AU7152098A - Method for solution phase synthesis of oligonucleotides - Google Patents

Method for solution phase synthesis of oligonucleotides

Info

Publication number
AU7152098A
AU7152098A AU71520/98A AU7152098A AU7152098A AU 7152098 A AU7152098 A AU 7152098A AU 71520/98 A AU71520/98 A AU 71520/98A AU 7152098 A AU7152098 A AU 7152098A AU 7152098 A AU7152098 A AU 7152098A
Authority
AU
Australia
Prior art keywords
oligonucleotides
phase synthesis
solution phase
solution
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU71520/98A
Inventor
Ken Hill
Jian-Ping Huang
Danny Mcgee
Wolfgang Pieken
Alecia Settle
Randall S. Smith
Yansheng Zhai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Nexstar Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc
Publication of AU7152098A publication Critical patent/AU7152098A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
AU71520/98A 1997-04-21 1998-04-20 Method for solution phase synthesis of oligonucleotides Abandoned AU7152098A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84382097A 1997-04-21 1997-04-21
US08843820 1997-04-21
PCT/US1998/008192 WO1998047910A1 (en) 1997-04-21 1998-04-20 Method for solution phase synthesis of oligonucleotides

Publications (1)

Publication Number Publication Date
AU7152098A true AU7152098A (en) 1998-11-13

Family

ID=25291099

Family Applications (1)

Application Number Title Priority Date Filing Date
AU71520/98A Abandoned AU7152098A (en) 1997-04-21 1998-04-20 Method for solution phase synthesis of oligonucleotides

Country Status (6)

Country Link
EP (1) EP0979233A4 (en)
JP (1) JP2001520660A (en)
AU (1) AU7152098A (en)
CA (1) CA2286320A1 (en)
IL (1) IL132377A0 (en)
WO (1) WO1998047910A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
GB9825687D0 (en) * 1998-11-25 1999-01-20 Link Technologies Ltd Oligonucleotide conjugation
AU2001259285A1 (en) * 2000-05-01 2001-11-12 Proligo Llc Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
DE10041221A1 (en) * 2000-08-22 2002-03-14 Deutsches Krebsforsch Process for the preparation of water-soluble saccharide conjugates and saccharide mimetics by the Diels-Alder reaction and their use as therapeutics or diagnostics
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
US7098326B2 (en) 2002-01-23 2006-08-29 Sigma-Aldrich Co. Methods for the integrated synthesis and purification of oligonucleotides
GB0229423D0 (en) * 2002-12-18 2003-01-22 Avecia Ltd Process
EP1585755B1 (en) 2002-12-31 2015-08-05 Sigma-Aldrich Co. LLC Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
JP4945129B2 (en) * 2004-01-27 2012-06-06 株式会社キラルジェン Fluorous carrier and method for producing oligonucleotide derivative using the same
CA2614049C (en) 2005-07-06 2014-12-02 Molly S. Shoichet Method of biomolecule immobilization on polymers using click-type chemistry
EP2147009A4 (en) * 2007-05-18 2014-01-08 Dharmacon Inc Novel chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides
DE102010001987A1 (en) 2010-02-16 2011-08-18 Evonik Röhm GmbH, 64293 Functional materials with reversible crosslinking
DE102010001992A1 (en) * 2010-02-16 2011-08-18 Evonik Röhm GmbH, 64293 Functional materials with controllable viscosity
JP5705512B2 (en) * 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 Oligonucleotide synthesis using highly dispersible liquid phase support
WO2015061246A1 (en) * 2013-10-21 2015-04-30 Isis Pharmaceuticals, Inc. Method for solution phase detritylation of oligomeric compounds
KR101889893B1 (en) * 2015-06-12 2018-08-22 애니젠 주식회사 Triphenylmethane Derivatives Having Selective Solubility and Their Uses
US10947262B2 (en) * 2016-06-14 2021-03-16 Biogen Ma Inc. Hydrophobic interaction chromatography for purification of oligonucleotides
KR102399022B1 (en) * 2016-06-20 2022-05-17 세키스이 메디칼 가부시키가이샤 Novel diphenylmethane protectant
JP6322350B1 (en) * 2016-11-11 2018-05-09 積水メディカル株式会社 New trityl protecting agent
CN109963861B (en) * 2016-11-11 2021-09-28 积水医疗株式会社 Novel trityl protective agent
WO2019123994A1 (en) * 2017-12-19 2019-06-27 積水メディカル株式会社 Novel alkyl diphenylmethane protection agent
CN116710491A (en) 2021-01-05 2023-09-05 伊鲁米纳公司 Composition comprising functional groups coupled to a substrate and method of making the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU627134A1 (en) * 1977-06-16 1978-10-05 Предприятие П/Я М-5885 Tetrafurfuryloxysilane producing method
AU6893691A (en) * 1990-01-26 1991-08-21 Isp Investments Inc. Alkenyl ethers and radiation curable compositions
GB9307014D0 (en) * 1993-04-02 1993-05-26 Laporte Plc Protecting group for use in oligodeoxyribonucleotide synthesis
EP0644196B1 (en) * 1993-09-17 1997-11-05 Novartis AG TTTr as a protecting group in nucleotide synthesis
US5597909A (en) * 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
JP2000500740A (en) * 1995-10-19 2000-01-25 プロリゴ・エルエルシー Solution-phase synthesis of oligonucleotides
US5874532A (en) * 1997-01-08 1999-02-23 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides and peptides
AU747242B2 (en) * 1997-01-08 2002-05-09 Proligo Llc Bioconjugation of macromolecules

