IL143323A0 - 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists - Google Patents

2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists

Info

Publication number
IL143323A0
IL143323A0 IL14332399A IL14332399A IL143323A0 IL 143323 A0 IL143323 A0 IL 143323A0 IL 14332399 A IL14332399 A IL 14332399A IL 14332399 A IL14332399 A IL 14332399A IL 143323 A0 IL143323 A0 IL 143323A0
Authority
IL
Israel
Prior art keywords
pyrazino
quinoxalin
tetrahydro
derivatives
5ht2c agonists
Prior art date
Application number
IL14332399A
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of IL143323A0 publication Critical patent/IL143323A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL14332399A 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists IL143323A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21347198A 1998-12-17 1998-12-17
PCT/US1999/029894 WO2000035922A1 (en) 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists

Publications (1)

Publication Number Publication Date
IL143323A0 true IL143323A0 (en) 2002-04-21

Family

ID=22795247

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14332399A IL143323A0 (en) 1998-12-17 1999-12-16 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists

Country Status (18)

Country Link
EP (1) EP1140940A1 (en)
JP (1) JP2002532504A (en)
KR (1) KR20010108025A (en)
CN (1) CN1240701C (en)
AR (1) AR022687A1 (en)
AU (1) AU3123400A (en)
BR (1) BR9916326A (en)
CA (1) CA2351385A1 (en)
CZ (1) CZ20012193A3 (en)
EA (1) EA200100671A1 (en)
HU (1) HUP0104773A3 (en)
IL (1) IL143323A0 (en)
NO (1) NO20013001L (en)
NZ (1) NZ512765A (en)
PL (1) PL348815A1 (en)
SK (1) SK8192001A3 (en)
WO (1) WO2000035922A1 (en)
ZA (1) ZA200104598B (en)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
US6956036B1 (en) 2000-03-17 2005-10-18 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2002010169A1 (en) * 2000-07-31 2002-02-07 F. Hoffmann-La Roche Ag Piperazine derivatives
US6759405B2 (en) 2000-11-03 2004-07-06 Wyeth Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
US6858604B2 (en) 2000-11-03 2005-02-22 Wyeth Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031197A1 (en) 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1,2,3,4,8,9,10,10A-OCTAHIDRO-7BH-CICLOPENTA (B) DIAZEPINO (6,7,1-HI) INDOL
DE60106641T2 (en) * 2000-11-03 2005-12-01 Wyeth CYCLOPENTA [B] [1,4] DIAZEPINO [6,7,1-HI] INDOLE AS 5HT2C ANTAGONISTS
AR031202A1 (en) 2000-11-03 2003-09-10 Wyeth Corp CYCLOPENTA (B) (1,4) DIAZEPINO (6,7,1-HI) INDOLES AND DERIVATIVES
US6784172B2 (en) 2000-11-03 2004-08-31 Wyeth Processes for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
AR031195A1 (en) 2000-11-03 2003-09-10 Wyeth Corp PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 1,2,3,4,8,9,10,10A-OCTAHIDRO-7BH-CICLOPENTA (B) (1,4) DIAZEPINO (6,7,1) DIAZEPINO (6,7, 1-HI) INDOL
EP1337518B1 (en) 2000-11-20 2009-06-17 Biovitrum AB (publ) Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
SE0004245D0 (en) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
GB0030710D0 (en) 2000-12-15 2001-01-31 Hoffmann La Roche Piperazine derivatives
WO2002059127A2 (en) * 2000-12-20 2002-08-01 Bristol-Myers Squibb Pharma Company Pyrazinoquinoxaline derivatives as serotonin agonists and antagonists
KR100539143B1 (en) 2000-12-27 2005-12-26 에프. 호프만-라 로슈 아게 Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands
WO2002074746A1 (en) * 2001-03-16 2002-09-26 Yamanouchi Pharmaceutical Co., Ltd. Benzazepine derivatives
BR0210238A (en) 2001-06-01 2004-07-20 Alcon Inc New Aryl-Amino-Propane Analogs and Their Use for the Treatment of Glaucoma
JP2004535418A (en) 2001-06-01 2004-11-25 アルコン，インコーポレイテッド Pyranoindazole and its use in treating glaucoma
EP1392658A4 (en) 2001-06-01 2004-10-13 Alcon Inc Novel fused indazoles and indoles and their use for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
EP1513831B1 (en) 2002-06-19 2010-01-06 Biovitrum AB (publ) Novel compounds, their use and preparation
WO2004054572A2 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
EP1581221B1 (en) 2002-12-19 2011-05-18 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
CL2004000826A1 (en) 2003-04-25 2005-03-04 Pfizer USE OF AN AGONIST FOR THE 5-HT2C RECEPTOR TO PREPARE A USEFUL MEDICINAL PRODUCT IN THE TREATMENT OF URINARY INCONTINENCE CAUSED BY STRESS, WITH THE CONDITION THAT THE AGONIST IS NOT 1- [6-CHLORINE-5- (TRIFLUOROMETIL) -2- PIRIDINIL] PIPERAZINA (ORG-129
CA2529750A1 (en) * 2003-06-20 2005-02-24 Arena Pharmaceuticals, Inc. N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases
GB0314967D0 (en) 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
WO2005053688A1 (en) 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
AR046890A1 (en) 2003-12-15 2005-12-28 Alcon Inc [1,4] OXAZINO [2,3-G] SUBSTITUTED INDAZOLS FOR THE TREATMENT OF GLAUCOMA.
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
JP2008514662A (en) * 2004-09-30 2008-05-08 エフ．ホフマン−ラ ロシュ アーゲー Benzoxazine and quinoxaline derivatives and uses
GT200500317A (en) 2004-11-05 2006-10-27 PROCESS TO PREPARE QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED FROM THEM
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
AR054849A1 (en) 2005-07-26 2007-07-18 Wyeth Corp DIAZEPINOQUINOLINAS, SYNTHESIS OF THE SAME, AND INTERMEDIARIES TO OBTAIN THEM
EP2018863B9 (en) 2006-05-16 2015-02-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical Condensed pyridine derivative and use thereof
KR101062376B1 (en) 2008-04-10 2011-09-06 한국화학연구원 Novel indole carboxylic acid bispyridyl carboxamide derivatives, preparation method thereof and composition containing the same as an active ingredient
KR101110199B1 (en) 2009-05-18 2012-03-14 한국화학연구원 Piperazine-quinoline derivatives, pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for prevention or treatment of central nervous system diseases containing the same as an active ingredient
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
EP2531485B1 (en) 2010-02-04 2019-04-24 The Board of Trustees of the University of Illionis Highly selective 5-ht(2c) receptor agonists having antagonist activity at the 5-ht(2b) receptor
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2012099952A2 (en) 2011-01-19 2012-07-26 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2016123164A1 (en) 2015-01-29 2016-08-04 The Board Of Trustees Of The University Of Illinois Cyclopropylmethanamines as selective 5-ht(2c) receptor agonists
WO2019131902A1 (en) 2017-12-27 2019-07-04 武田薬品工業株式会社 Therapeutic agent for stress urinary incontinence and fecal incontinence

