BE904671A - Imidazoquinoleines antithrombogenes cardiotoniques. - Google Patents

Imidazoquinoleines antithrombogenes cardiotoniques.

Info

Publication number
BE904671A
BE904671A BE0/216585A BE216585A BE904671A BE 904671 A BE904671 A BE 904671A BE 0/216585 A BE0/216585 A BE 0/216585A BE 216585 A BE216585 A BE 216585A BE 904671 A BE904671 A BE 904671A
Authority
BE
Belgium
Prior art keywords
imidazoquinoleins
antithrombogenic
cardiotonic
halogen
lower alkoxy
Prior art date
Application number
BE0/216585A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904671A publication Critical patent/BE904671A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Nouvelle série de 1,3-dihydro-2H-imidazo- (4,5-b) quinoléine -2-ones de formule où R1 est un atome d'halogène ou radical inférieur ou alcoxy inférieur, R2 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur et R3 est un atome d'hydrogène ou d'halogène ou radical alcoyle inférieur ou alcoxy inférieur. Ces composés sont inhibiteurs de l'agrétation des thrombocytes et/ou cardiotiniques.
BE0/216585A 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques. BE904671A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (1)

Publication Number Publication Date
BE904671A true BE904671A (fr) 1986-10-24

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216585A BE904671A (fr) 1985-04-25 1986-04-24 Imidazoquinoleines antithrombogenes cardiotoniques.

Country Status (32)

Country Link
US (1) US4668686A (fr)
KR (1) KR940000828B1 (fr)
CN (1) CN1016175B (fr)
AT (1) AT390257B (fr)
AU (1) AU592983B2 (fr)
BE (1) BE904671A (fr)
CA (1) CA1298836C (fr)
CH (1) CH675722A5 (fr)
CY (1) CY1641A (fr)
DE (1) DE3614132A1 (fr)
DK (3) DK164868C (fr)
EG (1) EG18104A (fr)
ES (3) ES8708229A1 (fr)
FI (1) FI83316C (fr)
FR (1) FR2581065B1 (fr)
GB (1) GB2174987B (fr)
GR (1) GR861086B (fr)
HK (1) HK64492A (fr)
HU (1) HU195813B (fr)
IL (1) IL78581A0 (fr)
IT (1) IT1215651B (fr)
LU (1) LU86406A1 (fr)
MY (1) MY102086A (fr)
NL (1) NL8601053A (fr)
NO (1) NO163406C (fr)
NZ (1) NZ215885A (fr)
OA (1) OA08242A (fr)
PT (1) PT82460B (fr)
SE (1) SE461468B (fr)
SG (1) SG29092G (fr)
SU (3) SU1450746A3 (fr)
YU (1) YU46054B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
MXPA06001669A (es) 2003-08-12 2006-04-28 3M Innovative Properties Co Compuestos que contienen imidazo-oxima sustituidos.
EP1658076B1 (fr) 2003-08-27 2013-03-06 3M Innovative Properties Company Imidazoquinolines substituees par aryloxy et arylalkyleneoxy
EP1660026A4 (fr) 2003-09-05 2008-07-16 3M Innovative Properties Co Traitement pour le lymphome a cellules b cd5+
RU2412942C2 (ru) 2003-10-03 2011-02-27 3М Инновейтив Пропертиз Компани Оксизамещенные имидазохинолины, способные модулировать биосинтез цитокинов
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AU2004291122A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
AU2004291101A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
NZ547467A (en) 2003-11-25 2010-06-25 3M Innovative Properties Co Substituted imidazo ring system and methods
JP2007517035A (ja) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン
WO2005066169A2 (fr) 2003-12-30 2005-07-21 3M Innovative Properties Company Sulfonamides d'imidazoquinolinyle, d'imidazopyridinyle et d'imidazonaphtyridinyle
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (fr) 2004-06-15 2005-12-29 3M Innovative Properties Company Imidazoquinolines et imidazonaphthyridines substituees par un heterocyclyle contenant un azote
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006009826A1 (fr) 2004-06-18 2006-01-26 3M Innovative Properties Company Thiazoloquinolines et thiazolonaphtyridines substitues par aryloxy et arylalkyleneoxy
WO2006065280A2 (fr) 2004-06-18 2006-06-22 3M Innovative Properties Company Composes a noyau imidazo a substitutif d'isoxazole, de dihydroisoxazole et d'oxadiazole
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
CA2592904C (fr) 2004-12-30 2015-04-07 3M Innovative Properties Company Composes chiraux a cycle [1,2]imidazo[4,5] fusionne
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
WO2006086634A2 (fr) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Composes cycliques imidazo[4,5-c] substitues par oxime et hydroxylamine et procedes associes
EP1863814A1 (fr) 2005-04-01 2007-12-12 Coley Pharmaceutical Group, Inc. Composes cycliques 1-pyrazolo (3,4-c) substitues comme modulateurs de la biosynthese de cytokine destines au traitement d'infections virales et de maladies neoplastiques
EP1869043A2 (fr) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines et analogues associes
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
RS54542B1 (en) 2006-08-02 2016-06-30 Cytokinetics, Inc. CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS INCLUDING IMIDAZOPYRIMIDINE
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
US7851484B2 (en) 2007-03-30 2010-12-14 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
AU2012281042B2 (en) 2011-07-13 2016-07-14 Cytokinetics, Inc. Combination ALS therapy
WO2024149378A1 (fr) * 2023-01-13 2024-07-18 上海超阳药业有限公司 Composé quinolinone et composé naphtyridinone et leur utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
NL8601053A (nl) 1986-11-17
HU195813B (en) 1988-07-28
CN1016175B (zh) 1992-04-08
SU1560056A3 (ru) 1990-04-23
DK165249C (da) 1993-03-22
CA1298836C (fr) 1992-04-14
ES557552A0 (es) 1988-07-16
FI861684A0 (fi) 1986-04-22
KR940000828B1 (ko) 1994-02-02
ES8708229A1 (es) 1987-10-01
SU1450746A3 (ru) 1989-01-07
DE3614132A1 (de) 1986-11-27
AU5641386A (en) 1986-10-30
DK164868B (da) 1992-08-31
FR2581065A1 (fr) 1986-10-31
DK190986A (da) 1986-10-26
NO163406B (no) 1990-02-12
FI83316C (fi) 1991-06-25
SE8601907L (sv) 1986-10-26
YU46054B (sh) 1992-12-21
YU116787A (en) 1988-04-30
PT82460A (en) 1986-05-01
NO861617L (no) 1986-10-27
NZ215885A (en) 1989-04-26
CY1641A (en) 1992-11-06
HK64492A (en) 1992-09-04
LU86406A1 (fr) 1986-11-05
DK165249B (da) 1992-10-26
DK164868C (da) 1993-01-11
SE8601907D0 (sv) 1986-04-24
FR2581065B1 (fr) 1990-02-02
ES557551A0 (es) 1988-02-16
ES554336A0 (es) 1987-10-01
FI861684A (fi) 1986-10-26
CN86102747A (zh) 1987-02-04
OA08242A (en) 1987-10-30
FI83316B (fi) 1991-03-15
PT82460B (pt) 1988-11-30
DK80291A (da) 1991-04-30
CH675722A5 (fr) 1990-10-31
KR860008177A (ko) 1986-11-12
AT390257B (de) 1990-04-10
IL78581A0 (en) 1986-08-31
EG18104A (en) 1992-09-30
SU1470192A3 (ru) 1989-03-30
NO163406C (no) 1990-05-23
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
MY102086A (en) 1992-03-31
DK190986D0 (da) 1986-04-24
GB2174987B (en) 1989-08-02
DK81091D0 (da) 1991-05-01
AU592983B2 (en) 1990-02-01
GB8610037D0 (en) 1986-05-29
IT8620206A0 (it) 1986-04-24
ATA112186A (de) 1989-09-15
ES8801829A1 (es) 1988-02-16
GR861086B (en) 1986-09-01
IT1215651B (it) 1990-02-22
GB2174987A (en) 1986-11-19
ES8802521A1 (es) 1988-07-16
DK165248B (da) 1992-10-26
DK80291D0 (da) 1991-04-30
SG29092G (en) 1992-05-15
SE461468B (sv) 1990-02-19
HUT42089A (en) 1987-06-29
US4668686A (en) 1987-05-26

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 19940430