Also Published As

Publication number Publication date
CA2286320A1 (en) 1998-10-29
EP0979233A4 (en) 2001-03-21
EP0979233A1 (en) 2000-02-16
WO1998047910A1 (en) 1998-10-29
JP2001520660A (en) 2001-10-30
IL132377A0 (en) 2001-03-19

Similar Documents

Publication Publication Date Title
AU7152098A (en) Method for solution phase synthesis of oligonucleotides
AU2792499A (en) Improved methods for synthesis of oligonucleotides
EP0996627A4 (en) Method for solution phase synthesis of oligonucleotides and peptides
AU2657095A (en) Synthesis of oligonucleotides
AU8589798A (en) Selective synthesis of organodiphosphite compounds
AU1254695A (en) Process for solid phase glycopeptide synthesis
HUP0002684A3 (en) Solution phase synthesis of oligonucleotides
AU3143695A (en) Improved methods of detritylation for oligonucleotide synthesis
AU3477599A (en) Solid phase synthesis of organic compounds via phosphitylating reagents
AU4945697A (en) Solid phase synthesis of heterocyclic compounds
PL335478A1 (en) Method of obtaining pharmaceutic compounds
AU1627799A (en) Parallel solution phase synthesis of lactams
AU6506198A (en) Process for preparation of aromatic compounds
IL123869A (en) Preparation process of nitroguanidine derivatives
AU1810399A (en) Method for synthesizing
AU6304098A (en) Reaction apparatus for solid phase synthesis and method of using the same
AU7752698A (en) Method for the synthesis of anti-microbial hydroxybenzoats
HU9800074D0 (en) Process for preparation of 1-alkyl-pirazole-5-carbonic acid-esters
AU7114498A (en) Supports for solid phase synthesis
AP2000001781A0 (en) Process for preparation of azacycloalkylalkanoyl pseudotetrapeptides
AU8436298A (en) Method for producing nitroguanidine derivatives
EG21226A (en) Process for preparing of new pharmaceutical compound
AU4911696A (en) Improved methods for h-phosphonate synthesis of oligonucleotides
AU4937700A (en) Process for the preparation of supports for solid phase synthesis
AU2491899A (en) Synthesis of n-silylated cyclopentaphenanthrene compounds

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase