EP1287404A4 - Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method - Google Patents

Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Info

Publication number
EP1287404A4
EP1287404A4 EP01932784A EP01932784A EP1287404A4 EP 1287404 A4 EP1287404 A4 EP 1287404A4 EP 01932784 A EP01932784 A EP 01932784A EP 01932784 A EP01932784 A EP 01932784A EP 1287404 A4 EP1287404 A4 EP 1287404A4
Authority
EP
European Patent Office
Prior art keywords
method
cycloaddition
bioconjugation
immobilizing oligonucleotides
oligonucleotides employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01932784A
Other languages
German (de)
French (fr)
Other versions
EP1287404A1 (en
Inventor
Wolfgang Pieken
Andreas Wolter
David P Sebesta
Michael Leuck
Hallie A Latham-Timmons
John Pilon
Gregory M Husar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proligo LLC
Original Assignee
Proligo LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US20156100P priority Critical
Priority to US201561P priority
Priority to US26502001P priority
Priority to US265020P priority
Application filed by Proligo LLC filed Critical Proligo LLC
Priority to PCT/US2001/013956 priority patent/WO2001084234A1/en
Publication of EP1287404A1 publication Critical patent/EP1287404A1/en
Publication of EP1287404A4 publication Critical patent/EP1287404A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/06Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/10Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with one amino group and at least two hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/22Amides of acids of phosphorus
    • C07F9/24Esteramides
    • C07F9/2404Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2408Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B50/00Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
EP01932784A 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method Withdrawn EP1287404A4 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US20156100P true 2000-05-01 2000-05-01
US201561P 2000-05-01
US26502001P true 2001-01-30 2001-01-30
US265020P 2001-01-30
PCT/US2001/013956 WO2001084234A1 (en) 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Publications (2)

Publication Number Publication Date
EP1287404A1 EP1287404A1 (en) 2003-03-05
EP1287404A4 true EP1287404A4 (en) 2003-10-15

Family

ID=26896865

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01932784A Withdrawn EP1287404A4 (en) 2000-05-01 2001-05-01 Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method

Country Status (4)

Country Link
EP (1) EP1287404A4 (en)
JP (1) JP2003535317A (en)
AU (1) AU5928501A (en)
WO (1) WO2001084234A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US6664061B2 (en) 1999-06-25 2003-12-16 Amersham Biosciences Ab Use and evaluation of a [2+2] photoaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
EP1307414A2 (en) * 2000-08-09 2003-05-07 Amersham Biosciences AB The use and evaluation of a 2+2] photocycloaddition in immobilization of oligonucleotides on a three-dimensional hydrogel matrix
AU2003210629A1 (en) 2002-01-23 2003-09-02 Proligo, Llc Methods for the integrated synthesis and purification of oligonucleotides
WO2004058794A1 (en) * 2002-12-31 2004-07-15 Proligo Llc Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
US7790835B2 (en) 2003-12-03 2010-09-07 Nektar Therapeutics Method of preparing maleimide functionalized polymers
US8758688B2 (en) 2003-12-22 2014-06-24 Imec Microelectronic structures for patterned deposition of molecules onto surfaces
WO2005085857A1 (en) * 2004-03-05 2005-09-15 Nisshinbo Industries, Inc. Immobilized biomolecule and method of detecting substance capable of interacting with biomolecule
JP4581571B2 (en) * 2004-09-06 2010-11-17 富士ゼロックス株式会社 Quantitative method of measuring the maleimidyl group of the particles
CA2614987C (en) 2005-07-19 2013-10-08 Nektar Therapeutics Al, Corporation Method for preparing polymer maleimides
GB0619182D0 (en) * 2006-09-29 2006-11-08 Leuven K U Res & Dev Oligonucleotide arrays
EP2368875B1 (en) * 2008-12-02 2014-09-03 Wako Pure Chemical Industries, Ltd. Photobase generator
JP2015518722A (en) * 2012-05-21 2015-07-06 アジレント・テクノロジーズ・インクAgilent Technologies, Inc. Retro Diels Alder reaction as a cleavable linker in DNA / RNA applications
JP5986872B2 (en) * 2012-10-05 2016-09-06 公益財団法人微生物化学研究会 Compound, method for producing compound, method for producing acetate derivative, method for producing atorvastatin, and method for recovering asymmetric ligand
MX363806B (en) 2013-07-01 2019-04-03 Illumina Inc Catalyst-free surface functionalization and polymer grafting.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030578A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
WO1998047910A1 (en) * 1997-04-21 1998-10-29 Proligo Llc Method for solution phase synthesis of oligonucleotides
US6171797B1 (en) * 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0680623A4 (en) * 1993-01-21 1996-07-24 Oregon State Chemical functionalization of surfaces.
WO1998030575A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Bioconjugation of macromolecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030578A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
WO1998047910A1 (en) * 1997-04-21 1998-10-29 Proligo Llc Method for solution phase synthesis of oligonucleotides
US6171797B1 (en) * 1999-10-20 2001-01-09 Agilent Technologies Inc. Methods of making polymeric arrays

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO0184234A1 *

Also Published As

Publication number Publication date
JP2003535317A (en) 2003-11-25
AU5928501A (en) 2001-11-12
EP1287404A1 (en) 2003-03-05
WO2001084234A1 (en) 2001-11-08

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Legal Events

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RIC1 Classification (correction)

Ipc: 7C 07C 215/10 B

Ipc: 7C 07H 19/04 B

Ipc: 7C 07B 61/00 B

Ipc: 7C 07C 271/16 B

Ipc: 7C 07H 19/00 A

Ipc: 7C 07F 9/24 B

Ipc: 7C 07F 7/18 B

Ipc: 7C 07H 21/00 B

Ipc: 7C 07D 207/46 B

A4 Despatch of supplementary search report

Effective date: 20030827

17Q First examination report

Effective date: 20040114

18D Deemed to be withdrawn

Effective date: 20040525