YU47072B - Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji - Google Patents
Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapijiInfo
- Publication number
- YU47072B YU47072B YU201789A YU201789A YU47072B YU 47072 B YU47072 B YU 47072B YU 201789 A YU201789 A YU 201789A YU 201789 A YU201789 A YU 201789A YU 47072 B YU47072 B YU 47072B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- beta
- nitro
- cyano
- trifluoromethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
BETA-D-FENILTIOKSILOZIDI, POSTUPAK ZA NJIHOVO DOBIJANJE, NJIHOVO KORISCENJE U TERAPIJI, beta-d-feniltioksilozidi formule: u kojoj X predstavlja atom sumpora ili atom kiseonika; R1, R2 i R3, identicni ili razliciti, predstavljaju svaki atom vodonika, nitro grupu, cijano grupu, grupu -CO-R, gde R predstavlja C1-C4 alkil grupu ili trifluorometil grupu, amino grupu, acetamido grupu (NHCOCH3), C1-C4 alkoksi grupu, trifluorometil grupu, fenil grupu koja je supstituisana sa jednom ili vise cijano, nitro ili trifluorometil grupa, R1 i R2 razmatrani zajedno, mogu da formiraju sa fenil grupom, za koju su vezani, beta-naftalenil grupu koja eventualno supstituisana sa jednom ili vise grupa cijano, nitro ili trifluorometil; i Y predstavlja atom vodonika ili alifaticnu acil grupu, naznacen time, sto: 1) reaguje jedinjenje formule u kojoj su X, R1, R2 i R3 kao sto je definisano gore, sa derivatom tioksiloze koji je izabran iz grupe koja sadrzi (i) halogenid aciltioksiloze formule (ii) peracilovane tioksiloze formule (iii) aciltioksilozil-trihloracetamidate formule u kojima Hal predstavlja takav atom halogena kao sto je Cl ili Br, pri cemu je atom broma pozeljan halogen i Y predstavlja acil grupu, narocito alifaticnu acil grupu koja sadrzi ukupan broj ugljenikovih atoma od 2-5 i to je pozeljno grupa acetil, u inertnom rastvaracu, u odnosu 1 mol jedinjenja II za oko 0.6-1,2 mola jedinjenja III, IV ili V, u prisustvu akceptora kiseline i/ili Lewis-ove kiseline i 2) ako je potrebno, vrsi se reakcija deacetilovanja na temperaturi izmedju 0°C i refluks temperature reakcione sredine, u C1-C4 nizem alkoholu pozeljno metanolu u prisustvu metalnog alkoholata, pozeljno Mg- ili Na-metilata, tako da se dobija jedinjenje formule I, gde je Y H. Prijava sadrzi jos 2 nezavisna i 15 zavisnih zahteva.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HR920788A HRP920788A2 (en) | 1989-10-17 | 1992-10-02 | New-beta-d-phenyl-thioxilosides, the process for obtaining them and therapeutical use thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8813688A FR2638749B1 (fr) | 1988-10-18 | 1988-10-18 | Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique |
| FR8908253A FR2648819B1 (fr) | 1989-06-21 | 1989-06-21 | Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU201789A YU201789A (en) | 1991-02-28 |
| YU47072B true YU47072B (sh) | 1994-12-28 |
Family
ID=26226940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU201789A YU47072B (sh) | 1988-10-18 | 1989-10-17 | Beta-d-feniltioksilozidi, postupak za njihovo dobijanje, njihovo korišćenje u terapiji |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5101048A (sh) |
| EP (1) | EP0365397B1 (sh) |
| JP (1) | JPH0826058B2 (sh) |
| KR (1) | KR930005990B1 (sh) |
| CN (1) | CN1024801C (sh) |
| AT (1) | ATE112283T1 (sh) |
| AU (1) | AU633853B2 (sh) |
| CA (1) | CA2000769A1 (sh) |
| DE (1) | DE68918548T2 (sh) |
| DK (1) | DK171401B1 (sh) |
| ES (1) | ES2064473T3 (sh) |
| FI (1) | FI98372C (sh) |
| HU (1) | HU203248B (sh) |
| IE (1) | IE63544B1 (sh) |
| IL (1) | IL91977A (sh) |
| NO (1) | NO171166C (sh) |
| NZ (1) | NZ231024A (sh) |
| PT (1) | PT92014B (sh) |
| RU (1) | RU1780538C (sh) |
| UA (1) | UA15921A (sh) |
| YU (1) | YU47072B (sh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2660313B1 (fr) * | 1990-04-02 | 1992-07-03 | Fournier Ind & Sante | Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| US5689657A (en) * | 1991-03-30 | 1997-11-18 | Deutsche Itt Industries Gmbh | Apparatus and methods for bus arbitration in a multimaster system |
