CY1625A - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives

Info

Publication number
CY1625A
CY1625A CY1625A CY162592A CY1625A CY 1625 A CY1625 A CY 1625A CY 1625 A CY1625 A CY 1625A CY 162592 A CY162592 A CY 162592A CY 1625 A CY1625 A CY 1625A
Authority
CY
Cyprus
Prior art keywords
podophyllotoxin derivatives
podophyllotoxin
derivatives
Prior art date
Application number
CY1625A
Other languages
English (en)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CY1625A publication Critical patent/CY1625A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
CY1625A 1987-08-04 1992-07-10 Podophyllotoxin derivatives CY1625A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
CY1625A true CY1625A (en) 1992-07-10

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
CY1625A CY1625A (en) 1987-08-04 1992-07-10 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (nl)
JP (1) JPH0699465B2 (nl)
KR (1) KR900006230B1 (nl)
CN (1) CN1027169C (nl)
AT (1) AT398974B (nl)
BE (1) BE1002982A4 (nl)
CA (1) CA1310637C (nl)
CH (1) CH676716A5 (nl)
CY (1) CY1625A (nl)
CZ (1) CZ286893B6 (nl)
DD (2) DD299067A5 (nl)
DE (1) DE3826562A1 (nl)
DK (2) DK169344B1 (nl)
ES (1) ES2010775A6 (nl)
FI (1) FI87790C (nl)
FR (1) FR2622193B1 (nl)
GB (1) GB2207674B (nl)
GR (1) GR1000490B (nl)
HK (1) HK6392A (nl)
HU (3) HU202547B (nl)
IE (1) IE61040B1 (nl)
IL (1) IL87290A (nl)
IT (1) IT1226825B (nl)
LU (2) LU87290A1 (nl)
MX (1) MX173843B (nl)
MY (1) MY104321A (nl)
NL (2) NL192683C (nl)
NO (4) NO170284C (nl)
NZ (1) NZ225615A (nl)
PT (1) PT88186B (nl)
SE (1) SE502214C2 (nl)
SG (1) SG101291G (nl)
SK (1) SK541288A3 (nl)
YU (3) YU143688A (nl)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (nl) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
EP0835303A4 (en) * 1995-06-07 2000-09-13 Univ Jefferson ANTIFUNGAL AGENTS AND THEIR IDENTIFICATION AND UTILIZATION METHODS
PT907379E (pt) 1996-04-01 2004-09-30 Epix Medical Inc Agentes de contraste bioactivados para imagiologia de diagnostico
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
DK1537146T3 (da) 2002-07-15 2011-04-04 Univ Texas Antistoffer, der binder til anioniske phospholipider og aminophospholipider, og deres anvendelse til behandling af virusinfektioner
CA2516056C (en) * 2003-01-06 2012-05-29 Angiochem Inc. Aprotinin and analogs as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
BRPI0520032A2 (pt) * 2005-02-18 2009-04-14 Angiochem Inc moléculas para transportar um composto através da barreira hematoencefálica
BRPI0613005A8 (pt) * 2005-07-15 2017-12-26 Angiochem Inc uso de polipeptídeos de aprotinina como veículos em conjugados farmacêuticos.
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
CA2710122A1 (en) 2007-12-20 2009-07-02 Novartis Ag Thiazole derivatives used as pi 3 kinase inhibitors
EP2279008B1 (en) * 2008-04-18 2019-03-06 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
WO2010043049A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Etoposide and doxorubicin conjugates for drug delivery
BRPI0920209A2 (pt) 2008-10-15 2015-12-22 Angiochem Inc conjugados de agonistas de glp-1 e usos dos mesmos
MX2011005963A (es) * 2008-12-05 2011-09-01 Angiochem Inc Conjugados de neurotensina o analogos de neurotensina y sus usos.
JP2012512185A (ja) 2008-12-17 2012-05-31 アンジオケム インコーポレーテッド 膜１型マトリックス金属タンパク質阻害剤およびその使用
MX2011011023A (es) 2009-04-20 2012-01-20 Angiochem Inc Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
CN102596993A (zh) 2009-07-02 2012-07-18 安吉奥开米公司 多聚体肽结合物以及其应用
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
CA2786294A1 (en) 2010-02-22 2011-08-25 F. Hoffmann-La Roche Ag Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
PL2670753T3 (pl) 2011-01-31 2017-05-31 Novartis Ag Nowe pochodne heterocykliczne
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
MX340452B (es) 2011-10-28 2016-07-08 Novartis Ag Novedosos derivados de purina y su uso en el tratamiento de enfermedades.
WO2013085922A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
WO2013173283A1 (en) 2012-05-16 2013-11-21 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
US9783535B2 (en) 2012-12-20 2017-10-10 Demerx, Inc. Substituted noribogaine
CA2930359C (en) 2013-12-06 2022-03-01 Novartis Ag Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
JP6823055B2 (ja) 2015-06-15 2021-01-27 アンジオケム インコーポレーテッド 軟髄膜癌腫症の治療方法
WO2017077445A1 (en) 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (nl) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
ES2010775A6 (es) 1989-12-01
SE502214C2 (sv) 1995-09-18
CN1027169C (zh) 1994-12-28
YU10490A (en) 1990-06-30
GB8818462D0 (en) 1988-09-07
MX9202851A (es) 1992-06-30
CZ541288A3 (cs) 1999-12-15
NL970042I1 (nl) 1998-03-02
NO172440B (no) 1993-04-13
DE3826562A1 (de) 1989-02-16
SE8802815D0 (sv) 1988-08-03
CN1061225A (zh) 1992-05-20
NL192683B (nl) 1997-08-01
NO172440C (no) 1993-07-21
US5041424A (en) 1991-08-20
NO920277L (no) 1989-02-24
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
NZ225615A (en) 1991-06-25
YU143688A (en) 1990-04-30
MX173843B (es) 1994-03-30
HUT47303A (en) 1989-02-28
NO883299L (no) 1989-02-24
DK434088A (da) 1989-02-05
SK279325B6 (sk) 1998-10-07
HU208147B (en) 1993-08-30
PT88186A (pt) 1989-06-30
HU905862D0 (en) 1991-03-28
FI883596A (fi) 1989-02-05
FI883596A0 (fi) 1988-08-01
SE8802815L (sv) 1989-02-05
SG101291G (en) 1992-01-17
CH676716A5 (nl) 1991-02-28
NO170284C (no) 1992-09-30
GR1000490B (el) 1992-07-30
ATA195588A (de) 1994-07-15
DK169344B1 (da) 1994-10-10
HK6392A (en) 1992-01-17
GB2207674B (en) 1991-09-11
IE61040B1 (en) 1994-09-07
CZ286893B6 (cs) 2000-07-12
FR2622193A1 (fr) 1989-04-28
IL87290A (en) 1993-01-31
NL8801934A (nl) 1989-03-01
FR2622193B1 (fr) 1993-12-17
KR900006230B1 (ko) 1990-08-27
HU202547B (en) 1991-03-28
AU2030688A (en) 1989-06-08
HU211960A9 (en) 1996-01-29
YU10390A (en) 1990-06-30
PT88186B (pt) 1995-07-03
NL192683C (nl) 1997-12-02
GB2207674A (en) 1989-02-08
SK541288A3 (en) 1998-10-07
NL970042I2 (nl) 2005-06-01
JPH01100188A (ja) 1989-04-18
DK434088D0 (da) 1988-08-03
US4904768A (en) 1990-02-27
AT398974B (de) 1995-02-27
DK11992D0 (da) 1992-01-31
IL87290A0 (en) 1989-01-31
NO920277D0 (no) 1992-01-22
NO920665L (no) 1989-02-24
DE3826562C2 (nl) 1993-04-08
IT1226825B (it) 1991-02-19
NO170284B (no) 1992-06-22
MY104321A (en) 1994-03-31
IT8821535A0 (it) 1988-07-28
KR890003790A (ko) 1989-04-18
DD299067A5 (de) 1992-03-26
FI87790B (fi) 1992-11-13
JPH0699465B2 (ja) 1994-12-07
IE882378L (en) 1989-02-04
AU610619B2 (en) 1991-05-23
BE1002982A4 (fr) 1991-10-15
DD274423A5 (de) 1989-12-20
NO920665D0 (no) 1992-02-20
GR880100512A (en) 1989-05-25
DK11992A (da) 1992-01-31
USRE35524E (en) 1997-06-03
NO883299D0 (no) 1988-07-26
LU87290A1 (fr) 1990-02-07
CA1310637C (en) 1992-11-24
LU90138I2 (fr) 1997-11-26

