EP0979233A4 - Verfahren zur synthese von oligonukleotiden in lösung - Google Patents
Verfahren zur synthese von oligonukleotiden in lösungInfo
- Publication number
- EP0979233A4 EP0979233A4 EP98918629A EP98918629A EP0979233A4 EP 0979233 A4 EP0979233 A4 EP 0979233A4 EP 98918629 A EP98918629 A EP 98918629A EP 98918629 A EP98918629 A EP 98918629A EP 0979233 A4 EP0979233 A4 EP 0979233A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- oligonucleotides
- phase synthesis
- solution phase
- solution
- synthesis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84382097A | 1997-04-21 | 1997-04-21 | |
US843820 | 1997-04-21 | ||
PCT/US1998/008192 WO1998047910A1 (en) | 1997-04-21 | 1998-04-20 | Method for solution phase synthesis of oligonucleotides |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0979233A1 EP0979233A1 (de) | 2000-02-16 |
EP0979233A4 true EP0979233A4 (de) | 2001-03-21 |
Family
ID=25291099
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98918629A Withdrawn EP0979233A4 (de) | 1997-04-21 | 1998-04-20 | Verfahren zur synthese von oligonukleotiden in lösung |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0979233A4 (de) |
JP (1) | JP2001520660A (de) |
AU (1) | AU7152098A (de) |
CA (1) | CA2286320A1 (de) |
IL (1) | IL132377A0 (de) |
WO (1) | WO1998047910A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7427678B2 (en) | 1998-01-08 | 2008-09-23 | Sigma-Aldrich Co. | Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method |
GB9825687D0 (en) * | 1998-11-25 | 1999-01-20 | Link Technologies Ltd | Oligonucleotide conjugation |
EP1287404A4 (de) * | 2000-05-01 | 2003-10-15 | Proligo Llc | Verfahren zur immobilisierung von oligonukleotiden, welches das cycloaddition-bikonjugierungs-verfahren anwendet |
DE10041221A1 (de) | 2000-08-22 | 2002-03-14 | Deutsches Krebsforsch | Verfahren zur Herstellung von wasserlöslichen Saccharidkonjugaten und Saccharidmimetika durch Diels-Alder-Reaktion und ihre Verwendung als Therapeutika oder Diagnostika |
US7172905B2 (en) | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
US7098326B2 (en) | 2002-01-23 | 2006-08-29 | Sigma-Aldrich Co. | Methods for the integrated synthesis and purification of oligonucleotides |
GB0229423D0 (en) | 2002-12-18 | 2003-01-22 | Avecia Ltd | Process |
AU2002361255A1 (en) | 2002-12-31 | 2004-07-22 | Proligo Llc | Methods and compositions for the tandem synthesis of two or more oligonuleotides on the same solid support |
WO2005070859A1 (ja) * | 2004-01-27 | 2005-08-04 | Takeshi Wada | フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法 |
US9290617B2 (en) | 2005-07-06 | 2016-03-22 | Molly S. Shoichet | Method of biomolecule immobilization on polymers using click-type chemistry |
EP2147009A4 (de) | 2007-05-18 | 2014-01-08 | Dharmacon Inc | Neuartige chromophore silylschutzgruppen und ihre verwendung in der chemischen synthese von oligonukleotiden |
DE102010001987A1 (de) * | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Funktionsmaterialien mit reversibler Vernetzung |
DE102010001992A1 (de) | 2010-02-16 | 2011-08-18 | Evonik Röhm GmbH, 64293 | Funktionsmaterialien mit steuerbarer Viskosität |
JP5705512B2 (ja) * | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
US9758546B2 (en) | 2013-10-21 | 2017-09-12 | Ionis Pharmaceuticals, Inc. | Method for solution phase detritylation of oligomeric compounds |
KR101889893B1 (ko) * | 2015-06-12 | 2018-08-22 | 애니젠 주식회사 | 선별적 용해도를 갖는 트리페닐메탄 유도체 및 그의 용도 |
AU2017284202B2 (en) * | 2016-06-14 | 2021-11-04 | Biogen Ma Inc. | Hydrophobic interaction chromatography for purification of oligonucleotides |
EP3473632B1 (de) * | 2016-06-20 | 2021-10-06 | Sekisui Medical Co., Ltd. | Neuartiges diphenylmethanschutzmittel |
JP6322350B1 (ja) * | 2016-11-11 | 2018-05-09 | 積水メディカル株式会社 | 新規トリチル保護剤 |
