MXPA05000872A - Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas. - Google Patents

Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas.

Info

Publication number
MXPA05000872A
MXPA05000872A MXPA05000872A MXPA05000872A MXPA05000872A MX PA05000872 A MXPA05000872 A MX PA05000872A MX PA05000872 A MXPA05000872 A MX PA05000872A MX PA05000872 A MXPA05000872 A MX PA05000872A MX PA05000872 A MXPA05000872 A MX PA05000872A
Authority
MX
Mexico
Prior art keywords
glycoproteins
gycosyltransferases
bacterial
synthesis
fucosyltransferases
Prior art date
Application number
MXPA05000872A
Other languages
English (en)
Inventor
Daniel James Bezila
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Publication of MXPA05000872A publication Critical patent/MXPA05000872A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)

Abstract

Esta invencion proporciona acido nucleico y secuencias de acido nucleico de fucosiltransferasas de Helicobactor pylori. La invencion tambien proporciona metodos para utilizar las fucosiltransferasas para sintetizar oligosacaridos, glicoproteinas, y glicolipidos.
MXPA05000872A 2002-07-23 2003-07-23 Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas. MXPA05000872A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39815602P 2002-07-23 2002-07-23
US42489402P 2002-11-08 2002-11-08
PCT/US2003/023155 WO2004009793A2 (en) 2002-07-23 2003-07-23 Synthesis of glycoproteins using bacterial gycosyltransferases

Publications (1)

Publication Number Publication Date
MXPA05000872A true MXPA05000872A (es) 2005-04-28

Family

ID=30773066

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05000872A MXPA05000872A (es) 2002-07-23 2003-07-23 Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas.

Country Status (10)

