DK0820520T3 - Forbedret enzymatisk syntese af oliogosaccharider - Google Patents

Forbedret enzymatisk syntese af oliogosaccharider

Info

Publication number
DK0820520T3
DK0820520T3 DK96911628T DK96911628T DK0820520T3 DK 0820520 T3 DK0820520 T3 DK 0820520T3 DK 96911628 T DK96911628 T DK 96911628T DK 96911628 T DK96911628 T DK 96911628T DK 0820520 T3 DK0820520 T3 DK 0820520T3
Authority
DK
Denmark
Prior art keywords
oliogosaccharides
enzymatic synthesis
enhanced enzymatic
sialyl
enhanced
Prior art date
Application number
DK96911628T
Other languages
English (en)
Inventor
Shawn Defrees
Robert J Bayer
Murray Ratcliffe
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/419,659 external-priority patent/US5876980A/en
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of DK0820520T3 publication Critical patent/DK0820520T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
DK96911628T 1995-04-11 1996-04-10 Forbedret enzymatisk syntese af oliogosaccharider DK0820520T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/419,659 US5876980A (en) 1995-04-11 1995-04-11 Enzymatic synthesis of oligosaccharides
US103595P 1995-07-11 1995-07-11
PCT/US1996/004790 WO1996032492A1 (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Publications (1)

Publication Number Publication Date
DK0820520T3 true DK0820520T3 (da) 2002-12-02

Family

ID=26668454

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96911628T DK0820520T3 (da) 1995-04-11 1996-04-10 Forbedret enzymatisk syntese af oliogosaccharider

Country Status (8)

Country Link
EP (1) EP0820520B1 (da)
JP (1) JPH11503328A (da)
AT (1) ATE222294T1 (da)
AU (1) AU5445396A (da)
DE (1) DE69623005T2 (da)
DK (1) DK0820520T3 (da)
ES (1) ES2180757T3 (da)
WO (1) WO1996032492A1 (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5922577A (en) * 1995-04-11 1999-07-13 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6033663A (en) * 1996-04-10 2000-03-07 Neose Technologies, Inc. Nucleic acids encoding GDP-Fucose pyrophosphorylase
JP2001507215A (ja) * 1997-01-16 2001-06-05 サイテル コーポレイション 組換え糖タンパク質のインビトロでの実用的なシアリル化
US6323008B1 (en) 1997-08-14 2001-11-27 Neose Technologies, Inc. Methods for producing sialyloligosaccharides in a dairy source
CA2361268C (en) * 1999-02-01 2014-06-10 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
KR100922085B1 (ko) 2002-07-18 2009-10-16 야마사 쇼유 가부시키가이샤 Ｃｍｐ-ｎ-아세틸뉴라민산의 제조 방법
EP1615945B1 (en) 2003-04-09 2011-09-28 BioGeneriX AG Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
JP5140242B2 (ja) * 2003-09-26 2013-02-06 ヤマサ醤油株式会社 Ｃｍｐ−ｎ−アセチルノイラミン酸の製造法
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
EP1814573B1 (en) 2004-10-29 2016-03-09 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
MX2007008229A (es) 2005-01-10 2007-09-11 Neose Technologies Inc Factor estimulador de colonias de granulocitos glicopegilado.
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
CN101516388B (zh) 2006-07-21 2012-10-31 诺和诺德公司 通过o-联糖基化序列的肽的糖基化
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
PL2144923T3 (pl) 2007-04-03 2013-12-31 Biogenerix Ag Sposoby leczenia z użyciem glikopegilowanego G-CSF
EP2170919B8 (en) 2007-06-12 2016-01-20 ratiopharm GmbH Improved process for the production of nucleotide sugars
DK2257311T3 (da) 2008-02-27 2014-06-30 Novo Nordisk As Konjugerede Faktor VIII-Molekyler
KR20140011296A (ko) 2010-07-16 2014-01-28 글리콤 에이/에스 올리고당의 유도체화
CA2830025A1 (en) * 2011-03-18 2012-09-27 Glycom A/S Synthesis of new fucose-containing carbohydrate derivatives
RU2013155452A (ru) * 2011-05-13 2015-06-20 Глюком А/С СПОСОБ ПОЛУЧЕНИЯ МОЛОЧНЫХ ОЛИГОСАХАРИДОВ ЧЕЛОВЕКА (HMOs) ИЛИ ИХ ПРЕДШЕСТВЕННИКОВ
EP2522232A1 (en) 2011-05-13 2012-11-14 Nestec S.A. Nutritional products comprising human milk oligosaccharides and methods for manufacture thereof
EP3744725A1 (en) 2011-05-13 2020-12-02 Glycom A/S Diversification of human milk oligosaccharides (hmos) or precursors thereof
WO2013190529A1 (en) * 2012-06-22 2013-12-27 Glycom A/S Glycosylated galactosyl disaccharddes, methods for their production and their use in consumable products
EP2864344A4 (en) * 2012-06-22 2015-12-23 Glycom As GALACTOSYL GLYCOSYLATED DISACCHARIDES, PROCESSES FOR THEIR PRODUCTION AND USE THEREOF IN CONSUMABLE PRODUCTS
KR101525230B1 (ko) * 2013-05-31 2015-06-01 주식회사 진켐 시알산 유도체의 제조방법
EP3426670A4 (en) 2016-03-07 2019-11-13 Glycom A/S SEPARATION OF OLIGOSACCHARIDES FROM A FERMENTATION BROTH
EP3645545A4 (en) 2017-06-30 2021-05-05 Glycom A/S PURIFICATION OF OLIGOSACCHARIDES
EP3456836A1 (en) 2017-09-13 2019-03-20 Glycom A/S Separation of sialylated oligosaccharides from fermentation broth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409817A (en) * 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
US5374541A (en) * 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides

