DK80291A - 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf - Google Patents

1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf Download PDF

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Publication number
DK80291A
DK80291A DK080291A DK80291A DK80291A DK 80291 A DK80291 A DK 80291A DK 080291 A DK080291 A DK 080291A DK 80291 A DK80291 A DK 80291A DK 80291 A DK80291 A DK 80291A
Authority
DK
Denmark
Prior art keywords
imidazooe4
baaquinolin
oner
tetrahydro
preparing
Prior art date
Application number
DK080291A
Other languages
English (en)
Other versions
DK165248C (da
DK165248B (da
DK80291D0 (da
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK80291A publication Critical patent/DK80291A/da
Publication of DK80291D0 publication Critical patent/DK80291D0/da
Publication of DK165248B publication Critical patent/DK165248B/da
Application granted granted Critical
Publication of DK165248C publication Critical patent/DK165248C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK080291A 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf DK165248C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US72686985 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
US83221286 1986-02-26

Publications (4)

Publication Number Publication Date
DK80291A true DK80291A (da) 1991-04-30
DK80291D0 DK80291D0 (da) 1991-04-30
DK165248B DK165248B (da) 1992-10-26
DK165248C DK165248C (da) 1993-03-22

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
US (1) US4668686A (da)
KR (1) KR940000828B1 (da)
CN (1) CN1016175B (da)
AT (1) AT390257B (da)
AU (1) AU592983B2 (da)
BE (1) BE904671A (da)
CA (1) CA1298836C (da)
CH (1) CH675722A5 (da)
CY (1) CY1641A (da)
DE (1) DE3614132A1 (da)
DK (3) DK164868C (da)
EG (1) EG18104A (da)
ES (3) ES8708229A1 (da)
FI (1) FI83316C (da)
FR (1) FR2581065B1 (da)
GB (1) GB2174987B (da)
GR (1) GR861086B (da)
HK (1) HK64492A (da)
HU (1) HU195813B (da)
IL (1) IL78581A0 (da)
IT (1) IT1215651B (da)
LU (1) LU86406A1 (da)
MY (1) MY102086A (da)
NL (1) NL8601053A (da)
NO (1) NO163406C (da)
NZ (1) NZ215885A (da)
OA (1) OA08242A (da)
PT (1) PT82460B (da)
SE (1) SE461468B (da)
SG (1) SG29092G (da)
SU (3) SU1450746A3 (da)
YU (1) YU46054B (da)

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US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
AU695301B2 (en) * 1993-07-06 1998-08-13 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
MXPA06001669A (es) 2003-08-12 2006-04-28 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos.
NZ545412A (en) 2003-08-27 2008-12-24 Coley Pharm Group Inc Aryloxy and arylalkyleneoxy substituted imidazoquinolines
JP2007504269A (ja) 2003-09-05 2007-03-01 スリーエム イノベイティブ プロパティズ カンパニー Ｃｄ５＋ｂ細胞リンパ腫の治療方法
EP1673087B1 (en) * 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
CN1906192A (zh) * 2003-11-14 2007-01-31 3M创新有限公司 羟胺取代的咪唑环化合物
WO2005048933A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006009826A1 (en) 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
CN101056877B (zh) * 2004-09-14 2010-06-09 诺华疫苗和诊断公司 咪唑并喹啉化合物
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2592904C (en) 2004-12-30 2015-04-07 3M Innovative Properties Company Chiral fused [1,2]imidazo[4,5-c] ring compounds
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
EP1846405A2 (en) 2005-02-11 2007-10-24 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo 4,5-c ring compounds and methods
CA2602683A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
CA2602590A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
DK2069352T5 (da) 2006-08-02 2017-04-03 Cytokinetics Inc Bestemte kemiske enheder, sammensætninger og fremgangsmåder
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
US10272082B2 (en) 2011-07-13 2019-04-30 Cytokinetics, Inc. Combination ALS therapy
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
FI861684A0 (fi) 1986-04-22
FI83316B (fi) 1991-03-15
PT82460B (pt) 1988-11-30
ES554336A0 (es) 1987-10-01
BE904671A (fr) 1986-10-24
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
DK165248B (da) 1992-10-26
YU116787A (en) 1988-04-30
FI83316C (fi) 1991-06-25
AU592983B2 (en) 1990-02-01
EG18104A (en) 1992-09-30
DK190986A (da) 1986-10-26
ES8801829A1 (es) 1988-02-16
NZ215885A (en) 1989-04-26
AU5641386A (en) 1986-10-30
KR860008177A (ko) 1986-11-12
CN1016175B (zh) 1992-04-08
SG29092G (en) 1992-05-15
GR861086B (en) 1986-09-01
MY102086A (en) 1992-03-31
ES8802521A1 (es) 1988-07-16
IT1215651B (it) 1990-02-22
SE461468B (sv) 1990-02-19
SU1450746A3 (ru) 1989-01-07
FR2581065A1 (fr) 1986-10-31
OA08242A (en) 1987-10-30
DK80291D0 (da) 1991-04-30
NL8601053A (nl) 1986-11-17
FR2581065B1 (fr) 1990-02-02
IL78581A0 (en) 1986-08-31
AT390257B (de) 1990-04-10
CN86102747A (zh) 1987-02-04
SE8601907L (sv) 1986-10-26
YU46054B (sh) 1992-12-21
DK190986D0 (da) 1986-04-24
CY1641A (en) 1992-11-06
ES557552A0 (es) 1988-07-16
DK165249C (da) 1993-03-22
GB8610037D0 (en) 1986-05-29
PT82460A (en) 1986-05-01
HK64492A (en) 1992-09-04
HU195813B (en) 1988-07-28
LU86406A1 (fr) 1986-11-05
DK164868B (da) 1992-08-31
FI861684L (fi) 1986-10-26
US4668686A (en) 1987-05-26
ATA112186A (de) 1989-09-15
ES8708229A1 (es) 1987-10-01
SE8601907D0 (sv) 1986-04-24
SU1560056A3 (ru) 1990-04-23
IT8620206A0 (it) 1986-04-24
CA1298836C (en) 1992-04-14
CH675722A5 (da) 1990-10-31
NO163406C (no) 1990-05-23
NO861617L (no) 1986-10-27
HUT42089A (en) 1987-06-29
DE3614132A1 (de) 1986-11-27
DK81091D0 (da) 1991-05-01
DK164868C (da) 1993-01-11
ES557551A0 (es) 1988-02-16
KR940000828B1 (ko) 1994-02-02
NO163406B (no) 1990-02-12
SU1470192A3 (ru) 1989-03-30
DK165249B (da) 1992-10-26
GB2174987A (en) 1986-11-19
GB2174987B (en) 1989-08-02

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