Similar Documents

Publication Publication Date Title
GB2207674B (en) Podophyllotoxin derivatives
GR3002864T3 (en) Azolylmethylcyclopropyl derivatives
YU234188A (en) Adenozine derivatives
EP0318704A3 (en) 3-cyano-4-phenyl-pyrrole derivatives
ZA884693B (en) Thiqurea derivatives
ZA881808B (en) Propiolophenone derivatives
EP0305322A3 (en) Isoxazole-beta-carboline derivatives
EP0297383A3 (en) Hydroxyethyl-azolyl derivatives
GB2205829B (en) 2-aryl-4-isoxazolin-3-one derivatives
EP0322164A3 (en) Ethanolamie derivatives
GB8705601D0 (en) Oxo-isoindolinyl derivatives
GB8726272D0 (en) 4-demethoxy anthra-cycline derivatives
GB2200910B (en) Thiopilocarpine derivatives
GB8704236D0 (en) Anthracycline-oestrone derivatives
GB8700016D0 (en) Quinolizinone derivatives
GB8715925D0 (en) Thiapentanamide derivatives
ZA884683B (en) Hydroxyethyl-azolyl derivatives
GB2211840B (en) Indenofuran derivatives
FI103571B1 (fi) Propoksibentseenijohdannaisia
IE871782L (en) 18-phenyloestrane derivatives
IE872733L (en) Halocyclopropane derivatives
IE870091L (en) Azabicyclo-benzyloxyphenyl-urea derivatives
IE870156L (en) Imidazo-quinoline derivatives
IE870414L (en) Furancarboxamide derivatives
IE870634L (en) Arylazolylmethylbenzocycloalkene derivatives