CZ305202B6 - Farmaceutický prostředek - Google Patents

Info

Publication number

CZ305202B6

CZ305202B6 CZ2003-2038A CZ20032038A CZ305202B6 CZ 305202 B6 CZ305202 B6 CZ 305202B6 CZ 20032038 A CZ20032038 A CZ 20032038A CZ 305202 B6 CZ305202 B6 CZ 305202B6

Authority

CZ

Czechia

Prior art keywords

inhibitors

hydrochloride

administered

cholesterol

combination

Prior art date

2001-01-26

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 title description 22
• 229930182558 Sterol Natural products 0.000 claims abstract description 56
• 235000003702 sterols Nutrition 0.000 claims abstract description 56
• 239000003112 inhibitor Substances 0.000 claims abstract description 55
• 150000003432 sterols Chemical class 0.000 claims abstract description 55
• 238000010521 absorption reaction Methods 0.000 claims abstract description 40
• 206010063985 Phytosterolaemia Diseases 0.000 claims abstract description 15
• 208000002227 Sitosterolemia Diseases 0.000 claims abstract description 15
• 239000003814 drug Substances 0.000 claims abstract description 11
• 241000124008 Mammalia Species 0.000 claims abstract description 8
• 150000003839 salts Chemical class 0.000 claims abstract description 7
• 238000004519 manufacturing process Methods 0.000 claims description 7
• 238000011282 treatment Methods 0.000 abstract description 16
• 238000002360 preparation method Methods 0.000 abstract description 6
• 230000002265 prevention Effects 0.000 abstract description 2
• 239000000203 mixture Substances 0.000 description 59
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• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 49
• -1 racemates Chemical class 0.000 description 28
• 239000003613 bile acid Substances 0.000 description 23
• 235000012000 cholesterol Nutrition 0.000 description 23
• 239000000243 solution Substances 0.000 description 23
• 229950005143 sitosterol Drugs 0.000 description 21
• HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 20
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 20
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• 239000000126 substance Substances 0.000 description 19
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• 239000000306 component Substances 0.000 description 18
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• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
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• 150000002632 lipids Chemical class 0.000 description 9
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• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
• OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1