NO920665L - Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen - Google Patents

Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Info

Publication number
NO920665L
NO920665L NO92920665A NO920665A NO920665L NO 920665 L NO920665 L NO 920665L NO 92920665 A NO92920665 A NO 92920665A NO 920665 A NO920665 A NO 920665A NO 920665 L NO920665 L NO 920665L
Authority
NO
Norway
Prior art keywords
compound
preparing
procedure
chemical
chemical compound
Prior art date
Application number
NO92920665A
Other languages
English (en)
Other versions
NO172440B (no
NO172440C (no
NO920665D0 (no
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO920665L publication Critical patent/NO920665L/no
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to NO920665A priority Critical patent/NO172440C/no
Publication of NO920665D0 publication Critical patent/NO920665D0/no
Publication of NO172440B publication Critical patent/NO172440B/no
Publication of NO172440C publication Critical patent/NO172440C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NO920665A 1987-08-04 1992-02-20 Kjemisk forbindelse NO172440C (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse

Publications (4)

Publication Number Publication Date
NO920665L true NO920665L (no) 1989-02-24
NO920665D0 NO920665D0 (no) 1992-02-20
NO172440B NO172440B (no) 1993-04-13
NO172440C NO172440C (no) 1993-07-21

Family

ID=26765636

Family Applications (4)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Country Status (34)

Country Link
US (3) US4904768A (no)
JP (1) JPH0699465B2 (no)
KR (1) KR900006230B1 (no)
CN (1) CN1027169C (no)
AT (1) AT398974B (no)
BE (1) BE1002982A4 (no)
CA (1) CA1310637C (no)
CH (1) CH676716A5 (no)
CY (1) CY1625A (no)
CZ (1) CZ286893B6 (no)
DD (2) DD299067A5 (no)
DE (1) DE3826562A1 (no)
DK (2) DK169344B1 (no)
ES (1) ES2010775A6 (no)
FI (1) FI87790C (no)
FR (1) FR2622193B1 (no)
GB (1) GB2207674B (no)
GR (1) GR1000490B (no)
HK (1) HK6392A (no)
HU (3) HU202547B (no)
IE (1) IE61040B1 (no)
IL (1) IL87290A (no)
IT (1) IT1226825B (no)
LU (2) LU87290A1 (no)
MX (1) MX173843B (no)
MY (1) MY104321A (no)
NL (2) NL192683C (no)
NO (4) NO170284C (no)
NZ (1) NZ225615A (no)
PT (1) PT88186B (no)
SE (1) SE502214C2 (no)
SG (1) SG101291G (no)
SK (1) SK541288A3 (no)
YU (3) YU143688A (no)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (no) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
CA2464311A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
DK1537146T3 (da) 2002-07-15 2011-04-04 Univ Texas Antistoffer, der binder til anioniske phospholipider og aminophospholipider, og deres anvendelse til behandling af virusinfektioner
CA2516056C (en) * 2003-01-06 2012-05-29 Angiochem Inc. Aprotinin and analogs as carriers across the blood-brain barrier
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MX2010005104A (es) 2007-11-09 2010-08-04 Peregrine Pharmaceuticals Inc Composiciones de anticuerpo anti-factor de crecimiento endotelial vascular y metodos.
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
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CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH544752A (de) * 1966-12-13 1974-01-15 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
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US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
ES2010775A6 (es) 1989-12-01
SE502214C2 (sv) 1995-09-18
CN1027169C (zh) 1994-12-28
YU10490A (en) 1990-06-30
GB8818462D0 (en) 1988-09-07
MX9202851A (es) 1992-06-30
CZ541288A3 (cs) 1999-12-15
NL970042I1 (nl) 1998-03-02
NO172440B (no) 1993-04-13
DE3826562A1 (de) 1989-02-16
SE8802815D0 (sv) 1988-08-03
CN1061225A (zh) 1992-05-20
NL192683B (no) 1997-08-01
NO172440C (no) 1993-07-21
US5041424A (en) 1991-08-20
NO920277L (no) 1989-02-24
FI87790C (fi) 1993-02-25
NO1998002I1 (no) 1998-01-14
NZ225615A (en) 1991-06-25
YU143688A (en) 1990-04-30
MX173843B (es) 1994-03-30
HUT47303A (en) 1989-02-28
NO883299L (no) 1989-02-24
DK434088A (da) 1989-02-05
SK279325B6 (sk) 1998-10-07
HU208147B (en) 1993-08-30
PT88186A (pt) 1989-06-30
HU905862D0 (en) 1991-03-28
FI883596A (fi) 1989-02-05
FI883596A0 (fi) 1988-08-01
SE8802815L (sv) 1989-02-05
SG101291G (en) 1992-01-17
CH676716A5 (no) 1991-02-28
NO170284C (no) 1992-09-30
GR1000490B (el) 1992-07-30
ATA195588A (de) 1994-07-15
DK169344B1 (da) 1994-10-10
HK6392A (en) 1992-01-17
GB2207674B (en) 1991-09-11
IE61040B1 (en) 1994-09-07
CZ286893B6 (cs) 2000-07-12
FR2622193A1 (fr) 1989-04-28
IL87290A (en) 1993-01-31
NL8801934A (nl) 1989-03-01
FR2622193B1 (fr) 1993-12-17
KR900006230B1 (ko) 1990-08-27
HU202547B (en) 1991-03-28
AU2030688A (en) 1989-06-08
HU211960A9 (en) 1996-01-29
YU10390A (en) 1990-06-30
PT88186B (pt) 1995-07-03
NL192683C (nl) 1997-12-02
GB2207674A (en) 1989-02-08
SK541288A3 (en) 1998-10-07
NL970042I2 (no) 2005-06-01
JPH01100188A (ja) 1989-04-18
DK434088D0 (da) 1988-08-03
US4904768A (en) 1990-02-27
AT398974B (de) 1995-02-27
DK11992D0 (da) 1992-01-31
IL87290A0 (en) 1989-01-31
CY1625A (en) 1992-07-10
NO920277D0 (no) 1992-01-22
DE3826562C2 (no) 1993-04-08
IT1226825B (it) 1991-02-19
NO170284B (no) 1992-06-22
MY104321A (en) 1994-03-31
IT8821535A0 (it) 1988-07-28
KR890003790A (ko) 1989-04-18
DD299067A5 (de) 1992-03-26
FI87790B (fi) 1992-11-13
JPH0699465B2 (ja) 1994-12-07
IE882378L (en) 1989-02-04
AU610619B2 (en) 1991-05-23
BE1002982A4 (fr) 1991-10-15
DD274423A5 (de) 1989-12-20
NO920665D0 (no) 1992-02-20
GR880100512A (en) 1989-05-25
DK11992A (da) 1992-01-31
USRE35524E (en) 1997-06-03
NO883299D0 (no) 1988-07-26
LU87290A1 (fr) 1990-02-07
CA1310637C (en) 1992-11-24
LU90138I2 (fr) 1997-11-26

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