YU46054B - Postupak za dobijanje imidazohinolinskih derivata - Google Patents

Postupak za dobijanje imidazohinolinskih derivata

Info

Publication number
YU46054B
YU46054B YU116787A YU116787A YU46054B YU 46054 B YU46054 B YU 46054B YU 116787 A YU116787 A YU 116787A YU 116787 A YU116787 A YU 116787A YU 46054 B YU46054 B YU 46054B
Authority
YU
Yugoslavia
Prior art keywords
formula
alkyl
hydrogen
alkoxy
halogen
Prior art date
Application number
YU116787A
Other languages
English (en)
Other versions
YU116787A (en
Inventor
N.A. Meanwell
J.J. Wright
Original Assignee
Bristol-Myers Squibb Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU66086A external-priority patent/YU45321B/xx
Application filed by Bristol-Myers Squibb Co. filed Critical Bristol-Myers Squibb Co.
Priority to YU116787A priority Critical patent/YU46054B/sh
Publication of YU116787A publication Critical patent/YU116787A/xx
Publication of YU46054B publication Critical patent/YU46054B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

POSTUPAK ZA DOBIJANJE IMIDAZOHINOLINSKIH DERIVATA formule u kojoj je R1 halogen, C1-4 alkil, C1-4 alkoksi ili trifluorometil; R2 je vodonik, halogen, C1-4 alkil ili C1-4 alkoksi; R3 je vodonik, halogen, C1-4 alkil ili C1-4 alkoksi; i R4 je vodonik ili C1-4 alkil, i njihovih farmaceutski prihvatljivih soli, hidrata i solvata, naznačen tim e, što se redukuje supstituisani hidantoin formule: u kojoj su R1, R2, R3 i R4 kao što je definisano gore i a i b su vodonikovi atomi ili kovalentna veza, hidrogenacijom u rastvaraču kao što je dimetilformamid, na pritisku od atmosferskog do nadpritiska od oko 4.2 bara, na temperaturi oko sobne i u prisustvu katalizatora, kao što je paladijum-na-uglju, da bi se dobio intermedijer formule: u kojoj R1, R2, R3 R4, a i b imaju značenja kao što je definisano gore, koji ciklizuju u jedinjenje formule: u kojoj su R1, R2, R3 i R4 kao što je definisano gore, u rastvaraču kao što je metanol ili etanol, na temperaturi refluksa reakcione smeše i u prisustvu kiseline, kao što je p-toluolsulfonska kiselina, pa se dobijeni intermedijer podvrgava dehidrogenaciji sa jodom, u rastvaraču kao što je dimetilformamid i na temperaturi refluksa, da bi se dobio željeni proizvod formule (XII); i što se jedinjenje formule (XII), prema potrebi, prevodi u svoju farmaceutski prihvatljivu so i izoluje u obliku hidrata ili solvata.
YU116787A 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata YU46054B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
YU66086A YU45321B (en) 1985-04-25 1986-04-22 Process for obtaining imidazocquinolinic derivatives
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Publications (2)

Publication Number Publication Date
YU116787A YU116787A (en) 1988-04-30
YU46054B true YU46054B (sh) 1992-12-21

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
YU116787A YU46054B (sh) 1985-04-25 1987-06-23 Postupak za dobijanje imidazohinolinskih derivata

Country Status (32)

