EP0979233A4 - Verfahren zur synthese von oligonukleotiden in lösung - Google Patents

Verfahren zur synthese von oligonukleotiden in lösung

Info

Publication number
EP0979233A4
EP0979233A4 EP98918629A EP98918629A EP0979233A4 EP 0979233 A4 EP0979233 A4 EP 0979233A4 EP 98918629 A EP98918629 A EP 98918629A EP 98918629 A EP98918629 A EP 98918629A EP 0979233 A4 EP0979233 A4 EP 0979233A4
Authority
EP
European Patent Office
Prior art keywords
oligonucleotides
phase synthesis
solution phase
solution
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP98918629A
Other languages
English (en)
French (fr)
Other versions
EP0979233A1 (de
Inventor
Wolfgang Pieken
Danny Mcgee
Alecia Settle
Yansheng Zhai
Jianping Huang
Ken Hill
Randall S Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Proligo LLC
Original Assignee
Proligo LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proligo LLC filed Critical Proligo LLC
Publication of EP0979233A1 publication Critical patent/EP0979233A1/de
Publication of EP0979233A4 publication Critical patent/EP0979233A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
EP98918629A 1997-04-21 1998-04-20 Verfahren zur synthese von oligonukleotiden in lösung Withdrawn EP0979233A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84382097A 1997-04-21 1997-04-21
US843820 1997-04-21
PCT/US1998/008192 WO1998047910A1 (en) 1997-04-21 1998-04-20 Method for solution phase synthesis of oligonucleotides

Publications (2)

Publication Number Publication Date
EP0979233A1 EP0979233A1 (de) 2000-02-16
EP0979233A4 true EP0979233A4 (de) 2001-03-21

Family

ID=25291099

Family Applications (1)

Application Number Title Priority Date Filing Date
EP98918629A Withdrawn EP0979233A4 (de) 1997-04-21 1998-04-20 Verfahren zur synthese von oligonukleotiden in lösung

Country Status (6)

Country Link
EP (1) EP0979233A4 (de)
JP (1) JP2001520660A (de)
AU (1) AU7152098A (de)
CA (1) CA2286320A1 (de)
IL (1) IL132377A0 (de)
WO (1) WO1998047910A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7427678B2 (en) 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
GB9825687D0 (en) * 1998-11-25 1999-01-20 Link Technologies Ltd Oligonucleotide conjugation
EP1287404A4 (de) * 2000-05-01 2003-10-15 Proligo Llc Verfahren zur immobilisierung von oligonukleotiden, welches das cycloaddition-bikonjugierungs-verfahren anwendet
DE10041221A1 (de) 2000-08-22 2002-03-14 Deutsches Krebsforsch Verfahren zur Herstellung von wasserlöslichen Saccharidkonjugaten und Saccharidmimetika durch Diels-Alder-Reaktion und ihre Verwendung als Therapeutika oder Diagnostika
US7172905B2 (en) 2001-08-07 2007-02-06 The University Of Chicago Polypeptide immobilization
US7098326B2 (en) 2002-01-23 2006-08-29 Sigma-Aldrich Co. Methods for the integrated synthesis and purification of oligonucleotides
GB0229423D0 (en) 2002-12-18 2003-01-22 Avecia Ltd Process
AU2002361255A1 (en) 2002-12-31 2004-07-22 Proligo Llc Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support
WO2005070859A1 (ja) * 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
US9290617B2 (en) 2005-07-06 2016-03-22 Molly S. Shoichet Method of biomolecule immobilization on polymers using click-type chemistry
EP2147009A4 (de) 2007-05-18 2014-01-08 Dharmacon Inc Neuartige chromophore silylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden
DE102010001987A1 (de) * 2010-02-16 2011-08-18 Evonik Röhm GmbH, 64293 Funktionsmaterialien mit reversibler Vernetzung
DE102010001992A1 (de) 2010-02-16 2011-08-18 Evonik Röhm GmbH, 64293 Funktionsmaterialien mit steuerbarer Viskosität
JP5705512B2 (ja) * 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
US9758546B2 (en) 2013-10-21 2017-09-12 Ionis Pharmaceuticals, Inc. Method for solution phase detritylation of oligomeric compounds
KR101889893B1 (ko) * 2015-06-12 2018-08-22 애니젠 주식회사 선별적 용해도를 갖는 트리페닐메탄 유도체 및 그의 용도
AU2017284202B2 (en) * 2016-06-14 2021-11-04 Biogen Ma Inc. Hydrophobic interaction chromatography for purification of oligonucleotides
EP3473632B1 (de) * 2016-06-20 2021-10-06 Sekisui Medical Co., Ltd. Neuartiges diphenylmethanschutzmittel
JP6322350B1 (ja) * 2016-11-11 2018-05-09 積水メディカル株式会社 新規トリチル保護剤
CN109963861B (zh) * 2016-11-11 2021-09-28 积水医疗株式会社 新型三苯甲基保护剂
CN111491941B (zh) * 2017-12-19 2023-08-08 积水医疗株式会社 新型烷基二苯甲烷保护剂

