YU47072B - Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji - Google Patents

Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji

Info

Publication number
YU47072B
YU47072B YU201789A YU201789A YU47072B YU 47072 B YU47072 B YU 47072B YU 201789 A YU201789 A YU 201789A YU 201789 A YU201789 A YU 201789A YU 47072 B YU47072 B YU 47072B
Authority
YU
Yugoslavia
Prior art keywords
group
beta
nitro
cyano
trifluoromethyl
Prior art date
Application number
YU201789A
Other languages
English (en)
Other versions
YU201789A (en
Inventor
S. Samreth
J. Millet
F. Bellamy
J. Basgrowicz
V. Barberousse
P. Renaut
Original Assignee
Fournier Industrie Et Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8813688A external-priority patent/FR2638749B1/fr
Priority claimed from FR8908253A external-priority patent/FR2648819B1/fr
Application filed by Fournier Industrie Et Sante filed Critical Fournier Industrie Et Sante
Publication of YU201789A publication Critical patent/YU201789A/xx
Priority to HR920788A priority Critical patent/HRP920788A2/hr
Publication of YU47072B publication Critical patent/YU47072B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/02—Monothiocarbamic acids; Derivatives thereof
    • C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

BETA-D-FENILTIOKSILOZIDI, POSTUPAK ZA NJIHOVO DOBIJANJE, NJIHOVO KORISCENJE U TERAPIJI, beta-d-feniltioksilozidi formule: u kojoj X predstavlja atom sumpora ili atom kiseonika; R1, R2 i R3, identicni ili razliciti, predstavljaju svaki atom vodonika, nitro grupu, cijano grupu, grupu -CO-R, gde R predstavlja C1-C4 alkil grupu ili trifluorometil grupu, amino grupu, acetamido grupu (NHCOCH3), C1-C4 alkoksi grupu, trifluorometil grupu, fenil grupu koja je supstituisana sa jednom ili vise cijano, nitro ili trifluorometil grupa, R1 i R2 razmatrani zajedno, mogu da formiraju sa fenil grupom, za koju su vezani, beta-naftalenil grupu koja eventualno supstituisana sa jednom ili vise grupa cijano, nitro ili trifluorometil; i Y predstavlja atom vodonika ili alifaticnu acil grupu, naznacen time, sto: 1) reaguje jedinjenje formule u kojoj su X, R1, R2 i R3 kao sto je definisano gore, sa derivatom tioksiloze koji je izabran iz grupe koja sadrzi (i) halogenid aciltioksiloze formule (ii) peracilovane tioksiloze formule (iii) aciltioksilozil-trihloracetamidate formule u kojima Hal predstavlja takav atom halogena kao sto je Cl ili Br, pri cemu je atom broma pozeljan halogen i Y predstavlja acil grupu, narocito alifaticnu acil grupu koja sadrzi ukupan broj ugljenikovih atoma od 2-5 i to je pozeljno grupa acetil, u inertnom rastvaracu, u odnosu 1 mol jedinjenja II za oko 0.6-1,2 mola jedinjenja III, IV ili V, u prisustvu akceptora kiseline i/ili Lewis-ove kiseline i 2) ako je potrebno, vrsi se reakcija deacetilovanja na temperaturi izmedju 0°C i refluks temperature reakcione sredine, u C1-C4 nizem alkoholu pozeljno metanolu u prisustvu metalnog alkoholata, pozeljno Mg- ili Na-metilata, tako da se dobija jedinjenje formule I, gde je Y H. Prijava sadrzi jos 2 nezavisna i 15 zavisnih zahteva.
YU201789A 1988-10-18 1989-10-17 Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji YU47072B (sh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HR920788A HRP920788A2 (en) 1989-10-17 1992-10-02 New-beta-d-phenyl-thioxilosides, the process for obtaining them and therapeutical use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8813688A FR2638749B1 (fr) 1988-10-18 1988-10-18 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique
FR8908253A FR2648819B1 (fr) 1989-06-21 1989-06-21 Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique

Publications (2)

Publication Number Publication Date
YU201789A YU201789A (en) 1991-02-28
YU47072B true YU47072B (sh) 1994-12-28

Family

ID=26226940

Family Applications (1)

Application Number Title Priority Date Filing Date
YU201789A YU47072B (sh) 1988-10-18 1989-10-17 Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji

Country Status (21)

