PT90214A - Processo de preparacao de compostos flavonoides substituidos, dos seus sais e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de compostos flavonoides substituidos, dos seus sais e de composicoes farmaceuticas que os contem

Info

Publication number
PT90214A
PT90214A PT90214A PT9021489A PT90214A PT 90214 A PT90214 A PT 90214A PT 90214 A PT90214 A PT 90214A PT 9021489 A PT9021489 A PT 9021489A PT 90214 A PT90214 A PT 90214A
Authority
PT
Portugal
Prior art keywords
salts
preparation
pharmaceutical compositions
compositions containing
flavonoid compounds
Prior art date
Application number
PT90214A
Other languages
English (en)
Other versions
PT90214B (pt
Inventor
Francois Collonges
Philippe Briet
Jean-Jacques Berthelon
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of PT90214A publication Critical patent/PT90214A/pt
Publication of PT90214B publication Critical patent/PT90214B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D345/00—Heterocyclic compounds containing rings having selenium or tellurium atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT90214A 1988-04-06 1989-04-06 Processo de preparacao de compostos flavonoides substituidos, dos seus sais e de composicoes farmaceuticas que os contem PT90214B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17831588A 1988-04-06 1988-04-06

Publications (2)

Publication Number Publication Date
PT90214A true PT90214A (pt) 1989-11-10
PT90214B PT90214B (pt) 1994-07-29

Family

ID=22652061

Family Applications (1)

Application Number Title Priority Date Filing Date
PT90214A PT90214B (pt) 1988-04-06 1989-04-06 Processo de preparacao de compostos flavonoides substituidos, dos seus sais e de composicoes farmaceuticas que os contem

Country Status (20)

