CA2218120A1 - Improved enzymatic synthesis of oligosaccharides - Google Patents

Improved enzymatic synthesis of oligosaccharides

Info

Publication number
CA2218120A1
CA2218120A1 CA002218120A CA2218120A CA2218120A1 CA 2218120 A1 CA2218120 A1 CA 2218120A1 CA 002218120 A CA002218120 A CA 002218120A CA 2218120 A CA2218120 A CA 2218120A CA 2218120 A1 CA2218120 A1 CA 2218120A1
Authority
CA
Canada
Prior art keywords
oligosaccharides
enzymatic synthesis
improved enzymatic
sialyl
improved
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002218120A
Other languages
French (fr)
Other versions
CA2218120C (en
Inventor
Shawn Defrees
Robert J. Bayer
Murray Ratcliffe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neose Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/419,659 external-priority patent/US5876980A/en
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1996/004790 external-priority patent/WO1996032492A1/en
Publication of CA2218120A1 publication Critical patent/CA2218120A1/en
Application granted granted Critical
Publication of CA2218120C publication Critical patent/CA2218120C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

The present invention provides improved methods for the preparation of sialyl galactosides. The methods use sialyl transferase cycle in which the reaction conditions are optimized to provide increased yields.
CA002218120A 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides Expired - Fee Related CA2218120C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/419,659 1995-04-11
US08/419,659 US5876980A (en) 1995-04-11 1995-04-11 Enzymatic synthesis of oligosaccharides
US103595P 1995-07-11 1995-07-11
US60/001,035 1995-07-11
PCT/US1996/004790 WO1996032492A1 (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Publications (2)

Publication Number Publication Date
CA2218120A1 true CA2218120A1 (en) 1996-10-17
CA2218120C CA2218120C (en) 2008-09-16

Family

ID=39760958

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002218120A Expired - Fee Related CA2218120C (en) 1995-04-11 1996-04-10 Improved enzymatic synthesis of oligosaccharides

Country Status (1)

Country Link
CA (1) CA2218120C (en)

Also Published As

Publication number Publication date
CA2218120C (en) 2008-09-16

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Legal Events

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MKLA Lapsed