AU3143695A - Improved methods of detritylation for oligonucleotide synthesis - Google Patents

Improved methods of detritylation for oligonucleotide synthesis

Info

Publication number
AU3143695A
AU3143695A AU31436/95A AU3143695A AU3143695A AU 3143695 A AU3143695 A AU 3143695A AU 31436/95 A AU31436/95 A AU 31436/95A AU 3143695 A AU3143695 A AU 3143695A AU 3143695 A AU3143695 A AU 3143695A
Authority
AU
Australia
Prior art keywords
detritylation
improved methods
oligonucleotide synthesis
oligonucleotide
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31436/95A
Inventor
Sudhir Agrawal
Ivan Habus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of AU3143695A publication Critical patent/AU3143695A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
AU31436/95A 1994-07-25 1995-07-24 Improved methods of detritylation for oligonucleotide synthesis Abandoned AU3143695A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27951794A 1994-07-25 1994-07-25
US279517 1994-07-25
PCT/US1995/009322 WO1996003417A1 (en) 1994-07-25 1995-07-24 Improved methods of detritylation for oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
AU3143695A true AU3143695A (en) 1996-02-22

Family

ID=23069337

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31436/95A Abandoned AU3143695A (en) 1994-07-25 1995-07-24 Improved methods of detritylation for oligonucleotide synthesis

Country Status (2)

Country Link
AU (1) AU3143695A (en)
WO (1) WO1996003417A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399765B1 (en) * 1999-03-17 2002-06-04 Isis Pharmaceuticals, Inc. Methods for removing dimethoxytrityl groups from oligonucleotides
US6664388B2 (en) 2001-03-08 2003-12-16 Applera Corporation Reagents for oligonucleotide cleavage and deprotection
US10539561B1 (en) 2001-08-30 2020-01-21 Customarray, Inc. Enzyme-amplified redox microarray detection process
US20060102471A1 (en) 2004-11-18 2006-05-18 Karl Maurer Electrode array device having an adsorbed porous reaction layer
US20070034513A1 (en) 2005-03-25 2007-02-15 Combimatrix Corporation Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
WO2007040500A1 (en) * 2005-09-23 2007-04-12 Agilent Techologies, Inc. Methods for in situ generation of nucleic acid molecules
US8855955B2 (en) 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
WO2012157723A1 (en) 2011-05-17 2012-11-22 味の素株式会社 Method for producing oligonucleotide
WO2015061246A1 (en) * 2013-10-21 2015-04-30 Isis Pharmaceuticals, Inc. Method for solution phase detritylation of oligomeric compounds
EP4161942B1 (en) 2021-03-19 2023-08-02 Bachem Holding AG Improved oligonucleotide synthesis suppressing depurination
WO2024061842A1 (en) 2022-09-19 2024-03-28 Bachem Holding Ag Improved oligonucleotide synthesis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3433649A1 (en) * 1984-09-13 1986-03-20 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig METHOD FOR PURIFYING SYNTHETIC OLIGONUCLEOTIDES
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US5149798A (en) * 1989-04-06 1992-09-22 Worcester Foundation For Experimental Biology Process for synthesizing oligonucleotides and their analogs adaptable to large scale syntheses
US5264562A (en) * 1989-10-24 1993-11-23 Gilead Sciences, Inc. Oligonucleotide analogs with novel linkages

Also Published As

Publication number Publication date
WO1996003417A1 (en) 1996-02-08

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