FR2648819B1 - Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique - Google Patents

Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique

Info

Publication number
FR2648819B1
FR2648819B1 FR8908253A FR8908253A FR2648819B1 FR 2648819 B1 FR2648819 B1 FR 2648819B1 FR 8908253 A FR8908253 A FR 8908253A FR 8908253 A FR8908253 A FR 8908253A FR 2648819 B1 FR2648819 B1 FR 2648819B1
Authority
FR
France
Prior art keywords
thioxylosides
therapeutics
beta
phenyl
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR8908253A
Other languages
English (en)
Other versions
FR2648819A1 (fr
Inventor
Samreth Soth
Barberousse Veronique
Renaut Patrice
Bellamy Francois
Millet Jean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fournier Innovation et Synergie SA
Original Assignee
Fournier Innovation et Synergie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Innovation et Synergie SA filed Critical Fournier Innovation et Synergie SA
Priority to FR8908253A priority Critical patent/FR2648819B1/fr
Priority to IE324089A priority patent/IE63544B1/en
Priority to DE68918548T priority patent/DE68918548T2/de
Priority to AT89402804T priority patent/ATE112283T1/de
Priority to EP89402804A priority patent/EP0365397B1/fr
Priority to ES89402804T priority patent/ES2064473T3/es
Priority to IL9197789A priority patent/IL91977A/en
Priority to FI894900A priority patent/FI98372C/fi
Priority to NZ231024A priority patent/NZ231024A/en
Priority to CA002000769A priority patent/CA2000769A1/fr
Priority to CN89107940A priority patent/CN1024801C/zh
Priority to UA4742255A priority patent/UA15921A/uk
Priority to AU43560/89A priority patent/AU633853B2/en
Priority to SU894742255A priority patent/RU1780538C/ru
Priority to DK516189A priority patent/DK171401B1/da
Priority to HU895336A priority patent/HU203248B/hu
Priority to YU201789A priority patent/YU47072B/sh
Priority to PT92014A priority patent/PT92014B/pt
Priority to NO894134A priority patent/NO171166C/no
Priority to US07/423,958 priority patent/US5101048A/en
Priority to JP1272749A priority patent/JPH0826058B2/ja
Priority to KR1019890014984A priority patent/KR930005990B1/ko
Publication of FR2648819A1 publication Critical patent/FR2648819A1/fr
Priority to US07/793,649 priority patent/US5246961A/en
Application granted granted Critical
Publication of FR2648819B1 publication Critical patent/FR2648819B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8908253A 1988-10-18 1989-06-21 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique Expired - Fee Related FR2648819B1 (fr)

Priority Applications (23)

Application Number Priority Date Filing Date Title
FR8908253A FR2648819B1 (fr) 1989-06-21 1989-06-21 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique
IE324089A IE63544B1 (en) 1988-10-18 1989-10-09 Novel Beta-d-phenylthioxylosides their method of preparation and their use in therapy
DE68918548T DE68918548T2 (de) 1988-10-18 1989-10-11 Beta-D-Phenylthioxyloside, Verfahren zu ihrer Herstellung und ihre therapeutische Verwendung.
AT89402804T ATE112283T1 (de) 1988-10-18 1989-10-11 Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre therapeutische verwendung.
EP89402804A EP0365397B1 (fr) 1988-10-18 1989-10-11 Nouveaux beta-D-phényl-thioxylosides, leur procédé de préparation et leur utilisation en thérapeutique
ES89402804T ES2064473T3 (es) 1988-10-18 1989-10-11 Procedimiento de preparacion de nuevos beta-d-fenil-tioxidos.
IL9197789A IL91977A (en) 1988-10-18 1989-10-12 B-D-Phenylthyloxylosides, their preparation and pharmaceutical preparations containing them
NZ231024A NZ231024A (en) 1988-10-18 1989-10-16 Beta-d-phenylthioxyloside derivatives, and therapeutic compositions thereof
CA002000769A CA2000769A1 (fr) 1988-10-18 1989-10-16 .beta.-d-phenylthioxylosides, methode de preparation et applications therapeutiques
FI894900A FI98372C (fi) 1988-10-18 1989-10-16 Menetelmä farmaseuttisesti käyttökelpoisten -D-fenyylitioksylosidien valmistamiseksi
SU894742255A RU1780538C (ru) 1988-10-18 1989-10-17 Способ получени @ - @ -фенилтиоксилозидов
AU43560/89A AU633853B2 (en) 1988-10-18 1989-10-17 Novel beta-d-phenylthioxylosides, their method of preparation and their use as therapeuticals
CN89107940A CN1024801C (zh) 1988-10-18 1989-10-17 新的β-D-苯基硫代木糖苷的制备方法
DK516189A DK171401B1 (da) 1988-10-18 1989-10-17 Beta-D-phenylthioxylosidderivater, terapeutisk middel omfattende disse, anvendelse af derivaterne til fremstilling af antithrombotiske lægemidler, fremgangsmåde til fremstilling af derivaterne samt acyl-beta-D-thioxylosylhalogenider og acylthioxylosyltrichloracetimidatertil brug ved fremstilling af derivaterne
HU895336A HU203248B (en) 1988-10-18 1989-10-17 Process for producing beta-d-phenylthioxylosides and pharmaceutical compositions comprising such compounds as active ingredient
YU201789A YU47072B (sh) 1988-10-18 1989-10-17 Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji
PT92014A PT92014B (pt) 1988-10-18 1989-10-17 Processo para a preparacao de beta-fenil-tioxilosidos
NO894134A NO171166C (no) 1988-10-18 1989-10-17 Analogifremgangsmaate for fremstilling av beta-d-fenyltioxylosider
UA4742255A UA15921A (uk) 1988-10-18 1989-10-17 СПОСІБ ОДЕРЖАHHЯ БЕtА-D-ФЕHІЛТІОКСИЛОЗИДІВ
US07/423,958 US5101048A (en) 1988-10-18 1989-10-18 β-D-phenylthioxylosides, their method of preparation and their use as therapeutic agents
JP1272749A JPH0826058B2 (ja) 1988-10-18 1989-10-18 β―Ｄ―フェニルチオキシロシドを含むオシド化合物
KR1019890014984A KR930005990B1 (ko) 1988-10-18 1989-10-18 β-D-페닐티오크실로시드 화합물과 그의 제조방법
US07/793,649 US5246961A (en) 1988-10-18 1991-11-18 β-d-phenylthioxylosides, and their use as therapeutic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8908253A FR2648819B1 (fr) 1989-06-21 1989-06-21 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique

Publications (2)

Publication Number Publication Date
FR2648819A1 FR2648819A1 (fr) 1990-12-28
FR2648819B1 true FR2648819B1 (fr) 1994-11-25

Family

ID=9382978

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8908253A Expired - Fee Related FR2648819B1 (fr) 1988-10-18 1989-06-21 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique

Country Status (1)

Country Link
FR (1) FR2648819B1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique

Also Published As

Publication number Publication date
FR2648819A1 (fr) 1990-12-28

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