YU48446B - Postupak za dobijanje novih derivata 1-(cikloheksil)-4- aril-4-piperidinkarboksilne kiseline - Google Patents

Postupak za dobijanje novih derivata 1-(cikloheksil)-4- aril-4-piperidinkarboksilne kiseline

Info

Publication number
YU48446B
YU48446B YU18381A YU18381A YU48446B YU 48446 B YU48446 B YU 48446B YU 18381 A YU18381 A YU 18381A YU 18381 A YU18381 A YU 18381A YU 48446 B YU48446 B YU 48446B
Authority
YU
Yugoslavia
Prior art keywords
formula
alkyloxy
methoxy
aryl
ethyloxy
Prior art date
Application number
YU18381A
Other languages
English (en)
Other versions
YU18381A (en
Inventor
Stokbroekx
Luyckx
Willems
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Priority to SI8110183A priority Critical patent/SI8110183A8/sl
Publication of YU18381A publication Critical patent/YU18381A/xx
Priority to HRP-183/81A priority patent/HRP930475B1/xx
Publication of YU48446B publication Critical patent/YU48446B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96Sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH DERIVATA 1-(CIKLOHEKSIL)-4- ARIL-4-PIPERIDINKARBOKSILNE KISELINE opšte formule i njihovih farmaceutski prihvatljivih adicionih soli sa kiselinama i stereohemijski izomernih oblika, pri čemu je u formuli: R1 vodonik ili metil; R je hidroksi, (C1-C4) alkiloksi, fenil (C1-C2) alkiloksi, ariloksi (C1-C3)alkiloksi, metoksi (C1C3) alkiloksi, dimetilaminoetiloksi, (1-pirolidinil)etiloksi, (4-morfolinil)etiloksi ili (1-piperidinil)etiloksi; Ar1 je fenil koji je opciono supstituisan sa jednim ili dva supstituenta koji su izabrani iz grupe koja sadrži bromo, fluoro, hloro, metil, metoksi i trifluorometil; i Ar2 je fenil koji je opciono supstituisan sa jednim ili dva supstituenta koji su izabrani iz grupe koja sadrži bromo, fluoro, hloro, (C1-C2)alkil, metoksi i trifluorometil; pri čemu je aril fenil koji je opciono supstituisan sa metil ili metoksi, naznačen time, što reaguje cikloheksanon formule: (II) u kojoj je Ar1 kao što je definisano ranije, sa piperidinom formule: (III) u kojoj su R, R1 i Ar2 kao što je definisano ranije, pri čemu se pomenuta reakcija vrši katalitičkom hidrogenizacijom reaktanata (II) i (III) u metanolu, etanolu ili 2-propanolu kao rastvaraču, na temperaturi izmedju sobne i 50В°C, pod normalnim pritiskom vodonika i u prisustvu paladijuma-na-uglju ili platine-na uglju kao katalizatora, pa se, prema potrebi, prevode jedinjenja formule (I) u terapeutski aktivne ne-toksične adicione soli sa kiselinama tretiranjem sa odgovarajućom kiselinom i, dalje, prema potrebi, prave se stereohemijski izomeri oblici jedinjenja formule (I).
YU18381A 1980-01-24 1981-01-23 Postupak za dobijanje novih derivata 1-(cikloheksil)-4- aril-4-piperidinkarboksilne kiseline YU48446B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8110183A SI8110183A8 (sl) 1980-01-24 1981-01-23 Novi derivati 1-(cikl0heksil)-4-aril-4-piperidinkarb0ksilne kisline
HRP-183/81A HRP930475B1 (en) 1980-01-24 1993-03-23 Process for the preparation of novel 1-(cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (2)

Publication Number Publication Date
YU18381A YU18381A (en) 1983-10-31
YU48446B true YU48446B (sh) 1998-07-10

Family

ID=26812674

Family Applications (1)

Application Number Title Priority Date Filing Date
YU18381A YU48446B (sh) 1980-01-24 1981-01-23 Postupak za dobijanje novih derivata 1-(cikloheksil)-4- aril-4-piperidinkarboksilne kiseline

Country Status (25)

