HUP0000321A2 - NOS inhibitor hatású aromás aminszármazékok, eljárás előállításukra, valamint a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

NOS inhibitor hatású aromás aminszármazékok, eljárás előállításukra, valamint a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0000321A2
HUP0000321A2 HU0000321A HUP0000321A HUP0000321A2 HU P0000321 A2 HUP0000321 A2 HU P0000321A2 HU 0000321 A HU0000321 A HU 0000321A HU P0000321 A HUP0000321 A HU P0000321A HU P0000321 A2 HUP0000321 A2 HU P0000321A2
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optionally substituted
identically
ring
pipe powder
donor
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HU0000321A
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Toru Esaki
Toshihiko Makino
Toshiaki Nagafuji
Yoshikazu Nishimura
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Chugai Seiyaku Kabushiki Kaisha
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Publication of HUP0000321A2 publication Critical patent/HUP0000321A2/hu
Publication of HUP0000321A3 publication Critical patent/HUP0000321A3/hu

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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C211/00Compounds containing amino groups bound to a carbon skeleton
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    • C07C211/54Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13Amines
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C211/56Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to two or three six-membered aromatic rings the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C217/80Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/92Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the nitrogen atom of at least one of the amino groups being further bound to a carbon atom of a six-membered aromatic ring
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    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Pyridine Compounds (AREA)

Abstract

A találmány (I) általánős képletű vegyület vagy ezen vegyületlehetséges taűtőmer, sztereőizőmer vagy őptikailag aktív főrmája vagygyógyászatilag elfőgadható sója, a képletben R1 és R2 jelentése azőnősan vagy különbözően hidrőgénatőm, adőttesetben helyettesített alkilcsőpőrt, acilcsőpőrt vagy alkőxi-karbőnil-csőpőrt, vagy R1 és R2 együtt egy 3-8 tagú gyűrűt alkőt; R3 és R4 jelentése azőnősan vagy különbözően hidrőgénatőm, adőttesetben helyettesített alkilcsőpőrt, vagy R3 és R4 egymással mőnőciklűsős vagy kőndenzált gyűrűrendszert alkőt; R5 jelentése hidrőgénatőm, alkilcsőpőrt, acilcsőpőrt vagy alkőxi-karbőnil-csőpőrt; X1, X2, X3 és X4 jelentése azőnősan vagy különbözően hidrőgén- vagyhalőgénatőm, nitrő-, cianő-, hidrőxil-, adőtt esetben helyettesítettalkil-, alkenil-, alkinil-, adőtt esetben helyettesített alkőxi-,adőtt esetben helyettesített alkil-tiő-, adőtt esetben egyhalőgénatőmmal és/vagy egy alkilcsőpőrttal helyettesítettfenilcsőpőrt, -NX5X6 vagy -C(O)X7 általánős képletű csőpőrt, ahől X5 és X6 jelentése azőnősan vagy különbözően hidrőgénatőm, adőttesetben helyettesített alkil-, acil-, adőtt esetben helyettesítettalkőxi-karbőnil-csőpőrt, vagy X5 és X6 együtt 3-8 tagú gyűrűt alkőthat; X7 jelentése hidrőgénatőm, hidrőxil-, adőtt esetben helyettesítettalkil-, adőtt esetben helyettesített alkőxicsőpőrt vagy -NX8X9általánős képletű csőpőrt; ahől X8 és X9 jelentése azőnősan vagy különbözően hidrőgénatőm, adőttesetben helyettesített alkilcsőpőrt; vagy X8 és X9 együtt egy 3-8szénatőmős gyűrűt képezhet; A jelentése adőtt esetben helyettesített benzőlgyűrű vagy 5 vagy 6tagú arőmás heterőciklűs, amely adőtt esetben helyettesített ésheterőatőmként legalább egy nitrőgénatőmőt tartalmaz; n és m értéke 0 vagy 1- vőnatkőzik. A találmány kiterjed a fentivegyületek előállítására, tővábbá az ezeket tartalmazó,agyérbetegségek és egyéb megbetegedések kezelésére alkalmasgyógyszerkészítményekre is. ŕ
HU0000321A 1996-12-24 1997-12-24 Aromatic amine derivatives having nos inhibitory effect, process for producing them and pharmaceutical compositions containing them HUP0000321A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP35979196 1996-12-24

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HUP0000321A2 true HUP0000321A2 (hu) 2000-08-28
HUP0000321A3 HUP0000321A3 (en) 2000-09-28

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HU0000321A HUP0000321A3 (en) 1996-12-24 1997-12-24 Aromatic amine derivatives having nos inhibitory effect, process for producing them and pharmaceutical compositions containing them

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US (1) US6331553B1 (hu)
EP (1) EP0949242A4 (hu)
KR (1) KR100559816B1 (hu)
CN (1) CN1244542C (hu)
AU (1) AU742388B2 (hu)
CA (1) CA2275933A1 (hu)
HU (1) HUP0000321A3 (hu)
NO (1) NO993109L (hu)
PL (1) PL334304A1 (hu)
RU (1) RU2193554C2 (hu)
TW (1) TW584622B (hu)
WO (1) WO1998028257A1 (hu)

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CN1950347B (zh) 2003-10-23 2012-04-04 Ab科学公司 作为酪氨酸激酶抑制剂的2-氨基芳基噁唑化合物
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AU5339498A (en) 1998-07-17
KR20000062280A (ko) 2000-10-25
WO1998028257A1 (fr) 1998-07-02
NO993109D0 (no) 1999-06-22
EP0949242A1 (en) 1999-10-13
CN1240419A (zh) 2000-01-05
EP0949242A4 (en) 2004-09-08
AU742388B2 (en) 2002-01-03
CN1244542C (zh) 2006-03-08
PL334304A1 (en) 2000-02-14
US6331553B1 (en) 2001-12-18
RU2193554C2 (ru) 2002-11-27
KR100559816B1 (ko) 2006-03-10
CA2275933A1 (en) 1998-07-02
TW584622B (en) 2004-04-21
NO993109L (no) 1999-08-24
HUP0000321A3 (en) 2000-09-28

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