CN109963861B (zh) * | 2016-11-11 | 2021-09-28 | 积水医疗株式会社 | 新型三苯甲基保护剂 |
CN111491941B (zh) * | 2017-12-19 | 2023-08-08 | 积水医疗株式会社 | 新型烷基二苯甲烷保护剂 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU627134A1 (ru) * | 1977-06-16 | 1978-10-05 | Предприятие П/Я М-5885 | Способ получени тетрафурфурилоксисилана |
WO1991011467A1 (en) * | 1990-01-26 | 1991-08-08 | Isp Investments Inc. | Alkenyl ethers and radiation curable compositions |
WO1994022802A1 (en) * | 1993-04-02 | 1994-10-13 | Laporte Plc | Protecting group for use in oligodeoxyribonucleotide synthesis |
EP0644196A1 (de) * | 1993-09-17 | 1995-03-22 | Ciba-Geigy Ag | TTTr als Schutzgruppe in der Nukleotidsynthese |
WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998030575A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580731A (en) * | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
US5597909A (en) * | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
-
1998
- 1998-04-20 EP EP98918629A patent/EP0979233A4/de not_active Withdrawn
- 1998-04-20 WO PCT/US1998/008192 patent/WO1998047910A1/en not_active Application Discontinuation
- 1998-04-20 IL IL13237798A patent/IL132377A0/xx unknown
- 1998-04-20 JP JP54450398A patent/JP2001520660A/ja active Pending
- 1998-04-20 AU AU71520/98A patent/AU7152098A/en not_active Abandoned
- 1998-04-20 CA CA002286320A patent/CA2286320A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU627134A1 (ru) * | 1977-06-16 | 1978-10-05 | Предприятие П/Я М-5885 | Способ получени тетрафурфурилоксисилана |
WO1991011467A1 (en) * | 1990-01-26 | 1991-08-08 | Isp Investments Inc. | Alkenyl ethers and radiation curable compositions |
WO1994022802A1 (en) * | 1993-04-02 | 1994-10-13 | Laporte Plc | Protecting group for use in oligodeoxyribonucleotide synthesis |
EP0644196A1 (de) * | 1993-09-17 | 1995-03-22 | Ciba-Geigy Ag | TTTr als Schutzgruppe in der Nukleotidsynthese |
WO1997014706A1 (en) * | 1995-10-19 | 1997-04-24 | Nexstar Pharmaceuticals, Inc. | Method for solution phase synthesis of oligonucleotides |
WO1998030578A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Method for solution phase synthesis of oligonucleotides and peptides |
WO1998030575A1 (en) * | 1997-01-08 | 1998-07-16 | Proligo Llc | Bioconjugation of macromolecules |
Non-Patent Citations (4)
Title |
---|
BATTEN, R.J. ET AL.: "Mew surface-coating materials: electron-beam curing of some silicone-containing acrylates", POLYMER, vol. 33, 1992, pages 3037 - 43, XP000941887 * |
CHEMICAL ABSTRACTS, vol. 89, no. 25, 1978, Columbus, Ohio, US; abstract no. 215211, MUKHAMADALIEV, N. ET AL.: "Tetrafurfuryloxysilane" page 577; column l; XP002157922 * |
H. SELIGER: "Scale-up of oligonucleotide synthesis in: Protocols for oligonucleotides and analogs (Editior: S. Agrawal)", METHODS IN MOLECULAR BIOLOGY, vol. 20, 1993, pages 391 - 403, XP002157921 * |
See also references of WO9847910A1 * |
Also Published As
Publication number | Publication date |
---|---|
AU7152098A (en) | 1998-11-13 |
JP2001520660A (ja) | 2001-10-30 |
WO1998047910A1 (en) | 1998-10-29 |
IL132377A0 (en) | 2001-03-19 |
CA2286320A1 (en) | 1998-10-29 |
EP0979233A1 (de) | 2000-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19991118 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: PROLIGO L.L.C. |
|
RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07H 19/00 A, 7C 07H 21/00 B, 7C 07H 21/02 B, 7C 07H 21/04 B, 7C 07H 19/10 B, 7C 07H 19/06 B, 7C 07H 19/16 B, 7C 07C 43/215 B, 7C 07C 43/225 B, 7C 07C 43/23 B, 7C 07F 7/02 B |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20010206 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20030110 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN |
|
18W | Application withdrawn |
Effective date: 20030429 |