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032639A (en) * 1976-03-22 1977-06-28 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension
US4089958A (en) * 1976-12-20 1978-05-16 American Home Products Corporation 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
US4203987A (en) * 1979-05-21 1980-05-20 American Home Products Corporation 3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones
GB8917333D0 (en) * 1989-07-28 1989-09-13 Merck Sharp & Dohme Therapeutic agents
EP0539209A1 (en) * 1991-10-24 1993-04-28 The Upjohn Company Benzo-isoquinoline derivatives and analogs and their use in therapeutics
AU4547796A (en) * 1995-02-03 1996-08-21 Sankyo Company Limited Hexahydropyrazinoquinoline derivatives

Also Published As

Publication number Publication date
PL348815A1 (en) 2002-06-17
JP2002532504A (en) 2002-10-02
HUP0104773A2 (en) 2002-04-29
ZA200104598B (en) 2002-09-05
CZ20012193A3 (en) 2001-12-12
KR20010108025A (en) 2001-12-07
NO20013001D0 (en) 2001-06-15
CN1240701C (en) 2006-02-08
SK8192001A3 (en) 2001-12-03
AU3123400A (en) 2000-07-03
BR9916326A (en) 2001-10-02
WO2000035922A1 (en) 2000-06-22
HUP0104773A3 (en) 2004-10-28
NO20013001L (en) 2001-06-15
NZ512765A (en) 2003-10-31
AR022687A1 (en) 2002-09-04
CA2351385A1 (en) 2000-06-22
EP1140940A1 (en) 2001-10-10
CN1330652A (en) 2002-01-09
EA200100671A1 (en) 2001-12-24

Similar Documents

Publication Publication Date Title
IL143323A0 (en) 2,3,4,4a-tetrahydro-1h-pyrazino (1,2-a) quinoxalin-5 (6h) one derivatives being 5ht2c agonists
HK1018439A1 (en) 5h-thiazolo (3,2-a) pyrimidine derivatives
SG71077A1 (en) 8-Substituted-1,3, 8-triaza-spiro (4.5)decan-4-on derivatives
HUP9903072A3 (en) 5,7-dihydroxy-chroman-4-on derivatives as immuno suppressive agents
SI0921125T1 (en) 1,3,8-Triazaspiro(4,5)decan-4-on derivatives
PL342542A1 (en) Substituted 2-phenyl-1-(3,4-diphydroxy-5-nitrophenyl)-ethanones
ZA987688B (en) 6,9-bridged erythromycin derivatives
ZA9811128B (en) 1,3,8-Triaza-spiro(4,5)decan-4-on derivatives
IL134996A0 (en) 6,11-bridged erythromycin derivatives
AP9901650A0 (en) 1,2, ,4-tetrahydro-benzofuro (3,2-c)pyridine derivatives
ZA9810920B (en) Fungicidal combinations comprising theino (2,3-d) pyrimidin-4-one
IL137792A0 (en) Alpha-methylstyrene dimer derivatives
EP1116726A4 (en) Ethylamine derivatives
HUP0004317A3 (en) 5-ht1f agonists
SG83135A1 (en) Di-or triaza-spiro(4,5)decane derivatives
PL339446A1 (en) Parenteral compositions containing carbamazepin or its derivatives
ZA993063B (en) 2"-deoxy hygromycin derivatives.
GB9806539D0 (en) Electroplating solution
HUP0100841A3 (en) Glycosidation of 4,5-epoxymorphinan-6-ols
GB9810998D0 (en) Antitumour 1,5-diazaanthraquinones
GB2334037B (en) Electroplating
ZA953775B (en) 8-Amino-pyrido(1,2,3-D,E)(1,3,4) Benzoxadiazine derivatives
GB2334036B (en) Electroplating
HK1018059A1 (en) Tetrahydroimidazo (2,1-A) isoquinoline derivatives.
PL352760A1 (en) Oxathiepino[6,5-b