AU5958196A - Novel base protecting groups for oligonucleotide synthesis - Google Patents

Novel base protecting groups for oligonucleotide synthesis

Info

Publication number
AU5958196A
AU5958196A AU59581/96A AU5958196A AU5958196A AU 5958196 A AU5958196 A AU 5958196A AU 59581/96 A AU59581/96 A AU 59581/96A AU 5958196 A AU5958196 A AU 5958196A AU 5958196 A AU5958196 A AU 5958196A
Authority
AU
Australia
Prior art keywords
protecting groups
oligonucleotide synthesis
novel base
base protecting
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU59581/96A
Inventor
Sudhir Agrawal
Theresa Devlin
Ivan Habus
Nan-Hui Ho
Radhakrishnan P Iyer
Dong Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/518,921 external-priority patent/US5614622A/en
Priority claimed from US08/519,318 external-priority patent/US6140482A/en
Priority claimed from US08/570,390 external-priority patent/US5955599A/en
Priority claimed from US08/598,320 external-priority patent/US6531589B1/en
Priority claimed from US08/606,915 external-priority patent/US5962674A/en
Application filed by Hybridon Inc filed Critical Hybridon Inc
Publication of AU5958196A publication Critical patent/AU5958196A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU59581/96A 1995-06-01 1996-05-31 Novel base protecting groups for oligonucleotide synthesis Abandoned AU5958196A (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US45719895A 1995-06-01 1995-06-01
US457198 1995-06-01
US518921 1995-08-24
US08/518,921 US5614622A (en) 1995-06-01 1995-08-24 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
US08/519,318 US6140482A (en) 1995-06-01 1995-08-25 Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same
US519318 1995-08-25
US08/570,390 US5955599A (en) 1995-06-01 1995-12-11 Process for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkages
US570390 1995-12-11
US598320 1996-02-08
US08/598,320 US6531589B1 (en) 1995-06-01 1996-02-08 Base protecting groups and synthons for oligonucleotide synthesis
US606915 1996-02-26
US08/606,915 US5962674A (en) 1995-06-01 1996-02-26 Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
PCT/US1996/008136 WO1996039414A1 (en) 1995-06-01 1996-05-31 Novel base protecting groups for oligonucleotide synthesis

Publications (1)

Publication Number Publication Date
AU5958196A true AU5958196A (en) 1996-12-24

Family

ID=23815816

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59581/96A Abandoned AU5958196A (en) 1995-06-01 1996-05-31 Novel base protecting groups for oligonucleotide synthesis

Country Status (2)

Country Link
AU (1) AU5958196A (en)
WO (1) WO1996039414A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509459B1 (en) 1995-06-01 2003-01-21 Hybridon, Inc. Base protecting groups and rapid process for oligonucleotide synthesis
WO1998033806A1 (en) * 1997-02-04 1998-08-06 Hybridon, Inc. Base protecting groups and process for oligonucleotide synthesis
DE19741715A1 (en) 1997-09-22 1999-03-25 Hoechst Ag New pentopyranosyl nucleoside compounds
DE19741738A1 (en) * 1997-09-22 1999-03-25 Hoechst Ag Linker nucleoside(s) containing alkenyloxy or phthalimido-alkyl groups
CA2357986C (en) * 1998-12-30 2014-02-11 Oligos Etc. Inc. Acid stable backbone modified end-blocked nucleic acids and therapeutic uses thereof
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
ATE538216T1 (en) * 2006-07-31 2012-01-15 Wanli Bi NUCLEIC ACID AMPLIFICATION USING A REVERSIBLY MODIFIED OLIGONUCLEOTIDE
US8785409B2 (en) 2007-01-30 2014-07-22 Geron Corporation Compounds having anti-adhesive effects on cancer cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
NL8700724A (en) * 1987-03-27 1988-10-17 Univ Eindhoven Tech POLY (DEOXYRIBONUCLEOTIDES), PHARMACEUTICAL COMPOSITIONS, USE AND PREPARATION OF THE POLY (DEOXYRIBONUCLEOTIDES).
DE69232699T2 (en) * 1991-10-15 2003-02-06 Isis Pharmaceutical Inc OLIGONUCLEOTIDES BONDED BY CHIRAL PHOSPHORATOMES

Also Published As

Publication number Publication date
WO1996039414A1 (en) 1996-12-12

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