HUP0102187A2 - Azolo-triazinok és -pirimidinek, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazása - Google Patents
Azolo-triazinok és -pirimidinek, ezeket tartalmazó gyógyászati készítmények, valamint e vegyületek alkalmazásaInfo
- Publication number
- HUP0102187A2 HUP0102187A2 HU0102187A HUP0102187A HUP0102187A2 HU P0102187 A2 HUP0102187 A2 HU P0102187A2 HU 0102187 A HU0102187 A HU 0102187A HU P0102187 A HUP0102187 A HU P0102187A HU P0102187 A2 HUP0102187 A2 HU P0102187A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- compounds
- dihydro
- pyrimidines
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- SHCRKMNTWSCEBT-UHFFFAOYSA-N N1N=NC=C2N=CC=C21 Chemical class N1N=NC=C2N=CC=C21 SHCRKMNTWSCEBT-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- -1 phenyl- Chemical group 0.000 abstract 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000962 organic group Chemical group 0.000 abstract 3
- 238000002360 preparation method Methods 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000004306 triazinyl group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
A találmány szerinti vegyületek (1) vagy (2) általános képletében Ajelentése nitrogénatom vagy CR általános képletű csoport; Z jelentésenitrogénatom vagy CR általános képletű csoport; Ar jelentése adottesetben helyettesített fenil-, naftil-, piridil-, pirimidinil-,triazinil-, furanil-, tienil-, benzotienil-, benzofuranil-, 2,3-dihidro-benzofuranil-, 2,3-dihidro-benzotenil-, indanil-, 1,2-benzpiranil-, 3,4-dihidro-1,2-benzpiranil- vagy tetralinilcsoport; Rjelentése hidrogén- vagy halogénatom, alkil-, alkenil-, alkinil-,cikloalkil-, cikloalkil-alkil- vagy halogén-alkil-csoport vagy CNképletű csoport; R1 jelentése hidrogénatom, halogénatom, CN vagy SHképletű csoport vagy szerves csoport; R3 jelentése hidrogénatom, SHképletű csoport vagy szerves csoport; és R14 jelentése szervescsoport. A találmány tárgyköréhez tartoznak továbbá a fentivegyületeket tartalmazó gyógyászati készítmények, valamint evegyületek alkalmazása gyógyászati készítmények előállítására. Atalálmány szerinti készítmények pszichiátriai és ideggyógyászatirendellenességek kezelésére alkalmazhatók. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68604796A | 1996-07-24 | 1996-07-24 | |
US2329096P | 1996-07-24 | 1996-07-24 | |
PCT/US1997/013072 WO1998003510A1 (en) | 1996-07-24 | 1997-07-23 | AZOLO TRIAZINES AND PYRIMIDINES |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0102187A2 true HUP0102187A2 (hu) | 2001-11-28 |
HUP0102187A3 HUP0102187A3 (en) | 2002-12-28 |
HU228962B1 HU228962B1 (en) | 2013-07-29 |
Family
ID=26696934
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102187A HU228962B1 (en) | 1996-07-24 | 1997-07-23 | Azolo triazines, pharmaceutical compositions containing them and use of the compounds |
HU0500549A HU229024B1 (en) | 1996-07-24 | 1997-07-23 | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0500549A HU229024B1 (en) | 1996-07-24 | 1997-07-23 | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP1908764A1 (hu) |
KR (1) | KR100548853B1 (hu) |
AR (1) | AR007994A1 (hu) |
AT (1) | ATE375344T1 (hu) |
AU (1) | AU747708B2 (hu) |
CZ (1) | CZ2005613A3 (hu) |
DE (1) | DE69738197T2 (hu) |
DK (1) | DK0915880T3 (hu) |
EA (1) | EA006626B1 (hu) |
ES (1) | ES2294800T3 (hu) |
HK (1) | HK1052693A1 (hu) |
HU (2) | HU228962B1 (hu) |
LV (1) | LV12292B (hu) |
PT (1) | PT915880E (hu) |
RO (1) | RO121272B1 (hu) |
TW (2) | TW542827B (hu) |
