SE8601907L - Antitrombogena och kardiotoniska imidazokinoliner - Google Patents

Antitrombogena och kardiotoniska imidazokinoliner

Info

Publication number
SE8601907L
SE8601907L SE8601907A SE8601907A SE8601907L SE 8601907 L SE8601907 L SE 8601907L SE 8601907 A SE8601907 A SE 8601907A SE 8601907 A SE8601907 A SE 8601907A SE 8601907 L SE8601907 L SE 8601907L
Authority
SE
Sweden
Prior art keywords
lower alkyl
halogen
hydrogen
cardiotonic
imidazokinolines
Prior art date
Application number
SE8601907A
Other languages
English (en)
Other versions
SE8601907D0 (sv
SE461468B (sv
Inventor
N A Meanwell
J J Wright
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8601907D0 publication Critical patent/SE8601907D0/sv
Publication of SE8601907L publication Critical patent/SE8601907L/sv
Publication of SE461468B publication Critical patent/SE461468B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE8601907A 1985-04-25 1986-04-24 Imidazo 4,5-b kinolin-2-on-derivat, foerfarande foer framstaellning av detta, mellanprodukter och en farmaceutisk beredning SE461468B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (3)

Publication Number Publication Date
SE8601907D0 SE8601907D0 (sv) 1986-04-24
SE8601907L true SE8601907L (sv) 1986-10-26
SE461468B SE461468B (sv) 1990-02-19

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8601907A SE461468B (sv) 1985-04-25 1986-04-24 Imidazo 4,5-b kinolin-2-on-derivat, foerfarande foer framstaellning av detta, mellanprodukter och en farmaceutisk beredning

Country Status (32)

Country Link
US (1) US4668686A (sv)
KR (1) KR940000828B1 (sv)
CN (1) CN1016175B (sv)
AT (1) AT390257B (sv)
AU (1) AU592983B2 (sv)
BE (1) BE904671A (sv)
CA (1) CA1298836C (sv)
CH (1) CH675722A5 (sv)
CY (1) CY1641A (sv)
DE (1) DE3614132A1 (sv)
DK (3) DK164868C (sv)
EG (1) EG18104A (sv)
ES (3) ES8708229A1 (sv)
FI (1) FI83316C (sv)
FR (1) FR2581065B1 (sv)
GB (1) GB2174987B (sv)
GR (1) GR861086B (sv)
HK (1) HK64492A (sv)
HU (1) HU195813B (sv)
IL (1) IL78581A0 (sv)
IT (1) IT1215651B (sv)
LU (1) LU86406A1 (sv)
MY (1) MY102086A (sv)
NL (1) NL8601053A (sv)
NO (1) NO163406C (sv)
NZ (1) NZ215885A (sv)
OA (1) OA08242A (sv)
PT (1) PT82460B (sv)
SE (1) SE461468B (sv)
SG (1) SG29092G (sv)
SU (3) SU1450746A3 (sv)
YU (1) YU46054B (sv)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
MXPA06001674A (es) 2003-08-12 2006-05-12 3M Innovative Properties Co Compuestos que contienen imidazo hidroxilamina-sustituidos.
BRPI0413998A (pt) 2003-08-27 2006-11-07 3M Innovative Properties Co imidazoquinolinas arilóxi e arilalquilenóxi substituìdas
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
MXPA06003705A (es) 2003-10-03 2006-06-20 3M Innovative Properties Co Imidazoquinolinas sustituidas con alcoxi.
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
WO2005048933A2 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
US8691837B2 (en) 2003-11-25 2014-04-08 3M Innovative Properties Company Substituted imidazo ring systems and methods
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
AU2004312508A1 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
EP1831221B1 (en) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituted chiral fused 1,2 imidazo 4,5-c ring compounds
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
EP1844201B1 (en) 2005-02-04 2016-08-24 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
MX2009001170A (es) 2006-08-02 2009-05-21 Cytokinetics Inc Determinadas entidades quimicas, composiciones y metodos.
WO2008121333A1 (en) * 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
AU2012281042B2 (en) 2011-07-13 2016-07-14 Cytokinetics, Inc. Combination ALS therapy
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
GR861086B (en) 1986-09-01
FI861684A0 (fi) 1986-04-22
EG18104A (en) 1992-09-30
IT8620206A0 (it) 1986-04-24
DK190986D0 (da) 1986-04-24
FI861684A (fi) 1986-10-26
DK164868C (da) 1993-01-11
GB2174987B (en) 1989-08-02
AU5641386A (en) 1986-10-30
AT390257B (de) 1990-04-10
DK81091D0 (da) 1991-05-01
HUT42089A (en) 1987-06-29
YU116787A (en) 1988-04-30
ES557552A0 (es) 1988-07-16
HU195813B (en) 1988-07-28
SU1450746A3 (ru) 1989-01-07
FI83316C (sv) 1991-06-25
KR940000828B1 (ko) 1994-02-02
CH675722A5 (sv) 1990-10-31
US4668686A (en) 1987-05-26
CN1016175B (zh) 1992-04-08
CY1641A (en) 1992-11-06
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
ES557551A0 (es) 1988-02-16
FR2581065A1 (fr) 1986-10-31
FI83316B (fi) 1991-03-15
DK165249C (da) 1993-03-22
YU46054B (sh) 1992-12-21
BE904671A (fr) 1986-10-24
PT82460A (en) 1986-05-01
OA08242A (en) 1987-10-30
MY102086A (en) 1992-03-31
SE8601907D0 (sv) 1986-04-24
FR2581065B1 (fr) 1990-02-02
NO163406C (no) 1990-05-23
DK80291D0 (da) 1991-04-30
SU1470192A3 (ru) 1989-03-30
LU86406A1 (fr) 1986-11-05
ATA112186A (de) 1989-09-15
DK164868B (da) 1992-08-31
ES8708229A1 (es) 1987-10-01
ES8801829A1 (es) 1988-02-16
SE461468B (sv) 1990-02-19
SG29092G (en) 1992-05-15
NZ215885A (en) 1989-04-26
DK165249B (da) 1992-10-26
IL78581A0 (en) 1986-08-31
DK190986A (da) 1986-10-26
PT82460B (pt) 1988-11-30
GB2174987A (en) 1986-11-19
IT1215651B (it) 1990-02-22
NO861617L (no) 1986-10-27
DK165248B (da) 1992-10-26
SU1560056A3 (ru) 1990-04-23
GB8610037D0 (en) 1986-05-29
KR860008177A (ko) 1986-11-12
CA1298836C (en) 1992-04-14
CN86102747A (zh) 1987-02-04
ES8802521A1 (es) 1988-07-16
ES554336A0 (es) 1987-10-01
HK64492A (en) 1992-09-04
DK80291A (da) 1991-04-30
NL8601053A (nl) 1986-11-17
NO163406B (no) 1990-02-12
DE3614132A1 (de) 1986-11-27
AU592983B2 (en) 1990-02-01

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