EE200000535A - Triasendatud 1,3,5-triasiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutami - Google Patents

Triasendatud 1,3,5-triasiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutami

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Publication number
EE200000535A
EE200000535A EEP200000535A EEP200000535A EE200000535A EE 200000535 A EE200000535 A EE 200000535A EE P200000535 A EEP200000535 A EE P200000535A EE P200000535 A EEP200000535 A EE P200000535A EE 200000535 A EE200000535 A EE 200000535A
Authority
EE
Estonia
Prior art keywords
compound
preparation
trisubstituted
medicament
treatment
Prior art date
Application number
EEP200000535A
Other languages
English (en)
Estonian (et)
Inventor
Adriaan Jan Janssen Paul
Joseph Kukla Michael
Frans Desir Daeyaert Frederik
De Corte Bart
Ren De Jonge Marc
Heeres Jan
Yung Ho Chih
W. Kavash Robert
Maria Henricus Koymans Lucien
William Ludovici Donald
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of EE200000535A publication Critical patent/EE200000535A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/50—Two nitrogen atoms with a halogen atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/66—Derivatives of melamine in which a hetero atom is directly attached to a nitrogen atom of melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EEP200000535A 1998-03-27 1999-03-24 Triasendatud 1,3,5-triasiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutami EE200000535A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7963398P 1998-03-27 1998-03-27
EP98201589A EP0945447A1 (en) 1998-03-27 1998-05-14 Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
PCT/EP1999/002044 WO1999050256A1 (en) 1998-03-27 1999-03-24 Trisubstituted 1,3,5-triazine derivatives for treatment of hiv infections

Publications (1)

Publication Number Publication Date
EE200000535A true EE200000535A (et) 2002-04-15

Family

ID=22151790

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000535A EE200000535A (et) 1998-03-27 1999-03-24 Triasendatud 1,3,5-triasiini derivaatide kasutamine ravimi valmistamiseks, mis on ette nähtud HIV nakkuse raviks, ühend, seda sisaldav farmatseutiline kompositsioon, meetod ühendi ja kompositsiooni valmistamiseks ning kombineeritud preparaat kasutami

Country Status (33)

Country Link
US (3) US6150360A (xx)
EP (2) EP0945447A1 (xx)
JP (1) JP2002511390A (xx)
KR (1) KR100593396B1 (xx)
CN (1) CN1157386C (xx)
AP (1) AP1475A (xx)
AR (1) AR018169A1 (xx)
AT (1) ATE295355T1 (xx)
AU (1) AU758624C (xx)
BG (1) BG64903B1 (xx)
BR (1) BR9909197A (xx)
CA (1) CA2324921C (xx)
DE (1) DE69925256T2 (xx)
DK (1) DK1066269T3 (xx)
EA (1) EA004540B1 (xx)
EE (1) EE200000535A (xx)
ES (1) ES2243056T3 (xx)
HK (1) HK1032394A1 (xx)
HR (1) HRP20000621A2 (xx)
HU (1) HUP0101372A3 (xx)
ID (1) ID26043A (xx)
IL (1) IL138670A (xx)
NO (1) NO317425B1 (xx)
NZ (1) NZ506787A (xx)
OA (1) OA11493A (xx)
PL (1) PL194660B1 (xx)
PT (1) PT1066269E (xx)
SI (1) SI1066269T1 (xx)
SK (1) SK14052000A3 (xx)
TR (1) TR200002761T2 (xx)
TW (1) TW570917B (xx)
WO (1) WO1999050256A1 (xx)
ZA (1) ZA200006042B (xx)

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AU783981C (en) 2000-05-08 2007-05-03 Janssen Pharmaceutica N.V. HIV replication inhibitors
US6858608B2 (en) * 2001-01-09 2005-02-22 Aventis Pharma S.A. Chemical derivatives and their application as antitelomerase agents
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US6958211B2 (en) 2001-08-08 2005-10-25 Tibotech Bvba Methods of assessing HIV integrase inhibitor therapy
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
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CA2575002C (en) * 2004-08-10 2015-01-20 Janssen Pharmaceutica N.V. Hiv inhibiting 1,2,4-triazin-6-one derivatives
WO2006035068A2 (en) 2004-09-30 2006-04-06 Tibotec Pharmaceuticals Ltd. Hiv inhibiting 5-carbo- or heterocyclic substituted pyrimidines
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Also Published As

Publication number Publication date
KR20010034270A (ko) 2001-04-25
ES2243056T3 (es) 2005-11-16
HUP0101372A2 (hu) 2001-10-28
DK1066269T3 (da) 2005-09-05
BG104716A (en) 2001-04-30
CA2324921C (en) 2009-05-12
DE69925256D1 (de) 2005-06-16
AU758624C (en) 2004-03-11
CA2324921A1 (en) 1999-10-07
AP1475A (en) 2005-10-03
US20020115668A1 (en) 2002-08-22
AU3599799A (en) 1999-10-18
AR018169A1 (es) 2001-10-31
US6150360A (en) 2000-11-21
ZA200006042B (en) 2001-10-26
NO20004809L (no) 2000-11-24
ID26043A (id) 2000-11-16
EP0945447A1 (en) 1999-09-29
HK1032394A1 (en) 2001-07-20
CN1295566A (zh) 2001-05-16
EA004540B1 (ru) 2004-06-24
HUP0101372A3 (en) 2003-02-28
BG64903B1 (bg) 2006-08-31
TW570917B (en) 2004-01-11
OA11493A (en) 2004-05-07
SK14052000A3 (sk) 2001-06-11
IL138670A (en) 2005-12-18
BR9909197A (pt) 2000-12-05
NO317425B1 (no) 2004-10-25
NO20004809D0 (no) 2000-09-26
AU758624B2 (en) 2003-03-27
US6774235B2 (en) 2004-08-10
CN1157386C (zh) 2004-07-14
TR200002761T2 (tr) 2001-01-22
KR100593396B1 (ko) 2006-06-28
AP2000001913A0 (en) 2000-09-30
HRP20000621A2 (en) 2001-04-30
PL343195A1 (en) 2001-07-30
PL194660B1 (pl) 2007-06-29
US6372729B1 (en) 2002-04-16
WO1999050256A1 (en) 1999-10-07
EA200000993A1 (ru) 2001-04-23
PT1066269E (pt) 2005-09-30
SI1066269T1 (en) 2005-10-31
NZ506787A (en) 2003-02-28
DE69925256T2 (de) 2006-02-23
JP2002511390A (ja) 2002-04-16
EP1066269A1 (en) 2001-01-10
EP1066269B1 (en) 2005-05-11
ATE295355T1 (de) 2005-05-15

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