DK165249C - Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf - Google Patents

Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Info

Publication number
DK165249C
DK165249C DK081091A DK81091A DK165249C DK 165249 C DK165249 C DK 165249C DK 081091 A DK081091 A DK 081091A DK 81091 A DK81091 A DK 81091A DK 165249 C DK165249 C DK 165249C
Authority
DK
Denmark
Prior art keywords
imidazooe4
baaquinolin
procedures
preparing
thion derivatives
Prior art date
Application number
DK081091A
Other languages
English (en)
Other versions
DK81091D0 (da
DK81091A (da
DK165249B (da
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DK81091D0 publication Critical patent/DK81091D0/da
Publication of DK81091A publication Critical patent/DK81091A/da
Publication of DK165249B publication Critical patent/DK165249B/da
Application granted granted Critical
Publication of DK165249C publication Critical patent/DK165249C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK081091A 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf DK165249C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US72686985 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents
US83221286 1986-02-26

Publications (4)

Publication Number Publication Date
DK81091D0 DK81091D0 (da) 1991-05-01
DK81091A DK81091A (da) 1991-05-01
DK165249B DK165249B (da) 1992-10-26
DK165249C true DK165249C (da) 1993-03-22

Family

ID=27111398

Family Applications (3)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da) 1985-04-25 1991-05-01 Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK190986A DK164868C (da) 1985-04-25 1986-04-24 Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da) 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country Link
US (1) US4668686A (da)
KR (1) KR940000828B1 (da)
CN (1) CN1016175B (da)
AT (1) AT390257B (da)
AU (1) AU592983B2 (da)
BE (1) BE904671A (da)
CA (1) CA1298836C (da)
CH (1) CH675722A5 (da)
CY (1) CY1641A (da)
DE (1) DE3614132A1 (da)
DK (3) DK164868C (da)
EG (1) EG18104A (da)
ES (3) ES8708229A1 (da)
FI (1) FI83316C (da)
FR (1) FR2581065B1 (da)
GB (1) GB2174987B (da)
GR (1) GR861086B (da)
HK (1) HK64492A (da)
HU (1) HU195813B (da)
IL (1) IL78581A0 (da)
IT (1) IT1215651B (da)
LU (1) LU86406A1 (da)
MY (1) MY102086A (da)
NL (1) NL8601053A (da)
NO (1) NO163406C (da)
NZ (1) NZ215885A (da)
OA (1) OA08242A (da)
PT (1) PT82460B (da)
SE (1) SE461468B (da)
SG (1) SG29092G (da)
SU (3) SU1450746A3 (da)
YU (1) YU46054B (da)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
TW593317B (en) * 1993-06-21 2004-06-21 Janssen Pharmaceutica Nv Positive cardiac inotropic and lusitropic pyrroloquinolinone derivatives
HUT74170A (en) * 1993-07-06 1996-11-28 Pfizer Bicyclic tetrahydro pyrazolopyridines
TW574214B (en) * 1994-06-08 2004-02-01 Pfizer Corticotropin releasing factor antagonists
US6664264B2 (en) * 2000-12-08 2003-12-16 3M Innovative Properties Company Thioether substituted imidazoquinolines
AR045261A1 (es) 2003-08-12 2005-10-19 3M Innovative Properties Co Compuestos que contienen imidazo quinolina o imidazo piridina sustituidos; composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos inmunomoduladores
ES2406730T3 (es) 2003-08-27 2013-06-07 3M Innovative Properties Company Imidazoquinolinas sustituidas con ariloxi y arilalquilenoxi
AU2004270201A1 (en) 2003-09-05 2005-03-17 3M Innovative Properties Company Treatment for CD5+ B cell lymphoma
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
US7897767B2 (en) 2003-11-14 2011-03-01 3M Innovative Properties Company Oxime substituted imidazoquinolines
CA2545825A1 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
EP1701955A1 (en) 2003-12-29 2006-09-20 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
WO2005066169A2 (en) 2003-12-30 2005-07-21 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
CA2559863A1 (en) 2004-03-24 2005-10-13 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
EP1797091A2 (en) * 2004-09-14 2007-06-20 Novartis Vaccines and Diagnostics, Inc. Imidazoquinoline compounds
JP5543068B2 (ja) 2004-12-30 2014-07-09 スリーエム イノベイティブ プロパティズ カンパニー キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
ES2392648T3 (es) 2004-12-30 2012-12-12 3M Innovative Properties Company Compuestos quirales sustituidos que contienen un núcleo 1,2-imidazo-4,5-c condensado
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2597587A1 (en) 2005-02-11 2006-08-17 Coley Pharmaceutical Group, Inc. Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
US7943610B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company Pyrazolopyridine-1,4-diamines and analogs thereof
JP2008538550A (ja) 2005-04-01 2008-10-30 コーリー ファーマシューティカル グループ，インコーポレイテッド ウイルス感染および腫瘍性疾患を処置するためのサイトカイン生合成の調節因子としての１−置換ピラゾロ（３，４−ｃ）環状化合物
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2666777A1 (en) 2006-08-02 2013-11-27 Cytokinetics, Inc. Certain chemical entities having an imidazo<4,5-b>pyrazin-2(3H)-one core, compositions and methods
EP2139478A4 (en) * 2007-03-30 2010-05-05 Cytokinetics Inc CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
WO2013010015A2 (en) 2011-07-13 2013-01-17 Cytokinetics, Inc. Combination als therapy
CN120265631A (zh) * 2023-01-13 2025-07-04 上海超阳药业有限公司 喹啉酮化合物和萘啶酮化合物及其用途

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US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
SU1470192A3 (ru) 1989-03-30
SU1450746A3 (ru) 1989-01-07
SE461468B (sv) 1990-02-19
AU5641386A (en) 1986-10-30
ES8802521A1 (es) 1988-07-16
HU195813B (en) 1988-07-28
EG18104A (en) 1992-09-30
ES554336A0 (es) 1987-10-01
ATA112186A (de) 1989-09-15
ES557551A0 (es) 1988-02-16
FI861684A0 (fi) 1986-04-22
DK164868C (da) 1993-01-11
CA1298836C (en) 1992-04-14
HK64492A (en) 1992-09-04
NL8601053A (nl) 1986-11-17
DK81091D0 (da) 1991-05-01
LU86406A1 (fr) 1986-11-05
DK165248B (da) 1992-10-26
SG29092G (en) 1992-05-15
GB2174987B (en) 1989-08-02
CN86102747A (zh) 1987-02-04
DK190986D0 (da) 1986-04-24
DK80291A (da) 1991-04-30
ES557552A0 (es) 1988-07-16
NO861617L (no) 1986-10-27
MY102086A (en) 1992-03-31
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
FI861684L (fi) 1986-10-26
NO163406C (no) 1990-05-23
ES8708229A1 (es) 1987-10-01
CY1641A (en) 1992-11-06
NO163406B (no) 1990-02-12
IT1215651B (it) 1990-02-22
DK190986A (da) 1986-10-26
SE8601907L (sv) 1986-10-26
AU592983B2 (en) 1990-02-01
DK164868B (da) 1992-08-31
YU46054B (sh) 1992-12-21
IL78581A0 (en) 1986-08-31
PT82460B (pt) 1988-11-30
FR2581065A1 (fr) 1986-10-31
DK165249B (da) 1992-10-26
SE8601907D0 (sv) 1986-04-24
AT390257B (de) 1990-04-10
DE3614132A1 (de) 1986-11-27
YU116787A (en) 1988-04-30
HUT42089A (en) 1987-06-29
KR860008177A (ko) 1986-11-12
SU1560056A3 (ru) 1990-04-23
FI83316B (fi) 1991-03-15
CH675722A5 (da) 1990-10-31
US4668686A (en) 1987-05-26
CN1016175B (zh) 1992-04-08
FR2581065B1 (fr) 1990-02-02
NZ215885A (en) 1989-04-26
BE904671A (fr) 1986-10-24
FI83316C (fi) 1991-06-25
GB8610037D0 (en) 1986-05-29
KR940000828B1 (ko) 1994-02-02
IT8620206A0 (it) 1986-04-24
GR861086B (en) 1986-09-01
PT82460A (en) 1986-05-01
ES8801829A1 (es) 1988-02-16
DK80291D0 (da) 1991-04-30
GB2174987A (en) 1986-11-19
OA08242A (en) 1987-10-30

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