IT1226825B - Derivati 4' fosfato di glucosidi della epipodofillotossina e relative composizioni farmaceutiche. - Google Patents

Derivati 4' fosfato di glucosidi della epipodofillotossina e relative composizioni farmaceutiche.

Info

Publication number
IT1226825B
IT1226825B IT8821535A IT2153588A IT1226825B IT 1226825 B IT1226825 B IT 1226825B IT 8821535 A IT8821535 A IT 8821535A IT 2153588 A IT2153588 A IT 2153588A IT 1226825 B IT1226825 B IT 1226825B
Authority
IT
Italy
Prior art keywords
phosphate
derivatives
pharmaceutical compositions
related pharmaceutical
epipodophyllotoxin glucosides
Prior art date
Application number
IT8821535A
Other languages
English (en)
Other versions
IT8821535A0 (it
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IT8821535A0 publication Critical patent/IT8821535A0/it
Application granted granted Critical
Publication of IT1226825B publication Critical patent/IT1226825B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
IT8821535A 1987-08-04 1988-07-28 Derivati 4' fosfato di glucosidi della epipodofillotossina e relative composizioni farmaceutiche. IT1226825B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
IT8821535A0 IT8821535A0 (it) 1988-07-28
IT1226825B true IT1226825B (it) 1991-02-19

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8821535A IT1226825B (it) 1987-08-04 1988-07-28 Derivati 4' fosfato di glucosidi della epipodofillotossina e relative composizioni farmaceutiche.

Country Status (34)

Country Link
US (3) US4904768A (it)
JP (1) JPH0699465B2 (it)
KR (1) KR900006230B1 (it)
CN (1) CN1027169C (it)
AT (1) AT398974B (it)
BE (1) BE1002982A4 (it)
CA (1) CA1310637C (it)
CH (1) CH676716A5 (it)
CY (1) CY1625A (it)
CZ (1) CZ286893B6 (it)
DD (2) DD274423A5 (it)
DE (1) DE3826562A1 (it)
DK (2) DK169344B1 (it)
ES (1) ES2010775A6 (it)
FI (1) FI87790C (it)
FR (1) FR2622193B1 (it)
GB (1) GB2207674B (it)
GR (1) GR1000490B (it)
HK (1) HK6392A (it)
HU (3) HU202547B (it)
IE (1) IE61040B1 (it)
IL (1) IL87290A (it)
IT (1) IT1226825B (it)
LU (2) LU87290A1 (it)
MX (1) MX173843B (it)
MY (1) MY104321A (it)
NL (2) NL192683C (it)
NO (4) NO170284C (it)
NZ (1) NZ225615A (it)
PT (1) PT88186B (it)
SE (1) SE502214C2 (it)
SG (1) SG101291G (it)
SK (1) SK279325B6 (it)
YU (3) YU143688A (it)