WO (1) | WO1998003510A1 (hu) |
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JP2585462B2 (ja) * | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ[1,5―a]ピリミジン誘導体 |
KR927003595A (ko) * | 1990-10-09 | 1992-12-18 | 오츠카 아키히코 | 피리미딘 유도체, 이의 제조방법 및 안드로겐 저해제 |
US5484760A (en) * | 1990-12-31 | 1996-01-16 | Monsanto Company | Herbicide antidotes as safeners for reducing phytotoxicity resulting from synergistic interaction between herbicides and other pesticides |
KR100191774B1 (ko) * | 1991-04-22 | 1999-06-15 | 오스카 아끼히꼬 | 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
DK0674641T3 (da) * | 1992-12-17 | 1999-09-27 | Pfizer | Pyrrolopyrimidiner som CRF-antagonister |
CN1046730C (zh) * | 1994-06-21 | 1999-11-24 | 株式会社大塚制药工场 | 吡唑并[1,5-a]嘧啶衍生物 |
AU716993B2 (en) * | 1995-05-12 | 2000-03-16 | Neurogen Corporation | Novel deazapurine derivatives; a new class of CRF1 specific ligands |
WO1997029109A1 (en) * | 1996-02-07 | 1997-08-14 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as crf receptor antagonists |
-
1997
- 1997-07-23 RO RO99-00078A patent/RO121272B1/ro unknown
- 1997-07-23 EP EP07015514A patent/EP1908764A1/en not_active Withdrawn
- 1997-07-23 ES ES97936222T patent/ES2294800T3/es not_active Expired - Lifetime
- 1997-07-23 EA EA200301042A patent/EA006626B1/ru not_active IP Right Cessation
- 1997-07-23 CZ CZ2005-613A patent/CZ2005613A3/cs unknown
- 1997-07-23 EP EP97936222A patent/EP0915880B1/en not_active Expired - Lifetime
- 1997-07-23 PT PT97936222T patent/PT915880E/pt unknown
- 1997-07-23 AU AU38942/97A patent/AU747708B2/en not_active Expired
- 1997-07-23 DK DK97936222T patent/DK0915880T3/da active
- 1997-07-23 KR KR1019997000568A patent/KR100548853B1/ko not_active IP Right Cessation
- 1997-07-23 DE DE69738197T patent/DE69738197T2/de not_active Expired - Lifetime
- 1997-07-23 AT AT97936222T patent/ATE375344T1/de active
- 1997-07-23 HU HU0102187A patent/HU228962B1/hu unknown
- 1997-07-23 WO PCT/US1997/013072 patent/WO1998003510A1/en active IP Right Grant
- 1997-07-23 HU HU0500549A patent/HU229024B1/hu unknown
- 1997-07-24 AR ARP970103368A patent/AR007994A1/es unknown
- 1997-07-25 TW TW086110640A patent/TW542827B/zh not_active IP Right Cessation
- 1997-07-25 TW TW092105694A patent/TWI238164B/zh not_active IP Right Cessation
-
1999
- 1999-01-20 LV LVP-99-13A patent/LV12292B/en unknown
-
2003
- 2003-07-02 HK HK03104703.7A patent/HK1052693A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EA006626B1 (ru) | 2006-02-24 |
EA200301042A1 (ru) | 2004-02-26 |
EP1908764A1 (en) | 2008-04-09 |
ATE375344T1 (de) | 2007-10-15 |
AU747708B2 (en) | 2002-05-23 |
HUP0102187A3 (en) | 2002-12-28 |
KR20000068010A (ko) | 2000-11-25 |
HK1052693A1 (zh) | 2003-09-26 |
HU228962B1 (en) | 2013-07-29 |
DK0915880T3 (da) | 2008-02-11 |
DE69738197T2 (de) | 2008-07-17 |
RO121272B1 (ro) | 2007-02-28 |
TWI238164B (en) | 2005-08-21 |
TW542827B (en) | 2003-07-21 |
HU0500549D0 (en) | 2005-08-29 |
LV12292A (lv) | 1999-06-20 |
WO1998003510A1 (en) | 1998-01-29 |
EP0915880A1 (en) | 1999-05-19 |
DE69738197D1 (de) | 2007-11-22 |
HU229024B1 (en) | 2013-07-29 |
TW200304916A (en) | 2003-10-16 |
LV12292B (en) | 1999-11-20 |
PT915880E (pt) | 2007-12-31 |
AU3894297A (en) | 1998-02-10 |
AR007994A1 (es) | 1999-11-24 |
EP0915880B1 (en) | 2007-10-10 |
KR100548853B1 (ko) | 2006-02-02 |
CZ2005613A3 (cs) | 2017-01-25 |
ES2294800T3 (es) | 2008-04-01 |
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