EP0979233A4 - Method for solution phase synthesis of oligonucleotides - Google Patents
Method for solution phase synthesis of oligonucleotidesInfo
- Publication number
- EP0979233A4 EP0979233A4 EP98918629A EP98918629A EP0979233A4 EP 0979233 A4 EP0979233 A4 EP 0979233A4 EP 98918629 A EP98918629 A EP 98918629A EP 98918629 A EP98918629 A EP 98918629A EP 0979233 A4 EP0979233 A4 EP 0979233A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- oligonucleotides
- phase synthesis
- solution phase
- solution
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84382097A | 1997-04-21 | 1997-04-21 | |
US843820 | 1997-04-21 | ||
PCT/US1998/008192 WO1998047910A1 (en) | 1997-04-21 | 1998-04-20 | Method for solution phase synthesis of oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0979233A1 EP0979233A1 (en) | 2000-02-16 |
EP0979233A4 true EP0979233A4 (en) | 2001-03-21 |
Family
ID=25291099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98918629A Withdrawn EP0979233A4 (en) | 1997-04-21 | 1998-04-20 | Method for solution phase synthesis of oligonucleotides |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0979233A4 (en) |
JP (1) | JP2001520660A (en) |
AU (1) | AU7152098A (en) |
CA (1) | CA2286320A1 (en) |
IL (1) | IL132377A0 (en) |
WO (1) | WO1998047910A1 (en) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
GB9825687D0 (en) * | 1998-11-25 | 1999-01-20 | Link Technologies Ltd | Oligonucleotide conjugation |
EP1287404A4 (en) * | 2000-05-01 | 2003-10-15 | Proligo Llc | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
DE10041221A1 (en) | 2000-08-22 | 2002-03-14 | Deutsches Krebsforsch | Process for the preparation of water-soluble saccharide conjugates and saccharide mimetics by the Diels-Alder reaction and their use as therapeutics or diagnostics |
US7172905B2 (en) | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
US7098326B2 (en) | 2002-01-23 | 2006-08-29 | Sigma-Aldrich Co. | Methods for the integrated synthesis and purification of oligonucleotides |
GB0229423D0 (en) * | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
AU2002361255A1 (en) | 2002-12-31 | 2004-07-22 | Proligo Llc | Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support |
WO2005070859A1 (en) * | 2004-01-27 | 2005-08-04 | Takeshi Wada | Fluorous supports and processes for production of oligonucleotide derivatives with the same |
US9290617B2 (en) | 2005-07-06 | 2016-03-22 | Molly S. Shoichet | Method of biomolecule immobilization on polymers using click-type chemistry |
US8759508B2 (en) | 2007-05-18 | 2014-06-24 | Ge Healthcare Dharmacon, Inc. | Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides |
DE102010001987A1 (en) | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Functional materials with reversible crosslinking |
DE102010001992A1 (en) * | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Functional materials with controllable viscosity |
JP5705512B2 (en) * | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | Oligonucleotide synthesis using highly dispersible liquid phase support |
US9758546B2 (en) | 2013-10-21 | 2017-09-12 | Ionis Pharmaceuticals, Inc. | Method for solution phase detritylation of oligomeric compounds |
KR101889893B1 (en) * | 2015-06-12 | 2018-08-22 | 애니젠 주식회사 | Triphenylmethane Derivatives Having Selective Solubility and Their Uses |
KR102461234B1 (en) * | 2016-06-14 | 2022-10-28 | 바이오젠 엠에이 인코포레이티드 | Hydrophobic Interaction Chromatography for Purification of Oligonucleotides |
ES2895120T3 (en) * | 2016-06-20 | 2022-02-17 | Sekisui Medical Co Ltd | New diphenylmethane protective agent |