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU627134A1 (ru) * 1977-06-16 1978-10-05 Предприятие П/Я М-5885 Способ получени тетрафурфурилоксисилана
WO1991011467A1 (en) * 1990-01-26 1991-08-08 Isp Investments Inc. Alkenyl ethers and radiation curable compositions
WO1994022802A1 (en) * 1993-04-02 1994-10-13 Laporte Plc Protecting group for use in oligodeoxyribonucleotide synthesis
EP0644196A1 (de) * 1993-09-17 1995-03-22 Ciba-Geigy Ag TTTr als Schutzgruppe in der Nukleotidsynthese
WO1997014706A1 (en) * 1995-10-19 1997-04-24 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides
WO1998030578A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
WO1998030575A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Bioconjugation of macromolecules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
US5597909A (en) * 1994-08-25 1997-01-28 Chiron Corporation Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU627134A1 (ru) * 1977-06-16 1978-10-05 Предприятие П/Я М-5885 Способ получени тетрафурфурилоксисилана
WO1991011467A1 (en) * 1990-01-26 1991-08-08 Isp Investments Inc. Alkenyl ethers and radiation curable compositions
WO1994022802A1 (en) * 1993-04-02 1994-10-13 Laporte Plc Protecting group for use in oligodeoxyribonucleotide synthesis
EP0644196A1 (de) * 1993-09-17 1995-03-22 Ciba-Geigy Ag TTTr als Schutzgruppe in der Nukleotidsynthese
WO1997014706A1 (en) * 1995-10-19 1997-04-24 Nexstar Pharmaceuticals, Inc. Method for solution phase synthesis of oligonucleotides
WO1998030578A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Method for solution phase synthesis of oligonucleotides and peptides
WO1998030575A1 (en) * 1997-01-08 1998-07-16 Proligo Llc Bioconjugation of macromolecules

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BATTEN, R.J. ET AL.: "Mew surface-coating materials: electron-beam curing of some silicone-containing acrylates", POLYMER, vol. 33, 1992, pages 3037 - 43, XP000941887 *
CHEMICAL ABSTRACTS, vol. 89, no. 25, 1978, Columbus, Ohio, US; abstract no. 215211, MUKHAMADALIEV, N. ET AL.: "Tetrafurfuryloxysilane" page 577; column l; XP002157922 *
H. SELIGER: "Scale-up of oligonucleotide synthesis in: Protocols for oligonucleotides and analogs (Editior: S. Agrawal)", METHODS IN MOLECULAR BIOLOGY, vol. 20, 1993, pages 391 - 403, XP002157921 *
See also references of WO9847910A1 *

Also Published As

Publication number Publication date
AU7152098A (en) 1998-11-13
JP2001520660A (ja) 2001-10-30
WO1998047910A1 (en) 1998-10-29
IL132377A0 (en) 2001-03-19
CA2286320A1 (en) 1998-10-29
EP0979233A1 (de) 2000-02-16

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