AU5381696A - Synthesis of bis-indolylmaleimides - Google Patents

Synthesis of bis-indolylmaleimides

Info

Publication number
AU5381696A
AU5381696A AU53816/96A AU5381696A AU5381696A AU 5381696 A AU5381696 A AU 5381696A AU 53816/96 A AU53816/96 A AU 53816/96A AU 5381696 A AU5381696 A AU 5381696A AU 5381696 A AU5381696 A AU 5381696A
Authority
AU
Australia
Prior art keywords
indolylmaleimides
bis
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU53816/96A
Inventor
James R. Gillig
Michael R. Jirousek
Upinder Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of AU5381696A publication Critical patent/AU5381696A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
AU53816/96A 1995-03-30 1996-03-27 Synthesis of bis-indolylmaleimides Abandoned AU5381696A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US413311 1989-09-27
US08/413,311 US5559228A (en) 1995-03-30 1995-03-30 Synthesis of bisindolylmaleimides
PCT/US1996/004437 WO1996030348A1 (en) 1995-03-30 1996-03-27 Synthesis of bis-indolylmaleimides

Publications (1)

Publication Number Publication Date
AU5381696A true AU5381696A (en) 1996-10-16

Family

ID=23636755

Family Applications (1)

Application Number Title Priority Date Filing Date
AU53816/96A Abandoned AU5381696A (en) 1995-03-30 1996-03-27 Synthesis of bis-indolylmaleimides

Country Status (6)

Country Link
US (1) US5559228A (en)
EP (1) EP0820446A4 (en)
JP (1) JP3014146B2 (en)
AU (1) AU5381696A (en)
CA (1) CA2216633C (en)
WO (1) WO1996030348A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725582B2 (en) * 1996-06-13 2000-10-12 Eli Lilly And Company Therapeutic treatment for cardiovascular diseases

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL124415A (en) * 1995-11-20 2003-11-23 Lilly Co Eli N, n'-bridged bisindolylmaleimides, their preparation and pharmaceutical compositions containing them
TR199802193T2 (en) * 1996-05-01 1999-02-22 Eli Lilly And Company Halo-Substituted Protein Kinase C Inhibitors.
EA001392B1 (en) * 1996-08-23 2001-02-26 Эли Лилли Энд Компани Synthesis of bisindolylmalimides
US6225301B1 (en) 1998-03-05 2001-05-01 Eli Lilly And Company Therapeutic treatment for renal dysfunction
US6103712A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for asthma
US6103713A (en) * 1998-03-05 2000-08-15 Eli Lilly And Company Therapeutic treatment for autoimmune diseases
US6291446B1 (en) 1998-03-05 2001-09-18 Eli Lilly And Company Therapeutic treatment for cytomegalovirus infection
GB0303319D0 (en) * 2003-02-13 2003-03-19 Novartis Ag Organic compounds
WO2006078421A2 (en) * 2005-01-04 2006-07-27 The Board Of Trustees Of The Leland Stanford Junior University Methods of increasing cerebral blood flow
RU2547148C2 (en) 2005-02-09 2015-04-10 Аркьюл, Инк. Compositions and methods of treating cancer
US8513292B2 (en) * 2007-06-22 2013-08-20 Arqule, Inc. Compositions and methods for the treatment of cancer
JP5425060B2 (en) * 2007-06-22 2014-02-26 アークル インコーポレイテッド Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for the treatment of cancer
CA2704282A1 (en) * 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
MX2019007354A (en) 2016-12-19 2019-10-21 Chromaderm Inc Methods of treating hyperpigmentation disorders.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
DE3914764A1 (en) * 1989-05-05 1990-11-08 Goedecke Ag New bis(1H-indol-3-yl) maleinimide derivs. - are inhibitors of protein kinase C for treatment of cardiovascular, CNS and immune system disorders
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (en) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh NEW TRISUBSTITUTED PYRROLE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE4005970A1 (en) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh NEW TRISUBSTITUTED MALEINIMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
GB9123396D0 (en) * 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
AU5100393A (en) * 1992-09-25 1994-04-26 Schering Corporation Diindolo compounds and pharmaceutical compositions containing them

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725582B2 (en) * 1996-06-13 2000-10-12 Eli Lilly And Company Therapeutic treatment for cardiovascular diseases

Also Published As

Publication number Publication date
EP0820446A4 (en) 2001-03-28
US5559228A (en) 1996-09-24
EP0820446A1 (en) 1998-01-28
CA2216633C (en) 2002-08-13
JPH11502857A (en) 1999-03-09
WO1996030348A1 (en) 1996-10-03
JP3014146B2 (en) 2000-02-28
CA2216633A1 (en) 1996-10-03

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