YU47308B - Supstituisani flavonoidi, njihove soli i postupak za njihovu proizvodnju - Google Patents

Supstituisani flavonoidi, njihove soli i postupak za njihovu proizvodnju

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Publication number
YU47308B
YU47308B YU69289A YU69289A YU47308B YU 47308 B YU47308 B YU 47308B YU 69289 A YU69289 A YU 69289A YU 69289 A YU69289 A YU 69289A YU 47308 B YU47308 B YU 47308B
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Prior art keywords
salts
procedure
production
substituted
substituted flavonoids
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YU69289A
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English (en)
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YU69289A (en
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Ph. BRIET
J.J. Berthelon
F. Collonges
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Lipha Lyonnaise Industrielle Pharmaceutique
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Publication of YU69289A publication Critical patent/YU69289A/xx
Publication of YU47308B publication Critical patent/YU47308B/sh

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Supstituisani flavonoidi, naznaceni time, sto imaju formulu u kojoj; X oznacava NH, O, Se ili S(O)n, gde je n=0, 1 ili 2; R1 je metil, bifenil eventualno supstituisan sa nitro ili fluoro, tri-fluorometilom, 2-piridilom ili 4-piridilom, fenil ili fenil supstituisan sa najmanje jednim iz grupe koju cine halogen, amino, nitro, hidrok-si, karboksi, (C1-C6)alkoksi, fenoksi, (C1-C12)alkil, trifluorometil, (C1-C6)alkilkarbonilamino, karbamoil, alkiltiazolil, aminotiazolil, benzoil, -N=N-NRaRb grupa, gde Ra i Rb su nezavisno vodonik ili (C1-C6)alkil, (C1-C6)alkilkarbonil, -O-Alk-NRaRb grupa, gde Alk je (C1-C6)alkilen, a Ra i Rb su isti kao sto je to gore navedeno; R2 je vodonik, hidroksi ili metoksi; ili R1 i R2 zajedno formiraju naftalenov sistem spojen sa nukleusom flavonoida; R3 i R4 su vodonik, (C1-C6)alkil, (C1-C6)alkoksi, -CH2COOH, hidroksil, halogen ili R3 i R4 zajedno formiraju benzenov sistem spojen sa nukleusom flavonoida; kada je R15 vodonik, R16 je karboksilni radikal; merkapto radikal; fosfonska grupa; tiazolil grupa eventualno supstituisana sa etok-sikarbonilom, fenilom ili karboksi; hidrazino grupa supstituisana sa aminotiokarbonil grupom ili imidazolinil grupom; grupa NR13R14 u kojoj su R13 i R14 nezavisno vodonik, imidazolinil, metil, fenil supstituisan sa halogenom, (C1-C6)alkoksi ili karboksi, -C(CH2OH)2CH3 grupa, (C1-C6)hidroksialkil grupa ili karbok-simetilen grupa ili R13 i R14 kada su uzeti zajedno formiraju N-metilpiperazinil grupu; (C1-C6)alkil grupa; grupa CONHR17 ili CSNHR17 gde je R17 (C1-C6)alkil ili vodonik; -COOCH(CH3)CO2Et; -SCOCH3; -SCH2CO2R10 gde je R10 vodonik ili metil; -O-(CH2)2-NEt2; -O-CH(CH2OH)2; -CH(CO2Et)2NHCOH3; -CH(COOH)NH2; ili kada R15 oznacava R-CH= gde je R vodonik, fenil, 2-bromofenil, 4-piridil ili 3-piridil, R16 je COOH; ili kada R16 oznacava =O, R15 je COOH, -CH=CH-COOH, -(CH2)2COOH, -CH3, CH2Br ili CH=CHAr gde je Ar H, fenil, 3-piridil ili 4-piridil, COOEt; ili kada je R15 =N-OH, R16 je metil ili vodonik; ili kada je R15 CH3, R16 je -O-COCH3 ili -C(CH3)CO2R10 gde je R10 isto kao gore; R15 i R16 uzeti zajedno predstavljaju grupu formule u kojoj su Q1 i Q2 nezavisno izabrani iz grupe: vodonik; COOR10; fenil eventualno supstituisan sa halogenom, -O(C1-C3)alkilen-COOR10; (C1-C3)alkil; -O-CS-NR10R11; -O(C1-C3)alkilen-NR10R11; hidroksil; (C1-C3)alkoksi; i NR10R11, gde su R10 i R11 nezavisno vodonik ili (C1-C6)alkil; ili R15 i R16 zajedno su in-dolizinil, imidazo /2,1-b/tiazolil, imidazo/2,1,-b/ biazolinil, tiazolil eventualno supstituisan sa amino, metil, fenil, imidazo-/1,2-a/piridil, pirolo/1,2-a/piridil ili tetrahidropiran supstituisan sa okso ili hidroksilnom grupom; ili kada R4 i R15 zajedno formiraju benzenovsistem, R16 je -COOH ili -CH2COOH, , CH2OH; ili kada R1 i R2 zajedno formiraju naftalenov sistem, R15 je H, a R16 je -COOH; ili kada R3 i R4 formiraju benzenov sistem, R15 je vodonik, a R16 je -COOH; ili kada je R15 hidroksil, R16 je -COOH, -CH2CH2COOH, -CH3 ili -CO2Et, i njihove fizioloski prihvat
YU69289A 1988-04-06 1989-04-06 Supstituisani flavonoidi, njihove soli i postupak za njihovu proizvodnju YU47308B (sh)