Country Link
US (1) US4369184A (sh)
EP (1) EP0034415B1 (sh)
AU (1) AU538130B2 (sh)
BG (2) BG35465A3 (sh)
CA (1) CA1187080A (sh)
CS (1) CS221818B2 (sh)
DE (1) DE3163787D1 (sh)
DK (1) DK152670C (sh)
ES (2) ES498793A0 (sh)
FI (1) FI76562C (sh)
GR (1) GR71898B (sh)
HK (1) HK81088A (sh)
HU (1) HU183293B (sh)
IE (1) IE50706B1 (sh)
IL (1) IL61968A (sh)
LU (1) LU88220I2 (sh)
MA (1) MA19046A1 (sh)
MY (1) MY8700593A (sh)
NL (1) NL930017I2 (sh)
NO (1) NO1994012I1 (sh)
NZ (1) NZ196117A (sh)
PH (1) PH16611A (sh)
PL (2) PL127483B1 (sh)
SU (1) SU1230467A3 (sh)
YU (1) YU48446B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk 1−ハイドロキシ−5−オキソ−5H−ピリド〔3,2−a〕フエノキサジン−3−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU1716995A (en) * 1994-03-18 1995-10-09 Ciba-Geigy Ag Aqueous solution of levocabastine for ophthalmic use
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
ATE298582T1 (de) 1996-04-19 2005-07-15 Alpha Therapeutic Corp Verfahren zur inaktivierung von viren und lyophilisierung von blutproteinen
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
PL373433A1 (en) * 2002-08-30 2005-08-22 Altana Pharma Ag The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis
AU2007205114B2 (en) 2006-01-06 2012-11-08 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
BRPI0712532A2 (pt) 2006-06-01 2013-04-02 Schering Plough Healthcare Prod Inc formulaÇÕes e composiÇÕes farmacÊuticas de fenilefrina para absorÇço colânica
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
CN101951886A (zh) * 2007-12-21 2011-01-19 先灵-普劳健康护理产品公司 增强羟甲唑啉的光稳定性
JP6083818B2 (ja) 2011-11-18 2017-02-22 ヘプタレス セラピューティクス リミテッドHeptares Therapeutics Limited ムスカリンm1受容体アゴニスト
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (sh) * 1965-06-29

Also Published As

Publication number Publication date
FI76562B (fi) 1988-07-29
HK81088A (en) 1988-10-14
HU183293B (en) 1984-04-28
FI76562C (fi) 1988-11-10
US4369184A (en) 1983-01-18
NL930017I1 (nl) 1993-05-03
CA1187080A (en) 1985-05-14
DK152670B (da) 1988-04-11
DE3163787D1 (en) 1984-07-05
DK152670C (da) 1988-08-22
NO1994012I1 (no) 1994-08-30
FI810193L (fi) 1981-07-25
NL930017I2 (nl) 1993-07-16
BG60472B2 (bg) 1995-04-28
CS221818B2 (en) 1983-04-29
EP0034415B1 (en) 1984-05-30
GR71898B (sh) 1983-08-11
ES8204421A1 (es) 1982-05-01
YU18381A (en) 1983-10-31
LU88220I2 (sh) 1994-02-03
PL233921A1 (sh) 1982-06-21
BG35465A3 (en) 1984-04-15
ES498793A0 (es) 1982-05-01
NZ196117A (en) 1984-05-31
ES8307219A1 (es) 1983-07-01
DK29381A (da) 1981-07-25
PL127483B1 (en) 1983-10-31
PH16611A (en) 1983-11-24
SU1230467A3 (ru) 1986-05-07
IL61968A (en) 1984-09-30
MA19046A1 (fr) 1981-10-01
IE50706B1 (en) 1986-06-25
IE810125L (en) 1981-07-24
MY8700593A (en) 1987-12-31
PL229365A1 (sh) 1982-03-29
ES508441A0 (es) 1983-07-01
IL61968A0 (en) 1981-02-27
EP0034415A1 (en) 1981-08-26
AU6625581A (en) 1981-07-30
PL127679B1 (en) 1983-11-30
AU538130B2 (en) 1984-08-02

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