Country Link
EP (1) EP0341104B1 (pt)
JP (1) JPH026473A (pt)
AT (1) ATE99302T1 (pt)
AU (1) AU630345B2 (pt)
CA (1) CA1325205C (pt)
DE (1) DE68911742T2 (pt)
DK (1) DK166789A (pt)
ES (1) ES2060799T3 (pt)
HU (1) HU206701B (pt)
IE (1) IE62858B1 (pt)
IL (1) IL89840A (pt)
IN (1) IN170909B (pt)
MA (1) MA21528A1 (pt)
NO (1) NO172344C (pt)
NZ (1) NZ228625A (pt)
OA (1) OA09036A (pt)
PT (1) PT90214B (pt)
SU (1) SU1739846A3 (pt)
YU (1) YU47308B (pt)
ZA (1) ZA892523B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85554A0 (en) * 1987-03-02 1988-08-31 Takeda Chemical Industries Ltd Chromone derivatives
EP0375819A1 (en) * 1988-12-20 1990-07-04 Merrell Dow Pharmaceuticals Inc. Novel derivatives of 1,7'-[imidazo-[1,2-a]pyridine]5'-(6'H)ones
AU634994B2 (en) * 1988-12-21 1993-03-11 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5703075A (en) * 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5977351A (en) * 1990-11-21 1999-11-02 Polaroid Corporation Benzpyrylium squarylium and croconylium dyes, and processes for their preparation and use
CA2070280A1 (en) * 1990-11-21 1992-05-22 Stephen J. Telfer Squarylium and croconylium dyes
US5405976A (en) * 1990-11-21 1995-04-11 Polaroid Corporation Benzpyrylium squarylium and croconylium dyes, and processes for their preparation and use
WO1994002145A2 (en) * 1992-07-22 1994-02-03 Genelabs Technologies, Inc. 2-aryl-4-quinolones as antitumor compounds
US5571822A (en) * 1994-09-30 1996-11-05 The University Of North Carolina At Chapel Hill Antitumor compounds
DE19850131A1 (de) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate
PL211300B1 (pl) 2002-04-17 2012-05-31 Cytokinetics Inc Związek i kompozycja zawierająca ten związek
EP1539727B1 (en) 2002-07-17 2009-02-18 Cytokinetics, Inc. Compounds, compositions, and methods for treating cellular proliferative diseases
JP4646626B2 (ja) * 2002-08-16 2011-03-09 アストラゼネカ アクチボラグ ホスホイノシチド３−キナーゼβの阻害
CN100430389C (zh) * 2002-08-16 2008-11-05 阿斯利康(瑞典)有限公司 抑制磷酸肌醇3-激酶β
RU2424245C2 (ru) * 2006-12-07 2011-07-20 Чайна Медикал Юнивёсити Новые гидрофильные производные 2-арил-4-хинолонов в качестве противораковых агентов
CA2738809C (en) * 2008-09-29 2015-11-24 Sirtris Pharmaceuticals, Inc. Quinazolinone, quinolone and related analogs as sirtuin modulators
WO2011023287A1 (en) * 2009-08-27 2011-03-03 Merck Patent Gmbh Use of faa and its derivatives in cosmetics and dermatology
WO2011029956A1 (en) * 2009-09-14 2011-03-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Flavones and flavanones derivates as dna methyltransferases inhibitors
WO2014018741A1 (en) 2012-07-27 2014-01-30 Emory University Heterocyclic flavone derivatives, compositions, and methods related thereto
CN102977065B (zh) * 2012-12-06 2014-10-29 云南烟草科学研究院 一种黄酮类化合物及其制备方法与应用
CN110615777A (zh) * 2019-08-19 2019-12-27 中国科学院长春应用化学研究所 化合物及其制备方法和应用
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
MX2023013080A (es) 2021-05-03 2023-11-16 Petra Pharma Corp Inhibidores alostericos de cromenona del fosfoinositido 3-quinasa (pi3k) para el tratamiento de enfermedades.
JP2024520417A (ja) 2021-05-27 2024-05-24 ペトラ・ファーマ・コーポレイション がんの治療のためのホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤
TW202329930A (zh) 2021-09-30 2023-08-01 美商佩特拉製藥公司 用於治療疾病之磷酸肌醇3-激酶(pi3k)之異位色烯酮抑制劑
EP4426434A1 (en) 2021-11-02 2024-09-11 Flare Therapeutics, Inc. Pparg inverse agonists and uses thereof
WO2023207881A1 (en) * 2022-04-24 2023-11-02 InventisBio Co., Ltd. Compounds, preparation methods and uses thereof
WO2024051778A1 (en) * 2022-09-09 2024-03-14 InventisBio Co., Ltd. Compounds, preparation methods and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1270567B (de) * 1961-05-19 1968-06-20 Klinge Co Chem Pharm Fab Verfahren zur Herstellung von basisch substituierten Flavonen
FR2516922A1 (fr) * 1981-11-25 1983-05-27 Lipha Acides (oxo-4-4h-(1)-benzopyran-8-yl) alcanoiques, sels et derives, preparation et medicament les contenant
JPS58225083A (ja) * 1982-06-23 1983-12-27 Nippon Shinyaku Co Ltd メチルフラボン誘導体
DE3311004A1 (de) * 1983-03-25 1984-09-27 Bayer Ag, 5090 Leverkusen Chromon- und thiochromon-8-aldehyde, sowie ein verfahren zu ihrer herstellung
JPS6023379A (ja) * 1983-07-18 1985-02-05 Shin Nippon Yakuhin Kk 新規３位置換メチルチオフラボン化合物及びその製造法
JPS6064976A (ja) * 1983-09-19 1985-04-13 Hokuriku Seiyaku Co Ltd Ν−置換フラボン−８−カルボキサミド誘導体，及びその製造方法
JPS60199817A (ja) * 1984-03-23 1985-10-09 Rikagaku Kenkyusho 制癌剤
DE3517950A1 (de) * 1985-05-18 1986-11-20 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2-thiochromenylidenacetessigestern
IL85554A0 (en) * 1987-03-02 1988-08-31 Takeda Chemical Industries Ltd Chromone derivatives
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

Also Published As

Publication number Publication date
IL89840A0 (en) 1989-12-15
YU47308B (sh) 1995-01-31
EP0341104A3 (en) 1989-11-29
HUT49600A (en) 1989-10-30
DK166789D0 (da) 1989-04-06
IL89840A (en) 1996-10-31
AU3250589A (en) 1989-10-12
IN170909B (pt) 1992-06-13
EP0341104B1 (en) 1993-12-29
NO891415L (no) 1989-10-09
ZA892523B (en) 1990-05-30
HU206701B (en) 1992-12-28
EP0341104A2 (en) 1989-11-08
MA21528A1 (fr) 1989-12-31
NO172344C (no) 1993-07-07
NZ228625A (en) 1992-03-26
IE891087L (en) 1989-10-06
PT90214B (pt) 1994-07-29
DE68911742D1 (de) 1994-02-10
ATE99302T1 (de) 1994-01-15
JPH026473A (ja) 1990-01-10
AU630345B2 (en) 1992-10-29
NO172344B (no) 1993-03-29
YU69289A (en) 1991-06-30
ES2060799T3 (es) 1994-12-01
CA1325205C (en) 1993-12-14
SU1739846A3 (ru) 1992-06-07
DE68911742T2 (de) 1994-04-28
NO891415D0 (no) 1989-04-05
DK166789A (da) 1989-10-07
OA09036A (en) 1991-03-31
IE62858B1 (en) 1995-03-08

Similar Documents

Publication Publication Date Title
PT90214A (pt) Processo de preparacao de compostos flavonoides substituidos, dos seus sais e de composicoes farmaceuticas que os contem
SE8602723L (sv) Tiazoler, deras framstellning och farmaceutiska kompositioner innehallande dem
PT90893A (pt) Processo de preparacao de derivados da pirimidina, de seus intermediarios e de composicoes farmaceuticas que os contem
PT95312A (pt) Processo para a preparacao de novos tienilcarboxilatos de aminoalcoois e dos seus produtos de quaternizacao, e de composicoes farmaceuticas que os contem
PT84171B (pt) Processo para a preparacao de derivados das n alfa-aril-sulfonilamiminoacil-p- -amidinofenil-alaninamidas, bem como dos seus derivados de sintese e das composicoes farmaceuticas que os contem
PT89793A (pt) Processo de preparacao de derivados de quinolina substituidos e de composicoes farmaceuticas que os contem
PT83896B (pt) Processo para a preparacao de novos conjugados da vinblastina e dos seus derivados, e de composicoes farmaceuticas que os contem
FI951789A0 (fi) Uusia taksaanijohdannaisia, niiden valmistus ja niitä sisältävät farmaseuttiset koostumukset
PT81893B (pt) Processo para a preparacao de derivados de labdano e de composicoes farmaceuticas que os contem
PT90743A (pt) Processo para a preparacao de derivados de hirudina com accao retardada e de composicoes farmaceuticas que os contem
IL88971A0 (en) Disubstituted pyridines,their preparation and pharmaceutical compositions containing them
PT89792A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem
PT89790A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem
FI945439A (fi) Uusia taksaanijohdannaisia, niiden valmistus ja niitä sisältävät koostumukset
IT8748689A0 (it) Derivati di azaspirodecano,loro sali,procedimento di preparazione,applicazione quali medicamenti e composizioni che li contengono
IT8548195A0 (it) Derivati della naftossazina, loro preparazione, loro applicazione come medicamenti e composizioni farmaceutiche che li contengono
PT89370A (pt) Processo para a preparacao de compostos derivados de mercapto-imidazolinas, dos seus intermedarios e de composicoes farmaceuticas contendo aqueles derivados
ES2016376B3 (es) Acido n,n-bis-(4-fluorofenil) carbamoilacetohidroxamico y composicion farmaceutica que lo contiene.
PT89791A (pt) Processo de preparacao de derivados da quinolina substituidos e de composicoes farmaceuticas que os contem
PT100949A (pt) Derivados de piridinol tri-substituidos e composicoes farmaceuticas, seu processo de preparacao e uso como medicamentos
PT89500A (pt) Processo para a preparacao de derivados de tetra-hidropiridina e de composicoes farmaceuticas que os contem
FR2583755B1 (fr) Derives de 10 a-methoxy-6-methyl-ergoline, leur preparation et leur application en tant que medicament
IT8522764A0 (it) Derivati di 4-ammino-butan-1,3-diolo, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
IT8619703A0 (it) Derivati della l-carnitina, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
PT89371A (pt) Processo de preparacao de 1-aralquil-1,2-di-hidropirimidina-2-tionas e de composicoes farmaceuticas que as contem

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19940103

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960731