FI87790C - Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt - Google Patents

Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt Download PDF

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Publication number
FI87790C
FI87790C FI883596A FI883596A FI87790C FI 87790 C FI87790 C FI 87790C FI 883596 A FI883596 A FI 883596A FI 883596 A FI883596 A FI 883596A FI 87790 C FI87790 C FI 87790C
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FI
Finland
Prior art keywords
formula
compound
alkyl
cycloalkyl
substituted
Prior art date
Application number
FI883596A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI883596A7 (fi
FI883596A0 (fi
FI87790B (fi
Inventor
John F Kadow
Mark G Saulnier
Peter D Senter
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of FI883596A0 publication Critical patent/FI883596A0/fi
Publication of FI883596A7 publication Critical patent/FI883596A7/fi
Application granted granted Critical
Publication of FI87790B publication Critical patent/FI87790B/fi
Publication of FI87790C publication Critical patent/FI87790C/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
FI883596A 1987-08-04 1988-08-01 Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt FI87790C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US8149387 1987-08-04
US19973188 1988-05-27
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (4)

Publication Number Publication Date
FI883596A0 FI883596A0 (fi) 1988-08-01
FI883596A7 FI883596A7 (fi) 1989-02-05
FI87790B FI87790B (fi) 1992-11-13
FI87790C true FI87790C (fi) 1993-02-25

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
FI883596A FI87790C (fi) 1987-08-04 1988-08-01 Foerfarande foer framstaellning av epipodofyllotoxinglukosid-4'-fosfatderivat med antitumoer effekt

Country Status (34)

Country Link
US (3) US4904768A (enExample)
JP (1) JPH0699465B2 (enExample)
KR (1) KR900006230B1 (enExample)
CN (1) CN1027169C (enExample)
AT (1) AT398974B (enExample)
BE (1) BE1002982A4 (enExample)
CA (1) CA1310637C (enExample)
CH (1) CH676716A5 (enExample)
CY (1) CY1625A (enExample)
CZ (1) CZ286893B6 (enExample)
DD (2) DD299067A5 (enExample)
DE (1) DE3826562A1 (enExample)
DK (2) DK169344B1 (enExample)
ES (1) ES2010775A6 (enExample)
FI (1) FI87790C (enExample)
FR (1) FR2622193B1 (enExample)
GB (1) GB2207674B (enExample)
GR (1) GR1000490B (enExample)
HK (1) HK6392A (enExample)
HU (3) HU208147B (enExample)
IE (1) IE61040B1 (enExample)
IL (1) IL87290A (enExample)
IT (1) IT1226825B (enExample)
LU (2) LU87290A1 (enExample)
MX (1) MX173843B (enExample)
MY (1) MY104321A (enExample)
NL (2) NL192683C (enExample)
NO (4) NO170284C (enExample)
NZ (1) NZ225615A (enExample)
PT (1) PT88186B (enExample)
SE (1) SE502214C2 (enExample)
SG (1) SG101291G (enExample)
SK (1) SK541288A3 (enExample)
YU (3) YU143688A (enExample)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
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IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
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EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
US20050009759A1 (en) * 2001-10-26 2005-01-13 Claude Monneret Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
KR20110025885A (ko) 2002-07-15 2011-03-11 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 포스파티딜에탄올아민에 결합하는 펩타이드, 및 바이러스 감염을 치료하는데 있어서 이의 용도
WO2004060403A2 (en) * 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
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US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
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CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
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US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CA2705152C (en) 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
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CN102510759A (zh) 2009-04-20 2012-06-20 安吉奥开米公司 利用与血管肽-2类似物结合的抗癌剂治疗卵巢癌
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CN102762565A (zh) 2010-02-22 2012-10-31 弗·哈夫曼-拉罗切有限公司 吡啶并[3,2-d]嘧啶PI3δ抑制剂化合物及使用方法
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
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US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
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JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
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Also Published As

