HUP0101372A2 - Triszubsztituált 1,3,5-triazin-származékok HIV-fertőzések kezelésére - Google Patents
Triszubsztituált 1,3,5-triazin-származékok HIV-fertőzések kezeléséreInfo
- Publication number
- HUP0101372A2 HUP0101372A2 HU0101372A HUP0101372A HUP0101372A2 HU P0101372 A2 HUP0101372 A2 HU P0101372A2 HU 0101372 A HU0101372 A HU 0101372A HU P0101372 A HUP0101372 A HU P0101372A HU P0101372 A2 HUP0101372 A2 HU P0101372A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- amino
- substituted
- mono
- Prior art date
Links
- 125000003363 1,3,5-triazinyl group Chemical class N1=C(N=CN=C1)* 0.000 title abstract 2
- 208000031886 HIV Infections Diseases 0.000 title abstract 2
- -1 carboxyl- Chemical group 0.000 abstract 10
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 125000004642 (C1-C12) alkoxy group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004951 trihalomethoxy group Chemical group 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/70—Other substituted melamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A találmány tárgya triszubsztituált 1,3,5-triazin-származékok HIV-fertőzések kezelésére. A találmány (I) általános képletű vegyületek N-oxidjai, gyógyá- szatilag elfogadható addíciós sói és sztereokémiaiizomer formáinak alkalmazására vonatkozik, ahol A jelentése CH, CR4vagy N; n étéke 0, 1, 2, 3 vagy 4; R1 és R2 jelentése egymástólfüggetlenül hidrogénatom, hidroxilcsoport, 1-12 szénatomos alkil-, 1-12 szénatomos alkoxi-, 1-12 szénatomos alkilkarbonil-, 1-12 szénatomosalkoxikarbonil-, aril-, amino-, mono- vagy di(1-12 szénatomos alkil)-amino-, mono- vagy di(1-12 szénatomos alkil)-aminokarbonilcsoport,ahol a fenti 1-12 szénatomos alkilcsoportok adott esetbenszubsztituálva lehetnek egy vagy két egymástól független hidroxil-, 1-6 szénatomos alkoxi-, hidroxi-(1-6 szénatomos alkoxi)-, karboxil-, 1-6szénatomos alkoxikarbonil-, ciano-, amino-, imino-, aminokarbonil-,aminokarbonilamino-, mono- vagy di(1-6 szénatomos alkil)amino-, aril-vagy Het csoporttal; vagy R1 és R2 együtt képezhet pirrolidinil-,piperidinil-, morfolinil-, azido-, mono- vagy di(1-12 szénatomosalkil)amino-(1-4 szénatomos alkilidén)-csoportot; R3 jelentésehidrogénatom, aril-, 1-6 szénatomos alkilkarbonil-, 1-6 szénatomosalkil-, 1-6 szénatomos alkoxikarbonil-, 1-6 szénatomos alkilcsoport,amely 1-6 szénatomos alkoxikarbonilcsoporttal van szubsztituálva; ésmindegyik R4 egymástól függetlenül lehet hidroxilcsoport, halogénatom,1-6 szénatomos alkil-, 1-6 szénatomos alkoxi-, ciano-, aminokarbonil-,nitro-, amino-, trihalogénmetil- vagy trihalogénmetoxicsoport; Ljelentése -X-R5 vagy -X-Alk-R6, ahol R5 és R6 egymástól függetlenüllehet indanil-, indolil- vagy fenilcsoport; ahol mindegyikszubsztituálva lehet; X jelentése -NR3-, -NH-NH-, -N=N-, -O-, -S-, -S(=O)- vagy -S(=O)2-; Alk jelentése 1-4 szénatomos alkándiilcsoport,az aril jelentése fenilcsoport vagy szubsztituált fenilcsoport; Hetjelentése telített vagy telítetlen heterociklusos csoport, ahol atelített heterociklusos csoport lehet pirrolidinil-, piperidinil-,homopiperidinil-, piperazinil-, morfolinil-, tetrahidrofuranil- vagytetrahidrotienilcsoport, amelyek