Country Link
US (1) US7524655B2 (es)
EP (1) EP1539989B1 (es)
JP (1) JP2005533525A (es)
AT (1) ATE506450T1 (es)
AU (2) AU2003254139A1 (es)
CA (1) CA2493258C (es)
DE (1) DE60336826D1 (es)
MX (1) MXPA05000872A (es)
NZ (1) NZ538439A (es)
WO (2) WO2004009838A2 (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
BRPI0408358A (pt) 2003-03-14 2006-03-21 Neose Technologies Inc polìmeros hidrossolúveis ramificados e seus conjugados
EP2338333B1 (en) 2003-04-09 2017-09-06 ratiopharm GmbH Glycopegylation methods and proteins/peptides produced by the methods
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
WO2006127896A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated factor ix
ES2380093T3 (es) 2003-05-09 2012-05-08 Biogenerix Ag Composiciones y métodos para la preparación de mutantes de glucosilación de la hormona del crecimiento humana
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
AU2005206796B2 (en) 2004-01-08 2011-06-16 Ratiopharm Gmbh O-linked glycosylation of peptides
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
EP1799249A2 (en) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegylated interferon alpha
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化
EP2514757A3 (en) 2005-01-10 2014-03-05 ratiopharm GmbH Glycopegylated granulocyte colony stimulating factor
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006108273A1 (en) 2005-04-11 2006-10-19 National Research Council Of Canada Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87
EP1888098A2 (en) 2005-05-25 2008-02-20 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
FI20055398A0 (fi) 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US8969033B2 (en) * 2005-11-02 2015-03-03 Battelle Energy Alliance, Llc Alteration and modulation of protein activity by varying post-translational modification
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
WO2008011633A2 (en) 2006-07-21 2008-01-24 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
KR20100016160A (ko) 2007-04-03 2010-02-12 바이오제너릭스 에이지 글리코페길화 g―csf를 이용하는 치료 방법
JP5876649B2 (ja) 2007-06-12 2016-03-02 ラツィオファルム ゲーエムベーハーratiopharm GmbH ヌクレオチド糖の改良製造法
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
US9732330B2 (en) 2008-01-25 2017-08-15 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
CA2708279A1 (en) * 2008-01-25 2009-07-30 Battelle Energy Alliance, Llc Thermal and acid tolerant beta-xylosidases, genes encoding, related organisms, and methods
US8492114B2 (en) 2008-01-25 2013-07-23 Battelle Energy Alliance, Llc Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes
US8497110B2 (en) 2008-01-31 2013-07-30 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
EP2235174A4 (en) 2008-01-31 2012-05-09 Battelle Energy Alliance Llc THERMOPHILIC AND THERMOACIDOPHILIC ENZYMES AND ENZYMES FOR THE DECOMPOSITION OF A BIOPOLYMER FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND RELATED ORGANISMS AND METHODS THEREOF
US8426185B2 (en) * 2008-01-31 2013-04-23 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
US8557557B2 (en) * 2008-01-31 2013-10-15 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from Alicyclobacillus acidocaldarius and related organisms, methods
JP2011512799A (ja) * 2008-02-22 2011-04-28 バテル エナジー アライアンス,エルエルシー アリサイクロバチルス・アシドカルダリウスにおける転写制御、ならびに関連遺伝子、タンパク質、および方法
CN102105588A (zh) 2008-02-26 2011-06-22 巴特勒能源同盟有限公司 来自酸热脂环酸杆菌的嗜热的与嗜热嗜酸的糖转运蛋白的基因和酶以及相关生物、方法
WO2010051049A2 (en) * 2008-02-27 2010-05-06 Battelle Energy Alliance, Llc Thermophilic and thermoacidophilic glycosylation genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
WO2009108806A1 (en) 2008-02-27 2009-09-03 Novo Nordisk A/S Conjugated factor viii molecules
JP2011512819A (ja) 2008-02-28 2011-04-28 バテル エナジー アライアンス,エルエルシー アリサイクロバチルス・アシドカルダリウスおよび関連生物体由来の好熱性および好熱好酸性バイオポリマー分解遺伝子および酵素、方法
EP2166085A1 (en) 2008-07-16 2010-03-24 Suomen Punainen Risti Veripalvelu Divalent modified cells
US8827992B2 (en) 2010-03-26 2014-09-09 Aesculap Ag Impedance mediated control of power delivery for electrosurgery
US20110275135A1 (en) 2010-05-05 2011-11-10 Battelle Energy Alliance, Llc Genetic elements, proteins, and associated methods including application of additional genetic information to gram (+) thermoacidophiles
MY186844A (en) * 2014-07-09 2021-08-25 Cadena Bio Inc Oligosaccharide compositions and methods for producing thereof
WO2016040531A1 (en) 2014-09-09 2016-03-17 Glycosyn LLC Alpha (1,3) fucosyltransferases for use in the production of fucosylated oligosaccharides
AU2016212030B2 (en) 2015-01-26 2021-06-17 Kaleido Biosciences, Inc. Glycan therapeutics and related methods thereof
ES2755042T3 (es) 2015-01-26 2020-04-21 Cadena Bio Inc Composiciones de oligosacáridos para el uso como alimento para animales y sus métodos para producirlas
JP2018517677A (ja) 2015-04-23 2018-07-05 カレイド・バイオサイエンシズ・インコーポレイテッド グリカン治療剤及び治療方法
WO2017175239A1 (en) 2016-04-05 2017-10-12 Council Of Scientific & Industrial Research A multifunctional recombinant nucleotide dependent glycosyltransferase protein and its method of glycosylation thereof
WO2019043457A2 (en) 2017-09-04 2019-03-07 89Bio Ltd. CONJUGATES OF MUTANT PEPTIDE FGF-21 AND USES THEREOF
EP3704161A1 (en) 2017-11-03 2020-09-09 Kaleido Biosciences, Inc. Methods of producing glycan polymers

