SE7703223L - 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav - Google Patents

2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Info

Publication number
SE7703223L
SE7703223L SE7703223A SE7703223A SE7703223L SE 7703223 L SE7703223 L SE 7703223L SE 7703223 A SE7703223 A SE 7703223A SE 7703223 A SE7703223 A SE 7703223A SE 7703223 L SE7703223 L SE 7703223L
Authority
SE
Sweden
Prior art keywords
alkyl
hydrogen
pyrazino
quinoxalin
tetrahydro
Prior art date
Application number
SE7703223A
Other languages
English (en)
Inventor
M E Freed
J R Potoski
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of SE7703223L publication Critical patent/SE7703223L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7703223A 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav SE7703223L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/668,872 US4032639A (en) 1976-03-22 1976-03-22 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Publications (1)

Publication Number Publication Date
SE7703223L true SE7703223L (sv) 1977-09-23

Family

ID=24684079

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7703223A SE7703223L (sv) 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Country Status (13)

Country Link
US (1) US4032639A (sv)
JP (1) JPS52114000A (sv)
AT (1) AT357540B (sv)
AU (1) AU506308B2 (sv)
BE (1) BE852737A (sv)
CA (1) CA1093557A (sv)
DE (1) DE2712573A1 (sv)
DK (1) DK122377A (sv)
FR (1) FR2345450A1 (sv)
GB (3) GB1538986A (sv)
NL (1) NL7702920A (sv)
SE (1) SE7703223L (sv)
ZA (1) ZA771381B (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4182869A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-Carbobenzoxypiperazine-2-carboxylic acid chemical intermediate
US4182872A (en) * 1976-03-22 1980-01-08 American Home Products Corporation 4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates
US4089958A (en) * 1976-12-20 1978-05-16 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
US4225713A (en) * 1977-08-03 1980-09-30 Freed Meier E Tetrahydro(1H)pyrazino(1,2-A)azaquinoxalin-5(6H)-ones and derivatives thereof
US4203987A (en) * 1979-05-21 1980-05-20 American Home Products Corporation 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones
US6369057B1 (en) 1991-04-15 2002-04-09 Aventis Pharma Deutschland Gmbh Quinoxalines, processes for their preparation and their use
ES2164639T3 (es) * 1991-04-15 2002-03-01 Aventis Pharma Gmbh Quinoxalinas, procedimiento para su preparacion y su empleo.
US5753653A (en) 1995-12-08 1998-05-19 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
DK0874830T3 (da) * 1995-12-08 2003-04-22 Agouron Pharma Metalloproteinaseinhibitor, farmaceutisk præparat indeholdende denne og den farmaceutiske anvendelse samt en fremgangsmåde til fremstilling deraf
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6372745B1 (en) * 1999-12-06 2002-04-16 American Home Products Corporation 2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
EA200100671A1 (ru) * 1998-12-17 2001-12-24 Американ Хоум Продактс Корпорейшн ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C
US6476032B2 (en) 1998-12-17 2002-11-05 Wyeth 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
DE102004058337A1 (de) * 2004-12-02 2006-06-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US20060211700A1 (en) * 2005-03-21 2006-09-21 Alcon, Inc. (R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one for controlling IOP and treating glaucoma
JP5710023B2 (ja) * 2011-12-14 2015-04-30 イハラケミカル工業株式会社 ジフェニルアミン化合物およびその製造方法
JPWO2014208296A1 (ja) * 2013-06-25 2017-02-23 イハラケミカル工業株式会社 ニトロベンゼン化合物を製造する方法
CN114096533B (zh) * 2019-09-10 2024-03-08 四川科伦博泰生物医药股份有限公司 一种三并环类化合物，包含其的药物组合物，其制备方法及其用途

Also Published As

Publication number Publication date
FR2345450A1 (fr) 1977-10-21
FR2345450B1 (sv) 1980-05-09
AT357540B (de) 1980-07-10
CA1093557A (en) 1981-01-13
US4032639A (en) 1977-06-28
NL7702920A (nl) 1977-09-26
AU506308B2 (en) 1979-12-20
GB1538988A (en) 1979-01-24
AU2304877A (en) 1978-09-14
DE2712573A1 (de) 1977-09-29
ZA771381B (en) 1978-10-25
JPS52114000A (en) 1977-09-24
DK122377A (da) 1977-09-23
GB1538987A (en) 1979-01-24
ATA189377A (de) 1979-12-15
GB1538986A (en) 1979-01-24
BE852737A (fr) 1977-09-22

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