Country Link
US (1) US5101048A (sh)
EP (1) EP0365397B1 (sh)
JP (1) JPH0826058B2 (sh)
KR (1) KR930005990B1 (sh)
CN (1) CN1024801C (sh)
AT (1) ATE112283T1 (sh)
AU (1) AU633853B2 (sh)
CA (1) CA2000769A1 (sh)
DE (1) DE68918548T2 (sh)
DK (1) DK171401B1 (sh)
ES (1) ES2064473T3 (sh)
FI (1) FI98372C (sh)
HU (1) HU203248B (sh)
IE (1) IE63544B1 (sh)
IL (1) IL91977A (sh)
NO (1) NO171166C (sh)
NZ (1) NZ231024A (sh)
PT (1) PT92014B (sh)
RU (1) RU1780538C (sh)
UA (1) UA15921A (sh)
YU (1) YU47072B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2660313B1 (fr) * 1990-04-02 1992-07-03 Fournier Ind & Sante Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique.
US5689657A (en) * 1991-03-30 1997-11-18 Deutsche Itt Industries Gmbh Apparatus and methods for bus arbitration in a multimaster system
HUP9601756A3 (en) * 1996-06-25 1999-05-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical compositions containing them
HUP9603341A3 (en) * 1996-12-04 1999-05-28 Richter Gedeon Vegyeszet Glucosides as blood-clotting-inhibitors and pharmaceutical compositions containing them
HUP9702348A3 (en) * 1997-12-04 2000-12-28 Richter Gedeon Vegyeszet New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them
US6291433B1 (en) 1999-06-11 2001-09-18 Fournier Industrie Et Sante Derivatives of α-D-Thioxyloside and their use against atheroma
FR2860234B1 (fr) * 2003-09-25 2005-12-23 Fournier Lab Sa Nouveaux derives 666 du thioxylose
FR2883561B1 (fr) * 2005-03-25 2009-03-20 Fournier S A Sa Lab Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique
FR2903698B1 (fr) * 2006-07-13 2009-01-30 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose.
FR2906247B1 (fr) * 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
FR2906248B1 (fr) * 2006-09-27 2008-12-26 Fournier S A Sa Lab Nouveaux derives de 5-thioxylopyranose
AU2013395144B2 (en) * 2013-07-25 2017-12-14 Scinopharm Taiwan, Ltd. Process for the production of Fondaparinux sodium

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3243425A (en) * 1962-10-29 1966-03-29 Purdue Research Foundation Novel sulfur-containing compounds
GR71911B (sh) * 1978-08-31 1983-08-16 Lilly Co Eli
US4264605A (en) * 1978-08-31 1981-04-28 Eli Lilly And Company 1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds
FR2492830A1 (fr) * 1980-10-29 1982-04-30 Sori Soc Rech Ind Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique
EP0118676B1 (en) * 1980-12-09 1987-09-23 Seikagaku Kogyo Co. Ltd. D-xylopyranoside series compounds and therapeutical compositions containing same
US4584012A (en) * 1982-11-10 1986-04-22 Monsanto Company 1-phenylthio-1-cyclopropanecarbonitrile and substituted phenylthio derivatives thereof as crop protectants
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
DE3543036A1 (de) * 1985-12-05 1987-06-11 Bayer Ag Verfahren zur herstellung von 4-mercaptobenzonitrilen und neue 4-mercaptobenzonitrile
FR2614893B1 (fr) * 1987-05-04 1989-12-22 Fournier Innovation Synergie Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique
ES2058580T3 (es) * 1988-11-03 1994-11-01 Fournier Ind & Sante Nuevos beta-d-feniltioxilosidos, su metodo de preparacion y su uso como medicamentos.

Also Published As

Publication number Publication date
HU895336D0 (en) 1990-01-28
DK516189D0 (da) 1989-10-17
PT92014A (pt) 1990-04-30
CA2000769A1 (en) 1990-04-18
NO171166B (no) 1992-10-26
DK171401B1 (da) 1996-10-14
FI98372B (fi) 1997-02-28
IL91977A0 (en) 1990-07-12
RU1780538C (ru) 1992-12-07
ES2064473T3 (es) 1995-02-01
KR930005990B1 (ko) 1993-07-01
CN1041948A (zh) 1990-05-09
IL91977A (en) 1994-08-26
DE68918548T2 (de) 1995-02-16
FI894900A0 (fi) 1989-10-16
HU203248B (en) 1991-06-28
DE68918548D1 (de) 1994-11-03
EP0365397B1 (fr) 1994-09-28
US5101048A (en) 1992-03-31
ATE112283T1 (de) 1994-10-15
AU4356089A (en) 1990-04-26
PT92014B (pt) 1995-05-31
JPH0826058B2 (ja) 1996-03-13
NO894134D0 (no) 1989-10-17
AU633853B2 (en) 1993-02-11
NO171166C (no) 1993-02-03
UA15921A (uk) 1997-06-30
YU201789A (en) 1991-02-28
FI98372C (fi) 1997-06-10
EP0365397A2 (fr) 1990-04-25
NZ231024A (en) 1990-12-21
CN1024801C (zh) 1994-06-01
NO894134L (no) 1990-04-19
HUT52106A (en) 1990-06-28
DK516189A (da) 1990-04-19
EP0365397A3 (en) 1990-09-05
IE63544B1 (en) 1995-05-17
IE893240L (en) 1990-04-18
KR900006312A (ko) 1990-05-07
JPH02164893A (ja) 1990-06-25

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