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
US5272066A (en) 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
US5595900A (en) 1990-02-14 1997-01-21 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules, and for the isolation of cloned genetic sequences that determine these structures
EP0576592B1 (en) 1991-03-18 2000-05-31 The Scripps Research Institute Oligosaccharide enzyme substrates and inhibitors: methods and compositions
NZ258525A (en) 1992-11-27 1997-05-26 Ciba Geigy Ag Proteins with glycosyltransferase activity and their recombinant production
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5409817A (en) 1993-05-04 1995-04-25 Cytel, Inc. Use of trans-sialidase and sialyltransferase for synthesis of sialylα2→3βgalactosides
US5426039A (en) 1993-09-08 1995-06-20 Bio-Rad Laboratories, Inc. Direct molecular cloning of primer extended DNA containing an alkane diol
WO1998020111A1 (en) 1996-11-08 1998-05-14 Cytel Corporation Improved expression vectors
WO1998055630A2 (en) * 1997-06-06 1998-12-10 The Governors Of The University Of Alberta Alpha-1,3-fucosyltransferase of helicobacter pylori
US6500661B1 (en) 1998-01-15 2002-12-31 Neose Technologies, Inc. Enzymatic conversion of GDP-mannose to GDP-fucose

Also Published As

Publication number Publication date
DE60336826D1 (de) 2011-06-01
NZ538439A (en) 2007-02-23
EP1539989B1 (en) 2011-04-20
WO2004009838A3 (en) 2006-04-06
US7524655B2 (en) 2009-04-28
WO2004009793A2 (en) 2004-01-29
CA2493258C (en) 2015-10-20
ATE506450T1 (de) 2011-05-15
WO2004009793A3 (en) 2004-05-13
AU2003254139A8 (en) 2004-02-09
CA2493258A1 (en) 2004-01-29
WO2004009838A2 (en) 2004-01-29
US20070148728A1 (en) 2007-06-28
AU2003256754A1 (en) 2004-02-09
AU2003254139A1 (en) 2004-02-09
EP1539989A4 (en) 2006-09-13
JP2005533525A (ja) 2005-11-10
EP1539989A2 (en) 2005-06-15

Similar Documents

Publication Publication Date Title
MXPA05000872A (es) Sintesis de glicoproteinas utilizando glicosiltransferasas bacterianas.
WO2003089618A3 (en) Transposon system and methods of use
MXPA05009682A (es) Metodos de radiofluorinacion de vectores biologicamente activos.
MY147970A (en) 2'-fluoro-2'deoxytetrahydrouridines as cytidine deaminase inhibitors
LUC00065I1 (es)
WO2003104425A3 (en) NEW STABLE ANTI-CD22 ANTIBODIES
AU2003205077A1 (en) Imaging agents and methods of imaging naaladase of psma
WO2005026184A3 (en) Synthesis and compositions of 2'-terminator nucleotides
ES2180757T3 (es) Sintesis enzimatica mejorada de oligosacaridos.
MX343752B (es) Antigenos de neisseria meningitidis y composiciones que los contienen.
EP1208085A4 (en) BENZANILIDE AS THE OPENER OF THE POTASSIUM CHANNEL
MY144524A (en) Technique to coordinate servicing of multiple network interfaces
MXPA02002901A (es) Enzimas de ruta de enfocado lisosomal.
WO2002072865A3 (en) Methods, kits and compositions of combination oligomers
WO2005069921A3 (en) H. pylori fucosyltransferases
EP1546306A4 (en) GENERATION OF DENDRITIC CELLS FROM CD34 PRECURSORS
EP1603932A4 (en) METHODS AND COMPOSITIONS FOR THE ENZYMATIC SYNTHESIS OF GANGLIOSIDES
MXPA05008360A (es) Oligonucleotidos inmunomoduladores cortos.
WO2004007664A3 (en) Nucleic acid vectors
AU2003294785A1 (en) Hair treatment compositions
ZA200604874B (en) Pharmaceutical compositions
AU2003248647A8 (en) Stereoselective synthesis of 1,2-disubstituted cycloalkyls
UA83203C2 (uk) Тіазол-(бі)циклоалкілкарбоксаніліди, засіб на їх основі та застосування для боротьби з небажаними мікроорганізмами
PL375044A1 (en) Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases
ATE408697T1 (de) Enzymatische umwandlung von gdp-mannose in gdp- fucose

Legal Events

Date Code Title Description
FA Abandonment or withdrawal