CN1240701C - 用作5HT2C激动剂的2,3,4,4a-四氢-1H-吡嗪并(1,2-a)喹喔啉-5(6H)酮衍生物 - Google Patents
用作5HT2C激动剂的2,3,4,4a-四氢-1H-吡嗪并(1,2-a)喹喔啉-5(6H)酮衍生物 Download PDFInfo
- Publication number
- CN1240701C CN1240701C CNB998144169A CN99814416A CN1240701C CN 1240701 C CN1240701 C CN 1240701C CN B998144169 A CNB998144169 A CN B998144169A CN 99814416 A CN99814416 A CN 99814416A CN 1240701 C CN1240701 C CN 1240701C
- Authority
- CN
- China
- Prior art keywords
- hydrogen
- compound
- pyrazine
- quinoxaline
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21347198A | 1998-12-17 | 1998-12-17 | |
US09/213,471 | 1998-12-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1330652A CN1330652A (zh) | 2002-01-09 |
CN1240701C true CN1240701C (zh) | 2006-02-08 |
Family
ID=22795247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB998144169A Expired - Fee Related CN1240701C (zh) | 1998-12-17 | 1999-12-16 | 用作5HT2C激动剂的2,3,4,4a-四氢-1H-吡嗪并(1,2-a)喹喔啉-5(6H)酮衍生物 |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1140940A1 (ru) |
JP (1) | JP2002532504A (ru) |
KR (1) | KR20010108025A (ru) |
CN (1) | CN1240701C (ru) |
AR (1) | AR022687A1 (ru) |
AU (1) | AU3123400A (ru) |
BR (1) | BR9916326A (ru) |
CA (1) | CA2351385A1 (ru) |
CZ (1) | CZ20012193A3 (ru) |
EA (1) | EA200100671A1 (ru) |
HU (1) | HUP0104773A3 (ru) |
IL (1) | IL143323A0 (ru) |
NO (1) | NO20013001D0 (ru) |
NZ (1) | NZ512765A (ru) |
PL (1) | PL348815A1 (ru) |
SK (1) | SK8192001A3 (ru) |
WO (1) | WO2000035922A1 (ru) |
ZA (1) | ZA200104598B (ru) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
US6806285B1 (en) | 2000-03-17 | 2004-10-19 | Alcon, Inc. | 5-Hydroxyl indole derivatives for treating glaucoma |
US7012090B1 (en) | 2000-03-17 | 2006-03-14 | Alcon, Inc. | Pyranoindoles for treating glaucoma |
US6956036B1 (en) | 2000-03-17 | 2005-10-18 | Alcon, Inc. | 6-hydroxy-indazole derivatives for treating glaucoma |
JP4180365B2 (ja) | 2000-07-31 | 2008-11-12 | エフ.ホフマン−ラ ロシュ アーゲー | ピペラジン誘導体 |
US6858604B2 (en) | 2000-11-03 | 2005-02-22 | Wyeth | Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6784172B2 (en) | 2000-11-03 | 2004-08-31 | Wyeth | Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
US6777407B2 (en) | 2000-11-03 | 2004-08-17 | Wyeth | Cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives |
AR031197A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de derivados de 1,2,3,4,8,9,10,10a-octahidro-7bh-ciclopenta(b) diazepino(6,7,1-hi)indol |
US6916922B2 (en) | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
AU2002239463A1 (en) * | 2000-11-03 | 2002-06-03 | Wyeth | Cyclopenta(b)(1,4) diazepino(6,7,1-hi)indoles as 5ht2c antagonists |
AR031200A1 (es) | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
JP4204315B2 (ja) | 2000-11-20 | 2009-01-07 | ビオヴィトルム・アクチボラゲット(プブリクト) | セロトニン5−ht2レセプターのアンタゴニストとしてのピペラジニルピラジン化合物 |
GB0030710D0 (en) | 2000-12-15 | 2001-01-31 | Hoffmann La Roche | Piperazine derivatives |
CA2431970A1 (en) | 2000-12-20 | 2002-08-01 | Bristol-Myers Squibb Pharma Company | Substituted pyrazinoquinoxaline derivatives as serotonin receptor agonists and antagonists |
ATE369368T1 (de) * | 2000-12-27 | 2007-08-15 | Hoffmann La Roche | Indolderivate und deren verwendung als 5-ht2b- und 5-ht2c-rezeptorliganden |
WO2002074746A1 (fr) * | 2001-03-16 | 2002-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de benzazepine |
