GR71898B - - Google Patents

Info

Publication number
GR71898B
GR71898B GR63814A GR810163814A GR71898B GR 71898 B GR71898 B GR 71898B GR 63814 A GR63814 A GR 63814A GR 810163814 A GR810163814 A GR 810163814A GR 71898 B GR71898 B GR 71898B
Authority
GR
Greece
Application number
GR63814A
Inventor
Raymond Stokbroekx
Marcel Luyckx
Joannes Willems
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of GR71898B publication Critical patent/GR71898B/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96Sulfur atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GR63814A 1980-01-24 1981-01-08 GR71898B (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11492480A 1980-01-24 1980-01-24
US06/191,631 US4369184A (en) 1980-01-24 1980-09-29 1-(Cyclohexyl)-4-aryl-4-piperidinecarboxylic acid derivatives

Publications (1)

Publication Number Publication Date
GR71898B true GR71898B (el) 1983-08-11

Family

ID=26812674

Family Applications (1)

Application Number Title Priority Date Filing Date
GR63814A GR71898B (el) 1980-01-24 1981-01-08

Country Status (25)

Country Link
US (1) US4369184A (el)
EP (1) EP0034415B1 (el)
AU (1) AU538130B2 (el)
BG (2) BG35465A3 (el)
CA (1) CA1187080A (el)
CS (1) CS221818B2 (el)
DE (1) DE3163787D1 (el)
DK (1) DK152670C (el)
ES (2) ES8204421A1 (el)
FI (1) FI76562C (el)
GR (1) GR71898B (el)
HK (1) HK81088A (el)
HU (1) HU183293B (el)
IE (1) IE50706B1 (el)
IL (1) IL61968A (el)
LU (1) LU88220I2 (el)
MA (1) MA19046A1 (el)
MY (1) MY8700593A (el)
NL (1) NL930017I2 (el)
NO (1) NO1994012I1 (el)
NZ (1) NZ196117A (el)
PH (1) PH16611A (el)
PL (2) PL127483B1 (el)
SU (1) SU1230467A3 (el)
YU (1) YU48446B (el)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6322584A (ja) * 1986-07-15 1988-01-30 Senjiyu Seiyaku Kk 1−ハイドロキシ−5−オキソ−5H−ピリド〔3,2−a〕フエノキサジン−3−カルボン酸エステル類
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
AU1716995A (en) * 1994-03-18 1995-10-09 Ciba-Geigy Ag Aqueous solution of levocabastine for ophthalmic use
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
ES2243994T5 (es) 1996-04-19 2009-10-29 Grifols Inc. Procedimiento para la inactivacion virica de proteinas de la sangre liofilizadas.
US6267986B1 (en) 1999-09-24 2001-07-31 Ranbaxy Laboratories Limited Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine
US20020146409A1 (en) * 2001-01-30 2002-10-10 Herring Steven W. Methods for stabilizing lyophilized blood proteins
ATE472329T1 (de) * 2002-08-30 2010-07-15 Nycomed Gmbh Verwendung der kombination von ciclesonid und antihistaminika zur behandlung von allergischer rhinitis
EP1976513B1 (en) * 2006-01-06 2016-08-24 Sunovion Pharmaceuticals Inc. Cycloalkylamines as monoamine reuptake inhibitors
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
ES2391585T3 (es) 2006-06-01 2012-11-28 Msd Consumer Care, Inc. Formulación farmacéutica de liberación sostenida que comprende fenilefrina
RU2010129833A (ru) * 2007-12-21 2012-01-27 Шеринг-Плау Хельскер Продактс, Инк. (Us) Повышение светоустойчивости оксиметазолина
AU2012338581B2 (en) 2011-11-18 2016-12-08 Heptares Therapeutics Limited Muscarinic M1 receptor agonists
US10259787B2 (en) 2016-10-14 2019-04-16 Heptares Therapeutics Limited Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1206436B (de) * 1957-07-05 1965-12-09 Janssen Pharmaceutica Nv Verfahren zur Herstellung von Derivaten von 2, 2-Diaryl-4-(4'-phenyl-piperidino)-butyronitrilen
NL127792C (el) * 1965-06-29

Also Published As

Publication number Publication date
IE50706B1 (en) 1986-06-25
IE810125L (en) 1981-07-24
PL127679B1 (en) 1983-11-30
BG35465A3 (en) 1984-04-15
NO1994012I1 (no) 1994-08-30
PL229365A1 (el) 1982-03-29
MA19046A1 (fr) 1981-10-01
SU1230467A3 (ru) 1986-05-07
AU538130B2 (en) 1984-08-02
DK152670B (da) 1988-04-11
PL233921A1 (el) 1982-06-21
LU88220I2 (el) 1994-02-03
BG60472B2 (bg) 1995-04-28
FI810193L (fi) 1981-07-25
CS221818B2 (en) 1983-04-29
IL61968A0 (en) 1981-02-27
AU6625581A (en) 1981-07-30
PL127483B1 (en) 1983-10-31
YU18381A (en) 1983-10-31
FI76562C (fi) 1988-11-10
EP0034415B1 (en) 1984-05-30
DK152670C (da) 1988-08-22
ES8307219A1 (es) 1983-07-01
HK81088A (en) 1988-10-14
PH16611A (en) 1983-11-24
ES498793A0 (es) 1982-05-01
DE3163787D1 (en) 1984-07-05
ES508441A0 (es) 1983-07-01
HU183293B (en) 1984-04-28
NZ196117A (en) 1984-05-31
CA1187080A (en) 1985-05-14
NL930017I1 (nl) 1993-05-03
US4369184A (en) 1983-01-18
EP0034415A1 (en) 1981-08-26
DK29381A (da) 1981-07-25
YU48446B (sh) 1998-07-10
FI76562B (fi) 1988-07-29
IL61968A (en) 1984-09-30
NL930017I2 (nl) 1993-07-16
ES8204421A1 (es) 1982-05-01
MY8700593A (en) 1987-12-31

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