mindegyike adott esetbenszubsztituálva lehet telítetlen aromás heterociklusos csoport lehetpirrolil-, furanil-, tienil-, piridinil-, pirimidinil-, pirazinil-vagy piridazinilcsoport, amelyek mindegyike adott esetben lehetszubsztituálva; gyógyszer előállítására, amellyel HIV-fertőzöttpáciensek kezelhetők. A találmány kiterjed továbbá az (I) általánosképletű vegyületek egy csoportjára is, amelyek új vegyületek, továbbáezek előállítására és az ezeket tartalmazó gyógyászati készítményekre. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7963398P | 1998-03-27 | 1998-03-27 | |
EP98201589A EP0945447A1 (en) | 1998-03-27 | 1998-05-14 | Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections |
PCT/EP1999/002044 WO1999050256A1 (en) | 1998-03-27 | 1999-03-24 | Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0101372A2 true HUP0101372A2 (hu) | 2001-10-28 |
HUP0101372A3 HUP0101372A3 (en) | 2003-02-28 |
Family
ID=22151790
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0101372A HUP0101372A3 (en) | 1998-03-27 | 1999-03-24 | Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections |
Country Status (33)
Country | Link |
---|---|
US (3) | US6150360A (hu) |
EP (2) | EP0945447A1 (hu) |
JP (1) | JP2002511390A (hu) |
KR (1) | KR100593396B1 (hu) |
CN (1) | CN1157386C (hu) |
AP (1) | AP1475A (hu) |
AR (1) | AR018169A1 (hu) |
AT (1) | ATE295355T1 (hu) |
AU (1) | AU758624C (hu) |
BG (1) | BG64903B1 (hu) |
BR (1) | BR9909197A (hu) |
CA (1) | CA2324921C (hu) |
DE (1) | DE69925256T2 (hu) |
DK (1) | DK1066269T3 (hu) |
EA (1) | EA004540B1 (hu) |
EE (1) | EE200000535A (hu) |
ES (1) | ES2243056T3 (hu) |
HK (1) | HK1032394A1 (hu) |
HR (1) | HRP20000621A2 (hu) |
HU (1) | HUP0101372A3 (hu) |
ID (1) | ID26043A (hu) |
IL (1) | IL138670A (hu) |
NO (1) | NO317425B1 (hu) |
NZ (1) | NZ506787A (hu) |
OA (1) | OA11493A (hu) |
PL (1) | PL194660B1 (hu) |
PT (1) | PT1066269E (hu) |
SI (1) | SI1066269T1 (hu) |
SK (1) | SK14052000A3 (hu) |
TR (1) | TR200002761T2 (hu) |
TW (1) | TW570917B (hu) |
WO (1) | WO1999050256A1 (hu) |
ZA (1) | ZA200006042B (hu) |
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SK285240B6 (sk) | 1999-09-24 | 2006-09-07 | Janssen Pharmaceutica N. V. | Antivírusové prostriedky |
DE19945982A1 (de) | 1999-09-24 | 2001-03-29 | Knoll Ag | Geschwindigkeitsbestimmte Partikel |
US6645964B1 (en) * | 1999-11-29 | 2003-11-11 | Aventis Pharma S.A. | Chemical derivatives and their application as antitelomerase agent |
US20020065270A1 (en) * | 1999-12-28 | 2002-05-30 | Moriarty Kevin Joseph | N-heterocyclic inhibitors of TNF-alpha expression |
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DK1282607T3 (en) | 2000-05-08 | 2016-02-01 | Janssen Pharmaceutica Nv | Prodrugs of HIV replication inhibiting pyrimidines |
US6858608B2 (en) * | 2001-01-09 | 2005-02-22 | Aventis Pharma S.A. | Chemical derivatives and their application as antitelomerase agents |
US6887873B2 (en) * | 2001-03-23 | 2005-05-03 | Aventis Pharma S.A. | Triazine derivatives and their application as antitelomerase agents |
US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
