DK165248C - 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf - Google Patents

1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf

Info

Publication number
DK165248C
DK165248C DK080291A DK80291A DK165248C DK 165248 C DK165248 C DK 165248C DK 080291 A DK080291 A DK 080291A DK 80291 A DK80291 A DK 80291A DK 165248 C DK165248 C DK 165248C
Authority
DK
Denmark
Prior art keywords
imidazooe4
baaquinolin
oner
tetrahydro
preparing
Prior art date
Application number
DK080291A
Other languages
English (en)
Other versions
DK80291D0 (da
DK80291A (da
DK165248B (da
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK80291D0 publication Critical patent/DK80291D0/da
Publication of DK80291A publication Critical patent/DK80291A/da
Publication of DK165248B publication Critical patent/DK165248B/da
Application granted granted Critical
Publication of DK165248C publication Critical patent/DK165248C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK080291A 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf DK165248C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US72686985 1985-04-25
US83221286 1986-02-26
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (4)

Publication Number Publication Date
DK80291D0 DK80291D0 (da) 1991-04-30
DK80291A DK80291A (da) 1991-04-30
DK165248B DK165248B (da) 1992-10-26
DK165248C true DK165248C (da) 1993-03-22

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
US (1) US4668686A (da)
KR (1) KR940000828B1 (da)
CN (1) CN1016175B (da)
AT (1) AT390257B (da)
AU (1) AU592983B2 (da)
BE (1) BE904671A (da)
CA (1) CA1298836C (da)
CH (1) CH675722A5 (da)
CY (1) CY1641A (da)
DE (1) DE3614132A1 (da)
DK (3) DK164868C (da)
EG (1) EG18104A (da)
ES (3) ES8708229A1 (da)
FI (1) FI83316C (da)
FR (1) FR2581065B1 (da)
GB (1) GB2174987B (da)
GR (1) GR861086B (da)
HK (1) HK64492A (da)
HU (1) HU195813B (da)
IL (1) IL78581A0 (da)
IT (1) IT1215651B (da)
LU (1) LU86406A1 (da)
MY (1) MY102086A (da)
NL (1) NL8601053A (da)
NO (1) NO163406C (da)
NZ (1) NZ215885A (da)
OA (1) OA08242A (da)
PT (1) PT82460B (da)
SE (1) SE461468B (da)
SG (1) SG29092G (da)
SU (3) SU1450746A3 (da)
YU (1) YU46054B (da)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
EP0707585A1 (en) * 1993-07-06 1996-04-24 Pfizer Inc. Bicyclic tetrahydro pyrazolopyridines
TW530047B (en) * 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
WO2005018556A2 (en) 2003-08-12 2005-03-03 3M Innovative Properties Company Hydroxylamine substituted imidazo-containing compounds
PH12006500401A1 (en) 2003-08-27 2005-03-10 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (en) 2003-09-05 2008-07-16 3M Innovative Properties Co TREATMENT FOR CD5 + B CELL LYMPHOMA
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
EP1673087B1 (en) 2003-10-03 2015-05-13 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
EP1685129A4 (en) 2003-11-14 2008-10-22 3M Innovative Properties Co OXIMSUBSTITUTED IMIDAZORING CONNECTIONS
WO2005048945A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
US8802853B2 (en) 2003-12-29 2014-08-12 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
AU2005228150A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en) 2004-06-15 2011-09-13 3M Innovative Properties Company Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
AU2005284835A1 (en) * 2004-09-14 2006-03-23 Novartis Vaccines And Diagnostics Inc. Imidazoquinoline compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
EP1863814A1 (en) 2005-04-01 2007-12-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
DK2583970T3 (da) 2006-08-02 2015-11-16 Cytokinetics Inc Bestemte kemiske enheder, sammensætninger og fremgangsmåder omfattende imidazopyrimidiner
WO2008121333A1 (en) 2007-03-30 2008-10-09 Cytokinetics, Incorporated Certain chemical entities, compositions and methods
WO2013010015A2 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination als therapy
WO2024149378A1 (zh) * 2023-01-13 2024-07-18 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
GB2174987B (en) 1989-08-02
FI83316B (fi) 1991-03-15
DK164868C (da) 1993-01-11
DK80291D0 (da) 1991-04-30
AU592983B2 (en) 1990-02-01
NZ215885A (en) 1989-04-26
SE461468B (sv) 1990-02-19
DE3614132A1 (de) 1986-11-27
CA1298836C (en) 1992-04-14
NO163406C (no) 1990-05-23
YU116787A (en) 1988-04-30
FI83316C (fi) 1991-06-25
DK190986D0 (da) 1986-04-24
ES554336A0 (es) 1987-10-01
IT8620206A0 (it) 1986-04-24
FR2581065A1 (fr) 1986-10-31
AU5641386A (en) 1986-10-30
ES8802521A1 (es) 1988-07-16
ES8708229A1 (es) 1987-10-01
CN1016175B (zh) 1992-04-08
HK64492A (en) 1992-09-04
NL8601053A (nl) 1986-11-17
ATA112186A (de) 1989-09-15
US4668686A (en) 1987-05-26
DK164868B (da) 1992-08-31
HUT42089A (en) 1987-06-29
BE904671A (fr) 1986-10-24
KR940000828B1 (ko) 1994-02-02
CH675722A5 (da) 1990-10-31
LU86406A1 (fr) 1986-11-05
FR2581065B1 (fr) 1990-02-02
DK80291A (da) 1991-04-30
DK165249B (da) 1992-10-26
SU1450746A3 (ru) 1989-01-07
ES8801829A1 (es) 1988-02-16
AT390257B (de) 1990-04-10
SU1560056A3 (ru) 1990-04-23
FI861684L (fi) 1986-10-26
DK165248B (da) 1992-10-26
GR861086B (en) 1986-09-01
PT82460A (en) 1986-05-01
EG18104A (en) 1992-09-30
IL78581A0 (en) 1986-08-31
CN86102747A (zh) 1987-02-04
SE8601907L (sv) 1986-10-26
CY1641A (en) 1992-11-06
SE8601907D0 (sv) 1986-04-24
DK165249C (da) 1993-03-22
KR860008177A (ko) 1986-11-12
ES557552A0 (es) 1988-07-16
SG29092G (en) 1992-05-15
SU1470192A3 (ru) 1989-03-30
GB2174987A (en) 1986-11-19
IT1215651B (it) 1990-02-22
YU46054B (sh) 1992-12-21
GB8610037D0 (en) 1986-05-29
NO861617L (no) 1986-10-27
FI861684A0 (fi) 1986-04-22
ES557551A0 (es) 1988-02-16
MY102086A (en) 1992-03-31
HU195813B (en) 1988-07-28
DK81091A (da) 1991-05-01
DK81091D0 (da) 1991-05-01
NO163406B (no) 1990-02-12
DK190986A (da) 1986-10-26
PT82460B (pt) 1988-11-30
OA08242A (en) 1987-10-30

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