EA200100671A1 - ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C - Google Patents
ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2CInfo
- Publication number
- EA200100671A1 EA200100671A1 EA200100671A EA200100671A EA200100671A1 EA 200100671 A1 EA200100671 A1 EA 200100671A1 EA 200100671 A EA200100671 A EA 200100671A EA 200100671 A EA200100671 A EA 200100671A EA 200100671 A1 EA200100671 A1 EA 200100671A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- carbon atoms
- alkyl
- represents hydrogen
- disorders
- aroyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
Настоящее изобретение предлагает соединения формулы (I)в которой R представляет водород или алкил с 1-6 атомами углерода; R' представляет водород, алкил с 1-6 атомами углерода, ацил с 2-7 атомами углерода или ароил; R, R, Rи R, каждый независимо, представляет водород, алкил с 1-6 атомами углерода, алкокси с 1-6 атомами углерода, галоген, трифторалкил, -CN, алкилсульфонамид с 1-6 атомами углерода, алкиламид с 1-6 атомами углерода, амино, алкиламино с 1-6 атомами углерода, диалкиламино с 1-6 атомами углерода в алкильном фрагменте, трифторалкокси с 1-6 атомами углерода, ацил с 2-7 атомами углерода или ароил; X представляет CRRили карбонильную группу; Rи R, каждый независимо, представляет водород или алкил с 1-6 атомами углерода; или их фармацевтически приемлемые соли, при условии, что, по меньшей мере, один из R, R, Rи Rне является водородом, и их энантиомеры, которые являются агонистами 5HT-рецептора, полезными для лечения расстройств, связанных с центральной нервной системой, таких как обсессивно-компульсивные нарушения; депрессия; тревога; состояние паники; шизофрения; мигрень; расстройства сна; расстройства аппетита; ожирение; диабет типа II и эпилепсия.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21347198A | 1998-12-17 | 1998-12-17 | |
PCT/US1999/029894 WO2000035922A1 (en) | 1998-12-17 | 1999-12-16 | 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200100671A1 true EA200100671A1 (ru) | 2001-12-24 |
Family
ID=22795247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200100671A EA200100671A1 (ru) | 1998-12-17 | 1999-12-16 | ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1140940A1 (ru) |
JP (1) | JP2002532504A (ru) |
KR (1) | KR20010108025A (ru) |
CN (1) | CN1240701C (ru) |
AR (1) | AR022687A1 (ru) |
AU (1) | AU3123400A (ru) |
BR (1) | BR9916326A (ru) |
CA (1) | CA2351385A1 (ru) |
CZ (1) | CZ20012193A3 (ru) |
EA (1) | EA200100671A1 (ru) |
HU (1) | HUP0104773A3 (ru) |
IL (1) | IL143323A0 (ru) |
NO (1) | NO20013001L (ru) |
NZ (1) | NZ512765A (ru) |
PL (1) | PL348815A1 (ru) |
SK (1) | SK8192001A3 (ru) |
WO (1) | WO2000035922A1 (ru) |
ZA (1) | ZA200104598B (ru) |
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US7141563B2 (en) | 2000-11-03 | 2006-11-28 | Wyeth | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives |
AR031199A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
ES2230382T3 (es) * | 2000-11-03 | 2005-05-01 | Wyeth | Ciclopental(b)(1,4)diazpino(6,7,1-hi)indoles como antagonistas de 5ht2c. |
AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
AR031202A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
AR031195A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta (b) (1,4) diazepino (6,7,1) diazepino (6,7,1-hi) indol |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
CA2449899C (en) | 2000-11-20 | 2010-04-06 | Biovitrum Ab | Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor |
GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
RU2003121406A (ru) | 2000-12-20 | 2004-12-27 | Бристол-Маерс Сквибб Фарма Компани (Us) | Производные замещенных пиразинохиноксалинов в качестве агонистов и антагонистов рецептора серотонина |
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EP1392292B1 (en) | 2001-06-01 | 2006-03-01 | Alcon, Inc. | Pyranoindazoles and their use for the treatment of glaucoma |
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CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
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CA2788416C (en) | 2010-02-04 | 2018-08-14 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-ht(2c) receptor agonists having antagonist activity at the 5-ht(2b) receptor |
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CN107810175B (zh) | 2015-01-29 | 2021-06-15 | 伊利诺伊大学评议会 | 作为选择性5-ht(2c)受体激动剂的环丙基甲胺 |
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-
1999
- 1999-12-16 WO PCT/US1999/029894 patent/WO2000035922A1/en not_active Application Discontinuation
- 1999-12-16 AU AU31234/00A patent/AU3123400A/en not_active Abandoned
- 1999-12-16 PL PL99348815A patent/PL348815A1/xx not_active Application Discontinuation
- 1999-12-16 KR KR1020017007583A patent/KR20010108025A/ko not_active Application Discontinuation
- 1999-12-16 EP EP99965285A patent/EP1140940A1/en not_active Withdrawn
- 1999-12-16 IL IL14332399A patent/IL143323A0/xx unknown
- 1999-12-16 AR ARP990106455A patent/AR022687A1/es not_active Application Discontinuation
- 1999-12-16 HU HU0104773A patent/HUP0104773A3/hu unknown
- 1999-12-16 CA CA002351385A patent/CA2351385A1/en not_active Abandoned
- 1999-12-16 EA EA200100671A patent/EA200100671A1/ru unknown
- 1999-12-16 CN CNB998144169A patent/CN1240701C/zh not_active Expired - Fee Related
- 1999-12-16 SK SK819-2001A patent/SK8192001A3/sk unknown
- 1999-12-16 JP JP2000588181A patent/JP2002532504A/ja not_active Withdrawn
- 1999-12-16 BR BR9916326-8A patent/BR9916326A/pt not_active IP Right Cessation
- 1999-12-16 CZ CZ20012193A patent/CZ20012193A3/cs unknown
- 1999-12-16 NZ NZ512765A patent/NZ512765A/en unknown
-
2001
- 2001-06-05 ZA ZA200104598A patent/ZA200104598B/en unknown
- 2001-06-15 NO NO20013001A patent/NO20013001L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0104773A3 (en) | 2004-10-28 |
CN1240701C (zh) | 2006-02-08 |
PL348815A1 (en) | 2002-06-17 |
AU3123400A (en) | 2000-07-03 |
JP2002532504A (ja) | 2002-10-02 |
WO2000035922A1 (en) | 2000-06-22 |
SK8192001A3 (en) | 2001-12-03 |
NO20013001D0 (no) | 2001-06-15 |
ZA200104598B (en) | 2002-09-05 |
KR20010108025A (ko) | 2001-12-07 |
IL143323A0 (en) | 2002-04-21 |
CZ20012193A3 (cs) | 2001-12-12 |
CA2351385A1 (en) | 2000-06-22 |
NZ512765A (en) | 2003-10-31 |
NO20013001L (no) | 2001-06-15 |
EP1140940A1 (en) | 2001-10-10 |
CN1330652A (zh) | 2002-01-09 |
AR022687A1 (es) | 2002-09-04 |
HUP0104773A2 (hu) | 2002-04-29 |
BR9916326A (pt) | 2001-10-02 |
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