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US17831588A 1988-04-06 1988-04-06

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YU69289A YU69289A (en) 1991-06-30
YU47308B true YU47308B (sh) 1995-01-31

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EP (1) EP0341104B1 (sh)
JP (1) JPH026473A (sh)
AT (1) ATE99302T1 (sh)
AU (1) AU630345B2 (sh)
CA (1) CA1325205C (sh)
DE (1) DE68911742T2 (sh)
DK (1) DK166789A (sh)
ES (1) ES2060799T3 (sh)
HU (1) HU206701B (sh)
IE (1) IE62858B1 (sh)
IL (1) IL89840A (sh)
IN (1) IN170909B (sh)
MA (1) MA21528A1 (sh)
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NZ (1) NZ228625A (sh)
OA (1) OA09036A (sh)
PT (1) PT90214B (sh)
SU (1) SU1739846A3 (sh)
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JPS60199817A (ja) * 1984-03-23 1985-10-09 Rikagaku Kenkyusho 制癌剤
DE3517950A1 (de) * 1985-05-18 1986-11-20 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2-thiochromenylidenacetessigestern
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US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

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PT90214B (pt) 1994-07-29
DE68911742T2 (de) 1994-04-28
IL89840A0 (en) 1989-12-15
JPH026473A (ja) 1990-01-10
IE62858B1 (en) 1995-03-08
IE891087L (en) 1989-10-06
AU630345B2 (en) 1992-10-29
ZA892523B (en) 1990-05-30
NO891415L (no) 1989-10-09
SU1739846A3 (ru) 1992-06-07
NO891415D0 (no) 1989-04-05
NO172344C (no) 1993-07-07
PT90214A (pt) 1989-11-10
YU69289A (en) 1991-06-30
ATE99302T1 (de) 1994-01-15
OA09036A (en) 1991-03-31
DK166789D0 (da) 1989-04-06
IN170909B (sh) 1992-06-13
DE68911742D1 (de) 1994-02-10
CA1325205C (en) 1993-12-14
ES2060799T3 (es) 1994-12-01
NZ228625A (en) 1992-03-26
EP0341104A3 (en) 1989-11-29
IL89840A (en) 1996-10-31
EP0341104B1 (en) 1993-12-29
HU206701B (en) 1992-12-28
MA21528A1 (fr) 1989-12-31
EP0341104A2 (en) 1989-11-08
AU3250589A (en) 1989-10-12
DK166789A (da) 1989-10-07
HUT49600A (en) 1989-10-30
NO172344B (no) 1993-03-29

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