| HUP9601756A3 (en) * | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
| HUP9603341A3 (en) * | 1996-12-04 | 1999-05-28 | Richter Gedeon Vegyeszet | Glucosides as blood-clotting-inhibitors and pharmaceutical compositions containing them |
| HUP9702348A3 (en) * | 1997-12-04 | 2000-12-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them |
| US6291433B1 (en) | 1999-06-11 | 2001-09-18 | Fournier Industrie Et Sante | Derivatives of α-D-Thioxyloside and their use against atheroma |
| FR2860234B1 (fr) * | 2003-09-25 | 2005-12-23 | Fournier Lab Sa | Nouveaux derives 666 du thioxylose |
| FR2883561B1 (fr) * | 2005-03-25 | 2009-03-20 | Fournier S A Sa Lab | Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique |
| FR2903698B1 (fr) * | 2006-07-13 | 2009-01-30 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose. |
| FR2906248B1 (fr) | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
| FR2906247B1 (fr) | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
| AU2013395144B2 (en) * | 2013-07-25 | 2017-12-14 | Scinopharm Taiwan, Ltd. | Process for the production of Fondaparinux sodium |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3243425A (en) * | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
| GR71911B (sh) * | 1978-08-31 | 1983-08-16 | Lilly Co Eli | |
| US4264605A (en) * | 1978-08-31 | 1981-04-28 | Eli Lilly And Company | 1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds |
| FR2492830A1 (fr) * | 1980-10-29 | 1982-04-30 | Sori Soc Rech Ind | Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique |
| DE3172379D1 (en) * | 1980-12-09 | 1985-10-24 | Seikagaku Kogyo Co Ltd | D-xylopyranoside series compounds and therapeutical compositions containing same |
| US4584012A (en) * | 1982-11-10 | 1986-04-22 | Monsanto Company | 1-phenylthio-1-cyclopropanecarbonitrile and substituted phenylthio derivatives thereof as crop protectants |
| FR2549476B1 (fr) * | 1983-07-20 | 1986-04-25 | Rech Ind | Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique |
| DE3543036A1 (de) * | 1985-12-05 | 1987-06-11 | Bayer Ag | Verfahren zur herstellung von 4-mercaptobenzonitrilen und neue 4-mercaptobenzonitrile |
| FR2614893B1 (fr) * | 1987-05-04 | 1989-12-22 | Fournier Innovation Synergie | Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique |
| ATE92074T1 (de) * | 1988-11-03 | 1993-08-15 | Fournier Ind & Sante | Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
-
1989
- 1989-10-09 IE IE324089A patent/IE63544B1/en not_active IP Right Cessation
- 1989-10-11 AT AT89402804T patent/ATE112283T1/de not_active IP Right Cessation
- 1989-10-11 EP EP89402804A patent/EP0365397B1/fr not_active Expired - Lifetime
- 1989-10-11 DE DE68918548T patent/DE68918548T2/de not_active Expired - Fee Related
- 1989-10-11 ES ES89402804T patent/ES2064473T3/es not_active Expired - Lifetime
- 1989-10-12 IL IL9197789A patent/IL91977A/en unknown
- 1989-10-16 CA CA002000769A patent/CA2000769A1/en not_active Abandoned
- 1989-10-16 FI FI894900A patent/FI98372C/fi not_active IP Right Cessation
- 1989-10-16 NZ NZ231024A patent/NZ231024A/en unknown
- 1989-10-17 CN CN89107940A patent/CN1024801C/zh not_active Expired - Fee Related
- 1989-10-17 HU HU895336A patent/HU203248B/hu not_active IP Right Cessation
- 1989-10-17 YU YU201789A patent/YU47072B/sh unknown
- 1989-10-17 RU SU894742255A patent/RU1780538C/ru active
- 1989-10-17 AU AU43560/89A patent/AU633853B2/en not_active Ceased
- 1989-10-17 PT PT92014A patent/PT92014B/pt not_active IP Right Cessation
- 1989-10-17 UA UA4742255A patent/UA15921A/uk unknown
- 1989-10-17 DK DK516189A patent/DK171401B1/da not_active IP Right Cessation
- 1989-10-17 NO NO894134A patent/NO171166C/no unknown
- 1989-10-18 US US07/423,958 patent/US5101048A/en not_active Expired - Fee Related
- 1989-10-18 KR KR1019890014984A patent/KR930005990B1/ko not_active IP Right Cessation
- 1989-10-18 JP JP1272749A patent/JPH0826058B2/ja not_active Expired - Lifetime
Also Published As
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