DK171401B1 - Beta-D-phenylthioxylosidderivater, terapeutisk middel omfattende disse, anvendelse af derivaterne til fremstilling af antithrombotiske lægemidler, fremgangsmåde til fremstilling af derivaterne samt acyl-beta-D-thioxylosylhalogenider og acylthioxylosyltrichloracetimidatertil brug ved fremstilling af derivaterne - Google Patents
Beta-D-phenylthioxylosidderivater, terapeutisk middel omfattende disse, anvendelse af derivaterne til fremstilling af antithrombotiske lægemidler, fremgangsmåde til fremstilling af derivaterne samt acyl-beta-D-thioxylosylhalogenider og acylthioxylosyltrichloracetimidatertil brug ved fremstilling af derivaterne Download PDFInfo
- Publication number
- DK171401B1 DK171401B1 DK516189A DK516189A DK171401B1 DK 171401 B1 DK171401 B1 DK 171401B1 DK 516189 A DK516189 A DK 516189A DK 516189 A DK516189 A DK 516189A DK 171401 B1 DK171401 B1 DK 171401B1
- Authority
- DK
- Denmark
- Prior art keywords
- group
- preparation
- acetyl
- xylopyranoside
- formula
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
- C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C333/02—Monothiocarbamic acids; Derivatives thereof
- C07C333/04—Monothiocarbamic acids; Derivatives thereof having nitrogen atoms of thiocarbamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8813688A FR2638749B1 (fr) | 1988-10-18 | 1988-10-18 | Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique |
| FR8813688 | 1988-10-18 | ||
| FR8908253A FR2648819B1 (fr) | 1989-06-21 | 1989-06-21 | Nouveaux (beta)-d-phenyl-thioxylosides, leur procede de preparation et leur utilisation en therapeutique |
| FR8908253 | 1989-06-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK516189D0 DK516189D0 (da) | 1989-10-17 |
| DK516189A DK516189A (da) | 1990-04-19 |
| DK171401B1 true DK171401B1 (da) | 1996-10-14 |
Family
ID=26226940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK516189A DK171401B1 (da) | 1988-10-18 | 1989-10-17 | Beta-D-phenylthioxylosidderivater, terapeutisk middel omfattende disse, anvendelse af derivaterne til fremstilling af antithrombotiske lægemidler, fremgangsmåde til fremstilling af derivaterne samt acyl-beta-D-thioxylosylhalogenider og acylthioxylosyltrichloracetimidatertil brug ved fremstilling af derivaterne |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5101048A (sh) |
| EP (1) | EP0365397B1 (sh) |
| JP (1) | JPH0826058B2 (sh) |
| KR (1) | KR930005990B1 (sh) |
| CN (1) | CN1024801C (sh) |
| AT (1) | ATE112283T1 (sh) |
| AU (1) | AU633853B2 (sh) |
| CA (1) | CA2000769A1 (sh) |
| DE (1) | DE68918548T2 (sh) |
| DK (1) | DK171401B1 (sh) |
| ES (1) | ES2064473T3 (sh) |
| FI (1) | FI98372C (sh) |
| HU (1) | HU203248B (sh) |
| IE (1) | IE63544B1 (sh) |
| IL (1) | IL91977A (sh) |
| NO (1) | NO171166C (sh) |
| NZ (1) | NZ231024A (sh) |
| PT (1) | PT92014B (sh) |
| RU (1) | RU1780538C (sh) |
| UA (1) | UA15921A (sh) |
| YU (1) | YU47072B (sh) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2660313B1 (fr) * | 1990-04-02 | 1992-07-03 | Fournier Ind & Sante | Nouveau sulfonyl-phenyl-betha-d-thioxylosides, leur procede de preparation et leur utilisation en therapeutique. |
| US5689657A (en) * | 1991-03-30 | 1997-11-18 | Deutsche Itt Industries Gmbh | Apparatus and methods for bus arbitration in a multimaster system |
| HUP9601756A3 (en) * | 1996-06-25 | 1999-05-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical compositions containing them |
| HUP9603341A3 (en) * | 1996-12-04 | 1999-05-28 | Richter Gedeon Vegyeszet | Glucosides as blood-clotting-inhibitors and pharmaceutical compositions containing them |
| HUP9702348A3 (en) * | 1997-12-04 | 2000-12-28 | Richter Gedeon Vegyeszet | New anticoagulant glycosides and pharmaceutical conew anticoagulant glycosides and pharmaceutical compositions containing them mpositions containing them |
