ES2180757T3 - Sintesis enzimatica mejorada de oligosacaridos. - Google Patents
Sintesis enzimatica mejorada de oligosacaridos.Info
- Publication number
- ES2180757T3 ES2180757T3 ES96911628T ES96911628T ES2180757T3 ES 2180757 T3 ES2180757 T3 ES 2180757T3 ES 96911628 T ES96911628 T ES 96911628T ES 96911628 T ES96911628 T ES 96911628T ES 2180757 T3 ES2180757 T3 ES 2180757T3
- Authority
- ES
- Spain
- Prior art keywords
- oligosacarids
- enzymatic synthesis
- improved
- synthesis improved
- sialyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
LA PRESENTE INVENCION PROPORCIONA METODOS MEJORADOS PARA LA PREPARACION DE GALACTOSIDOS DE SIALILO. LOS METODOS UTILIZAN UN CICLO DE SIALIL TRANSFERASA EN EL QUE LAS CONDICIONES DE REACCION ESTAN OPTIMIZADAS PARA PROPORCIONAR RENDIMIENTOS AUMENTADOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/419,659 US5876980A (en) | 1995-04-11 | 1995-04-11 | Enzymatic synthesis of oligosaccharides |
US103595P | 1995-07-11 | 1995-07-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2180757T3 true ES2180757T3 (es) | 2003-02-16 |
Family
ID=26668454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96911628T Expired - Lifetime ES2180757T3 (es) | 1995-04-11 | 1996-04-10 | Sintesis enzimatica mejorada de oligosacaridos. |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0820520B1 (es) |
JP (1) | JPH11503328A (es) |
AT (1) | ATE222294T1 (es) |
AU (1) | AU5445396A (es) |
DE (1) | DE69623005T2 (es) |
DK (1) | DK0820520T3 (es) |
ES (1) | ES2180757T3 (es) |
WO (1) | WO1996032492A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888984A (en) * | 1994-05-12 | 1999-03-30 | Dermal Research Laboratories, Inc. | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
US6030815A (en) * | 1995-04-11 | 2000-02-29 | Neose Technologies, Inc. | Enzymatic synthesis of oligosaccharides |
US5922577A (en) * | 1995-04-11 | 1999-07-13 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
WO1997037682A1 (en) * | 1996-04-10 | 1997-10-16 | Cytel Corporation | Nucleic acids encoding gdp-fucose pyrophosphorylase |
JP2001507215A (ja) * | 1997-01-16 | 2001-06-05 | サイテル コーポレイション | 組換え糖タンパク質のインビトロでの実用的なシアリル化 |
US6323008B1 (en) | 1997-08-14 | 2001-11-27 | Neose Technologies, Inc. | Methods for producing sialyloligosaccharides in a dairy source |
AU2745700A (en) | 1999-02-01 | 2000-08-18 | Dermal Research Laboratories, Inc. | A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same |
US20010051349A1 (en) | 2000-02-17 | 2001-12-13 | Glycominds Ltd. | Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof |
US7879824B2 (en) | 2001-07-31 | 2011-02-01 | Dermal Research Laboratories, Inc. | Methods of preventing or treating diseases and conditions using complex carbohydrates |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
CN100413974C (zh) | 2002-07-18 | 2008-08-27 | 雅玛山酱油株式会社 | Cmp-n-乙酰神经氨酸的制造方法 |
EP2055189A1 (en) | 2003-04-09 | 2009-05-06 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
JP5140242B2 (ja) * | 2003-09-26 | 2013-02-06 | ヤマサ醤油株式会社 | Cmp−n−アセチルノイラミン酸の製造法 |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
DK2586456T3 (en) | 2004-10-29 | 2016-03-21 | Ratiopharm Gmbh | Conversion and glycopegylation of fibroblast growth factor (FGF) |
EP1858543B1 (en) | 2005-01-10 | 2013-11-27 | BioGeneriX AG | Glycopegylated granulocyte colony stimulating factor |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
EP2049144B8 (en) | 2006-07-21 | 2015-02-18 | ratiopharm GmbH | Glycosylation of peptides via o-linked glycosylation sequences |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
PL2144923T3 (pl) | 2007-04-03 | 2013-12-31 | Biogenerix Ag | Sposoby leczenia z użyciem glikopegilowanego G-CSF |
US9493499B2 (en) | 2007-06-12 | 2016-11-15 | Novo Nordisk A/S | Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography |
RU2573587C2 (ru) | 2008-02-27 | 2016-01-20 | Ново Нордиск А/С | Конъюгированные молекулы фактора viii |
JP2013531049A (ja) * | 2010-07-16 | 2013-08-01 | グリコム アー/エス | オリゴ糖の誘導体化 |
AU2012232727A1 (en) * | 2011-03-18 | 2013-09-26 | Glycom A/S | Synthesis of new fucose-containing carbohydrate derivatives |
AU2012257395A1 (en) * | 2011-05-13 | 2013-12-12 | Glycom A/S | Method for generating human milk oligosaccharides (HMOs) or precursors thereof |
EP2522232A1 (en) | 2011-05-13 | 2012-11-14 | Nestec S.A. | Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof |
KR20140036226A (ko) | 2011-05-13 | 2014-03-25 | 글리콤 에이/에스 | 모유 올리고사카라이드(hmo) 또는 그의 전구체의 다양화 |
WO2013190531A1 (en) * | 2012-06-22 | 2013-12-27 | Glycom A/S | Glycosylated galactosyl disaccharides, methods for their production and their use in consumable products |
WO2013190529A1 (en) * | 2012-06-22 | 2013-12-27 | Glycom A/S | Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products |
KR101525230B1 (ko) * | 2013-05-31 | 2015-06-01 | 주식회사 진켐 | 시알산 유도체의 제조방법 |
US10899782B2 (en) | 2016-03-07 | 2021-01-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
WO2019003135A1 (en) | 2017-06-30 | 2019-01-03 | Glycom A/S | PURIFICATION OF OLIGOSACCHARIDES |
EP3456836A1 (en) | 2017-09-13 | 2019-03-20 | Glycom A/S | Separation of sialylated oligosaccharides from fermentation broth |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5409817A (en) * | 1993-05-04 | 1995-04-25 | Cytel, Inc. | Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides |
US5374541A (en) * | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
-
1996
- 1996-04-10 ES ES96911628T patent/ES2180757T3/es not_active Expired - Lifetime
- 1996-04-10 DE DE69623005T patent/DE69623005T2/de not_active Expired - Fee Related
- 1996-04-10 WO PCT/US1996/004790 patent/WO1996032492A1/en active IP Right Grant
- 1996-04-10 AT AT96911628T patent/ATE222294T1/de not_active IP Right Cessation
- 1996-04-10 AU AU54453/96A patent/AU5445396A/en not_active Abandoned
- 1996-04-10 JP JP8531084A patent/JPH11503328A/ja active Pending
- 1996-04-10 DK DK96911628T patent/DK0820520T3/da active
- 1996-04-10 EP EP96911628A patent/EP0820520B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH11503328A (ja) | 1999-03-26 |
DK0820520T3 (da) | 2002-12-02 |
EP0820520B1 (en) | 2002-08-14 |
ATE222294T1 (de) | 2002-08-15 |
DE69623005T2 (de) | 2003-04-03 |
DE69623005D1 (de) | 2002-09-19 |
WO1996032492A1 (en) | 1996-10-17 |
AU5445396A (en) | 1996-10-30 |
EP0820520A1 (en) | 1998-01-28 |
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