NL970042I1 - 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit. - Google Patents

4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Info

Publication number
NL970042I1
NL970042I1 NL970042C NL970042C NL970042I1 NL 970042 I1 NL970042 I1 NL 970042I1 NL 970042 C NL970042 C NL 970042C NL 970042 C NL970042 C NL 970042C NL 970042 I1 NL970042 I1 NL 970042I1
Authority
NL
Netherlands
Prior art keywords
demethyl
well
pharmaceutical composition
tumor activity
glucoside compound
Prior art date
Application number
NL970042C
Other languages
English (en)
Other versions
NL970042I2 (nl
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NL970042I1 publication Critical patent/NL970042I1/nl
Publication of NL970042I2 publication Critical patent/NL970042I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NL970042C 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit. NL970042I1 (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
NL970042I1 true NL970042I1 (nl) 1998-03-02
NL970042I2 NL970042I2 (nl) 2005-06-01

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8801934A NL192683C (nl) 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit
NL970042C NL970042I1 (nl) 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NL8801934A NL192683C (nl) 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit

Country Status (34)

Country Link
US (3) US4904768A (nl)
JP (1) JPH0699465B2 (nl)
KR (1) KR900006230B1 (nl)
CN (1) CN1027169C (nl)
AT (1) AT398974B (nl)
BE (1) BE1002982A4 (nl)
CA (1) CA1310637C (nl)
CH (1) CH676716A5 (nl)
CY (1) CY1625A (nl)
CZ (1) CZ286893B6 (nl)
DD (2) DD299067A5 (nl)
DE (1) DE3826562A1 (nl)
DK (2) DK169344B1 (nl)
ES (1) ES2010775A6 (nl)
FI (1) FI87790C (nl)
FR (1) FR2622193B1 (nl)
GB (1) GB2207674B (nl)
GR (1) GR1000490B (nl)
HK (1) HK6392A (nl)
HU (3) HU208147B (nl)
IE (1) IE61040B1 (nl)
IL (1) IL87290A (nl)
IT (1) IT1226825B (nl)
LU (2) LU87290A1 (nl)
MX (1) MX173843B (nl)
MY (1) MY104321A (nl)
NL (2) NL192683C (nl)
NO (4) NO170284C (nl)
NZ (1) NZ225615A (nl)
PT (1) PT88186B (nl)
SE (1) SE502214C2 (nl)
SG (1) SG101291G (nl)
SK (1) SK541288A3 (nl)
YU (3) YU143688A (nl)

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US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (nl) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
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WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
EP1438319A1 (en) * 2001-10-26 2004-07-21 Centre National De La Recherche Scientifique (Cnrs) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
NZ537690A (en) 2002-07-15 2009-07-31 Univ Texas Antibodies binding to anionic phospholipids and aminophospholipids and their use in treating viral infections
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CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (nl) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481095A (de) * 1966-12-13 1969-11-15 Sandoz Ag Vefahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
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Also Published As

Publication number Publication date
CA1310637C (en) 1992-11-24
DD299067A5 (de) 1992-03-26
AT398974B (de) 1995-02-27
NO920277D0 (no) 1992-01-22
HU202547B (en) 1991-03-28
IT8821535A0 (it) 1988-07-28
NO170284C (no) 1992-09-30
FI87790C (fi) 1993-02-25
KR900006230B1 (ko) 1990-08-27
HU211960A9 (en) 1996-01-29
DD274423A5 (de) 1989-12-20
JPH0699465B2 (ja) 1994-12-07
YU10490A (en) 1990-06-30
SE8802815D0 (sv) 1988-08-03
ES2010775A6 (es) 1989-12-01
PT88186A (pt) 1989-06-30
DK434088A (da) 1989-02-05
NL192683C (nl) 1997-12-02
HU208147B (en) 1993-08-30
CH676716A5 (nl) 1991-02-28
US5041424A (en) 1991-08-20
SK279325B6 (sk) 1998-10-07
DK169344B1 (da) 1994-10-10
GB8818462D0 (en) 1988-09-07
NO1998002I1 (no) 1998-01-14
GB2207674B (en) 1991-09-11
NO920277L (no) 1989-02-24
MX173843B (es) 1994-03-30
NO883299D0 (no) 1988-07-26
CY1625A (en) 1992-07-10
NO920665D0 (no) 1992-02-20
LU90138I2 (fr) 1997-11-26
DE3826562C2 (nl) 1993-04-08
YU10390A (en) 1990-06-30
US4904768A (en) 1990-02-27
ATA195588A (de) 1994-07-15
LU87290A1 (fr) 1990-02-07
GR880100512A (en) 1989-05-25
IE61040B1 (en) 1994-09-07
NO170284B (no) 1992-06-22
HUT47303A (en) 1989-02-28
AU2030688A (en) 1989-06-08
PT88186B (pt) 1995-07-03
FR2622193B1 (fr) 1993-12-17
NZ225615A (en) 1991-06-25
GR1000490B (el) 1992-07-30
FI883596A (fi) 1989-02-05
NL8801934A (nl) 1989-03-01
IL87290A (en) 1993-01-31
KR890003790A (ko) 1989-04-18
GB2207674A (en) 1989-02-08
HK6392A (en) 1992-01-17
DE3826562A1 (de) 1989-02-16
NO172440C (no) 1993-07-21
CN1027169C (zh) 1994-12-28
MX9202851A (es) 1992-06-30
YU143688A (en) 1990-04-30
DK11992A (da) 1992-01-31
SE502214C2 (sv) 1995-09-18
FI883596A0 (fi) 1988-08-01
NO172440B (no) 1993-04-13
NO920665L (no) 1989-02-24
SE8802815L (sv) 1989-02-05
DK11992D0 (da) 1992-01-31
SK541288A3 (en) 1998-10-07
JPH01100188A (ja) 1989-04-18
AU610619B2 (en) 1991-05-23
FI87790B (fi) 1992-11-13
DK434088D0 (da) 1988-08-03
CZ541288A3 (cs) 1999-12-15
SG101291G (en) 1992-01-17
HU905862D0 (en) 1991-03-28
NL970042I2 (nl) 2005-06-01
IE882378L (en) 1989-02-04
IL87290A0 (en) 1989-01-31
NL192683B (nl) 1997-08-01
FR2622193A1 (fr) 1989-04-28
IT1226825B (it) 1991-02-19
USRE35524E (en) 1997-06-03
CN1061225A (zh) 1992-05-20
MY104321A (en) 1994-03-31
BE1002982A4 (fr) 1991-10-15
NO883299L (no) 1989-02-24
CZ286893B6 (cs) 2000-07-12

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