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US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (it) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
ES2217408T3 (es) 1996-04-01 2004-11-01 Epix Medical, Inc. Agentes diagnosticos de contraste para formacion de imagenes bioactivados.
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
EP1438319A1 (en) * 2001-10-26 2004-07-21 Centre National De La Recherche Scientifique (Cnrs) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
NZ596825A (en) 2002-07-15 2013-06-28 Univ Texas Duramycin peptides and their use in imaging
EP1583562B1 (en) * 2003-01-06 2011-06-15 Angiochem Inc. Angiopep-1, related compounds, and uses thereof
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
ATE551422T1 (de) * 2005-02-18 2012-04-15 Angiochem Inc Aprotininpolypeptide zum transport einer verbindung durch die blut-hirn-schranke
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CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
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MX2011004019A (es) 2008-10-15 2011-06-24 Angiochem Inc Conjugados de etoposido y doxorubicina para entrega de farmacos.
US8921314B2 (en) 2008-10-15 2014-12-30 Angiochem, Inc. Conjugates of GLP-1 agonists and uses thereof
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US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US8440651B2 (en) 2010-02-22 2013-05-14 F. Hoffmann-La Roche Ag Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
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US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
AP2014007601A0 (en) 2011-10-28 2014-04-30 Novartis Ag Novel purine derivatives and their use in the treatment of disease
EP2788003A4 (en) * 2011-12-09 2015-05-27 Demerx Inc PHOSPHATESTER OF NORIBOGAIN
NZ700924A (en) 2012-05-16 2016-02-26 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
WO2014098877A1 (en) 2012-12-20 2014-06-26 Demerx, Inc. Substituted noribogaine
DK3076969T3 (da) 2013-12-06 2021-11-22 Novartis Ag Doseringsregime for en alfa-isoform-selektiv phosphatidylinositol-3-kinase-hæmmer
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (it) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481095A (de) * 1966-12-13 1969-11-15 Sandoz Ag Vefahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
NO172440C (no) 1993-07-21
HK6392A (en) 1992-01-17
IL87290A0 (en) 1989-01-31
JPH01100188A (ja) 1989-04-18
FI87790B (fi) 1992-11-13
NO170284B (no) 1992-06-22
IL87290A (en) 1993-01-31
ES2010775A6 (es) 1989-12-01
DK11992D0 (da) 1992-01-31
MY104321A (en) 1994-03-31
NO920665L (no) 1989-02-24
USRE35524E (en) 1997-06-03
HU211960A9 (en) 1996-01-29
NO920277L (no) 1989-02-24
IE882378L (en) 1989-02-04
NL8801934A (nl) 1989-03-01
GR880100512A (en) 1989-05-25
JPH0699465B2 (ja) 1994-12-07
PT88186B (pt) 1995-07-03
PT88186A (pt) 1989-06-30
CZ286893B6 (cs) 2000-07-12
CZ541288A3 (cs) 1999-12-15
IT8821535A0 (it) 1988-07-28
AU610619B2 (en) 1991-05-23
MX173843B (es) 1994-03-30
US4904768A (en) 1990-02-27
HUT47303A (en) 1989-02-28
YU10490A (en) 1990-06-30
FI87790C (fi) 1993-02-25
DD274423A5 (de) 1989-12-20
CY1625A (en) 1992-07-10
MX9202851A (es) 1992-06-30
HU208147B (en) 1993-08-30
NL970042I2 (it) 2005-06-01
GB2207674A (en) 1989-02-08
DE3826562A1 (de) 1989-02-16
GR1000490B (el) 1992-07-30
SE8802815L (sv) 1989-02-05
NO883299D0 (no) 1988-07-26
CA1310637C (en) 1992-11-24
SG101291G (en) 1992-01-17
LU87290A1 (fr) 1990-02-07
DK434088D0 (da) 1988-08-03
CN1027169C (zh) 1994-12-28
GB2207674B (en) 1991-09-11
NO920277D0 (no) 1992-01-22
DD299067A5 (de) 1992-03-26
DK169344B1 (da) 1994-10-10
DE3826562C2 (it) 1993-04-08
LU90138I2 (fr) 1997-11-26
DK434088A (da) 1989-02-05
NO172440B (no) 1993-04-13
KR900006230B1 (ko) 1990-08-27
SE8802815D0 (sv) 1988-08-03
GB8818462D0 (en) 1988-09-07
IE61040B1 (en) 1994-09-07
SK541288A3 (en) 1998-10-07
BE1002982A4 (fr) 1991-10-15
SK279325B6 (sk) 1998-10-07
NL192683B (it) 1997-08-01
NL192683C (nl) 1997-12-02
CH676716A5 (it) 1991-02-28
ATA195588A (de) 1994-07-15
US5041424A (en) 1991-08-20
NO170284C (no) 1992-09-30
HU905862D0 (en) 1991-03-28
DK11992A (da) 1992-01-31
CN1061225A (zh) 1992-05-20
NO1998002I1 (no) 1998-01-14
NO883299L (no) 1989-02-24
NL970042I1 (nl) 1998-03-02
YU143688A (en) 1990-04-30
FR2622193A1 (fr) 1989-04-28
HU202547B (en) 1991-03-28
FR2622193B1 (fr) 1993-12-17
NO920665D0 (no) 1992-02-20
SE502214C2 (sv) 1995-09-18
KR890003790A (ko) 1989-04-18
AT398974B (de) 1995-02-27
FI883596A (fi) 1989-02-05
FI883596A0 (fi) 1988-08-01
NZ225615A (en) 1991-06-25
YU10390A (en) 1990-06-30
AU2030688A (en) 1989-06-08

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