FI87790C - Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt - Google Patents

Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt Download PDF

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Publication number
FI87790C
FI87790C FI883596A FI883596A FI87790C FI 87790 C FI87790 C FI 87790C FI 883596 A FI883596 A FI 883596A FI 883596 A FI883596 A FI 883596A FI 87790 C FI87790 C FI 87790C
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FI
Finland
Prior art keywords
formula
compound
alkyl
cycloalkyl
substituted
Prior art date
Application number
FI883596A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI87790B (fi
FI883596A0 (fi
FI883596A7 (fi
Inventor
John F Kadow
Mark G Saulnier
Peter D Senter
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of FI883596A0 publication Critical patent/FI883596A0/fi
Publication of FI883596A7 publication Critical patent/FI883596A7/fi
Application granted granted Critical
Publication of FI87790B publication Critical patent/FI87790B/fi
Publication of FI87790C publication Critical patent/FI87790C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Cable Accessories (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
FI883596A 1987-08-04 1988-08-01 Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt FI87790C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US8149387 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives
US19973188 1988-05-27

Publications (4)

Publication Number Publication Date
FI883596A0 FI883596A0 (fi) 1988-08-01
FI883596A7 FI883596A7 (fi) 1989-02-05
FI87790B FI87790B (fi) 1992-11-13
FI87790C true FI87790C (fi) 1993-02-25

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883596A FI87790C (fi) 1987-08-04 1988-08-01 Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD274423A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU208147B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK279325B6 (enExample)
YU (3) YU143688A (enExample)

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US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
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US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
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US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
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EP2281578A3 (en) 2002-07-15 2011-04-13 Board of Regents, The University of Texas System Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in treating viral infections and cancer
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Also Published As

Publication number Publication date
CH676716A5 (enExample) 1991-02-28
AT398974B (de) 1995-02-27
HK6392A (en) 1992-01-17
SK541288A3 (en) 1998-10-07
NO170284C (no) 1992-09-30
NO170284B (no) 1992-06-22
LU87290A1 (fr) 1990-02-07
CZ541288A3 (cs) 1999-12-15
IT1226825B (it) 1991-02-19
CZ286893B6 (cs) 2000-07-12
IT8821535A0 (it) 1988-07-28
NO1998002I1 (no) 1998-01-14
NL8801934A (nl) 1989-03-01
ATA195588A (de) 1994-07-15
IE882378L (en) 1989-02-04
MY104321A (en) 1994-03-31
KR890003790A (ko) 1989-04-18
NO920277D0 (no) 1992-01-22
JPH01100188A (ja) 1989-04-18
ES2010775A6 (es) 1989-12-01
YU143688A (en) 1990-04-30
NO883299D0 (no) 1988-07-26
US5041424A (en) 1991-08-20
DK11992A (da) 1992-01-31
IL87290A (en) 1993-01-31
DK434088D0 (da) 1988-08-03
YU10490A (en) 1990-06-30
DE3826562C2 (enExample) 1993-04-08
NL970042I1 (nl) 1998-03-02
GB8818462D0 (en) 1988-09-07
DK434088A (da) 1989-02-05
NO883299L (no) 1989-02-24
FR2622193B1 (fr) 1993-12-17
HU202547B (en) 1991-03-28
HU208147B (en) 1993-08-30
GB2207674B (en) 1991-09-11
FI87790B (fi) 1992-11-13
IL87290A0 (en) 1989-01-31
HUT47303A (en) 1989-02-28
US4904768A (en) 1990-02-27
NO920277L (no) 1989-02-24
NL192683C (nl) 1997-12-02
GB2207674A (en) 1989-02-08
HU905862D0 (en) 1991-03-28
AU610619B2 (en) 1991-05-23
GR1000490B (el) 1992-07-30
NO172440B (no) 1993-04-13
SE502214C2 (sv) 1995-09-18
FR2622193A1 (fr) 1989-04-28
LU90138I2 (fr) 1997-11-26
NO920665L (no) 1989-02-24
PT88186B (pt) 1995-07-03
BE1002982A4 (fr) 1991-10-15
MX173843B (es) 1994-03-30
SE8802815D0 (sv) 1988-08-03
DK11992D0 (da) 1992-01-31
DE3826562A1 (de) 1989-02-16
PT88186A (pt) 1989-06-30
YU10390A (en) 1990-06-30
KR900006230B1 (ko) 1990-08-27
GR880100512A (en) 1989-05-25
DD299067A5 (de) 1992-03-26
HU211960A9 (en) 1996-01-29
FI883596A0 (fi) 1988-08-01
SG101291G (en) 1992-01-17
USRE35524E (en) 1997-06-03
SE8802815L (sv) 1989-02-05
CY1625A (en) 1992-07-10
CA1310637C (en) 1992-11-24
DK169344B1 (da) 1994-10-10
DD274423A5 (de) 1989-12-20
CN1027169C (zh) 1994-12-28
NO172440C (no) 1993-07-21
NZ225615A (en) 1991-06-25
AU2030688A (en) 1989-06-08
MX9202851A (es) 1992-06-30
FI883596A7 (fi) 1989-02-05
NO920665D0 (no) 1992-02-20
SK279325B6 (sk) 1998-10-07
NL192683B (enExample) 1997-08-01
IE61040B1 (en) 1994-09-07
JPH0699465B2 (ja) 1994-12-07
CN1061225A (zh) 1992-05-20
NL970042I2 (enExample) 2005-06-01

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Spc suppl protection certif: L74

Extension date: 20110412

FG Patent granted

Owner name: BRISTOL-MYERS SQUIBB COMPANY

MA Patent expired