YU46711B - Postupak za dobijanje novih tioksilozida - Google Patents

Postupak za dobijanje novih tioksilozida

Info

Publication number
YU46711B
YU46711B YU86988A YU86988A YU46711B YU 46711 B YU46711 B YU 46711B YU 86988 A YU86988 A YU 86988A YU 86988 A YU86988 A YU 86988A YU 46711 B YU46711 B YU 46711B
Authority
YU
Yugoslavia
Prior art keywords
formula
group
halogen atom
acyl group
thioxylosides
Prior art date
Application number
YU86988A
Other languages
English (en)
Other versions
YU86988A (en
Inventor
S. Samreth
F. Bellamy
J. Millet
Original Assignee
Fournier Industrie Et Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Industrie Et Sante filed Critical Fournier Industrie Et Sante
Priority to YU01036/89A priority Critical patent/YU103689A/xx
Publication of YU86988A publication Critical patent/YU86988A/xx
Priority to HR920802A priority patent/HRP920802A2/hr
Publication of YU46711B publication Critical patent/YU46711B/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH BETA-D-FENIL-TIOKSILOZIDA, formule: u kojoj je: R atom vodonika, atom halogena, nitro ili cijano grupa, A je s ili O, B je CH2, CHOH ili CO, Y je atom vodonika ili acil grupa; i njihovih epimera kada je B CHOH, naznačen time, što reaguje jedinjenje formule: u kojoj su A, B i R kao što je definisano gore, sa derivatom tioksiloze koji je izabran iz grupe koja sadrži haloaciltioksilozide i aciltiok-silozide formula: u kojima Hal predstavlja takav atom halogena kao što je Cl ili Br, pri čemu je brom poželjan atom halogena i Y predstavlja acil grupu, naročito C2-C5 alifatičnu acil grupu i poželjno CH3CO grupu, u inertnom rastvaraču, u odnosu 1 mol jedinjenja II za oko 1.1 do 1.2 mola derivata tioksiloze formule VIIIa ili VIIIb, u prisustvu akceptora kiseline ili Lewis-ove kiseline, i, prema potrebi, vrši se reakcija deacetilovanja na temperaturi izmedju obične (15-25 C) i temperature refluksa reakcione sredine, u C1-C4 nižem alkoholu, poželjno metanolu u prisustvu metalnog alkoholata, poželjno magnezijum-metilata ili natrijum-metilata.
YU86988A 1987-05-04 1988-05-04 Postupak za dobijanje novih tioksilozida YU46711B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
YU01036/89A YU103689A (en) 1987-05-04 1989-05-19 Process for obtaining new 4-(mercapto-phenyl)-methanone
HR920802A HRP920802A2 (en) 1987-05-04 1992-10-02 Process for obtaining new beta-d-phenyl-thioxylosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8706237A FR2614893B1 (fr) 1987-05-04 1987-05-04 Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
YU86988A YU86988A (en) 1989-10-31
YU46711B true YU46711B (sh) 1994-04-05

Family

ID=9350723

Family Applications (1)

Application Number Title Priority Date Filing Date
YU86988A YU46711B (sh) 1987-05-04 1988-05-04 Postupak za dobijanje novih tioksilozida

Country Status (29)

