ATE113956T1 - Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung. - Google Patents

Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Info

Publication number
ATE113956T1
ATE113956T1 AT90402403T AT90402403T ATE113956T1 AT E113956 T1 ATE113956 T1 AT E113956T1 AT 90402403 T AT90402403 T AT 90402403T AT 90402403 T AT90402403 T AT 90402403T AT E113956 T1 ATE113956 T1 AT E113956T1
Authority
AT
Austria
Prior art keywords
group
benzopyranone
atom
beta
substituents
Prior art date
Application number
AT90402403T
Other languages
English (en)
Inventor
Soth Samreth
Veronique Barberousse
Patrice Ruelle De Plomb Renaut
Francois Bellamy
Jean Millet
Original Assignee
Fournier Ind & Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8912452A external-priority patent/FR2652353B1/fr
Priority claimed from FR9003401A external-priority patent/FR2659659B1/fr
Application filed by Fournier Ind & Sante filed Critical Fournier Ind & Sante
Application granted granted Critical
Publication of ATE113956T1 publication Critical patent/ATE113956T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/075—Benzo[b]pyran-2-ones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Dental Preparations (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Cultivation Of Plants (AREA)
AT90402403T 1989-09-22 1990-08-31 Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung. ATE113956T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8912452A FR2652353B1 (fr) 1989-09-22 1989-09-22 Nouveaux benzopyran-2-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
FR9003401A FR2659659B1 (fr) 1990-03-16 1990-03-16 Nouveaux benzopyran-4-one-beta-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.

Publications (1)

Publication Number Publication Date
ATE113956T1 true ATE113956T1 (de) 1994-11-15

Family

ID=26227568

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90402403T ATE113956T1 (de) 1989-09-22 1990-08-31 Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.

Country Status (24)

Country Link
US (1) US5169838A (de)
EP (1) EP0421829B1 (de)
JP (1) JPH07103147B2 (de)
KR (1) KR0142670B1 (de)
CN (1) CN1027268C (de)
AT (1) ATE113956T1 (de)
AU (2) AU631456B2 (de)
CA (1) CA2024476C (de)
DE (1) DE69014064T2 (de)
DK (1) DK0421829T3 (de)
ES (1) ES2066165T3 (de)
FI (1) FI100183B (de)
GR (1) GR3014966T3 (de)
HR (1) HRP920811B1 (de)
HU (1) HU207867B (de)
IE (1) IE65092B1 (de)
IL (1) IL95582A (de)
NO (1) NO172987C (de)
NZ (1) NZ245783A (de)
PT (1) PT95369B (de)
RU (1) RU1838323C (de)
SK (1) SK463890A3 (de)
UA (1) UA13476A (de)
YU (1) YU47867B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2801055B1 (fr) * 1999-11-17 2002-02-08 Fournier Ind & Sante Derives de beta-d-5-thioxylose, procede de preparation et utilisation en therapeutique
FR2824559B1 (fr) 2001-05-11 2004-02-13 Fournier Lab Sa Nouveaux derives 5-thio-beta-xylopyronasides, procede de preparation, compositions pharmaceutiques les contenant et leur utilisation en therapeutique
FR2846966A1 (fr) * 2002-11-07 2004-05-14 Fournier Lab Sa Derive du 4-methyl-2-oxo-2h-1-benzopyran-7-yl 5-thio-beta-d- xylopyranoside, son procede de preparation et composition pharmaceutique le contenant
AU2004245146B2 (en) * 2003-06-11 2010-01-21 Merck Frosst Canada Ltd 7-(1,3-thiazol-2-yl)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors
FR2860234B1 (fr) 2003-09-25 2005-12-23 Fournier Lab Sa Nouveaux derives 666 du thioxylose
AR054226A1 (es) * 2005-02-18 2007-06-13 Smithkline Beecham Corp Composicion farmaceutica en forma de comprimido que comprende el compuesto 4-metil-2oxo-2h-1-benzopiran-7-il-tio-b-d-xilopiranosido, uso de sulfato de dermatan y de dicho compuesto para prepararla y metodo para su preparacion
FR2903698B1 (fr) * 2006-07-13 2009-01-30 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose.
FR2906247B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
FR2906248B1 (fr) 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
US20090075914A1 (en) * 2007-09-13 2009-03-19 Protia, Llc Deuterium-enriched odiparcil
CN101397315B (zh) * 2007-09-24 2013-08-07 中国医学科学院药物研究所 香豆素苷类化合物、其制法和其药物组合物与用途
US10092540B2 (en) 2013-10-04 2018-10-09 Inventiva Method of treatment of a mucopolysaccharidosis
FR3011468B1 (fr) * 2013-10-04 2015-12-04 Inventiva Utilisation de l'odiparcil dans le traitement d'une mucopolysaccharidose

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2034306A1 (de) * 1970-07-10 1972-01-20 Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof 2 (3,4 Dimethyl-cumarin 7 yl) oxy alkylcarbonsaure Derivate und Verfahren zu ihrer Herstellung
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
JPS6013788A (ja) * 1983-07-05 1985-01-24 Yamanouchi Pharmaceut Co Ltd 新規なクマリン誘導体
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
US4681954A (en) * 1985-10-07 1987-07-21 Pennwalt Corporation 7,8,9,10-tetrahydro-6-oxo-6H-dibenzo(b,d)pyranyloxy-propanes
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
YU47867B (sh) 1996-02-19
JPH03120292A (ja) 1991-05-22
CA2024476A1 (en) 1991-03-23
DK0421829T3 (da) 1995-01-16
SK280827B6 (sk) 2000-08-14
EP0421829A1 (de) 1991-04-10
CN1050544A (zh) 1991-04-10
AU2539792A (en) 1992-11-26
EP0421829B1 (de) 1994-11-09
KR910006283A (ko) 1991-04-29
FI100183B (fi) 1997-10-15
HU207867B (en) 1993-06-28
HRP920811B1 (en) 1998-12-31
ES2066165T3 (es) 1995-03-01
HU906005D0 (en) 1991-03-28
GR3014966T3 (en) 1995-05-31
UA13476A (uk) 1997-04-25
NZ245783A (en) 1993-07-27
HUT55794A (en) 1991-06-28
PT95369B (pt) 1997-06-30
IL95582A (en) 2001-06-14
SK463890A3 (en) 2000-08-14
IL95582A0 (en) 1991-06-30
IE903414A1 (en) 1991-04-10
NO172987B (no) 1993-06-28
AU631456B2 (en) 1992-11-26
AU642829B2 (en) 1993-10-28
IE65092B1 (en) 1995-10-04
YU178790A (sh) 1992-12-21
NO904088D0 (no) 1990-09-19
PT95369A (pt) 1991-05-22
DE69014064T2 (de) 1995-05-18
DE69014064D1 (de) 1994-12-15
KR0142670B1 (ko) 1998-07-01
FI904614A0 (fi) 1990-09-19
HRP920811A2 (en) 1995-10-31
NO172987C (no) 1993-10-06
CN1027268C (zh) 1995-01-04
CA2024476C (en) 1999-10-12
NO904088L (no) 1991-03-25
RU1838323C (ru) 1993-08-30
US5169838A (en) 1992-12-08
JPH07103147B2 (ja) 1995-11-08
AU6253190A (en) 1991-03-28

Similar Documents

Publication Publication Date Title
ATE113956T1 (de) Benzopyranon-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
AR003955A1 (es) Derivados de n-(indol-2-carbonil)-glicinamidas, procedimiento para su obtencion y composiciones que los contienen.
ATE57699T1 (de) Pyridoncarbonsauere-derivate und verfahren zu ihrer herstellung.
DE3865230D1 (de) Beta-d-phenyl-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
DE60020587D1 (de) Zwischenprodukte für die herstellung von 5- nitro- benzofuran oder benzothiophenderivaten und ihre verwendungen
ATE51622T1 (de) Beta-carbolin-3-oxadiazolylderivate, verfahren zu ihrer herstellung und ihre verwendung.
GR3029856T3 (en) Triazine derivative, production and use thereof.
ATE121385T1 (de) Harnstoffderivate, ihre herstellung und ihre verwendung bei der therapie.
ATE111909T1 (de) Heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
DE3873524D1 (de) Iodierte polymere, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel.
ATE147635T1 (de) Tetra-aza-makrozyklen, verfahren zu ihrer herstellung und ihre anwendung in nmr-bildformung
DE69523259D1 (de) Amine Derivate, ihre Herstellung und Anwendung
DE68902386D1 (de) N-pyridinyl-9h-carbazol-9-amine, verfahren zu ihrer herstellung und ihre verwendung als medikamente.
WO1989001330A3 (en) W-arylsulphonamidoalkanoic acids for treatment of thromboxane mediated diseases
DK0401623T3 (da) Fremgangsmåde til fremstilling af 7-(3-amino- og 3-aminomethyl-1-pyrrolidinyl)-3-quinoloncarboxylsyrer og -napthyridoncarbo
ATE130007T1 (de) Sulphonylphenyl-beta-d-thioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
ES2053621T3 (es) Un procedimiento para preparar ciertas oxazolonas triciclicas cardiotonicas.
ATE23340T1 (de) 3-alkylthio-2-0-carbamoylpropan-1,2-diol-1-0phosphocholine und verfahren zu ihrer herstellung.
ATE79374T1 (de) Nicotinoylpiperazin-derivate, verfahren zu ihrer herstellung und ihre verwendung in der therapie.
ES2112774A1 (es) Nuevos derivados azolicos con actividad antifungica.
TH9091EX (th) สารประกอบเบนซ์แอมีดต่างๆ การเตรียมและการใช้สารประกอบเหล่านี้เป็นสารฆ่าแมลง
TH21404A (th) "การใช้ 5-เอธิล-1,4-ไดไฮโดรไพริดีน"

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee