HK6392A - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives Download PDF

Info

Publication number
HK6392A
HK6392A HK63/92A HK6392A HK6392A HK 6392 A HK6392 A HK 6392A HK 63/92 A HK63/92 A HK 63/92A HK 6392 A HK6392 A HK 6392A HK 6392 A HK6392 A HK 6392A
Authority
HK
Hong Kong
Prior art keywords
substd
alkyl
opt
aralkyl
cycloalkyl
Prior art date
Application number
HK63/92A
Other languages
English (en)
Inventor
G Saulnier Mark
D Senter Peter
F Kadow John
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK6392A publication Critical patent/HK6392A/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
HK63/92A 1987-08-04 1992-01-16 Podophyllotoxin derivatives HK6392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
HK6392A true HK6392A (en) 1992-01-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
HK63/92A HK6392A (en) 1987-08-04 1992-01-16 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD299067A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU208147B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK541288A3 (enExample)
YU (3) YU143688A (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
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IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
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US20050009759A1 (en) * 2001-10-26 2005-01-13 Claude Monneret Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
KR20110025885A (ko) 2002-07-15 2011-03-11 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도
WO2004060403A2 (en) * 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
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US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
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CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
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US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
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AU2012213080B2 (en) 2011-01-31 2014-03-27 Novartis Ag Novel heterocyclic derivatives
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
PL2771342T3 (pl) 2011-10-28 2016-11-30 Nowe pochodne puryny i ich zastosowanie w leczeniu chorób
WO2013085922A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
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Also Published As

Publication number Publication date
SE8802815D0 (sv) 1988-08-03
ES2010775A6 (es) 1989-12-01
FI883596A7 (fi) 1989-02-05
LU90138I2 (fr) 1997-11-26
US4904768A (en) 1990-02-27
GB2207674A (en) 1989-02-08
CN1027169C (zh) 1994-12-28
HU208147B (en) 1993-08-30
NL192683C (nl) 1997-12-02
CN1061225A (zh) 1992-05-20
CH676716A5 (enExample) 1991-02-28
NO920665D0 (no) 1992-02-20
YU10390A (en) 1990-06-30
IT1226825B (it) 1991-02-19
SE8802815L (sv) 1989-02-05
NO170284C (no) 1992-09-30
NZ225615A (en) 1991-06-25
AU2030688A (en) 1989-06-08
IT8821535A0 (it) 1988-07-28
NO883299L (no) 1989-02-24
BE1002982A4 (fr) 1991-10-15
IL87290A (en) 1993-01-31
MY104321A (en) 1994-03-31
AT398974B (de) 1995-02-27
HUT47303A (en) 1989-02-28
LU87290A1 (fr) 1990-02-07
GB8818462D0 (en) 1988-09-07
GB2207674B (en) 1991-09-11
FI883596A0 (fi) 1988-08-01
NO172440C (no) 1993-07-21
FR2622193B1 (fr) 1993-12-17
DK11992A (da) 1992-01-31
DK434088A (da) 1989-02-05
SK279325B6 (sk) 1998-10-07
DD299067A5 (de) 1992-03-26
DE3826562A1 (de) 1989-02-16
HU202547B (en) 1991-03-28
KR890003790A (ko) 1989-04-18
USRE35524E (en) 1997-06-03
PT88186A (pt) 1989-06-30
DD274423A5 (de) 1989-12-20
US5041424A (en) 1991-08-20
NO172440B (no) 1993-04-13
SG101291G (en) 1992-01-17
NO920277L (no) 1989-02-24
DK169344B1 (da) 1994-10-10
MX9202851A (es) 1992-06-30
JPH0699465B2 (ja) 1994-12-07
CY1625A (en) 1992-07-10
YU143688A (en) 1990-04-30
DE3826562C2 (enExample) 1993-04-08
SE502214C2 (sv) 1995-09-18
NO170284B (no) 1992-06-22
NL970042I2 (enExample) 2005-06-01
CZ541288A3 (cs) 1999-12-15
JPH01100188A (ja) 1989-04-18
GR880100512A (en) 1989-05-25
SK541288A3 (en) 1998-10-07
FI87790C (fi) 1993-02-25
PT88186B (pt) 1995-07-03
CZ286893B6 (cs) 2000-07-12
HU211960A9 (en) 1996-01-29
NO920277D0 (no) 1992-01-22
NL8801934A (nl) 1989-03-01
DK434088D0 (da) 1988-08-03
NL192683B (enExample) 1997-08-01
NL970042I1 (nl) 1998-03-02
ATA195588A (de) 1994-07-15
FI87790B (fi) 1992-11-13
IL87290A0 (en) 1989-01-31
NO1998002I1 (no) 1998-01-14
YU10490A (en) 1990-06-30
IE61040B1 (en) 1994-09-07
MX173843B (es) 1994-03-30
CA1310637C (en) 1992-11-24
DK11992D0 (da) 1992-01-31
NO920665L (no) 1989-02-24
KR900006230B1 (ko) 1990-08-27
NO883299D0 (no) 1988-07-26
AU610619B2 (en) 1991-05-23
IE882378L (en) 1989-02-04
GR1000490B (el) 1992-07-30
HU905862D0 (en) 1991-03-28
FR2622193A1 (fr) 1989-04-28

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Effective date: 20080802