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US7169785B2 (en) * | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
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JP2002509140A (ja) * | 1998-01-13 | 2002-03-26 | アナディーズ・ファーマスーティカルズ,インコーポレイテッド | トリアジン抗ウイルス化合物 |
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1998
- 1998-05-14 EP EP98201589A patent/EP0945447A1/en not_active Withdrawn
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1999
- 1999-03-24 EE EEP200000535A patent/EE200000535A/xx unknown
- 1999-03-24 DE DE69925256T patent/DE69925256T2/de not_active Expired - Fee Related
- 1999-03-24 ES ES99917863T patent/ES2243056T3/es not_active Expired - Lifetime
- 1999-03-24 SI SI9930807T patent/SI1066269T1/xx unknown
- 1999-03-24 DK DK99917863T patent/DK1066269T3/da active
- 1999-03-24 SK SK1405-2000A patent/SK14052000A3/sk unknown
- 1999-03-24 TR TR2000/02761T patent/TR200002761T2/xx unknown
- 1999-03-24 PT PT99917863T patent/PT1066269E/pt unknown
- 1999-03-24 CA CA002324921A patent/CA2324921C/en not_active Expired - Fee Related
- 1999-03-24 NZ NZ506787A patent/NZ506787A/xx unknown
- 1999-03-24 AT AT99917863T patent/ATE295355T1/de not_active IP Right Cessation
- 1999-03-24 CN CNB998044474A patent/CN1157386C/zh not_active Expired - Fee Related
- 1999-03-24 EA EA200000993A patent/EA004540B1/ru not_active IP Right Cessation
- 1999-03-24 KR KR1020007007971A patent/KR100593396B1/ko not_active IP Right Cessation
- 1999-03-24 BR BR9909197-6A patent/BR9909197A/pt not_active Application Discontinuation
- 1999-03-24 EP EP99917863A patent/EP1066269B1/en not_active Expired - Lifetime
- 1999-03-24 AP APAP/P/2000/001913A patent/AP1475A/en active
- 1999-03-24 ID IDW20001895A patent/ID26043A/id unknown
- 1999-03-24 AU AU35997/99A patent/AU758624C/en not_active Ceased
- 1999-03-24 HU HU0101372A patent/HUP0101372A3/hu unknown
- 1999-03-24 JP JP2000541160A patent/JP2002511390A/ja active Pending
- 1999-03-24 WO PCT/EP1999/002044 patent/WO1999050256A1/en not_active Application Discontinuation
- 1999-03-24 PL PL99343195A patent/PL194660B1/pl not_active IP Right Cessation
- 1999-03-25 US US09/276,362 patent/US6150360A/en not_active Expired - Fee Related
- 1999-03-26 AR ARP990101363A patent/AR018169A1/es unknown
- 1999-03-26 TW TW088104756A patent/TW570917B/zh not_active IP Right Cessation
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2000
- 2000-08-08 US US09/634,340 patent/US6372729B1/en not_active Expired - Fee Related
- 2000-08-28 BG BG104716A patent/BG64903B1/bg unknown
- 2000-09-19 HR HR20000621A patent/HRP20000621A2/hr not_active Application Discontinuation
- 2000-09-25 IL IL13867000A patent/IL138670A/xx not_active IP Right Cessation
- 2000-09-26 NO NO20004809A patent/NO317425B1/no unknown
- 2000-09-27 OA OA1200000266A patent/OA11493A/en unknown
- 2000-10-26 ZA ZA200006042A patent/ZA200006042B/xx unknown
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2001
- 2001-04-20 HK HK01102801A patent/HK1032394A1/xx not_active IP Right Cessation
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2002
- 2002-02-05 US US10/067,383 patent/US6774235B2/en not_active Expired - Fee Related
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