EP3539968B1 (en) * | 2016-11-11 | 2021-07-14 | Sekisui Medical Co., Ltd. | Novel trityl protecting agent |
JP6322350B1 (en) * | 2016-11-11 | 2018-05-09 | 積水メディカル株式会社 | New trityl protecting agent |
KR20200100048A (en) * | 2017-12-19 | 2020-08-25 | 세키스이 메디칼 가부시키가이샤 | New alkyldiphenylmethane protective agent |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU627134A1 (en) * | 1977-06-16 | 1978-10-05 | Предприятие П/Я М-5885 | Tetrafurfuryloxysilane producing method |
WO1991011467A1 (en) * | 1990-01-26 | 1991-08-08 | Isp Investments Inc. | Alkenyl ethers and radiation curable compositions |
WO1994022802A1 (en) * | 1993-04-02 | 1994-10-13 | Laporte Plc | Protecting group for use in oligodeoxyribonucleotide synthesis |
EP0644196A1 (en) * | 1993-09-17 | 1995-03-22 | Ciba-Geigy Ag | TTTr as a protecting group in nucleotide synthesis |
WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998030575A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5597909A (en) * | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
US5580731A (en) * | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
-
1998
- 1998-04-20 IL IL13237798A patent/IL132377A0/en unknown
- 1998-04-20 AU AU71520/98A patent/AU7152098A/en not_active Abandoned
- 1998-04-20 EP EP98918629A patent/EP0979233A4/en not_active Withdrawn
- 1998-04-20 JP JP54450398A patent/JP2001520660A/en active Pending
- 1998-04-20 WO PCT/US1998/008192 patent/WO1998047910A1/en not_active Application Discontinuation
- 1998-04-20 CA CA002286320A patent/CA2286320A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU627134A1 (en) * | 1977-06-16 | 1978-10-05 | Предприятие П/Я М-5885 | Tetrafurfuryloxysilane producing method |
WO1991011467A1 (en) * | 1990-01-26 | 1991-08-08 | Isp Investments Inc. | Alkenyl ethers and radiation curable compositions |
WO1994022802A1 (en) * | 1993-04-02 | 1994-10-13 | Laporte Plc | Protecting group for use in oligodeoxyribonucleotide synthesis |
EP0644196A1 (en) * | 1993-09-17 | 1995-03-22 | Ciba-Geigy Ag | TTTr as a protecting group in nucleotide synthesis |
WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998030575A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
Non-Patent Citations (4)
Title |
---|
BATTEN, R.J. ET AL.: "Mew surface-coating materials: electron-beam curing of some silicone-containing acrylates", POLYMER, vol. 33, 1992, pages 3037 - 43, XP000941887 * |
CHEMICAL ABSTRACTS, vol. 89, no. 25, 1978, Columbus, Ohio, US; abstract no. 215211, MUKHAMADALIEV, N. ET AL.: "Tetrafurfuryloxysilane" page 577; column l; XP002157922 * |
H. SELIGER: "Scale-up of oligonucleotide synthesis in: Protocols for oligonucleotides and analogs (Editior: S. Agrawal)", METHODS IN MOLECULAR BIOLOGY, vol. 20, 1993, pages 391 - 403, XP002157921 * |
See also references of WO9847910A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU7152098A (en) | 1998-11-13 |
WO1998047910A1 (en) | 1998-10-29 |
JP2001520660A (en) | 2001-10-30 |
CA2286320A1 (en) | 1998-10-29 |
IL132377A0 (en) | 2001-03-19 |
EP0979233A1 (en) | 2000-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19991118 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: PROLIGO L.L.C. |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07H 19/00 A, 7C 07H 21/00 B, 7C 07H 21/02 B, 7C 07H 21/04 B, 7C 07H 19/10 B, 7C 07H 19/06 B, 7C 07H 19/16 B, 7C 07C 43/215 B, 7C 07C 43/225 B, 7C 07C 43/23 B, 7C 07F 7/02 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20010206 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
17Q | First examination report despatched |
Effective date: 20030110 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20030429 |