CN1512879A (zh) | 2001-06-01 | 2004-07-14 | �Ƹ��� | 新的芳氨基丙烷类似物及其用于治疗青光眼的用途 |
DE60209486T2 (de) | 2001-06-01 | 2006-08-03 | Alcon Inc. | Pyranoindazole und ihre verwendung in der glaukombehandlung |
JP2004532887A (ja) | 2001-06-01 | 2004-10-28 | アルコン,インコーポレイテッド | 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用 |
TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
TW200307540A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
IL165220A0 (en) | 2002-06-19 | 2005-12-18 | Biovitrum Ab | Novel compounds, their use and preparation |
WO2004054572A2 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
WO2004056324A2 (en) | 2002-12-19 | 2004-07-08 | Bristol-Myers Squibb Company | Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists |
CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
EA200600071A1 (ru) * | 2003-06-20 | 2006-08-25 | Арена Фармасьютикалз, Инк. | Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором |
GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
US7476687B2 (en) | 2003-11-26 | 2009-01-13 | Alcon, Inc. | Substituted furo[2,3-g]indazoles for the treatment of glaucoma |
US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
WO2005058911A2 (en) | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
EP2400300A1 (en) | 2004-08-25 | 2011-12-28 | Takeda Pharmaceutical Company Limited | Method of screening preventives/remedies for stress urinary incontinence |
EP1797051B1 (en) * | 2004-09-30 | 2010-08-11 | F. Hoffmann-La Roche AG | Benzoxazine and quinoxaline derivatives and uses |
GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
WO2006062839A1 (en) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
JP5520051B2 (ja) | 2007-11-15 | 2014-06-11 | 武田薬品工業株式会社 | 縮合ピリジン誘導体およびその用途 |
KR101062376B1 (ko) | 2008-04-10 | 2011-09-06 | 한국화학연구원 | 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물 |
KR101110199B1 (ko) | 2009-05-18 | 2012-03-14 | 한국화학연구원 | 피페라진-퀴놀린 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계 질환의 예방 또는 치료용 약학적 조성물 |
WO2011044134A1 (en) | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof |
JPWO2011071136A1 (ja) | 2009-12-11 | 2013-04-22 | アステラス製薬株式会社 | 線維筋痛症治療剤 |
AU2011212930B2 (en) | 2010-02-04 | 2016-02-11 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-HT(2C) receptor agonists having antagonist activity at the 5-HT(2B) receptor |
US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
WO2012099952A2 (en) | 2011-01-19 | 2012-07-26 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
US10407381B2 (en) | 2015-01-29 | 2019-09-10 | The Board Of Trustees Of The University Of Illinois | Cyclopropylmethanamines as selective 5-HT(2C) receptor agonists |
US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4032639A (en) * | 1976-03-22 | 1977-06-28 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension |
US4089958A (en) * | 1976-12-20 | 1978-05-16 | American Home Products Corporation | 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof |
US4203987A (en) * | 1979-05-21 | 1980-05-20 | American Home Products Corporation | 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones |
GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
AU4547796A (en) * | 1995-02-03 | 1996-08-21 | Sankyo Company Limited | Hexahydropyrazinoquinoline derivatives |
