07-03
NO172440C (no) 1993-07-21

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Free format text: PRODUCT NAME: ETOPOSIDE PHOSPHATE; NAT. REGISTRATION NO/DATE: NL 21192 19960520; FIRST REGISTRATION: SE - 12512 19960412

Spc suppl protection certif: 96C0035

Filing date: 19961003

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