Publication number Publication date
SE8802815D0 (sv) 1988-08-03
ES2010775A6 (es) 1989-12-01
FI883596A7 (fi) 1989-02-05
LU90138I2 (fr) 1997-11-26
US4904768A (en) 1990-02-27
GB2207674A (en) 1989-02-08
CN1027169C (zh) 1994-12-28
HU208147B (en) 1993-08-30
NL192683C (nl) 1997-12-02
CN1061225A (zh) 1992-05-20
CH676716A5 (enExample) 1991-02-28
NO920665D0 (no) 1992-02-20
YU10390A (en) 1990-06-30
IT1226825B (it) 1991-02-19
SE8802815L (sv) 1989-02-05
NO170284C (no) 1992-09-30
NZ225615A (en) 1991-06-25
AU2030688A (en) 1989-06-08
IT8821535A0 (it) 1988-07-28
NO883299L (no) 1989-02-24
BE1002982A4 (fr) 1991-10-15
IL87290A (en) 1993-01-31
MY104321A (en) 1994-03-31
AT398974B (de) 1995-02-27
HUT47303A (en) 1989-02-28
LU87290A1 (fr) 1990-02-07
GB8818462D0 (en) 1988-09-07
GB2207674B (en) 1991-09-11
FI883596A0 (fi) 1988-08-01
NO172440C (no) 1993-07-21
FR2622193B1 (fr) 1993-12-17
DK11992A (da) 1992-01-31
DK434088A (da) 1989-02-05
SK279325B6 (sk) 1998-10-07
DD299067A5 (de) 1992-03-26
DE3826562A1 (de) 1989-02-16
HU202547B (en) 1991-03-28
KR890003790A (ko) 1989-04-18
USRE35524E (en) 1997-06-03
PT88186A (pt) 1989-06-30
DD274423A5 (de) 1989-12-20
US5041424A (en) 1991-08-20
NO172440B (no) 1993-04-13
HK6392A (en) 1992-01-17
SG101291G (en) 1992-01-17
NO920277L (no) 1989-02-24
DK169344B1 (da) 1994-10-10
MX9202851A (es) 1992-06-30
JPH0699465B2 (ja) 1994-12-07
CY1625A (en) 1992-07-10
YU143688A (en) 1990-04-30
DE3826562C2 (enExample) 1993-04-08
SE502214C2 (sv) 1995-09-18
NO170284B (no) 1992-06-22
NL970042I2 (enExample) 2005-06-01
CZ541288A3 (cs) 1999-12-15
JPH01100188A (ja) 1989-04-18
GR880100512A (en) 1989-05-25
SK541288A3 (en) 1998-10-07
PT88186B (pt) 1995-07-03
CZ286893B6 (cs) 2000-07-12
HU211960A9 (en) 1996-01-29
NO920277D0 (no) 1992-01-22
NL8801934A (nl) 1989-03-01
DK434088D0 (da) 1988-08-03
NL192683B (enExample) 1997-08-01
NL970042I1 (nl) 1998-03-02
ATA195588A (de) 1994-07-15
FI87790B (fi) 1992-11-13
IL87290A0 (en) 1989-01-31
NO1998002I1 (no) 1998-01-14
YU10490A (en) 1990-06-30
IE61040B1 (en) 1994-09-07
MX173843B (es) 1994-03-30
CA1310637C (en) 1992-11-24
DK11992D0 (da) 1992-01-31
NO920665L (no) 1989-02-24
KR900006230B1 (ko) 1990-08-27
NO883299D0 (no) 1988-07-26
AU610619B2 (en) 1991-05-23
IE882378L (en) 1989-02-04
GR1000490B (el) 1992-07-30
HU905862D0 (en) 1991-03-28
FR2622193A1 (fr) 1989-04-28

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Spc suppl protection certif: L74

Extension date: 20110412

FG Patent granted

Owner name: BRISTOL-MYERS SQUIBB COMPANY

MA Patent expired