-
1999
- 1999-12-16 SK SK819-2001A patent/SK8192001A3/sk unknown
- 1999-12-16 EA EA200100671A patent/EA200100671A1/ru unknown
- 1999-12-16 PL PL99348815A patent/PL348815A1/xx not_active Application Discontinuation
- 1999-12-16 CA CA002351385A patent/CA2351385A1/en not_active Abandoned
- 1999-12-16 WO PCT/US1999/029894 patent/WO2000035922A1/en not_active Application Discontinuation
- 1999-12-16 AR ARP990106455A patent/AR022687A1/es not_active Application Discontinuation
- 1999-12-16 BR BR9916326-8A patent/BR9916326A/pt not_active IP Right Cessation
- 1999-12-16 AU AU31234/00A patent/AU3123400A/en not_active Abandoned
- 1999-12-16 CZ CZ20012193A patent/CZ20012193A3/cs unknown
- 1999-12-16 EP EP99965285A patent/EP1140940A1/en not_active Withdrawn
- 1999-12-16 KR KR1020017007583A patent/KR20010108025A/ko not_active Application Discontinuation
- 1999-12-16 HU HU0104773A patent/HUP0104773A3/hu unknown
- 1999-12-16 CN CNB998144169A patent/CN1240701C/zh not_active Expired - Fee Related
- 1999-12-16 NZ NZ512765A patent/NZ512765A/en unknown
- 1999-12-16 IL IL14332399A patent/IL143323A0/xx unknown
- 1999-12-16 JP JP2000588181A patent/JP2002532504A/ja not_active Withdrawn
-
2001
- 2001-06-05 ZA ZA200104598A patent/ZA200104598B/en unknown
- 2001-06-15 NO NO20013001A patent/NO20013001D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CZ20012193A3 (cs) | 2001-12-12 |
SK8192001A3 (en) | 2001-12-03 |
PL348815A1 (en) | 2002-06-17 |
EA200100671A1 (ru) | 2001-12-24 |
AU3123400A (en) | 2000-07-03 |
HUP0104773A2 (hu) | 2002-04-29 |
EP1140940A1 (en) | 2001-10-10 |
JP2002532504A (ja) | 2002-10-02 |
WO2000035922A1 (en) | 2000-06-22 |
AR022687A1 (es) | 2002-09-04 |
IL143323A0 (en) | 2002-04-21 |
CN1330652A (zh) | 2002-01-09 |
KR20010108025A (ko) | 2001-12-07 |
NZ512765A (en) | 2003-10-31 |
NO20013001L (no) | 2001-06-15 |
BR9916326A (pt) | 2001-10-02 |
HUP0104773A3 (en) | 2004-10-28 |
NO20013001D0 (no) | 2001-06-15 |
CA2351385A1 (en) | 2000-06-22 |
ZA200104598B (en) | 2002-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1240701C (zh) | 用作5HT2C激动剂的2,3,4,4a-四氢-1H-吡嗪并(1,2-a)喹喔啉-5(6H)酮衍生物 | |
CN1036456C (zh) | 氨基取代的吡唑 | |
CN1036920C (zh) | 含杂环碳酸衍生物 | |
CN1084748C (zh) | 氨基甲基-2,3,8,9-四氢-7H-1,4-二氧杂环己烯并[2,3-e]吲哚-8-酮及其衍生物和用途 | |
CN100351236C (zh) | 用作5-羟色胺-6配体的1-杂环基烷基-3-磺酰基-吲哚衍生物,其制备方法和用途 | |
CN1036652C (zh) | 碱式季酰胺,其制备方法及其药物组合物 | |
CN1128263A (zh) | 具有药理学活性的吡咯并嘧啶类衍生物 | |
CN1234738A (zh) | 奥氮平二水合物d | |
CN1202107A (zh) | 选择性β3肾上腺素兴奋剂 | |
CN1133043A (zh) | 双环芳族化合物用作治疗剂 | |
CN1270585A (zh) | 取代的1,2,3,4-四氢化萘衍生物 | |
CN86106428A (zh) | 抗肿瘤方法及其化合物 | |
CN1131144A (zh) | 甘氨酰胺衍生物及其制法和含有它们的药物 | |
CN1093859C (zh) | 新型吲哚-2,3-二酮-3-肟衍生物 | |
CN1867552A (zh) | 用于淀粉样蛋白积聚性疾病的探针、用于染色淀粉样蛋白的试剂、用于治疗或预防淀粉样蛋白积聚性疾病的药物、以及用于诊断神经原纤维缠结的探针以及用于染色神经原纤维缠结的试剂 | |
CN1620290A (zh) | 作为5-羟色胺-6配体的吲哚基烷基胺衍生物 | |
CN1468224A (zh) | 用作α-2拮抗剂的喹啉衍生物 | |
CN1278727A (zh) | 单胺氧化酶抑制剂和h5-ht1B拮抗剂或部分激动剂的组合 | |
CN1111986A (zh) | 治疗肠应激综合症的异噁唑衍生物 | |
CN1437596A (zh) | 苯基哌嗪基衍生物 | |
CN1798744A (zh) | 作为nmda/nr2b拮抗剂的3-氟-哌啶化合物 | |
CN1041943A (zh) | 吡咯并[3,2-e]吡唑并[1,5-a]嘧啶衍生物及含有上述成份的药物 | |
CN1234801A (zh) | 5h-吡咯并[2,1-c][1,4]-苯并二氮杂䓬的3-甲酰胺衍生物 | |
CN1030586A (zh) | (8β)-1-烷基-6-(取代的)麦角灵环烷基酰胺类化合物 | |
CN1437598A (zh) | 新吲哚衍生物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060208 Termination date: 20100118 |