| US6291433B1 (en) | 1999-06-11 | 2001-09-18 | Fournier Industrie Et Sante | Derivatives of α-D-Thioxyloside and their use against atheroma |
| FR2860234B1 (fr) * | 2003-09-25 | 2005-12-23 | Fournier Lab Sa | Nouveaux derives 666 du thioxylose |
| FR2883561B1 (fr) * | 2005-03-25 | 2009-03-20 | Fournier S A Sa Lab | Nouveaux composes derives du 5-thioxylose et leur utilisation therapeutique |
| FR2903698B1 (fr) * | 2006-07-13 | 2009-01-30 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose. |
| FR2906247B1 (fr) * | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
| FR2906248B1 (fr) * | 2006-09-27 | 2008-12-26 | Fournier S A Sa Lab | Nouveaux derives de 5-thioxylopyranose |
| CA2919203C (en) * | 2013-07-25 | 2018-11-27 | Lung-Huang Kuo | Process for the production of fondaparinux sodium |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3243425A (en) * | 1962-10-29 | 1966-03-29 | Purdue Research Foundation | Novel sulfur-containing compounds |
| GR71911B (sh) * | 1978-08-31 | 1983-08-16 | Lilly Co Eli | |
| US4264605A (en) * | 1978-08-31 | 1981-04-28 | Eli Lilly And Company | 1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds |
| FR2492830A1 (fr) * | 1980-10-29 | 1982-04-30 | Sori Soc Rech Ind | Nouveaux composes appartenant a la famille des benzoyl- et a-hydroxybenzyl-phenyl-osides, leur procede de preparation et leur application en therapeutique |
| EP0117413B1 (en) * | 1980-12-09 | 1987-08-26 | Seikagaku Kogyo Co. Ltd. | D-xylopyranoside series compounds and therapeutical compositions containing same |
| US4584012A (en) * | 1982-11-10 | 1986-04-22 | Monsanto Company | 1-phenylthio-1-cyclopropanecarbonitrile and substituted phenylthio derivatives thereof as crop protectants |
| FR2549476B1 (fr) * | 1983-07-20 | 1986-04-25 | Rech Ind | Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique |
| DE3543036A1 (de) * | 1985-12-05 | 1987-06-11 | Bayer Ag | Verfahren zur herstellung von 4-mercaptobenzonitrilen und neue 4-mercaptobenzonitrile |
| FR2614893B1 (fr) * | 1987-05-04 | 1989-12-22 | Fournier Innovation Synergie | Nouveaux b-d-phenyl-thioxylosides, leur procede de preparation et leur application en therapeutique |
| ATE92074T1 (de) * | 1988-11-03 | 1993-08-15 | Fournier Ind & Sante | Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. |
-
1989
- 1989-10-09 IE IE324089A patent/IE63544B1/en not_active IP Right Cessation
- 1989-10-11 ES ES89402804T patent/ES2064473T3/es not_active Expired - Lifetime
- 1989-10-11 AT AT89402804T patent/ATE112283T1/de not_active IP Right Cessation
- 1989-10-11 EP EP89402804A patent/EP0365397B1/fr not_active Expired - Lifetime
- 1989-10-11 DE DE68918548T patent/DE68918548T2/de not_active Expired - Fee Related
- 1989-10-12 IL IL9197789A patent/IL91977A/en unknown
- 1989-10-16 CA CA002000769A patent/CA2000769A1/en not_active Abandoned
- 1989-10-16 FI FI894900A patent/FI98372C/fi not_active IP Right Cessation
- 1989-10-16 NZ NZ231024A patent/NZ231024A/en unknown
- 1989-10-17 PT PT92014A patent/PT92014B/pt not_active IP Right Cessation
- 1989-10-17 RU SU894742255A patent/RU1780538C/ru active
- 1989-10-17 UA UA4742255A patent/UA15921A/uk unknown
- 1989-10-17 CN CN89107940A patent/CN1024801C/zh not_active Expired - Fee Related
- 1989-10-17 HU HU895336A patent/HU203248B/hu not_active IP Right Cessation
- 1989-10-17 DK DK516189A patent/DK171401B1/da not_active IP Right Cessation
- 1989-10-17 AU AU43560/89A patent/AU633853B2/en not_active Ceased
- 1989-10-17 YU YU201789A patent/YU47072B/sh unknown
- 1989-10-17 NO NO894134A patent/NO171166C/no unknown
- 1989-10-18 US US07/423,958 patent/US5101048A/en not_active Expired - Fee Related
- 1989-10-18 JP JP1272749A patent/JPH0826058B2/ja not_active Expired - Lifetime
- 1989-10-18 KR KR1019890014984A patent/KR930005990B1/ko not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |