HUP0104773A2 - 5HT2c agonista 2,34,4a-tetrahidro-1H-pirazino[1,2-a]-kinoxalin-5(6H)-on-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

5HT2c agonista 2,34,4a-tetrahidro-1H-pirazino[1,2-a]-kinoxalin-5(6H)-on-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0104773A2
HUP0104773A2 HU0104773A HUP0104773A HUP0104773A2 HU P0104773 A2 HUP0104773 A2 HU P0104773A2 HU 0104773 A HU0104773 A HU 0104773A HU P0104773 A HUP0104773 A HU P0104773A HU P0104773 A2 HUP0104773 A2 HU P0104773A2
Authority
HU
Hungary
Prior art keywords
group
alkyl
hydrogen atom
pyrazino
quinoxalin
Prior art date
Application number
HU0104773A
Other languages
English (en)
Inventor
James Albert Nelson
Annmarie Louise Sabb
Gregory Scott Welmaker
Original Assignee
American Home Products Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corporation filed Critical American Home Products Corporation
Publication of HUP0104773A2 publication Critical patent/HUP0104773A2/hu
Publication of HUP0104773A3 publication Critical patent/HUP0104773A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A tal lm ny t rgya (I) ltal nos képletű vegyületek és enantiomerjei -ahol R jelentése hidrogénatom vagy 1-6 szénatomos alkilcsoport; R'jelentése hidrogénatom vagy 1-6 szénatomos alkil-, 2-7 szénatomosacil- vagy aroilcsoport; R1, R2, R3 és R4 egym stól függetlenüljelenthet hidrogénatomot, 1-6 szénatomos alkil-, 1-6 szénatomosalkoxicsoportot, halogénatomot, trifluor-alkil- vagy cianocsoportot,1-6 szénatomos alkil-szulfonamidot, 1-6 szénatomos alkilamidot,amino-, 1-6 szénatomos alkil-amino-, 1-6 szénatomos alkilcsoportottartalmazó dialkil-amino-, 1-6 szénatomos trifluor-alkoxi-, 2-7szénatomos acil- vagy aroilcsoportot; X jelentése CR5R6 vagykarbonilcsoport; R5 és R6 egym stól függetlenül hidrogénatom vagy 1-6szénatomos alkilcsoport; azzal a megk"téssel, hogy R1, R2, R3 vagy R4k"zül legal bb kettő hidrogénatomtól eltérő - melyek 5HT2C receptoragonist k, és a k"zponti idegrendszert érintő betegségek kezelésérealkalmasak, mint péld ul kényszerképzet rendellenesség, depresszió,szorong s, skizofrénia, migrén, alv si rendellenességek, evésirendellenességek, elhíz s, II típusú diabétesz és epilepszia. A tal lmny t rgya tov bb a vegyületeket tartalmazó gyógyszerkészítményekre isvonatkozik. Ó
HU0104773A 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them HUP0104773A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21347198A 1998-12-17 1998-12-17
PCT/US1999/029894 WO2000035922A1 (en) 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists

Publications (2)

Publication Number Publication Date
HUP0104773A2 true HUP0104773A2 (hu) 2002-04-29
HUP0104773A3 HUP0104773A3 (en) 2004-10-28

Family

ID=22795247

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0104773A HUP0104773A3 (en) 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them

Country Status (18)

Country Link
EP (1) EP1140940A1 (hu)
JP (1) JP2002532504A (hu)
KR (1) KR20010108025A (hu)
CN (1) CN1240701C (hu)
AR (1) AR022687A1 (hu)
AU (1) AU3123400A (hu)
BR (1) BR9916326A (hu)
CA (1) CA2351385A1 (hu)
CZ (1) CZ20012193A3 (hu)
EA (1) EA200100671A1 (hu)
HU (1) HUP0104773A3 (hu)
IL (1) IL143323A0 (hu)
NO (1) NO20013001D0 (hu)
NZ (1) NZ512765A (hu)
PL (1) PL348815A1 (hu)
SK (1) SK8192001A3 (hu)
WO (1) WO2000035922A1 (hu)
ZA (1) ZA200104598B (hu)

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Also Published As

Publication number Publication date
BR9916326A (pt) 2001-10-02
IL143323A0 (en) 2002-04-21
KR20010108025A (ko) 2001-12-07
EP1140940A1 (en) 2001-10-10
ZA200104598B (en) 2002-09-05
NO20013001L (no) 2001-06-15
CZ20012193A3 (cs) 2001-12-12
PL348815A1 (en) 2002-06-17
CN1240701C (zh) 2006-02-08
WO2000035922A1 (en) 2000-06-22
AU3123400A (en) 2000-07-03
HUP0104773A3 (en) 2004-10-28
CA2351385A1 (en) 2000-06-22
EA200100671A1 (ru) 2001-12-24
NO20013001D0 (no) 2001-06-15
NZ512765A (en) 2003-10-31
AR022687A1 (es) 2002-09-04
JP2002532504A (ja) 2002-10-02
CN1330652A (zh) 2002-01-09
SK8192001A3 (en) 2001-12-03

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