Country Link
US (2) US4877808A (sh)
EP (1) EP0290321B1 (sh)
JP (1) JPH07103144B2 (sh)
KR (1) KR960015109B1 (sh)
CN (1) CN1020614C (sh)
AT (1) ATE68000T1 (sh)
AU (1) AU602210B2 (sh)
CA (1) CA1323373C (sh)
CZ (1) CZ278365B6 (sh)
DD (1) DD269852A5 (sh)
DE (1) DE3865230D1 (sh)
DK (1) DK169873B1 (sh)
ES (1) ES2026669T3 (sh)
FI (1) FI87655C (sh)
FR (1) FR2614893B1 (sh)
GR (1) GR3003415T3 (sh)
HU (1) HU203362B (sh)
IE (1) IE61386B1 (sh)
IL (1) IL86133A (sh)
MA (1) MA21260A1 (sh)
NO (1) NO167035C (sh)
NZ (1) NZ224447A (sh)
OA (1) OA08840A (sh)
PT (1) PT87382B (sh)
SK (1) SK297988A3 (sh)
SU (1) SU1567124A3 (sh)
TN (1) TNSN88041A1 (sh)
YU (1) YU46711B (sh)
ZA (1) ZA883031B (sh)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5246961A (en) * 1988-10-18 1993-09-21 Fournier Industrie Et Sante β-d-phenylthioxylosides, and their use as therapeutic agents
FR2648819B1 (fr) * 1989-06-21 1994-11-25 Fournier Innovation Synergie Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique
IE63544B1 (en) * 1988-10-18 1995-05-17 Fournier Ind & Sante Novel Beta-d-phenylthioxylosides their method of preparation and their use in therapy
ATE113956T1 (de) * 1989-09-22 1994-11-15 Fournier Ind & Sante Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
FR2652353B1 (fr) * 1989-09-22 1994-02-11 Fournier Industrie Sante Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR2659659B1 (fr) * 1990-03-16 1995-03-10 Fournier Ind & Sante Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR2660313B1 (fr) * 1990-04-02 1992-07-03 Fournier Ind & Sante Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR2688221B1 (fr) * 1992-03-09 1994-05-20 Fournier Industrie Sante Estratrienol-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
WO1994020116A1 (en) * 1993-03-10 1994-09-15 University Of Alabama Research Foundation Artificial primers for glycogen synthesis
HUP9601756A3 (en) * 1996-06-25 1999-05-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical compositions containing them
HUP9603341A3 (en) * 1996-12-04 1999-05-28 Richter Gedeon Vegyeszet Glucosides as blood-clotting-inhibitors and pharmaceutical compositions containing them
CA2335799A1 (en) * 1998-06-24 1999-12-29 Fournier Industrie Et Sante Novel compounds derived from .alpha.-d-xylose, preparation method and therapeutic use
US6291433B1 (en) 1999-06-11 2001-09-18 Fournier Industrie Et Sante Derivatives of α-D-Thioxyloside and their use against atheroma
ATE377017T1 (de) * 2002-01-31 2007-11-15 Morphochem Ag Komb Chemie Verbindungen, die faktor xa-aktiv t inhibieren
DE10300049A1 (de) * 2003-01-03 2004-07-15 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen, die Faktor VIIa inhibieren
FR2860234B1 (fr) * 2003-09-25 2005-12-23 Fournier Lab Sa Nouveaux derives 666 du thioxylose
FR2883561B1 (fr) * 2005-03-25 2009-03-20 Fournier S A Sa Lab Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique
FR2903698B1 (fr) * 2006-07-13 2009-01-30 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose.
FR2906247B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
FR2906248B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3243425A (en) * 1962-10-29 1966-03-29 Purdue Research Foundation Novel sulfur-containing compounds
US3949002A (en) * 1970-11-13 1976-04-06 Imperial Chemical Industries Limited Process for producing sulfone containing thiophenols
GB1585962A (en) * 1976-10-14 1981-03-11 Lilly Industries Ltd Benzophenone derivatives
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US4515782A (en) * 1983-08-29 1985-05-07 American Cyanamid Company Substituted phenyl-1-thio(poly-O-sulfo)-α(or β)-D-glucopyranosides
DE3725640A1 (de) * 1987-08-03 1989-02-23 Bayer Ag Verfahren zur herstellung von thiophenolen und neue thiophenole

Also Published As

Publication number Publication date
YU86988A (en) 1989-10-31
EP0290321A1 (fr) 1988-11-09
OA08840A (fr) 1989-03-31
CZ278365B6 (en) 1993-12-15
HUT46923A (en) 1988-12-28
FI87655C (fi) 1993-02-10
NZ224447A (en) 1990-09-26
DD269852A5 (de) 1989-07-12
DK239788D0 (da) 1988-05-03
PT87382B (pt) 1992-08-31
CN88102569A (zh) 1988-12-14
SK278297B6 (en) 1996-09-04
DK239788A (da) 1988-11-05
HU203362B (en) 1991-07-29
IL86133A (en) 1992-05-25
AU602210B2 (en) 1990-10-04
DK169873B1 (da) 1995-03-20
JPS63280092A (ja) 1988-11-17
AU1521988A (en) 1988-11-10
US4996347A (en) 1991-02-26
EP0290321B1 (fr) 1991-10-02
IL86133A0 (en) 1988-11-15
TNSN88041A1 (fr) 1990-07-10
KR880013916A (ko) 1988-12-22
FR2614893B1 (fr) 1989-12-22
GR3003415T3 (en) 1993-02-17
JPH07103144B2 (ja) 1995-11-08
CA1323373C (en) 1993-10-19
ATE68000T1 (de) 1991-10-15
NO167035C (no) 1991-09-25
FR2614893A1 (fr) 1988-11-10
MA21260A1 (fr) 1988-12-31
SU1567124A3 (ru) 1990-05-23
US4877808A (en) 1989-10-31
CN1020614C (zh) 1993-05-12
SK297988A3 (en) 1996-09-04
FI882043A0 (fi) 1988-05-02
ES2026669T3 (es) 1992-05-01
KR960015109B1 (ko) 1996-10-28
NO881921L (no) 1988-11-07
DE3865230D1 (de) 1991-11-07
NO167035B (no) 1991-06-17
FI87655B (fi) 1992-10-30
ZA883031B (en) 1988-11-01
IE881324L (en) 1988-11-04
FI882043A (fi) 1988-11-05
PT87382A (pt) 1989-05-31
IE61386B1 (en) 1994-11-02
CZ297988A3 (en) 1993-07-14
NO881921D0 (no) 1988-05-02

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