Country Link
US (1) US4668686A (sh)
KR (1) KR940000828B1 (sh)
CN (1) CN1016175B (sh)
AT (1) AT390257B (sh)
AU (1) AU592983B2 (sh)
BE (1) BE904671A (sh)
CA (1) CA1298836C (sh)
CH (1) CH675722A5 (sh)
CY (1) CY1641A (sh)
DE (1) DE3614132A1 (sh)
DK (3) DK164868C (sh)
EG (1) EG18104A (sh)
ES (3) ES8708229A1 (sh)
FI (1) FI83316C (sh)
FR (1) FR2581065B1 (sh)
GB (1) GB2174987B (sh)
GR (1) GR861086B (sh)
HK (1) HK64492A (sh)
HU (1) HU195813B (sh)
IL (1) IL78581A0 (sh)
IT (1) IT1215651B (sh)
LU (1) LU86406A1 (sh)
MY (1) MY102086A (sh)
NL (1) NL8601053A (sh)
NO (1) NO163406C (sh)
NZ (1) NZ215885A (sh)
OA (1) OA08242A (sh)
PT (1) PT82460B (sh)
SE (1) SE461468B (sh)
SG (1) SG29092G (sh)
SU (3) SU1450746A3 (sh)
YU (1) YU46054B (sh)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
AU2004266658A1 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
KR101106812B1 (ko) 2003-08-27 2012-01-19 쓰리엠 이노베이티브 프로퍼티즈 컴파니 아릴옥시 및 아릴알킬렌옥시 치환된 이미다조퀴놀린
EP1660026A4 (en) 2003-09-05 2008-07-16 3M Innovative Properties Co TREATMENT FOR CD5 + B CELL LYMPHOMA
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
JP5043435B2 (ja) 2003-10-03 2012-10-10 スリーエム イノベイティブ プロパティズ カンパニー アルコキシ置換イミダゾキノリン
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
JP2007511535A (ja) * 2003-11-14 2007-05-10 スリーエム イノベイティブ プロパティズ カンパニー ヒドロキシルアミン置換イミダゾ環化合物
WO2005051317A2 (en) 2003-11-25 2005-06-09 3M Innovative Properties Company Substituted imidazo ring systems and methods
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
JP2007517044A (ja) 2003-12-30 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー イミダゾキノリニル、イミダゾピリジニル、およびイミダゾナフチリジニルスルホンアミド
WO2005094531A2 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7943609B2 (en) 2004-12-30 2011-05-17 3M Innovative Proprerties Company Chiral fused [1,2]imidazo[4,5-C] ring compounds
WO2006083440A2 (en) 2004-12-30 2006-08-10 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
EP1846405A2 (en) 2005-02-11 2007-10-24 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo 4,5-c ring compounds and methods
CA2602590A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
JP2008535832A (ja) 2005-04-01 2008-09-04 コーリー ファーマシューティカル グループ，インコーポレイテッド ピラゾロピリジン−１，４−ジアミン、およびそのアナログ
US7906506B2 (en) 2006-07-12 2011-03-15 3M Innovative Properties Company Substituted chiral fused [1,2] imidazo [4,5-c] ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
ES2439590T3 (es) 2006-08-02 2014-01-23 Cytokinetics, Inc. Ciertas entidades químicas, composiciones y métodos
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
WO2008121333A1 (en) 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
CA2849213A1 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination of riluzole and ck-2017357 for treating als

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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
HUT42089A (en) 1987-06-29
GB2174987A (en) 1986-11-19
LU86406A1 (fr) 1986-11-05
NO163406B (no) 1990-02-12
DK165249B (da) 1992-10-26
DK80291A (da) 1991-04-30
ATA112186A (de) 1989-09-15
CN86102747A (zh) 1987-02-04
FI861684A0 (fi) 1986-04-22
GB2174987B (en) 1989-08-02
NL8601053A (nl) 1986-11-17
IL78581A0 (en) 1986-08-31
YU116787A (en) 1988-04-30
FR2581065A1 (fr) 1986-10-31
SU1450746A3 (ru) 1989-01-07
KR860008177A (ko) 1986-11-12
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
HK64492A (en) 1992-09-04
ES8802521A1 (es) 1988-07-16
IT8620206A0 (it) 1986-04-24
PT82460A (en) 1986-05-01
SU1560056A3 (ru) 1990-04-23
AT390257B (de) 1990-04-10
DK190986A (da) 1986-10-26
FI861684A (fi) 1986-10-26
FR2581065B1 (fr) 1990-02-02
BE904671A (fr) 1986-10-24
FI83316C (fi) 1991-06-25
DK80291D0 (da) 1991-04-30
SU1470192A3 (ru) 1989-03-30
OA08242A (en) 1987-10-30
DK165248B (da) 1992-10-26
NO163406C (no) 1990-05-23
ES557552A0 (es) 1988-07-16
IT1215651B (it) 1990-02-22
DK165249C (da) 1993-03-22
KR940000828B1 (ko) 1994-02-02
AU592983B2 (en) 1990-02-01
CN1016175B (zh) 1992-04-08
FI83316B (fi) 1991-03-15
SE8601907D0 (sv) 1986-04-24
NO861617L (no) 1986-10-27
ES8801829A1 (es) 1988-02-16
ES557551A0 (es) 1988-02-16
NZ215885A (en) 1989-04-26
EG18104A (en) 1992-09-30
ES8708229A1 (es) 1987-10-01
CY1641A (en) 1992-11-06
AU5641386A (en) 1986-10-30
ES554336A0 (es) 1987-10-01
CH675722A5 (sh) 1990-10-31
MY102086A (en) 1992-03-31
SG29092G (en) 1992-05-15
CA1298836C (en) 1992-04-14
HU195813B (en) 1988-07-28
DK81091D0 (da) 1991-05-01
DK164868C (da) 1993-01-11
DK190986D0 (da) 1986-04-24
PT82460B (pt) 1988-11-30
SE461468B (sv) 1990-02-19
SE8601907L (sv) 1986-10-26
DK164868B (da) 1992-08-31
GR861086B (en) 1986-09-01
US4668686A (en) 1987-05-26
DE3614132A1 (de) 1986-11-27
GB8610037D0 (en) 1986-05-29

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