Also Published As

Publication number Publication date
EP0820520A1 (en) 1998-01-28
DE69623005D1 (de) 2002-09-19
EP0820520B1 (en) 2002-08-14
WO1996032492A1 (en) 1996-10-17
ATE222294T1 (de) 2002-08-15
JPH11503328A (ja) 1999-03-26
DE69623005T2 (de) 2003-04-03
AU5445396A (en) 1996-10-30
ES2180757T3 (es) 2003-02-16

Similar Documents

Publication Publication Date Title
DK0820520T3 (da) Forbedret enzymatisk syntese af oliogosaccharider
DE69611442D1 (de) Enzymatische synthese von glykosidischen verbindungen
ZA200002263B (en) Process for the synthesis of nucleoside analogs.
MXPA05000872A (es) Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas.
DE69713887D1 (de) Herstellung von verzweigten tensiden
ATE308550T1 (de) Verwendungen von sulfatierten fuko- oligosacchariden zum pflanzenschutz
ES2105698T3 (es) Oligonucleotidos modificados con 7-deazapurina.
IL150257A0 (en) Galactomaninan oligosaccharides, pharmaceutical compositions containing the same and methods for the production thereof
DK1083903T3 (da) Brobundne indenopyrrolocarbazoler
ZA9811833B (en) Pharmaceutical compositions of uridine triphosphate.
ITTO960495A0 (it) Procedimento per accrescere il flusso per elettrotrasporto di polipep-tidi.
UA66866C2 (uk) Синтез морфолінових похідних
DK1140933T3 (da) Fremgangsmåde til fremstilling af N6-substituerede deaza-adenosinderivater
DK0927766T3 (da) Enzymatisk fremgangsmåde til fremstilling af (S)-cyanhydriner
ATE292676T1 (de) Varianten der cyclomaltodextrin glucanotransferase
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona
DE59803066D1 (de) Substituierte benzyloxyimino-verbindungen
YU1500A (sh) Postupak za dobijanje aminskih derivata alkiloksifuranona, dobijena jedinjenja i korišćenje ovih jedinjenja
CA2218120A1 (en) Improved enzymatic synthesis of oligosaccharides
DK1019521T3 (da) Fremgangsmåde til biotransformation af colchiconforbindelser til de tilsvarende 3-glycosylderivater
MX9704836A (es) Proceso para la fabricaciom de acetonilbenzamidas.
ES2183543T3 (es) Derivado de tiocolchicosida, su preparacion y su aplicacion en terapeutica.
ATE399211T1 (de) Enzymatische synthese von gangliosiden
DK0857720T3 (da) Fremgangsmåde til syntese af desoxypyridinolin
HN1998000164A (es) Procedimiento de sintesis de pirrol amidas